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Protein

Protein SAAL1

Gene

SAAL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in promoting the proliferation of synovial fibroblasts in response to proinflammatory stimuli.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SAAL1
Alternative name(s):
Synoviocyte proliferation-associated in collagen-induced arthritis protein 11 Publication
Short name:
SPACIA1
Gene namesi
Name:SAAL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000166788.9
HGNCiHGNC:25158 SAAL1
neXtProtiNX_Q96ER3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi113174
OpenTargetsiENSG00000166788
PharmGKBiPA142670959

Polymorphism and mutation databases

BioMutaiSAAL1
DMDMi209572677

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002795401 – 474Protein SAAL1Add BLAST474

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6PhosphoserineBy similarity1
Modified residuei387PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96ER3
MaxQBiQ96ER3
PaxDbiQ96ER3
PeptideAtlasiQ96ER3
PRIDEiQ96ER3
ProteomicsDBi76442

PTM databases

iPTMnetiQ96ER3
PhosphoSitePlusiQ96ER3

Expressioni

Tissue specificityi

Highly expressed in testis and ovary, and to a lesser extent in the lung, spleen and the heart (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000166788 Expressed in 147 organ(s), highest expression level in small intestine Peyer's patch
CleanExiHS_SAAL1
ExpressionAtlasiQ96ER3 baseline and differential
GenevisibleiQ96ER3 HS

Organism-specific databases

HPAiHPA039003
HPA039004

Interactioni

Protein-protein interaction databases

BioGridi125228, 51 interactors
IntActiQ96ER3, 10 interactors
STRINGi9606.ENSP00000432487

Structurei

3D structure databases

ProteinModelPortaliQ96ER3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SAAL1 family.Curated

Phylogenomic databases

eggNOGiENOG410IMST Eukaryota
ENOG4110KPS LUCA
GeneTreeiENSGT00510000048056
HOGENOMiHOG000154242
HOVERGENiHBG061166
InParanoidiQ96ER3
PhylomeDBiQ96ER3
TreeFamiTF323873

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
SUPFAMiSSF48371 SSF48371, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q96ER3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDRNPSPPPP GRDKEEEEEV AGGDCIGSTV YSKHWLFGVL SGLIQIVSPE
60 70 80 90 100
NTKSSSDDEE QLTELDEEME NEICRVWDMS MDEDVALFLQ EFNAPDIFMG
110 120 130 140 150
VLAKSKCPRL REICVGILGN MACFQEICVS ISSDKNLGQV LLHCLYDSDP
160 170 180 190 200
PTLLETSRLL LTCLSQAEVA SVWVERIQEH PAIYDSICFI MSSSTNVDLL
210 220 230 240 250
VKVGEVVDKL FDLDEKLMLE WVRNGAAQPL DQPQEESEEQ PVFRLVPCIL
260 270 280 290 300
EAAKQVRSEN PEWLDVYMHI LQLLTTVDDG IQAIVHCPDT GKDIWNLLFD
310 320 330 340 350
LVCHEFCQSD DPPIILQEQK TVLASVFSVL SAIYASQTEQ EYLKIEKVDL
360 370 380 390 400
PLIDSLIRVL QNMEQCQKKP ENSAESNTEE TKRTDLTQDD FHLKILKDIL
410 420 430 440 450
CEFLSNIFQA LTKETVAQGV KEGQLSKQKC SSAFQNLLPF YSPVVEDFIK
460 470
ILREVDKALA DDLEKNFPSL KVQT
Length:474
Mass (Da):53,558
Last modified:October 14, 2008 - v2
Checksum:iC206C80827F49681
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PRZ1E9PRZ1_HUMAN
Protein SAAL1
SAAL1
476Annotation score:
J3KND1J3KND1_HUMAN
Protein SAAL1
SAAL1 hCG_15540
473Annotation score:
H0YEK5H0YEK5_HUMAN
Protein SAAL1
SAAL1
264Annotation score:
E9PMD2E9PMD2_HUMAN
Protein SAAL1
SAAL1
353Annotation score:
E9PL53E9PL53_HUMAN
Protein SAAL1
SAAL1
209Annotation score:
H0YCN7H0YCN7_HUMAN
Protein SAAL1
SAAL1
149Annotation score:
H0YDM3H0YDM3_HUMAN
Protein SAAL1
SAAL1
133Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10P → PP in AAH12010 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053846315I → V. Corresponds to variant dbSNP:rs35525096Ensembl.1
Natural variantiVAR_053847426S → G. Corresponds to variant dbSNP:rs28930681Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC090099 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68419.1
BC012010 mRNA Translation: AAH12010.1
CCDSiCCDS31439.1
RefSeqiNP_612430.2, NM_138421.2
UniGeneiHs.591998

Genome annotation databases

EnsembliENST00000524803; ENSP00000432487; ENSG00000166788
GeneIDi113174
KEGGihsa:113174
UCSCiuc001mnq.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC090099 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68419.1
BC012010 mRNA Translation: AAH12010.1
CCDSiCCDS31439.1
RefSeqiNP_612430.2, NM_138421.2
UniGeneiHs.591998

3D structure databases

ProteinModelPortaliQ96ER3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125228, 51 interactors
IntActiQ96ER3, 10 interactors
STRINGi9606.ENSP00000432487

PTM databases

iPTMnetiQ96ER3
PhosphoSitePlusiQ96ER3

Polymorphism and mutation databases

BioMutaiSAAL1
DMDMi209572677

Proteomic databases

EPDiQ96ER3
MaxQBiQ96ER3
PaxDbiQ96ER3
PeptideAtlasiQ96ER3
PRIDEiQ96ER3
ProteomicsDBi76442

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000524803; ENSP00000432487; ENSG00000166788
GeneIDi113174
KEGGihsa:113174
UCSCiuc001mnq.4 human

Organism-specific databases

CTDi113174
DisGeNETi113174
EuPathDBiHostDB:ENSG00000166788.9
GeneCardsiSAAL1
H-InvDBiHIX0009481
HGNCiHGNC:25158 SAAL1
HPAiHPA039003
HPA039004
neXtProtiNX_Q96ER3
OpenTargetsiENSG00000166788
PharmGKBiPA142670959
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IMST Eukaryota
ENOG4110KPS LUCA
GeneTreeiENSGT00510000048056
HOGENOMiHOG000154242
HOVERGENiHBG061166
InParanoidiQ96ER3
PhylomeDBiQ96ER3
TreeFamiTF323873

Miscellaneous databases

ChiTaRSiSAAL1 human
GenomeRNAii113174
PROiPR:Q96ER3

Gene expression databases

BgeeiENSG00000166788 Expressed in 147 organ(s), highest expression level in small intestine Peyer's patch
CleanExiHS_SAAL1
ExpressionAtlasiQ96ER3 baseline and differential
GenevisibleiQ96ER3 HS

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
SUPFAMiSSF48371 SSF48371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSAAL1_HUMAN
AccessioniPrimary (citable) accession number: Q96ER3
Secondary accession number(s): A6NH05
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: October 14, 2008
Last modified: October 10, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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