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Protein

Coiled-coil domain-containing protein 51

Gene

CCDC51

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 51
Gene namesi
Name:CCDC51
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000164051.13
HGNCiHGNC:25714 CCDC51
neXtProtiNX_Q96ER9

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Transmembranei387 – 407HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000164051
PharmGKBiPA142672167

Polymorphism and mutation databases

BioMutaiCCDC51
DMDMi152032342

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002888681 – 411Coiled-coil domain-containing protein 51Add BLAST411

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei70PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96ER9
MaxQBiQ96ER9
PaxDbiQ96ER9
PeptideAtlasiQ96ER9
PRIDEiQ96ER9
ProteomicsDBi76443
76444 [Q96ER9-2]

PTM databases

iPTMnetiQ96ER9
PhosphoSitePlusiQ96ER9
SwissPalmiQ96ER9

Expressioni

Gene expression databases

BgeeiENSG00000164051
CleanExiHS_CCDC51
ExpressionAtlasiQ96ER9 baseline and differential
GenevisibleiQ96ER9 HS

Organism-specific databases

HPAiHPA010980
HPA011408

Interactioni

Protein-protein interaction databases

BioGridi122831, 47 interactors
IntActiQ96ER9, 4 interactors

Structurei

3D structure databases

ProteinModelPortaliQ96ER9
SMRiQ96ER9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili111 – 173Sequence analysisAdd BLAST63

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHSU Eukaryota
ENOG4111WD5 LUCA
GeneTreeiENSGT00390000001709
HOGENOMiHOG000111419
HOVERGENiHBG100936
InParanoidiQ96ER9
OMAiYVNRVRL
OrthoDBiEOG091G0CXE
PhylomeDBiQ96ER9
TreeFamiTF318449

Family and domain databases

InterProiView protein in InterPro
IPR037660 CCDC51
PANTHERiPTHR28624 PTHR28624, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96ER9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMGRSPGFAM QHIVGVPHVL VRRGLLGRDL FMTRTLCSPG PSQPGEKRPE
60 70 80 90 100
EVALGLHHRL PALGRALGHS IQQRATSTAK TWWDRYEEFV GLNEVREAQG
110 120 130 140 150
KVTEAEKVFM VARGLVREAR EDLEVHQAKL KEVRDRLDRV SREDSQYLEL
160 170 180 190 200
ATLEHRMLQE EKRLRTAYLR AEDSEREKFS LFSAAVRESH EKERTRAERT
210 220 230 240 250
KNWSLIGSVL GALIGVAGST YVNRVRLQEL KALLLEAQKG PVSLQEAIRE
260 270 280 290 300
QASSYSRQQR DLHNLMVDLR GLVHAAGPGQ DSGSQAGSPP TRDRDVDVLS
310 320 330 340 350
AALKEQLSHS RQVHSCLEGL REQLDGLEKT CSQMAGVVQL VKSAAHPGLV
360 370 380 390 400
EPADGAMPSF LLEQGSMILA LSDTEQRLEA QVNRNTIYST LVTCVTFVAT
410
LPVLYMLFKA S
Length:411
Mass (Da):45,811
Last modified:May 29, 2007 - v2
Checksum:iD99F1D8AF9EB8C04
GO
Isoform 2 (identifier: Q96ER9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-109: Missing.

Note: No experimental confirmation available.
Show »
Length:302
Mass (Da):33,657
Checksum:i12C2189386744A44
GO

Sequence cautioni

The sequence AAH11993 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032515360F → S. Corresponds to variant dbSNP:rs7618609Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0258001 – 109Missing in isoform 2. 1 PublicationAdd BLAST109

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022498 mRNA Translation: BAB14060.1
BC011993 mRNA Translation: AAH11993.1 Different initiation.
CCDSiCCDS2766.2 [Q96ER9-1]
CCDS58830.1 [Q96ER9-2]
RefSeqiNP_001243893.1, NM_001256964.1 [Q96ER9-1]
NP_001243894.1, NM_001256965.2 [Q96ER9-2]
NP_001243895.1, NM_001256966.2 [Q96ER9-2]
NP_001243896.1, NM_001256967.2 [Q96ER9-2]
NP_001243897.1, NM_001256968.2 [Q96ER9-2]
NP_001243898.1, NM_001256969.2 [Q96ER9-2]
NP_078937.3, NM_024661.4 [Q96ER9-1]
UniGeneiHs.187657
Hs.740720

Genome annotation databases

EnsembliENST00000395694; ENSP00000379047; ENSG00000164051 [Q96ER9-1]
ENST00000412398; ENSP00000401194; ENSG00000164051 [Q96ER9-2]
ENST00000442740; ENSP00000392898; ENSG00000164051 [Q96ER9-2]
ENST00000447018; ENSP00000412300; ENSG00000164051 [Q96ER9-2]
GeneIDi79714
KEGGihsa:79714
UCSCiuc003ctd.3 human [Q96ER9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCCD51_HUMAN
AccessioniPrimary (citable) accession number: Q96ER9
Secondary accession number(s): Q9HA01
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: June 20, 2018
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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