UniProtKB - Q96EK9 (KTI12_HUMAN)
Protein
Protein KTI12 homolog
Gene
KTI12
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 8 – 15 | ATPSequence analysis | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
- tRNA wobble uridine modification Source: GO_Central
Keywordsi
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q96EK9 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein KTI12 homolog |
Gene namesi | Name:KTI12 ORF Names:SBBI81 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000198841.3 |
HGNCi | HGNC:25160, KTI12 |
neXtProti | NX_Q96EK9 |
Subcellular locationi
Other locations
- Elongator holoenzyme complex Source: GO_Central
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000198841 |
PharmGKBi | PA142671571 |
Miscellaneous databases
Pharosi | Q96EK9, Tdark |
Polymorphism and mutation databases
BioMutai | KTI12 |
DMDMi | 74751844 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000285686 | 1 – 354 | Protein KTI12 homologAdd BLAST | 354 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 184 | PhosphoserineCombined sources | 1 | |
Modified residuei | 200 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q96EK9 |
jPOSTi | Q96EK9 |
MassIVEi | Q96EK9 |
MaxQBi | Q96EK9 |
PaxDbi | Q96EK9 |
PeptideAtlasi | Q96EK9 |
PRIDEi | Q96EK9 |
ProteomicsDBi | 76421 |
PTM databases
iPTMneti | Q96EK9 |
PhosphoSitePlusi | Q96EK9 |
SwissPalmi | Q96EK9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000198841, Expressed in bone marrow and 140 other tissues |
Genevisiblei | Q96EK9, HS |
Organism-specific databases
HPAi | ENSG00000198841, Low tissue specificity |
Interactioni
Binary interactionsi
Q96EK9
With | #Exp. | IntAct |
---|---|---|
FHL3 [Q13643] | 3 | EBI-7951092,EBI-741101 |
Protein-protein interaction databases
BioGRIDi | 125220, 5 interactors |
IntActi | Q96EK9, 3 interactors |
MINTi | Q96EK9 |
STRINGi | 9606.ENSP00000360676 |
Miscellaneous databases
RNActi | Q96EK9, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the KTI12 family.Curated
Phylogenomic databases
eggNOGi | KOG3062, Eukaryota |
GeneTreei | ENSGT00390000002443 |
HOGENOMi | CLU_027147_0_0_1 |
InParanoidi | Q96EK9 |
OMAi | PMTRWDS |
OrthoDBi | 1300128at2759 |
PhylomeDBi | Q96EK9 |
TreeFami | TF312974 |
Family and domain databases
InterProi | View protein in InterPro IPR013641, KTI12/PSTK IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF08433, KTI12, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
i Sequence
Sequence statusi: Complete.
Q96EK9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPLVVFCGLP YSGKSRRAEE LRVALAAEGR AVYVVDDAAV LGAEDPAVYG
60 70 80 90 100
DSAREKALRG ALRASVERRL SRHDVVILDS LNYIKGFRYE LYCLARAART
110 120 130 140 150
PLCLVYCVRP GGPIAGPQVA GANENPGRNV SVSWRPRAEE DGRAQAAGSS
160 170 180 190 200
VLRELHTADS VVNGSAQADV PKELEREESG AAESPALVTP DSEKSAKHGS
210 220 230 240 250
GAFYSPELLE ALTLRFEAPD SRNRWDRPLF TLVGLEEPLP LAGIRSALFE
260 270 280 290 300
NRAPPPHQST QSQPLASGSF LHQLDQVTSQ VLAGLMEAQK SAVPGDLLTL
310 320 330 340 350
PGTTEHLRFT RPLTMAELSR LRRQFISYTK MHPNNENLPQ LANMFLQYLS
QSLH
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_032046 | 191 | D → E. Corresponds to variant dbSNP:rs2783175Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF327348 mRNA Translation: AAL56009.1 AL445685 Genomic DNA No translation available. BC012173 mRNA Translation: AAH12173.1 |
CCDSi | CCDS562.1 |
RefSeqi | NP_612426.1, NM_138417.2 |
Genome annotation databases
Ensembli | ENST00000371614; ENSP00000360676; ENSG00000198841 |
GeneIDi | 112970 |
KEGGi | hsa:112970 |
UCSCi | uc001ctj.2, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF327348 mRNA Translation: AAL56009.1 AL445685 Genomic DNA No translation available. BC012173 mRNA Translation: AAH12173.1 |
CCDSi | CCDS562.1 |
RefSeqi | NP_612426.1, NM_138417.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 125220, 5 interactors |
IntActi | Q96EK9, 3 interactors |
MINTi | Q96EK9 |
STRINGi | 9606.ENSP00000360676 |
PTM databases
iPTMneti | Q96EK9 |
PhosphoSitePlusi | Q96EK9 |
SwissPalmi | Q96EK9 |
Polymorphism and mutation databases
BioMutai | KTI12 |
DMDMi | 74751844 |
Proteomic databases
EPDi | Q96EK9 |
jPOSTi | Q96EK9 |
MassIVEi | Q96EK9 |
MaxQBi | Q96EK9 |
PaxDbi | Q96EK9 |
PeptideAtlasi | Q96EK9 |
PRIDEi | Q96EK9 |
ProteomicsDBi | 76421 |
Protocols and materials databases
Antibodypediai | 32985, 52 antibodies |
DNASUi | 112970 |
Genome annotation databases
Ensembli | ENST00000371614; ENSP00000360676; ENSG00000198841 |
GeneIDi | 112970 |
KEGGi | hsa:112970 |
UCSCi | uc001ctj.2, human |
Organism-specific databases
CTDi | 112970 |
EuPathDBi | HostDB:ENSG00000198841.3 |
GeneCardsi | KTI12 |
HGNCi | HGNC:25160, KTI12 |
HPAi | ENSG00000198841, Low tissue specificity |
neXtProti | NX_Q96EK9 |
OpenTargetsi | ENSG00000198841 |
PharmGKBi | PA142671571 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3062, Eukaryota |
GeneTreei | ENSGT00390000002443 |
HOGENOMi | CLU_027147_0_0_1 |
InParanoidi | Q96EK9 |
OMAi | PMTRWDS |
OrthoDBi | 1300128at2759 |
PhylomeDBi | Q96EK9 |
TreeFami | TF312974 |
Enzyme and pathway databases
PathwayCommonsi | Q96EK9 |
Miscellaneous databases
BioGRID-ORCSi | 112970, 493 hits in 856 CRISPR screens |
GenomeRNAii | 112970 |
Pharosi | Q96EK9, Tdark |
PROi | PR:Q96EK9 |
RNActi | Q96EK9, protein |
Gene expression databases
Bgeei | ENSG00000198841, Expressed in bone marrow and 140 other tissues |
Genevisiblei | Q96EK9, HS |
Family and domain databases
InterProi | View protein in InterPro IPR013641, KTI12/PSTK IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF08433, KTI12, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KTI12_HUMAN | |
Accessioni | Q96EK9Primary (citable) accession number: Q96EK9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 2007 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 132 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations