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Protein

DAZ-associated protein 1

Gene

DAZAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

RNA-binding protein, which may be required during spermatogenesis.

GO - Molecular functioni

  • poly(G) binding Source: UniProtKB
  • poly(U) RNA binding Source: UniProtKB
  • RNA binding Source: UniProtKB
  • RNA stem-loop binding Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, RNA-binding
Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
DAZ-associated protein 1
Alternative name(s):
Deleted in azoospermia-associated protein 1
Gene namesi
Name:DAZAP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000071626.16
HGNCiHGNC:2683 DAZAP1
MIMi607430 gene
neXtProtiNX_Q96EP5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi26528
OpenTargetsiENSG00000071626
PharmGKBiPA27153

Polymorphism and mutation databases

DMDMi44887869

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000815651 – 407DAZ-associated protein 1Add BLAST407

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1 Publication1
Modified residuei150N6-acetyllysine1 Publication1
Modified residuei253Omega-N-methylarginineCombined sources1

Post-translational modificationi

Acetylation at Lys-150 is predominantly observed in the nuclear fraction, and may regulate nucleocytoplasmic transport.2 Publications

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

EPDiQ96EP5
MaxQBiQ96EP5
PaxDbiQ96EP5
PeptideAtlasiQ96EP5
PRIDEiQ96EP5
ProteomicsDBi76437
76438 [Q96EP5-2]

2D gel databases

REPRODUCTION-2DPAGEiIPI00165230

PTM databases

iPTMnetiQ96EP5
PhosphoSitePlusiQ96EP5
SwissPalmiQ96EP5

Expressioni

Tissue specificityi

Mainly expressed in testis. Expressed to a lower level in thymus. Weakly or not expressed in heart, liver, brain, placenta, lung, skeletal muscle, kidney and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000071626
CleanExiHS_DAZAP1
ExpressionAtlasiQ96EP5 baseline and differential
GenevisibleiQ96EP5 HS

Organism-specific databases

HPAiHPA004201
HPA004631

Interactioni

Subunit structurei

Interacts with DAZ and DAZL.1 Publication

Protein-protein interaction databases

BioGridi117730, 84 interactors
IntActiQ96EP5, 12 interactors
MINTiQ96EP5
STRINGi9606.ENSP00000233078

Structurei

Secondary structure

1407
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 12Combined sources7
Helixi23 – 31Combined sources9
Beta strandi36 – 43Combined sources8
Beta strandi45 – 47Combined sources3
Beta strandi50 – 60Combined sources11
Helixi63 – 70Combined sources8
Beta strandi72 – 75Combined sources4
Beta strandi78 – 81Combined sources4
Beta strandi114 – 119Combined sources6
Helixi126 – 133Combined sources8
Beta strandi134 – 137Combined sources4
Beta strandi139 – 144Combined sources6
Turni148 – 150Combined sources3
Beta strandi155 – 163Combined sources9
Helixi164 – 173Combined sources10
Beta strandi177 – 180Combined sources4
Beta strandi184 – 187Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DGSNMR-A110-195[»]
2DH8NMR-A1-92[»]
ProteinModelPortaliQ96EP5
SMRiQ96EP5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96EP5

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 97RRM 1PROSITE-ProRule annotationAdd BLAST88
Domaini113 – 190RRM 2PROSITE-ProRule annotationAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi222 – 385Pro-richAdd BLAST164

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4205 Eukaryota
ENOG410YA8Z LUCA
GeneTreeiENSGT00900000140835
HOGENOMiHOG000234441
HOVERGENiHBG002295
InParanoidiQ96EP5
KOiK14411
OMAiQPDFPYS
OrthoDBiEOG091G1CPI
PhylomeDBiQ96EP5
TreeFamiTF314808

Family and domain databases

CDDicd12574 RRM1_DAZAP1, 1 hit
cd12327 RRM2_DAZAP1, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR034134 DAZAP1_RRM1
IPR034131 DAZAP1_RRM2
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96EP5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNNSGADEIG KLFVGGLDWS TTQETLRSYF SQYGEVVDCV IMKDKTTNQS
60 70 80 90 100
RGFGFVKFKD PNCVGTVLAS RPHTLDGRNI DPKPCTPRGM QPERTRPKEG
110 120 130 140 150
WQKGPRSDNS KSNKIFVGGI PHNCGETELR EYFKKFGVVT EVVMIYDAEK
160 170 180 190 200
QRPRGFGFIT FEDEQSVDQA VNMHFHDIMG KKVEVKRAEP RDSKSQAPGQ
210 220 230 240 250
PGASQWGSRV VPNAANGWAG QPPPTWQQGY GPQGMWVPAG QAIGGYGPPP
260 270 280 290 300
AGRGAPPPPP PFTSYIVSTP PGGFPPPQGF PQGYGAPPQF SFGYGPPPPP
310 320 330 340 350
PDQFAPPGVP PPPATPGAAP LAFPPPPSQA APDMSKPPTA QPDFPYGQYA
360 370 380 390 400
GYGQDLSGFG QGFSDPSQQP PSYGGPSVPG SGGPPAGGSG FGRGQNHNVQ

GFHPYRR
Length:407
Mass (Da):43,383
Last modified:December 1, 2001 - v1
Checksum:iCFEB42903F4D5AFB
GO
Isoform 2 (identifier: Q96EP5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     350-407: AGYGQDLSGF...NVQGFHPYRR → GLGSYSPAPPGCGPHFVYSLMVRLSSDVA

Note: No experimental confirmation available.
Show »
Length:378
Mass (Da):40,530
Checksum:iF8DDAD1AFDD37C3E
GO

Sequence cautioni

The sequence BAB71295 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti109N → Y in AAF78364 (PubMed:10857750).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035480381S → T in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_009441350 – 407AGYGQ…HPYRR → GLGSYSPAPPGCGPHFVYSL MVRLSSDVA in isoform 2. 1 PublicationAdd BLAST58

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF181719 mRNA Translation: AAF78364.1
BC012062 mRNA Translation: AAH12062.1
AK056850 mRNA Translation: BAB71295.1 Different initiation.
CCDSiCCDS12065.1 [Q96EP5-1]
CCDS12066.1 [Q96EP5-2]
RefSeqiNP_061832.2, NM_018959.3 [Q96EP5-1]
NP_733829.1, NM_170711.2 [Q96EP5-2]
UniGeneiHs.222510

Genome annotation databases

EnsembliENST00000233078; ENSP00000233078; ENSG00000071626 [Q96EP5-1]
ENST00000336761; ENSP00000337132; ENSG00000071626 [Q96EP5-2]
GeneIDi26528
KEGGihsa:26528
UCSCiuc002lsm.5 human [Q96EP5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDAZP1_HUMAN
AccessioniPrimary (citable) accession number: Q96EP5
Secondary accession number(s): Q96MJ3, Q9NRR9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: December 1, 2001
Last modified: June 20, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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