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Protein

28S ribosomal protein S24, mitochondrial

Gene

MRPS24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S24, mitochondrial
Short name:
MRP-S24
Short name:
S24mt
Alternative name(s):
Mitochondrial small ribosomal subunit protein uS3m1 Publication
bMRP-47
Short name:
bMRP47
Gene namesi
Name:MRPS24
ORF Names:HSPC335
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000062582.13
HGNCiHGNC:14510 MRPS24
MIMi611986 gene
neXtProtiNX_Q96EL2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000062582
PharmGKBiPA31012

Polymorphism and mutation databases

BioMutaiMRPS24

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 35MitochondrionBy similarityAdd BLAST35
ChainiPRO_000027306636 – 16728S ribosomal protein S24, mitochondrialAdd BLAST132

Proteomic databases

EPDiQ96EL2
MaxQBiQ96EL2
PaxDbiQ96EL2
PeptideAtlasiQ96EL2
PRIDEiQ96EL2
ProteomicsDBi76423
TopDownProteomicsiQ96EL2

PTM databases

iPTMnetiQ96EL2
PhosphoSitePlusiQ96EL2

Expressioni

Gene expression databases

BgeeiENSG00000062582 Expressed in 94 organ(s), highest expression level in muscle of leg
CleanExiHS_MRPS24
ExpressionAtlasiQ96EL2 baseline and differential
GenevisibleiQ96EL2 HS

Organism-specific databases

HPAiHPA020983

Interactioni

Subunit structurei

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.1 Publication

Protein-protein interaction databases

BioGridi122357, 48 interactors
CORUMiQ96EL2
IntActiQ96EL2, 9 interactors
MINTiQ96EL2
STRINGi9606.ENSP00000318158

Structurei

3D structure databases

ProteinModelPortaliQ96EL2
SMRiQ96EL2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IY06 Eukaryota
ENOG4111JJW LUCA
GeneTreeiENSGT00390000011179
HOGENOMiHOG000252979
HOVERGENiHBG093920
InParanoidiQ96EL2
KOiK17403
OMAiYKCPVKL
OrthoDBiEOG091G0TCJ
PhylomeDBiQ96EL2
TreeFamiTF324311

Family and domain databases

InterProiView protein in InterPro
IPR026146 MRPS24
PANTHERiPTHR21244 PTHR21244, 1 hit
PfamiView protein in Pfam
PF14955 MRP-S24, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q96EL2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAASVCSGLL GPRVLSWSRE LPCAWRALHT SPVCAKNRAA RVRVSKGDKP
60 70 80 90 100
VTYEEAHAPH YIAHRKGWLS LHTGNLDGED HAAERTVEDV FLRKFMWGTF
110 120 130 140 150
PGCLADQLVL KRRGNQLEIC AVVLRQLSPH KYYFLVGYSE TLLSYFYKCP
160
VRLHLQTVPS KVVYKYL
Length:167
Mass (Da):19,015
Last modified:December 1, 2001 - v1
Checksum:iD48DCB3803CFB37E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VYR5F8VYR5_HUMAN
28S ribosomal protein S24, mitochon...
MRPS24
72Annotation score:

Sequence cautioni

The sequence AAF29013 differs from that shown. Reason: Frameshift at positions 27 and 45.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03007797W → R. Corresponds to variant dbSNP:rs670573Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161453 mRNA Translation: AAF29013.1 Frameshift.
CH236951 Genomic DNA Translation: EAL24009.1
CH471073 Genomic DNA Translation: EAW94173.1
BC012167 mRNA Translation: AAH12167.1
BC054865 mRNA Translation: AAH54865.1
AB061207 Genomic DNA Translation: BAB54957.1
CCDSiCCDS5473.1
RefSeqiNP_114403.1, NM_032014.2
UniGeneiHs.284286

Genome annotation databases

EnsembliENST00000317534; ENSP00000318158; ENSG00000062582
GeneIDi64951
KEGGihsa:64951
UCSCiuc003tit.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161453 mRNA Translation: AAF29013.1 Frameshift.
CH236951 Genomic DNA Translation: EAL24009.1
CH471073 Genomic DNA Translation: EAW94173.1
BC012167 mRNA Translation: AAH12167.1
BC054865 mRNA Translation: AAH54865.1
AB061207 Genomic DNA Translation: BAB54957.1
CCDSiCCDS5473.1
RefSeqiNP_114403.1, NM_032014.2
UniGeneiHs.284286

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AC1-167[»]
ProteinModelPortaliQ96EL2
SMRiQ96EL2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122357, 48 interactors
CORUMiQ96EL2
IntActiQ96EL2, 9 interactors
MINTiQ96EL2
STRINGi9606.ENSP00000318158

PTM databases

iPTMnetiQ96EL2
PhosphoSitePlusiQ96EL2

Polymorphism and mutation databases

BioMutaiMRPS24

Proteomic databases

EPDiQ96EL2
MaxQBiQ96EL2
PaxDbiQ96EL2
PeptideAtlasiQ96EL2
PRIDEiQ96EL2
ProteomicsDBi76423
TopDownProteomicsiQ96EL2

Protocols and materials databases

DNASUi64951
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317534; ENSP00000318158; ENSG00000062582
GeneIDi64951
KEGGihsa:64951
UCSCiuc003tit.2 human

Organism-specific databases

CTDi64951
EuPathDBiHostDB:ENSG00000062582.13
GeneCardsiMRPS24
HGNCiHGNC:14510 MRPS24
HPAiHPA020983
MIMi611986 gene
neXtProtiNX_Q96EL2
OpenTargetsiENSG00000062582
PharmGKBiPA31012
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IY06 Eukaryota
ENOG4111JJW LUCA
GeneTreeiENSGT00390000011179
HOGENOMiHOG000252979
HOVERGENiHBG093920
InParanoidiQ96EL2
KOiK17403
OMAiYKCPVKL
OrthoDBiEOG091G0TCJ
PhylomeDBiQ96EL2
TreeFamiTF324311

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

ChiTaRSiMRPS24 human
GeneWikiiMRPS24
GenomeRNAii64951
PROiPR:Q96EL2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000062582 Expressed in 94 organ(s), highest expression level in muscle of leg
CleanExiHS_MRPS24
ExpressionAtlasiQ96EL2 baseline and differential
GenevisibleiQ96EL2 HS

Family and domain databases

InterProiView protein in InterPro
IPR026146 MRPS24
PANTHERiPTHR21244 PTHR21244, 1 hit
PfamiView protein in Pfam
PF14955 MRP-S24, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRT24_HUMAN
AccessioniPrimary (citable) accession number: Q96EL2
Secondary accession number(s): A4D1U9
, P82668, Q96Q23, Q9P047
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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