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Protein

39S ribosomal protein L53, mitochondrial

Gene

MRPL53

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L53, mitochondrial
Short name:
L53mt
Short name:
MRP-L53
Alternative name(s):
Mitochondrial large ribosomal subunit protein mL531 Publication
Gene namesi
Name:MRPL53
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000204822.6
HGNCiHGNC:16684 MRPL53
MIMi611857 gene
neXtProtiNX_Q96EL3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30986

Polymorphism and mutation databases

BioMutaiMRPL53
DMDMi74731579

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000261664? – 11239S ribosomal protein L53, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

EPDiQ96EL3
MaxQBiQ96EL3
PaxDbiQ96EL3
PeptideAtlasiQ96EL3
PRIDEiQ96EL3
ProteomicsDBi76424
TopDownProteomicsiQ96EL3

PTM databases

iPTMnetiQ96EL3
PhosphoSitePlusiQ96EL3
SwissPalmiQ96EL3

Expressioni

Gene expression databases

BgeeiENSG00000204822 Expressed in 94 organ(s), highest expression level in heart
CleanExiHS_MRPL53
ExpressionAtlasiQ96EL3 baseline and differential
GenevisibleiQ96EL3 HS

Organism-specific databases

HPAiHPA056185

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. mL53 is located at the L7/L12 stalk.3 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi125521, 61 interactors
CORUMiQ96EL3
IntActiQ96EL3, 28 interactors
MINTiQ96EL3
STRINGi9606.ENSP00000258105

Structurei

Secondary structure

1112
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ96EL3
SMRiQ96EL3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410J0VJ Eukaryota
ENOG4111ZNN LUCA
GeneTreeiENSGT00390000001440
HOGENOMiHOG000230705
HOVERGENiHBG057368
InParanoidiQ96EL3
KOiK17434
OMAiRATNLNC
OrthoDBiEOG091G16T7
PhylomeDBiQ96EL3
TreeFamiTF300292

Family and domain databases

InterProiView protein in InterPro
IPR019716 Ribosomal_L53_mit
PfamiView protein in Pfam
PF10780 MRP_L53, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q96EL3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAALARLGL RPVKQVRVQF CPFEKNVEST RTFLQTVSSE KVRSTNLNCS
60 70 80 90 100
VIADVRHDGS EPCVDVLFGD GHRLIMRGAH LTALEMLTAF ASHIRARDAA
110
GSGDKPGADT GR
Length:112
Mass (Da):12,107
Last modified:December 1, 2001 - v1
Checksum:iBFC43FF93A148C36
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B9A051B9A051_HUMAN
39S ribosomal protein L53, mitochon...
MRPL53
70Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0294754A → S. Corresponds to variant dbSNP:rs1047911Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC012163 mRNA Translation: AAH12163.1
CCDSiCCDS1944.1
RefSeqiNP_444278.1, NM_053050.4
UniGeneiHs.534527

Genome annotation databases

EnsembliENST00000258105; ENSP00000258105; ENSG00000204822
GeneIDi116540
KEGGihsa:116540
UCSCiuc002sln.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC012163 mRNA Translation: AAH12163.1
CCDSiCCDS1944.1
RefSeqiNP_444278.1, NM_053050.4
UniGeneiHs.534527

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40k1-112[»]
3J9Melectron microscopy3.50k1-112[»]
5OOLelectron microscopy3.06k1-112[»]
5OOMelectron microscopy3.03k1-112[»]
ProteinModelPortaliQ96EL3
SMRiQ96EL3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125521, 61 interactors
CORUMiQ96EL3
IntActiQ96EL3, 28 interactors
MINTiQ96EL3
STRINGi9606.ENSP00000258105

PTM databases

iPTMnetiQ96EL3
PhosphoSitePlusiQ96EL3
SwissPalmiQ96EL3

Polymorphism and mutation databases

BioMutaiMRPL53
DMDMi74731579

Proteomic databases

EPDiQ96EL3
MaxQBiQ96EL3
PaxDbiQ96EL3
PeptideAtlasiQ96EL3
PRIDEiQ96EL3
ProteomicsDBi76424
TopDownProteomicsiQ96EL3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258105; ENSP00000258105; ENSG00000204822
GeneIDi116540
KEGGihsa:116540
UCSCiuc002sln.4 human

Organism-specific databases

CTDi116540
EuPathDBiHostDB:ENSG00000204822.6
GeneCardsiMRPL53
H-InvDBiHIX0022694
HIX0077799
HGNCiHGNC:16684 MRPL53
HPAiHPA056185
MIMi611857 gene
neXtProtiNX_Q96EL3
PharmGKBiPA30986
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0VJ Eukaryota
ENOG4111ZNN LUCA
GeneTreeiENSGT00390000001440
HOGENOMiHOG000230705
HOVERGENiHBG057368
InParanoidiQ96EL3
KOiK17434
OMAiRATNLNC
OrthoDBiEOG091G16T7
PhylomeDBiQ96EL3
TreeFamiTF300292

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

GenomeRNAii116540
PROiPR:Q96EL3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204822 Expressed in 94 organ(s), highest expression level in heart
CleanExiHS_MRPL53
ExpressionAtlasiQ96EL3 baseline and differential
GenevisibleiQ96EL3 HS

Family and domain databases

InterProiView protein in InterPro
IPR019716 Ribosomal_L53_mit
PfamiView protein in Pfam
PF10780 MRP_L53, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRM53_HUMAN
AccessioniPrimary (citable) accession number: Q96EL3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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