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UniProtKB - Q96EN8 (MOCOS_HUMAN)

Entry version 154 (17 Jun 2020)
Sequence version 2 (18 May 2010)
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Protein

Molybdenum cofactor sulfurase

Gene

MOCOS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. In vitro, the C-terminal domain is able to reduce N-hydroxylated prodrugs, such as benzamidoxime.UniRule annotation1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pyridoxal 5'-phosphateUniRule annotation

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=15 µM for benzamidoxime1 Publication
  1. Vmax=0.24 nmol/min/mg enzyme1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei424UniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processMolybdenum cofactor biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-947581 Molybdenum cofactor biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Molybdenum cofactor sulfuraseUniRule annotation (EC:2.8.1.9UniRule annotation)
Short name:
MCSUniRule annotation
Short name:
MOSUniRule annotation
Short name:
MoCo sulfuraseUniRule annotation
Short name:
hMCS
Alternative name(s):
Molybdenum cofactor sulfurtransferaseUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MOCOSUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000075643.5

Human Gene Nomenclature Database

More...HGNCi		HGNC:18234 MOCOS

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613274 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96EN8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Xanthinuria 2 (XAN2)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by excretion of very large amounts of xanthine in the urine and a tendency to form xanthine stones. Uric acid is strikingly diminished in serum and urine. In addition, XAN2 patients cannot metabolize allopurinol into oxypurinol due to dual deficiency of xanthine dehydrogenase and aldehyde oxidase.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02752857A → P in XAN2. 1 PublicationCorresponds to variant dbSNP:rs886037854EnsemblClinVar.1
Natural variantiVAR_027533294T → I in XAN2. 1 PublicationCorresponds to variant dbSNP:rs577279030Ensembl.1
Natural variantiVAR_045899776R → C in XAN2. 1 PublicationCorresponds to variant dbSNP:rs750896617EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...DisGeNETi		55034

MalaCards human disease database

More...MalaCardsi		MOCOS
MIMi603592 phenotype

Open Targets

More...OpenTargetsi		ENSG00000075643

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		93602 Xanthinuria type II

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134964534

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96EN8 Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB00114 Pyridoxal phosphate

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MOCOS

Domain mapping of disease mutations (DMDM)

More...DMDMi		296438294

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002499521 – 888Molybdenum cofactor sulfuraseAdd BLAST888

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei34PhosphoserineCombined sources1
Modified residuei264N6-(pyridoxal phosphate)lysineUniRule annotation1
Modified residuei528PhosphoserineCombined sources1
Modified residuei530PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-979

Encyclopedia of Proteome Dynamics

More...EPDi		Q96EN8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96EN8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96EN8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96EN8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96EN8

PeptideAtlas

More...PeptideAtlasi		Q96EN8

PRoteomics IDEntifications database

More...PRIDEi		Q96EN8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		76426

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96EN8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96EN8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000075643 Expressed in liver and 131 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96EN8 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000075643 Tissue enhanced (intestine, liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120363, 28 interactors

Protein interaction database and analysis system

More...IntActi		Q96EN8, 25 interactors

Molecular INTeraction database

More...MINTi		Q96EN8

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000261326

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96EN8 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini706 – 867MOSCUniRule annotationAdd BLAST162

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2142 Eukaryota
COG0520 LUCA
COG3217 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157051

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_010913_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96EN8

KEGG Orthology (KO)

More...KOi		K15631

Identification of Orthologs from Complete Genome Data

More...OMAi		EWCLVHQ

Database of Orthologous Groups

More...OrthoDBi		394559at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96EN8

TreeFam database of animal gene trees

More...TreeFami		TF105761

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.640.10, 1 hit
3.90.1150.10, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_03050 MOCOS, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000192 Aminotrans_V_dom
IPR005302 MoCF_Sase_C
IPR028886 MoCo_sulfurase
IPR005303 MOSC_N
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
IPR011037 Pyrv_Knase-like_insert_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00266 Aminotran_5, 1 hit
PF03473 MOSC, 1 hit
PF03476 MOSC_N, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50800 SSF50800, 1 hit
SSF53383 SSF53383, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51340 MOSC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q96EN8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGAAAESGR ELWTFAGSRD PSAPRLAYGY GPGSLRELRA REFSRLAGTV 
        60         70         80         90        100
YLDHAGATLF SQSQLESFTS DLMENTYGNP HSQNISSKLT HDTVEQVRYR 
       110        120        130        140        150
ILAHFHTTAE DYTVIFTAGS TAALKLVAEA FPWVSQGPES SGSRFCYLTD 
       160        170        180        190        200
SHTSVVGMRN VTMAINVIST PVRPEDLWSA EERSASASNP DCQLPHLFCY 
       210        220        230        240        250
PAQSNFSGVR YPLSWIEEVK SGRLHPVSTP GKWFVLLDAA SYVSTSPLDL 
       260        270        280        290        300
SAHQADFVPI SFYKIFGFPT GLGALLVHNR AAPLLRKTYF GGGTASAYLA 
       310        320        330        340        350
GEDFYIPRQS VAQRFEDGTI SFLDVIALKH GFDTLERLTG GMENIKQHTF 
       360        370        380        390        400
TLAQYTYVAL SSLQYPNGAP VVRIYSDSEF SSPEVQGPII NFNVLDDKGN 
       410        420        430        440        450
IIGYSQVDKM ASLYNIHLRT GCFCNTGACQ RHLGISNEMV RKHFQAGHVC 
       460        470        480        490        500
GDNMDLIDGQ PTGSVRISFG YMSTLDDVQA FLRFIIDTRL HSSGDWPVPQ 
       510        520        530        540        550
AHADTGETGA PSADSQADVI PAVMGRRSLS PQEDALTGSR VWNNSSTVNA 
       560        570        580        590        600
VPVAPPVCDV ARTQPTPSEK AAGVLEGALG PHVVTNLYLY PIKSCAAFEV 
       610        620        630        640        650
TRWPVGNQGL LYDRSWMVVN HNGVCLSQKQ EPRLCLIQPF IDLRQRIMVI 
       660        670        680        690        700
KAKGMEPIEV PLEENSERTQ IRQSRVCADR VSTYDCGEKI SSWLSTFFGR 
       710        720        730        740        750
PCHLIKQSSN SQRNAKKKHG KDQLPGTMAT LSLVNEAQYL LINTSSILEL 
       760        770        780        790        800
HRQLNTSDEN GKEELFSLKD LSLRFRANII INGKRAFEEE KWDEISIGSL 
       810        820        830        840        850
RFQVLGPCHR CQMICIDQQT GQRNQHVFQK LSESRETKVN FGMYLMHASL 
       860        870        880 
DLSSPCFLSV GSQVLPVLKE NVEGHDLPAS EKHQDVTS
Length:888
Mass (Da):98,120
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i07DB9457516E8C06
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti119G → E in BAD96606 (PubMed:14702039).Curated1
Sequence conflicti689K → E in BAD96606 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02752857A → P in XAN2. 1 PublicationCorresponds to variant dbSNP:rs886037854EnsemblClinVar.1
Natural variantiVAR_027529120S → N. Corresponds to variant dbSNP:rs3744900Ensembl.1
Natural variantiVAR_027530170T → I2 PublicationsCorresponds to variant dbSNP:rs623053Ensembl.1
Natural variantiVAR_027531184S → G3 PublicationsCorresponds to variant dbSNP:rs540967Ensembl.1
Natural variantiVAR_027532225H → R4 PublicationsCorresponds to variant dbSNP:rs623558Ensembl.1
Natural variantiVAR_027533294T → I in XAN2. 1 PublicationCorresponds to variant dbSNP:rs577279030Ensembl.1
Natural variantiVAR_027534358V → M3 PublicationsCorresponds to variant dbSNP:rs678560Ensembl.1
Natural variantiVAR_027535495D → N. Corresponds to variant dbSNP:rs8088347Ensembl.1
Natural variantiVAR_027536541V → L. Corresponds to variant dbSNP:rs672924Ensembl.1
Natural variantiVAR_027537703H → N2 PublicationsCorresponds to variant dbSNP:rs594445Ensembl.1
Natural variantiVAR_045899776R → C in XAN2. 1 PublicationCorresponds to variant dbSNP:rs750896617EnsemblClinVar.1
Natural variantiVAR_027538867V → A. Corresponds to variant dbSNP:rs1057251Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK000740 mRNA Translation: BAA91353.1
AK222886 mRNA Translation: BAD96606.1
AC023043 Genomic DNA No translation available.
BC012079 mRNA Translation: AAH12079.1
AL834481 mRNA Translation: CAD39140.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11919.1

Protein sequence database of the Protein Information Resource

More...PIRi		JC7680

NCBI Reference Sequences

More...RefSeqi		NP_060417.2, NM_017947.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000261326; ENSP00000261326; ENSG00000075643

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55034

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55034

UCSC genome browser

More...UCSCi		uc002kzq.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000740 mRNA Translation: BAA91353.1
AK222886 mRNA Translation: BAD96606.1
AC023043 Genomic DNA No translation available.
BC012079 mRNA Translation: AAH12079.1
AL834481 mRNA Translation: CAD39140.1
CCDSiCCDS11919.1
PIRiJC7680
RefSeqiNP_060417.2, NM_017947.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi120363, 28 interactors
IntActiQ96EN8, 25 interactors
MINTiQ96EN8
STRINGi9606.ENSP00000261326

Chemistry databases

DrugBankiDB00114 Pyridoxal phosphate

PTM databases

iPTMnetiQ96EN8
PhosphoSitePlusiQ96EN8

Polymorphism and mutation databases

BioMutaiMOCOS
DMDMi296438294

Proteomic databases

CPTACiCPTAC-979
EPDiQ96EN8
jPOSTiQ96EN8
MassIVEiQ96EN8
MaxQBiQ96EN8
PaxDbiQ96EN8
PeptideAtlasiQ96EN8
PRIDEiQ96EN8
ProteomicsDBi76426

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		41960 47 antibodies

The DNASU plasmid repository

More...DNASUi		55034

Genome annotation databases

EnsembliENST00000261326; ENSP00000261326; ENSG00000075643
GeneIDi55034
KEGGihsa:55034
UCSCiuc002kzq.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55034
DisGeNETi55034
EuPathDBiHostDB:ENSG00000075643.5

GeneCards: human genes, protein and diseases

More...GeneCardsi		MOCOS
HGNCiHGNC:18234 MOCOS
HPAiENSG00000075643 Tissue enhanced (intestine, liver)
MalaCardsiMOCOS
MIMi603592 phenotype
613274 gene
neXtProtiNX_Q96EN8
OpenTargetsiENSG00000075643
Orphaneti93602 Xanthinuria type II
PharmGKBiPA134964534

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2142 Eukaryota
COG0520 LUCA
COG3217 LUCA
GeneTreeiENSGT00940000157051
HOGENOMiCLU_010913_0_1_1
InParanoidiQ96EN8
KOiK15631
OMAiEWCLVHQ
OrthoDBi394559at2759
PhylomeDBiQ96EN8
TreeFamiTF105761

Enzyme and pathway databases

ReactomeiR-HSA-947581 Molybdenum cofactor biosynthesis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		55034 1 hit in 786 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MOCOS human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MOCOS

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55034
PharosiQ96EN8 Tbio

Protein Ontology

More...PROi		PR:Q96EN8
RNActiQ96EN8 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000075643 Expressed in liver and 131 other tissues
GenevisibleiQ96EN8 HS

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
HAMAPiMF_03050 MOCOS, 1 hit
InterProiView protein in InterPro
IPR000192 Aminotrans_V_dom
IPR005302 MoCF_Sase_C
IPR028886 MoCo_sulfurase
IPR005303 MOSC_N
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
IPR011037 Pyrv_Knase-like_insert_dom_sf
PfamiView protein in Pfam
PF00266 Aminotran_5, 1 hit
PF03473 MOSC, 1 hit
PF03476 MOSC_N, 1 hit
SUPFAMiSSF50800 SSF50800, 1 hit
SSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS51340 MOSC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMOCOS_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96EN8
Secondary accession number(s): Q53GP5, Q8N3A4, Q9NWM7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: May 18, 2010
Last modified: June 17, 2020
This is version 154 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
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