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Entry version 149 (17 Jun 2020)
Sequence version 1 (01 Dec 2001)
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Protein

Small glutamine-rich tetratricopeptide repeat-containing protein beta

Gene

SGTB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Small glutamine-rich tetratricopeptide repeat-containing protein beta
Alternative name(s):
Beta-SGT
Small glutamine-rich protein with tetratricopeptide repeats 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SGTB
Synonyms:SGT2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000197860.9

Human Gene Nomenclature Database

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HGNCi
HGNC:23567 SGTB

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q96EQ0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000197860

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134957805

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96EQ0 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SGTB

Domain mapping of disease mutations (DMDM)

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DMDMi
41018109

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001063681 – 304Small glutamine-rich tetratricopeptide repeat-containing protein betaAdd BLAST304

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei131N6-acetyllysineBy similarity1
Modified residuei293PhosphoserineBy similarity1
Modified residuei295PhosphoserineCombined sources1
Modified residuei297PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96EQ0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96EQ0

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q96EQ0

MaxQB - The MaxQuant DataBase

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MaxQBi
Q96EQ0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96EQ0

PeptideAtlas

More...
PeptideAtlasi
Q96EQ0

PRoteomics IDEntifications database

More...
PRIDEi
Q96EQ0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
76440

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96EQ0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96EQ0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000197860 Expressed in endothelial cell and 199 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96EQ0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96EQ0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000197860 Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomerize.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q96EQ0
With#Exp.IntAct
ABCG4 [Q9H172]3EBI-744081,EBI-8584118
ADAT2 [Q7Z6V5]3EBI-744081,EBI-2809203
ADIPOQ [Q15848]3EBI-744081,EBI-10827839
AGR2 [O95994]6EBI-744081,EBI-712648
AGR3 [Q8TD06]8EBI-744081,EBI-3925742
ASPH - isoform 6 [Q12797-6]3EBI-744081,EBI-12092171
BTC [P35070]3EBI-744081,EBI-6590057
C1QA [P02745]3EBI-744081,EBI-1220209
C1QL4 [Q86Z23]3EBI-744081,EBI-12062109
C1QTNF5 [Q9BXJ0]3EBI-744081,EBI-19947914
C1QTNF6 [Q9BXI9]3EBI-744081,EBI-10301084
C5orf46 [Q6UWT4]3EBI-744081,EBI-11986083
CALR [P27797]3EBI-744081,EBI-1049597
CCL3L3 [P16619]3EBI-744081,EBI-12934095
CD200R1 - isoform 4 [Q8TD46-4]3EBI-744081,EBI-12824513
CD3D [P04234]3EBI-744081,EBI-3862416
CD68 [P34810]3EBI-744081,EBI-2826276
CD79B [P40259]3EBI-744081,EBI-2873732
CD99L2 [Q8TCZ2]6EBI-744081,EBI-2824782
CDH15 [P55291]3EBI-744081,EBI-10215061
CMPK1 - isoform 3 [P30085-3]3EBI-744081,EBI-23373346
COL10A1 [Q03692]3EBI-744081,EBI-2528309
COL1A2 [A0A0S2Z3K0]3EBI-744081,EBI-16431143
COL1A2 [P08123]3EBI-744081,EBI-983038
COLQ [Q9Y215]3EBI-744081,EBI-1637847
COMP [P49747]3EBI-744081,EBI-2531022
CREB3L3 [Q68CJ9]3EBI-744081,EBI-852194
CSH1 [P0DML2]3EBI-744081,EBI-13375302
CSH2 [P0DML3]3EBI-744081,EBI-12167441
CTAG1A [P78358]3EBI-744081,EBI-1188472
CYB5R1 [Q9UHQ9]3EBI-744081,EBI-953870
DEFA6 [Q01524]3EBI-744081,EBI-10222451
DEXI [O95424]3EBI-744081,EBI-724515
DMKN [Q6E0U4]3EBI-744081,EBI-7943171
ECM1 [Q16610]3EBI-744081,EBI-947964
EFEMP2 [O95967]8EBI-744081,EBI-743414
EMCN - isoform 2 [Q9ULC0-2]5EBI-744081,EBI-12164849
ERP29 [P30040]6EBI-744081,EBI-946830
ETNK1 [Q9HBU6]3EBI-744081,EBI-2834493
EVA1A [Q9H8M9]3EBI-744081,EBI-715362
FBN1 [P35555]3EBI-744081,EBI-2505934
FGF21 [Q9NSA1]3EBI-744081,EBI-3909329
FZD7 [O75084]3EBI-744081,EBI-746917
GALNT11 - isoform 2 [Q8NCW6-2]3EBI-744081,EBI-13364322
GGH [Q92820]3EBI-744081,EBI-3045534
GIP [P09681]3EBI-744081,EBI-8588553
GPX7 [Q96SL4]5EBI-744081,EBI-749411
GYPA [P02724]3EBI-744081,EBI-702665
HSP90B1 [Q96GW1]3EBI-744081,EBI-12885352
HSPA13 [P48723]5EBI-744081,EBI-750892
IL6R [P08887]3EBI-744081,EBI-299383
IL6ST [P40189]4EBI-744081,EBI-1030834
IL6ST [Q17RA0]3EBI-744081,EBI-10238517
ITPRIP [Q8IWB1]3EBI-744081,EBI-2556412
ITPRIPL1 - isoform 2 [Q6GPH6-2]3EBI-744081,EBI-12337095
KCNE5 [Q9UJ90]3EBI-744081,EBI-11981259
KRT1 [P04264]3EBI-744081,EBI-298429
LAT - isoform 2 [O43561-2]3EBI-744081,EBI-8070286
LCN2 [P80188]3EBI-744081,EBI-11911016
LHB [P01229]3EBI-744081,EBI-11659791
LMO2 - isoform 3 [P25791-3]3EBI-744081,EBI-11959475
MYDGF [Q969H8]3EBI-744081,EBI-718622
NAXD [Q8IW45]3EBI-744081,EBI-8650724
NME3 [Q13232]5EBI-744081,EBI-713684
OSMR [Q99650]3EBI-744081,EBI-2804080
PAGE3 [Q5JUK9]3EBI-744081,EBI-10244544
PDIA6 [Q15084]3EBI-744081,EBI-1043087
PGRMC1 [O00264]3EBI-744081,EBI-1045534
PODXL - isoform 2 [O00592-2]3EBI-744081,EBI-12407415
PPIB [P23284]4EBI-744081,EBI-359252
PPIC [P45877]3EBI-744081,EBI-953909
PRAP1 [Q96NZ9]3EBI-744081,EBI-2116102
PRB1 [A5D903]3EBI-744081,EBI-10173935
PRB3 [Q04118]3EBI-744081,EBI-13360404
PRR4 [Q16378]3EBI-744081,EBI-738624
PSORS1C2 [Q9UIG4]3EBI-744081,EBI-11974061
RAI2 [Q9Y5P3]5EBI-744081,EBI-746228
RCN1 [Q15293]3EBI-744081,EBI-948278
RNASE10 [Q5GAN6]3EBI-744081,EBI-12423312
RNF144A [P50876]3EBI-744081,EBI-2340657
RNF170 - isoform 5 [Q96K19-5]3EBI-744081,EBI-12055631
SDC4 [P31431]3EBI-744081,EBI-3913237
SDF2L1 [Q9HCN8]3EBI-744081,EBI-2339921
SELENOM [Q8WWX9]5EBI-744081,EBI-10277687
SERPINE1 [P05121]6EBI-744081,EBI-953978
SERPINF1 [P36955]3EBI-744081,EBI-2932733
SERPINI2 [O75830]4EBI-744081,EBI-750144
SGCA [Q16586]3EBI-744081,EBI-5663553
SGTA [O43765]3EBI-744081,EBI-347996
SHISA5 - isoform 3 [Q8N114-3]3EBI-744081,EBI-13369834
SIL1 [Q9H173]3EBI-744081,EBI-2840325
SLPI [P03973]3EBI-744081,EBI-355293
SOD3 [P08294]3EBI-744081,EBI-10195782
SPINK4 [O60575]3EBI-744081,EBI-13336697
SPP1 [P10451]3EBI-744081,EBI-723648
SRGN [P10124]3EBI-744081,EBI-744915
SYT11 [Q9BT88]3EBI-744081,EBI-751770
SYT4 [Q9H2B2]3EBI-744081,EBI-751132
TFF1 [P04155]5EBI-744081,EBI-743871
TMEM108 [Q6UXF1]3EBI-744081,EBI-7100456
TMEM123 [Q8N131]3EBI-744081,EBI-749248
TMUB1 [Q9BVT8]3EBI-744081,EBI-11425701
TNFRSF19 - isoform 2 [Q9NS68-2]3EBI-744081,EBI-12089038
TNFSF13 - isoform Gamma [O75888-3]3EBI-744081,EBI-12856452
TXNDC12 [O95881]6EBI-744081,EBI-2564581
UBL4A [P11441]4EBI-744081,EBI-356983
UPK3A [O75631]3EBI-744081,EBI-10188907
VEGFC [P49767]3EBI-744081,EBI-3405539
VWC2 [Q2TAL6]3EBI-744081,EBI-11957238
WFDC12 [Q8WWY7]3EBI-744081,EBI-11958577
ZG16 [O60844]5EBI-744081,EBI-746479
ZG16B [Q96DA0]5EBI-744081,EBI-953824
A0A1U9X8X83EBI-744081,EBI-17234977

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
120042, 90 interactors

Protein interaction database and analysis system

More...
IntActi
Q96EQ0, 192 interactors

Molecular INTeraction database

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MINTi
Q96EQ0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000370395

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96EQ0 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96EQ0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati15 – 49TPR 1Add BLAST35
Repeati85 – 118TPR 2Add BLAST34
Repeati119 – 152TPR 3Add BLAST34
Repeati153 – 186TPR 4Add BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi267 – 279Gln-richAdd BLAST13

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SGT family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0553 Eukaryota
COG0457 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158321

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_044224_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96EQ0

Identification of Orthologs from Complete Genome Data

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OMAi
LTSMNKY

Database of Orthologous Groups

More...
OrthoDBi
687493at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96EQ0

TreeFam database of animal gene trees

More...
TreeFami
TF313092

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.25.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032374 SGTA_dimer
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR001440 TPR_1
IPR019734 TPR_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16546 SGTA_dimer, 1 hit
PF00515 TPR_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00028 TPR, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q96EQ0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSIKHLVYA VIRFLREQSQ MDTYTSDEQE SLEVAIQCLE TVFKISPEDT
60 70 80 90 100
HLAVSQPLTE MFTSSFCKND VLPLSNSVPE DVGKADQLKD EGNNHMKEEN
110 120 130 140 150
YAAAVDCYTQ AIELDPNNAV YYCNRAAAQS KLGHYTDAIK DCEKAIAIDS
160 170 180 190 200
KYSKAYGRMG LALTALNKFE EAVTSYQKAL DLDPENDSYK SNLKIAEQKL
210 220 230 240 250
REVSSPTGTG LSFDMASLIN NPAFISMAAS LMQNPQVQQL MSGMMTNAIG
260 270 280 290 300
GPAAGVGGLT DLSSLIQAGQ QFAQQIQQQN PELIEQLRNH IRSRSFSSSA

EEHS
Length:304
Mass (Da):33,429
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i10819155C4E150FB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RFW1D6RFW1_HUMAN
Small glutamine-rich tetratricopept...
SGTB
195Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF368281 mRNA Translation: AAP29459.1
AK096321 mRNA Translation: BAC04761.1
BC012044 mRNA Translation: AAH12044.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS3988.1

NCBI Reference Sequences

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RefSeqi
NP_061945.1, NM_019072.2
XP_005248605.1, XM_005248548.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000381007; ENSP00000370395; ENSG00000197860

Database of genes from NCBI RefSeq genomes

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GeneIDi
54557

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:54557

UCSC genome browser

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UCSCi
uc003jud.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF368281 mRNA Translation: AAP29459.1
AK096321 mRNA Translation: BAC04761.1
BC012044 mRNA Translation: AAH12044.1
CCDSiCCDS3988.1
RefSeqiNP_061945.1, NM_019072.2
XP_005248605.1, XM_005248548.3

3D structure databases

SMRiQ96EQ0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120042, 90 interactors
IntActiQ96EQ0, 192 interactors
MINTiQ96EQ0
STRINGi9606.ENSP00000370395

PTM databases

iPTMnetiQ96EQ0
PhosphoSitePlusiQ96EQ0

Polymorphism and mutation databases

BioMutaiSGTB
DMDMi41018109

Proteomic databases

EPDiQ96EQ0
jPOSTiQ96EQ0
MassIVEiQ96EQ0
MaxQBiQ96EQ0
PaxDbiQ96EQ0
PeptideAtlasiQ96EQ0
PRIDEiQ96EQ0
ProteomicsDBi76440

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
23800 105 antibodies

The DNASU plasmid repository

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DNASUi
54557

Genome annotation databases

EnsembliENST00000381007; ENSP00000370395; ENSG00000197860
GeneIDi54557
KEGGihsa:54557
UCSCiuc003jud.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
54557
EuPathDBiHostDB:ENSG00000197860.9

GeneCards: human genes, protein and diseases

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GeneCardsi
SGTB
HGNCiHGNC:23567 SGTB
HPAiENSG00000197860 Tissue enhanced (brain)
neXtProtiNX_Q96EQ0
OpenTargetsiENSG00000197860
PharmGKBiPA134957805

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0553 Eukaryota
COG0457 LUCA
GeneTreeiENSGT00940000158321
HOGENOMiCLU_044224_0_0_1
InParanoidiQ96EQ0
OMAiLTSMNKY
OrthoDBi687493at2759
PhylomeDBiQ96EQ0
TreeFamiTF313092

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
54557 1 hit in 787 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SGTB human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
54557
PharosiQ96EQ0 Tbio

Protein Ontology

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PROi
PR:Q96EQ0
RNActiQ96EQ0 protein

Gene expression databases

BgeeiENSG00000197860 Expressed in endothelial cell and 199 other tissues
ExpressionAtlasiQ96EQ0 baseline and differential
GenevisibleiQ96EQ0 HS

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR032374 SGTA_dimer
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR001440 TPR_1
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF16546 SGTA_dimer, 1 hit
PF00515 TPR_1, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSGTB_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96EQ0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: December 1, 2001
Last modified: June 17, 2020
This is version 149 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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