UniProtKB - Q96EP5 (DAZP1_HUMAN)
Protein
DAZ-associated protein 1
Gene
DAZAP1
Organism
Homo sapiens (Human)
Status
Functioni
RNA-binding protein, which may be required during spermatogenesis.
GO - Molecular functioni
- mRNA 3'-UTR binding Source: GO_Central
- poly(G) binding Source: UniProtKB
- poly(U) RNA binding Source: UniProtKB
- RNA binding Source: UniProtKB
- RNA stem-loop binding Source: Ensembl
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- cell population proliferation Source: Ensembl
- maternal placenta development Source: Ensembl
- positive regulation of mRNA splicing, via spliceosome Source: GO_Central
- spermatogenesis Source: GO_Central
Keywordsi
Molecular function | Developmental protein, RNA-binding |
Biological process | Differentiation, Spermatogenesis |
Names & Taxonomyi
Protein namesi | Recommended name: DAZ-associated protein 1Alternative name(s): Deleted in azoospermia-associated protein 1 |
Gene namesi | Name:DAZAP1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2683 DAZAP1 |
MIMi | 607430 gene |
neXtProti | NX_Q96EP5 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Other locations
- Cytoplasm 1 Publication
Note: Predominantly cytoplasmic (By similarity). Nuclear at some stages of spermatozoides development. In midpachytene spermatocytes, it is localized in both the cytoplasm and the nuclei and is clearly excluded from the sex vesicles. In round spermatids, it localizes mainly in the nuclei, whereas in elongated spermatids, it localizes to the cytoplasm (By similarity).By similarity
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Other locations
- protein-containing complex Source: UniProtKB
- ribonucleoprotein complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 26528 |
OpenTargetsi | ENSG00000071626 |
PharmGKBi | PA27153 |
Miscellaneous databases
Pharosi | Q96EP5 |
Polymorphism and mutation databases
BioMutai | DAZAP1 |
DMDMi | 44887869 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000081565 | 1 – 407 | DAZ-associated protein 1Add BLAST | 407 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources1 Publication | 1 | |
Modified residuei | 150 | N6-acetyllysine1 Publication | 1 | |
Modified residuei | 253 | Omega-N-methylarginineCombined sources | 1 |
Post-translational modificationi
Acetylation at Lys-150 is predominantly observed in the nuclear fraction, and may regulate nucleocytoplasmic transport.2 Publications
Keywords - PTMi
Acetylation, MethylationProteomic databases
EPDi | Q96EP5 |
jPOSTi | Q96EP5 |
MassIVEi | Q96EP5 |
MaxQBi | Q96EP5 |
PaxDbi | Q96EP5 |
PeptideAtlasi | Q96EP5 |
PRIDEi | Q96EP5 |
ProteomicsDBi | 76437 [Q96EP5-1] 76438 [Q96EP5-2] |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00165230 |
PTM databases
iPTMneti | Q96EP5 |
PhosphoSitePlusi | Q96EP5 |
SwissPalmi | Q96EP5 |
Expressioni
Tissue specificityi
Mainly expressed in testis. Expressed to a lower level in thymus. Weakly or not expressed in heart, liver, brain, placenta, lung, skeletal muscle, kidney and pancreas.1 Publication
Gene expression databases
Bgeei | ENSG00000071626 Expressed in 225 organ(s), highest expression level in oviduct epithelium |
ExpressionAtlasi | Q96EP5 baseline and differential |
Genevisiblei | Q96EP5 HS |
Organism-specific databases
HPAi | HPA004201 HPA004631 |
Interactioni
Subunit structurei
Interacts with DAZ and DAZL.
1 PublicationProtein-protein interaction databases
BioGridi | 117730, 116 interactors |
IntActi | Q96EP5, 16 interactors |
MINTi | Q96EP5 |
STRINGi | 9606.ENSP00000233078 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q96EP5 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q96EP5 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 10 – 97 | RRM 1PROSITE-ProRule annotationAdd BLAST | 88 | |
Domaini | 113 – 190 | RRM 2PROSITE-ProRule annotationAdd BLAST | 78 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 222 – 385 | Pro-richAdd BLAST | 164 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG4205 Eukaryota ENOG410YA8Z LUCA |
GeneTreei | ENSGT00940000156757 |
HOGENOMi | HOG000234441 |
InParanoidi | Q96EP5 |
KOi | K14411 |
OMAi | GPILCLH |
OrthoDBi | 1565323at2759 |
PhylomeDBi | Q96EP5 |
TreeFami | TF314808 |
Family and domain databases
CDDi | cd12574 RRM1_DAZAP1, 1 hit cd12327 RRM2_DAZAP1, 1 hit |
Gene3Di | 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR037366 BOULE/DAZ IPR034134 DAZAP1_RRM1 IPR034131 DAZAP1_RRM2 IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR000504 RRM_dom |
PANTHERi | PTHR11176 PTHR11176, 2 hits |
Pfami | View protein in Pfam PF00076 RRM_1, 2 hits |
SMARTi | View protein in SMART SM00360 RRM, 2 hits |
SUPFAMi | SSF54928 SSF54928, 2 hits |
PROSITEi | View protein in PROSITE PS50102 RRM, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q96EP5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNNSGADEIG KLFVGGLDWS TTQETLRSYF SQYGEVVDCV IMKDKTTNQS
60 70 80 90 100
RGFGFVKFKD PNCVGTVLAS RPHTLDGRNI DPKPCTPRGM QPERTRPKEG
110 120 130 140 150
WQKGPRSDNS KSNKIFVGGI PHNCGETELR EYFKKFGVVT EVVMIYDAEK
160 170 180 190 200
QRPRGFGFIT FEDEQSVDQA VNMHFHDIMG KKVEVKRAEP RDSKSQAPGQ
210 220 230 240 250
PGASQWGSRV VPNAANGWAG QPPPTWQQGY GPQGMWVPAG QAIGGYGPPP
260 270 280 290 300
AGRGAPPPPP PFTSYIVSTP PGGFPPPQGF PQGYGAPPQF SFGYGPPPPP
310 320 330 340 350
PDQFAPPGVP PPPATPGAAP LAFPPPPSQA APDMSKPPTA QPDFPYGQYA
360 370 380 390 400
GYGQDLSGFG QGFSDPSQQP PSYGGPSVPG SGGPPAGGSG FGRGQNHNVQ
GFHPYRR
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7EQ55 | K7EQ55_HUMAN | DAZ-associated protein 1 | DAZAP1 | 406 | Annotation score: | ||
K7EK33 | K7EK33_HUMAN | DAZ-associated protein 1 | DAZAP1 | 406 | Annotation score: | ||
K7EQ02 | K7EQ02_HUMAN | DAZ-associated protein 1 | DAZAP1 | 327 | Annotation score: |
Sequence cautioni
The sequence BAB71295 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 109 | N → Y in AAF78364 (PubMed:10857750).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035480 | 381 | S → T in a breast cancer sample; somatic mutation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_009441 | 350 – 407 | AGYGQ…HPYRR → GLGSYSPAPPGCGPHFVYSL MVRLSSDVA in isoform 2. 1 PublicationAdd BLAST | 58 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF181719 mRNA Translation: AAF78364.1 BC012062 mRNA Translation: AAH12062.1 AK056850 mRNA Translation: BAB71295.1 Different initiation. |
CCDSi | CCDS12065.1 [Q96EP5-1] CCDS12066.1 [Q96EP5-2] |
RefSeqi | NP_061832.2, NM_018959.3 [Q96EP5-1] NP_733829.1, NM_170711.2 [Q96EP5-2] |
Genome annotation databases
Ensembli | ENST00000233078; ENSP00000233078; ENSG00000071626 [Q96EP5-1] ENST00000336761; ENSP00000337132; ENSG00000071626 [Q96EP5-2] |
GeneIDi | 26528 |
KEGGi | hsa:26528 |
UCSCi | uc002lsm.5 human [Q96EP5-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF181719 mRNA Translation: AAF78364.1 BC012062 mRNA Translation: AAH12062.1 AK056850 mRNA Translation: BAB71295.1 Different initiation. |
CCDSi | CCDS12065.1 [Q96EP5-1] CCDS12066.1 [Q96EP5-2] |
RefSeqi | NP_061832.2, NM_018959.3 [Q96EP5-1] NP_733829.1, NM_170711.2 [Q96EP5-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2DGS | NMR | - | A | 110-195 | [»] | |
2DH8 | NMR | - | A | 1-92 | [»] | |
SMRi | Q96EP5 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGridi | 117730, 116 interactors |
IntActi | Q96EP5, 16 interactors |
MINTi | Q96EP5 |
STRINGi | 9606.ENSP00000233078 |
PTM databases
iPTMneti | Q96EP5 |
PhosphoSitePlusi | Q96EP5 |
SwissPalmi | Q96EP5 |
Polymorphism and mutation databases
BioMutai | DAZAP1 |
DMDMi | 44887869 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00165230 |
Proteomic databases
EPDi | Q96EP5 |
jPOSTi | Q96EP5 |
MassIVEi | Q96EP5 |
MaxQBi | Q96EP5 |
PaxDbi | Q96EP5 |
PeptideAtlasi | Q96EP5 |
PRIDEi | Q96EP5 |
ProteomicsDBi | 76437 [Q96EP5-1] 76438 [Q96EP5-2] |
Protocols and materials databases
DNASUi | 26528 |
Genome annotation databases
Ensembli | ENST00000233078; ENSP00000233078; ENSG00000071626 [Q96EP5-1] ENST00000336761; ENSP00000337132; ENSG00000071626 [Q96EP5-2] |
GeneIDi | 26528 |
KEGGi | hsa:26528 |
UCSCi | uc002lsm.5 human [Q96EP5-1] |
Organism-specific databases
CTDi | 26528 |
DisGeNETi | 26528 |
GeneCardsi | DAZAP1 |
HGNCi | HGNC:2683 DAZAP1 |
HPAi | HPA004201 HPA004631 |
MIMi | 607430 gene |
neXtProti | NX_Q96EP5 |
OpenTargetsi | ENSG00000071626 |
PharmGKBi | PA27153 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4205 Eukaryota ENOG410YA8Z LUCA |
GeneTreei | ENSGT00940000156757 |
HOGENOMi | HOG000234441 |
InParanoidi | Q96EP5 |
KOi | K14411 |
OMAi | GPILCLH |
OrthoDBi | 1565323at2759 |
PhylomeDBi | Q96EP5 |
TreeFami | TF314808 |
Miscellaneous databases
ChiTaRSi | DAZAP1 human |
EvolutionaryTracei | Q96EP5 |
GeneWikii | DAZ_associated_protein_1 |
GenomeRNAii | 26528 |
Pharosi | Q96EP5 |
PROi | PR:Q96EP5 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000071626 Expressed in 225 organ(s), highest expression level in oviduct epithelium |
ExpressionAtlasi | Q96EP5 baseline and differential |
Genevisiblei | Q96EP5 HS |
Family and domain databases
CDDi | cd12574 RRM1_DAZAP1, 1 hit cd12327 RRM2_DAZAP1, 1 hit |
Gene3Di | 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR037366 BOULE/DAZ IPR034134 DAZAP1_RRM1 IPR034131 DAZAP1_RRM2 IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR000504 RRM_dom |
PANTHERi | PTHR11176 PTHR11176, 2 hits |
Pfami | View protein in Pfam PF00076 RRM_1, 2 hits |
SMARTi | View protein in SMART SM00360 RRM, 2 hits |
SUPFAMi | SSF54928 SSF54928, 2 hits |
PROSITEi | View protein in PROSITE PS50102 RRM, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DAZP1_HUMAN | |
Accessioni | Q96EP5Primary (citable) accession number: Q96EP5 Secondary accession number(s): Q96MJ3, Q9NRR9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 2004 |
Last sequence update: | December 1, 2001 | |
Last modified: | November 13, 2019 | |
This is version 164 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references