UniProtKB - Q96EH3 (MASU1_HUMAN)
Mitochondrial assembly of ribosomal large subunit protein 1
MALSU1
Functioni
GO - Molecular functioni
- ribosomal large subunit binding Source: GO_Central
GO - Biological processi
- negative regulation of mitochondrial translation Source: UniProtKB
- negative regulation of ribosome biogenesis Source: GO_Central
- negative regulation of translation Source: GO_Central
- ribosomal large subunit biogenesis Source: UniProtKB
Keywordsi
Biological process | Ribosome biogenesis |
Enzyme and pathway databases
PathwayCommonsi | Q96EH3 |
Names & Taxonomyi
Protein namesi | Recommended name: Mitochondrial assembly of ribosomal large subunit protein 1 |
Gene namesi | Name:MALSU1 Synonyms:C7orf30 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000156928.4 |
HGNCi | HGNC:21721, MALSU1 |
MIMi | 614624, gene |
neXtProti | NX_Q96EH3 |
Subcellular locationi
Mitochondrion
- Mitochondrion matrix 1 Publication5 Publications
Note: Colocalizes with MRPL12 and/or MRPL14.2 Publications
Cytosol
- cytosol Source: HPA
Mitochondrion
- mitochondrial matrix Source: UniProtKB-SubCell
- mitochondrion Source: UniProtKB
Keywords - Cellular componenti
MitochondrionPathology & Biotechi
Organism-specific databases
DisGeNETi | 115416 |
OpenTargetsi | ENSG00000156928 |
PharmGKBi | PA134866345 |
Miscellaneous databases
Pharosi | Q96EH3, Tbio |
Polymorphism and mutation databases
BioMutai | MALSU1 |
DMDMi | 74731563 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000228108 | 1 – 234 | Mitochondrial assembly of ribosomal large subunit protein 1Add BLAST | 234 |
Proteomic databases
EPDi | Q96EH3 |
jPOSTi | Q96EH3 |
MassIVEi | Q96EH3 |
MaxQBi | Q96EH3 |
PaxDbi | Q96EH3 |
PeptideAtlasi | Q96EH3 |
PRIDEi | Q96EH3 |
ProteomicsDBi | 76407 |
PTM databases
iPTMneti | Q96EH3 |
PhosphoSitePlusi | Q96EH3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000156928, Expressed in sperm and 225 other tissues |
Genevisiblei | Q96EH3, HS |
Organism-specific databases
HPAi | ENSG00000156928, Low tissue specificity |
Interactioni
Subunit structurei
Associates with the mitochondrial ribosome large subunit (39S) via interaction with MRPL12 and/or MRPL14 (PubMed:22238375, PubMed:23171548, PubMed:28892042). The interaction generates steric hindrance that is expected to prevent premature association of the 28S and 39S ribosomal subunits (PubMed:28892042).
Identified in a complex composed of MALSU1, MIEF1 upstream open reading frame protein and NDUFAB1; within the trimeric complex, MIEF1 upstream open reading frame protein functions as a bridging scaffold that interacts with MALSU1 on one side, and with NDUFAB1 on the other side (PubMed:28892042).
Interacts with MRPL12 and MRPL14 (PubMed:23171548, PubMed:22829778, PubMed:22238375).
4 PublicationsBinary interactionsi
Hide detailsQ96EH3
Protein-protein interaction databases
BioGRIDi | 125433, 53 interactors |
IntActi | Q96EH3, 47 interactors |
MINTi | Q96EH3 |
STRINGi | 9606.ENSP00000419370 |
Miscellaneous databases
RNActi | Q96EH3, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q96EH3 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3212, Eukaryota |
GeneTreei | ENSGT00390000015035 |
HOGENOMi | CLU_1277285_0_0_1 |
InParanoidi | Q96EH3 |
OMAi | CKHDPHV |
OrthoDBi | 1590818at2759 |
PhylomeDBi | Q96EH3 |
TreeFami | TF326763 |
Family and domain databases
Gene3Di | 3.30.460.10, 1 hit |
HAMAPi | MF_01477, Iojap_RsfS, 1 hit |
InterProi | View protein in InterPro IPR004394, Iojap/RsfS/C7orf30 IPR043519, NT_sf |
PANTHERi | PTHR21043, PTHR21043, 1 hit |
SUPFAMi | SSF81301, SSF81301, 1 hit |
TIGRFAMsi | TIGR00090, rsfS_iojap_ybeB, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MGPGGRVARL LAPLMWRRAV SSVAGSAVGA EPGLRLLAVQ RLPVGAAFCR
60 70 80 90 100
ACQTPNFVRG LHSEPGLEER AEGTVNEGRP ESDAADHTGP KFDIDMMVSL
110 120 130 140 150
LRQENARDIC VIQVPPEMRY TDYFVIVSGT STRHLHAMAF YVVKMYKHLK
160 170 180 190 200
CKRDPHVKIE GKDTDDWLCV DFGSMVIHLM LPETREIYEL EKLWTLRSYD
210 220 230
DQLAQIAPET VPEDFILGIE DDTSSVTPVE LKCE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK316559 mRNA Translation: BAG38148.1 AK127742 mRNA Translation: BAG54562.1 AC005082 Genomic DNA No translation available. CH236948 Genomic DNA Translation: EAL24258.1 CH471073 Genomic DNA Translation: EAW93785.1 BC012331 mRNA Translation: AAH12331.1 |
CCDSi | CCDS5381.1 |
RefSeqi | NP_612455.1, NM_138446.1 |
Genome annotation databases
Ensembli | ENST00000466681; ENSP00000419370; ENSG00000156928 |
GeneIDi | 115416 |
KEGGi | hsa:115416 |
UCSCi | uc003swd.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK316559 mRNA Translation: BAG38148.1 AK127742 mRNA Translation: BAG54562.1 AC005082 Genomic DNA No translation available. CH236948 Genomic DNA Translation: EAL24258.1 CH471073 Genomic DNA Translation: EAW93785.1 BC012331 mRNA Translation: AAH12331.1 |
CCDSi | CCDS5381.1 |
RefSeqi | NP_612455.1, NM_138446.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5OOL | electron microscopy | 3.06 | u | 1-234 | [»] | |
5OOM | electron microscopy | 3.03 | u | 1-234 | [»] | |
SMRi | Q96EH3 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 125433, 53 interactors |
IntActi | Q96EH3, 47 interactors |
MINTi | Q96EH3 |
STRINGi | 9606.ENSP00000419370 |
PTM databases
iPTMneti | Q96EH3 |
PhosphoSitePlusi | Q96EH3 |
Polymorphism and mutation databases
BioMutai | MALSU1 |
DMDMi | 74731563 |
Proteomic databases
EPDi | Q96EH3 |
jPOSTi | Q96EH3 |
MassIVEi | Q96EH3 |
MaxQBi | Q96EH3 |
PaxDbi | Q96EH3 |
PeptideAtlasi | Q96EH3 |
PRIDEi | Q96EH3 |
ProteomicsDBi | 76407 |
Protocols and materials databases
Antibodypediai | 12100, 51 antibodies |
Genome annotation databases
Ensembli | ENST00000466681; ENSP00000419370; ENSG00000156928 |
GeneIDi | 115416 |
KEGGi | hsa:115416 |
UCSCi | uc003swd.2, human |
Organism-specific databases
CTDi | 115416 |
DisGeNETi | 115416 |
EuPathDBi | HostDB:ENSG00000156928.4 |
GeneCardsi | MALSU1 |
HGNCi | HGNC:21721, MALSU1 |
HPAi | ENSG00000156928, Low tissue specificity |
MIMi | 614624, gene |
neXtProti | NX_Q96EH3 |
OpenTargetsi | ENSG00000156928 |
PharmGKBi | PA134866345 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3212, Eukaryota |
GeneTreei | ENSGT00390000015035 |
HOGENOMi | CLU_1277285_0_0_1 |
InParanoidi | Q96EH3 |
OMAi | CKHDPHV |
OrthoDBi | 1590818at2759 |
PhylomeDBi | Q96EH3 |
TreeFami | TF326763 |
Enzyme and pathway databases
PathwayCommonsi | Q96EH3 |
Miscellaneous databases
BioGRID-ORCSi | 115416, 79 hits in 844 CRISPR screens |
ChiTaRSi | MALSU1, human |
GeneWikii | C7orf30 |
GenomeRNAii | 115416 |
Pharosi | Q96EH3, Tbio |
PROi | PR:Q96EH3 |
RNActi | Q96EH3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000156928, Expressed in sperm and 225 other tissues |
Genevisiblei | Q96EH3, HS |
Family and domain databases
Gene3Di | 3.30.460.10, 1 hit |
HAMAPi | MF_01477, Iojap_RsfS, 1 hit |
InterProi | View protein in InterPro IPR004394, Iojap/RsfS/C7orf30 IPR043519, NT_sf |
PANTHERi | PTHR21043, PTHR21043, 1 hit |
SUPFAMi | SSF81301, SSF81301, 1 hit |
TIGRFAMsi | TIGR00090, rsfS_iojap_ybeB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MASU1_HUMAN | |
Accessioni | Q96EH3Primary (citable) accession number: Q96EH3 Secondary accession number(s): A4D154 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 21, 2006 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 139 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families