UniProtKB - Q96EL1 (INKA1_HUMAN)
Protein
PAK4-inhibitor INKA1
Gene
INKA1
Organism
Homo sapiens (Human)
Status
Functioni
Inhibitor of the serine/threonine-protein kinase PAK4 (PubMed:26607847). Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity (PubMed:26607847).1 Publication
Caution
It is uncertain whether Met-1 or Met-3 is the initiator.Curated
GO - Molecular functioni
- protein kinase binding Source: UniProtKB
- protein serine/threonine kinase inhibitor activity Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q96EL1 |
Names & Taxonomyi
Protein namesi | Recommended name: PAK4-inhibitor INKA1CuratedAlternative name(s): Induced in neural crest by AP2-alpha protein homolog1 Publication Short name: HInca1 Publication Inka box actin regulator 1Imported |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:32480, INKA1 |
neXtProti | NX_Q96EL1 |
VEuPathDBi | HostDB:ENSG00000185614.4 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 389119 |
PharmGKBi | PA143485330 |
Miscellaneous databases
Pharosi | Q96EL1, Tdark |
Genetic variation databases
BioMutai | FAM212A |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000239717 | 1 – 287 | PAK4-inhibitor INKA1Add BLAST | 287 |
Proteomic databases
EPDi | Q96EL1 |
jPOSTi | Q96EL1 |
MassIVEi | Q96EL1 |
PaxDbi | Q96EL1 |
PeptideAtlasi | Q96EL1 |
PRIDEi | Q96EL1 |
ProteomicsDBi | 76422 |
PTM databases
iPTMneti | Q96EL1 |
PhosphoSitePlusi | Q96EL1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000185614, Expressed in stomach and 186 other tissues |
ExpressionAtlasi | Q96EL1, baseline and differential |
Genevisiblei | Q96EL1, HS |
Organism-specific databases
HPAi | ENSG00000185614, Tissue enhanced (blood, skin) |
Interactioni
Subunit structurei
Interacts with PAK4 (PubMed:26607847).
1 PublicationBinary interactionsi
Hide detailsQ96EL1
GO - Molecular functioni
- protein kinase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 132984, 8 interactors |
IntActi | Q96EL1, 12 interactors |
STRINGi | 9606.ENSP00000329735 |
Miscellaneous databases
RNActi | Q96EL1, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q96EL1 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 168 – 205 | Inka box 11 PublicationAdd BLAST | 38 | |
Regioni | 261 – 287 | Inka box 21 PublicationAdd BLAST | 27 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 65 – 73 | Poly-Glu | 9 |
Domaini
Contains 2 Inka boxes (also named iBox or inca box) (PubMed:26607847). The Inka boxes bind and inhibit PAK4 by binding a substrate-like manner (PubMed:26607847).1 Publication
Sequence similaritiesi
Belongs to the INKA family.Curated
Phylogenomic databases
eggNOGi | ENOG502R5BS, Eukaryota |
HOGENOMi | CLU_077157_0_0_1 |
InParanoidi | Q96EL1 |
OMAi | DVQPRHQ |
OrthoDBi | 1263048at2759 |
PhylomeDBi | Q96EL1 |
TreeFami | TF332839 |
Family and domain databases
InterProi | View protein in InterPro IPR029267, FAM212 IPR039201, Inka |
PANTHERi | PTHR28615, PTHR28615, 1 hit |
Pfami | View protein in Pfam PF15342, FAM212, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q96EL1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDMHSARLDS FLSQLRWELL CGRDTGSPSM PGPLQPTSQT GPDVQPSHQL
60 70 80 90 100
RASGALEEDS VCCVEEEEEE EEEAVVTEDR DAALGGPREH ALDWDSGFSE
110 120 130 140 150
VSGSTWREEE LPVSQRPAPS AQPLRRQCLS VSGLPMPSRA PVASVPPVHH
160 170 180 190 200
PRPKSTPDAC LEHWQGLEAE DWTAALLNRG RSRQPLVLGD NCFADLVHNW
210 220 230 240 250
MELPETGSEG GDGGGHRARA RPPQFLLGLS EQLRRRLARA RRTAMAGKRL
260 270 280
SCPPRPEPEL PADVSRFAAL MSCRSRQPII CNDVSYL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A499FIG1 | A0A499FIG1_HUMAN | PAK4-inhibitor INKA1 | INKA1 | 285 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC139451 Genomic DNA No translation available. BC012170 mRNA Translation: AAH12170.2 |
RefSeqi | NP_976248.1, NM_203370.1 |
Genome annotation databases
GeneIDi | 389119 |
KEGGi | hsa:389119 |
UCSCi | uc003cxq.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC139451 Genomic DNA No translation available. BC012170 mRNA Translation: AAH12170.2 |
RefSeqi | NP_976248.1, NM_203370.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4XBR | X-ray | 2.94 | A | 168-205 | [»] | |
4XBU | X-ray | 2.06 | B | 169-192 | [»] | |
SMRi | Q96EL1 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 132984, 8 interactors |
IntActi | Q96EL1, 12 interactors |
STRINGi | 9606.ENSP00000329735 |
PTM databases
iPTMneti | Q96EL1 |
PhosphoSitePlusi | Q96EL1 |
Genetic variation databases
BioMutai | FAM212A |
Proteomic databases
EPDi | Q96EL1 |
jPOSTi | Q96EL1 |
MassIVEi | Q96EL1 |
PaxDbi | Q96EL1 |
PeptideAtlasi | Q96EL1 |
PRIDEi | Q96EL1 |
ProteomicsDBi | 76422 |
Protocols and materials databases
Antibodypediai | 46012, 77 antibodies |
DNASUi | 389119 |
Genome annotation databases
GeneIDi | 389119 |
KEGGi | hsa:389119 |
UCSCi | uc003cxq.1, human |
Organism-specific databases
CTDi | 389119 |
DisGeNETi | 389119 |
GeneCardsi | INKA1 |
HGNCi | HGNC:32480, INKA1 |
HPAi | ENSG00000185614, Tissue enhanced (blood, skin) |
neXtProti | NX_Q96EL1 |
PharmGKBi | PA143485330 |
VEuPathDBi | HostDB:ENSG00000185614.4 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502R5BS, Eukaryota |
HOGENOMi | CLU_077157_0_0_1 |
InParanoidi | Q96EL1 |
OMAi | DVQPRHQ |
OrthoDBi | 1263048at2759 |
PhylomeDBi | Q96EL1 |
TreeFami | TF332839 |
Enzyme and pathway databases
PathwayCommonsi | Q96EL1 |
Miscellaneous databases
BioGRID-ORCSi | 389119, 7 hits in 878 CRISPR screens |
GenomeRNAii | 389119 |
Pharosi | Q96EL1, Tdark |
PROi | PR:Q96EL1 |
RNActi | Q96EL1, protein |
Gene expression databases
Bgeei | ENSG00000185614, Expressed in stomach and 186 other tissues |
ExpressionAtlasi | Q96EL1, baseline and differential |
Genevisiblei | Q96EL1, HS |
Family and domain databases
InterProi | View protein in InterPro IPR029267, FAM212 IPR039201, Inka |
PANTHERi | PTHR28615, PTHR28615, 1 hit |
Pfami | View protein in Pfam PF15342, FAM212, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | INKA1_HUMAN | |
Accessioni | Q96EL1Primary (citable) accession number: Q96EL1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 13, 2006 |
Last sequence update: | May 8, 2019 | |
Last modified: | February 10, 2021 | |
This is version 117 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families