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Protein

Mitochondrial assembly of ribosomal large subunit protein 1

Gene

MALSU1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for normal mitochondrial ribosome function and mitochondrial translation (PubMed:22238375, PubMed:23171548). May play a role in ribosome biogenesis by preventing premature association of the 28S and 39S ribosomal subunits (Probable). Interacts with mitochondrial ribosomal protein L14 (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits (Probable). Addition to isolated mitochondrial ribosomal subunits partially inhibits translation, probably by interfering with the association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes (Probable). May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome (PubMed:22238376, PubMed:23171548). May function as a ribosomal silencing factor (Probable).2 Publications3 Publications

GO - Molecular functioni

  • ribosomal large subunit binding Source: GO_Central

GO - Biological processi

  • negative regulation of mitochondrial translation Source: UniProtKB
  • negative regulation of ribosome biogenesis Source: GO_Central
  • negative regulation of translation Source: GO_Central
  • ribosomal large subunit biogenesis Source: UniProtKB

Keywordsi

Biological processRibosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial assembly of ribosomal large subunit protein 1
Gene namesi
Name:MALSU1
Synonyms:C7orf30
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000156928.4
HGNCiHGNC:21721 MALSU1
MIMi614624 gene
neXtProtiNX_Q96EH3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000156928
PharmGKBiPA134866345

Polymorphism and mutation databases

BioMutaiMALSU1
DMDMi74731563

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002281081 – 234Mitochondrial assembly of ribosomal large subunit protein 1Add BLAST234

Proteomic databases

EPDiQ96EH3
MaxQBiQ96EH3
PaxDbiQ96EH3
PeptideAtlasiQ96EH3
PRIDEiQ96EH3
ProteomicsDBi76407

PTM databases

iPTMnetiQ96EH3
PhosphoSitePlusiQ96EH3

Expressioni

Gene expression databases

BgeeiENSG00000156928 Expressed in 211 organ(s), highest expression level in sperm
CleanExiHS_C7orf30
GenevisibleiQ96EH3 HS

Organism-specific databases

HPAiHPA020487
HPA052210

Interactioni

Subunit structurei

Associates with the mitochondrial ribosome large subunit (39S) via interaction with MRPL12 and/or MRPL14 (PubMed:22238375, PubMed:23171548, PubMed:28892042). The interaction generates steric hindrance that is expected to prevent premature association of the 28S and 39S ribosomal subunits (PubMed:28892042). Intentified in a complex composed of MALSU1, MIEF1 upstream open reading frame protein and NDUFAB1; within the trimeric complex MIEF1 upstream open reading frame protein functions as a bridging scaffold that interacts with MALSU1 on one side, and with NDUFAB1 on the other side (PubMed:28892042). Interacts with MRPL12 and MRPL14 (PubMed:23171548, PubMed:22829778, PubMed:22238375).4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
DCTDP323215EBI-2339737,EBI-739870

Protein-protein interaction databases

BioGridi125433, 40 interactors
IntActiQ96EH3, 18 interactors
MINTiQ96EH3
STRINGi9606.ENSP00000419370

Structurei

Secondary structure

1234
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ96EH3
SMRiQ96EH3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Iojap/RsfS family.Curated

Phylogenomic databases

eggNOGiKOG3212 Eukaryota
COG0799 LUCA
GeneTreeiENSGT00390000015035
HOGENOMiHOG000252940
HOVERGENiHBG081123
InParanoidiQ96EH3
OMAiIVKMYKH
OrthoDBiEOG091G0TZ9
PhylomeDBiQ96EH3
TreeFamiTF326763

Family and domain databases

HAMAPiMF_01477 Iojap_RsfS, 1 hit
InterProiView protein in InterPro
IPR004394 Iojap/RsfS/C7orf30
PANTHERiPTHR21043 PTHR21043, 1 hit
TIGRFAMsiTIGR00090 rsfS_iojap_ybeB, 1 hit

Sequencei

Sequence statusi: Complete.

Q96EH3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGPGGRVARL LAPLMWRRAV SSVAGSAVGA EPGLRLLAVQ RLPVGAAFCR
60 70 80 90 100
ACQTPNFVRG LHSEPGLEER AEGTVNEGRP ESDAADHTGP KFDIDMMVSL
110 120 130 140 150
LRQENARDIC VIQVPPEMRY TDYFVIVSGT STRHLHAMAF YVVKMYKHLK
160 170 180 190 200
CKRDPHVKIE GKDTDDWLCV DFGSMVIHLM LPETREIYEL EKLWTLRSYD
210 220 230
DQLAQIAPET VPEDFILGIE DDTSSVTPVE LKCE
Length:234
Mass (Da):26,170
Last modified:December 1, 2001 - v1
Checksum:iD0B1CD0C9562FF2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK316559 mRNA Translation: BAG38148.1
AK127742 mRNA Translation: BAG54562.1
AC005082 Genomic DNA No translation available.
CH236948 Genomic DNA Translation: EAL24258.1
CH471073 Genomic DNA Translation: EAW93785.1
BC012331 mRNA Translation: AAH12331.1
CCDSiCCDS5381.1
RefSeqiNP_612455.1, NM_138446.1
UniGeneiHs.87385

Genome annotation databases

EnsembliENST00000466681; ENSP00000419370; ENSG00000156928
GeneIDi115416
KEGGihsa:115416
UCSCiuc003swd.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK316559 mRNA Translation: BAG38148.1
AK127742 mRNA Translation: BAG54562.1
AC005082 Genomic DNA No translation available.
CH236948 Genomic DNA Translation: EAL24258.1
CH471073 Genomic DNA Translation: EAW93785.1
BC012331 mRNA Translation: AAH12331.1
CCDSiCCDS5381.1
RefSeqiNP_612455.1, NM_138446.1
UniGeneiHs.87385

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5OOLelectron microscopy3.06u1-234[»]
5OOMelectron microscopy3.03u1-234[»]
ProteinModelPortaliQ96EH3
SMRiQ96EH3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125433, 40 interactors
IntActiQ96EH3, 18 interactors
MINTiQ96EH3
STRINGi9606.ENSP00000419370

PTM databases

iPTMnetiQ96EH3
PhosphoSitePlusiQ96EH3

Polymorphism and mutation databases

BioMutaiMALSU1
DMDMi74731563

Proteomic databases

EPDiQ96EH3
MaxQBiQ96EH3
PaxDbiQ96EH3
PeptideAtlasiQ96EH3
PRIDEiQ96EH3
ProteomicsDBi76407

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000466681; ENSP00000419370; ENSG00000156928
GeneIDi115416
KEGGihsa:115416
UCSCiuc003swd.2 human

Organism-specific databases

CTDi115416
EuPathDBiHostDB:ENSG00000156928.4
GeneCardsiMALSU1
H-InvDBiHIX0201159
HGNCiHGNC:21721 MALSU1
HPAiHPA020487
HPA052210
MIMi614624 gene
neXtProtiNX_Q96EH3
OpenTargetsiENSG00000156928
PharmGKBiPA134866345
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3212 Eukaryota
COG0799 LUCA
GeneTreeiENSGT00390000015035
HOGENOMiHOG000252940
HOVERGENiHBG081123
InParanoidiQ96EH3
OMAiIVKMYKH
OrthoDBiEOG091G0TZ9
PhylomeDBiQ96EH3
TreeFamiTF326763

Miscellaneous databases

ChiTaRSiMALSU1 human
GeneWikiiC7orf30
GenomeRNAii115416
PROiPR:Q96EH3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000156928 Expressed in 211 organ(s), highest expression level in sperm
CleanExiHS_C7orf30
GenevisibleiQ96EH3 HS

Family and domain databases

HAMAPiMF_01477 Iojap_RsfS, 1 hit
InterProiView protein in InterPro
IPR004394 Iojap/RsfS/C7orf30
PANTHERiPTHR21043 PTHR21043, 1 hit
TIGRFAMsiTIGR00090 rsfS_iojap_ybeB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMASU1_HUMAN
AccessioniPrimary (citable) accession number: Q96EH3
Secondary accession number(s): A4D154
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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