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Entry version 126 (16 Oct 2019)
Sequence version 1 (01 Dec 2001)
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Protein

Protein KTI12 homolog

Gene

KTI12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi8 – 15ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein KTI12 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KTI12
ORF Names:SBBI81
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:25160 KTI12

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96EK9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000198841

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671571

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96EK9

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KTI12

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74751844

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002856861 – 354Protein KTI12 homologAdd BLAST354

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei184PhosphoserineCombined sources1
Modified residuei200PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q96EK9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96EK9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96EK9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96EK9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96EK9

PeptideAtlas

More...
PeptideAtlasi
Q96EK9

PRoteomics IDEntifications database

More...
PRIDEi
Q96EK9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
76421

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96EK9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96EK9

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q96EK9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198841 Expressed in 126 organ(s), highest expression level in right adrenal gland

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96EK9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA031203
HPA031204
HPA031205

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
FHL3Q136433EBI-7951092,EBI-741101

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
125220, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q96EK9, 3 interactors

Molecular INTeraction database

More...
MINTi
Q96EK9

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000360676

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the KTI12 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3062 Eukaryota
COG4088 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000002443

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000247843

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96EK9

KEGG Orthology (KO)

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KOi
K15456

Identification of Orthologs from Complete Genome Data

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OMAi
PMTRWDS

Database of Orthologous Groups

More...
OrthoDBi
1300128at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96EK9

TreeFam database of animal gene trees

More...
TreeFami
TF312974

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013641 KTI12/PSTK
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08433 KTI12, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q96EK9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLVVFCGLP YSGKSRRAEE LRVALAAEGR AVYVVDDAAV LGAEDPAVYG
60 70 80 90 100
DSAREKALRG ALRASVERRL SRHDVVILDS LNYIKGFRYE LYCLARAART
110 120 130 140 150
PLCLVYCVRP GGPIAGPQVA GANENPGRNV SVSWRPRAEE DGRAQAAGSS
160 170 180 190 200
VLRELHTADS VVNGSAQADV PKELEREESG AAESPALVTP DSEKSAKHGS
210 220 230 240 250
GAFYSPELLE ALTLRFEAPD SRNRWDRPLF TLVGLEEPLP LAGIRSALFE
260 270 280 290 300
NRAPPPHQST QSQPLASGSF LHQLDQVTSQ VLAGLMEAQK SAVPGDLLTL
310 320 330 340 350
PGTTEHLRFT RPLTMAELSR LRRQFISYTK MHPNNENLPQ LANMFLQYLS

QSLH
Length:354
Mass (Da):38,616
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i877F297D28AF1E24
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_032046191D → E. Corresponds to variant dbSNP:rs2783175Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF327348 mRNA Translation: AAL56009.1
AL445685 Genomic DNA No translation available.
BC012173 mRNA Translation: AAH12173.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS562.1

NCBI Reference Sequences

More...
RefSeqi
NP_612426.1, NM_138417.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000371614; ENSP00000360676; ENSG00000198841

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
112970

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:112970

UCSC genome browser

More...
UCSCi
uc001ctj.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF327348 mRNA Translation: AAL56009.1
AL445685 Genomic DNA No translation available.
BC012173 mRNA Translation: AAH12173.1
CCDSiCCDS562.1
RefSeqiNP_612426.1, NM_138417.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi125220, 4 interactors
IntActiQ96EK9, 3 interactors
MINTiQ96EK9
STRINGi9606.ENSP00000360676

PTM databases

iPTMnetiQ96EK9
PhosphoSitePlusiQ96EK9
SwissPalmiQ96EK9

Polymorphism and mutation databases

BioMutaiKTI12
DMDMi74751844

Proteomic databases

EPDiQ96EK9
jPOSTiQ96EK9
MassIVEiQ96EK9
MaxQBiQ96EK9
PaxDbiQ96EK9
PeptideAtlasiQ96EK9
PRIDEiQ96EK9
ProteomicsDBi76421

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
112970

Genome annotation databases

EnsembliENST00000371614; ENSP00000360676; ENSG00000198841
GeneIDi112970
KEGGihsa:112970
UCSCiuc001ctj.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
112970

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KTI12
HGNCiHGNC:25160 KTI12
HPAiHPA031203
HPA031204
HPA031205
neXtProtiNX_Q96EK9
OpenTargetsiENSG00000198841
PharmGKBiPA142671571

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3062 Eukaryota
COG4088 LUCA
GeneTreeiENSGT00390000002443
HOGENOMiHOG000247843
InParanoidiQ96EK9
KOiK15456
OMAiPMTRWDS
OrthoDBi1300128at2759
PhylomeDBiQ96EK9
TreeFamiTF312974

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
112970
PharosiQ96EK9

Protein Ontology

More...
PROi
PR:Q96EK9

Gene expression databases

BgeeiENSG00000198841 Expressed in 126 organ(s), highest expression level in right adrenal gland
GenevisibleiQ96EK9 HS

Family and domain databases

InterProiView protein in InterPro
IPR013641 KTI12/PSTK
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF08433 KTI12, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKTI12_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96EK9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: December 1, 2001
Last modified: October 16, 2019
This is version 126 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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