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Entry version 112 (02 Dec 2020)
Sequence version 1 (01 Dec 2001)
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Protein

Zinc fingers and homeoboxes protein 1, isoform 2

Gene

ZHX1-C8orf76

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q96EF9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc fingers and homeoboxes protein 1, isoform 2
Alternative name(s):
ZHX1-C8orf76 readthrough transcript protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZHX1-C8orf76
Synonyms:C8orf76
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...
EuPathDBi
HostDB:ENSG00000259305.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:42975, ZHX1-C8orf76

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96EF9

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96EF9, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZHX1-C8orf76

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74731558

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004159391 – 292Zinc fingers and homeoboxes protein 1, isoform 2Add BLAST292

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96EF9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96EF9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96EF9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96EF9

PeptideAtlas

More...
PeptideAtlasi
Q96EF9

PRoteomics IDEntifications database

More...
PRIDEi
Q96EF9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
76404 [Q96EF9-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96EF9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000259305, Expressed in liver and 111 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96EF9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96EF9, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000259305, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000481928

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96EF9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96EF9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QW95, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000011435

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_044858_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96EF9

Database of Orthologous Groups

More...
OrthoDBi
113584at2759

TreeFam database of animal gene trees

More...
TreeFami
TF332319

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041404, DUF5588
IPR011990, TPR-like_helical_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR31919, PTHR31919, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17826, DUF5588, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452, SSF48452, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 2 (identifier: Q96EF9-1) [UniParc]FASTAAdd to basket
Also known as: ZHX1-C8orf76

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLRKLWQWFY EETESSDDVE VLTLKKFKGD LAYRRQEYQK ALQEYSSISE
60 70 80 90 100
KLSSTNFAMK RDVQEGQARC LAHLGRHMEA LEIAANLENK ATNTDHLTTV
110 120 130 140 150
LYLQLAICSS LQNLEKTIFC LQKLISLHPF NPWNWGKLAE AYLNLGPALS
160 170 180 190 200
AALASSQKQH SFTSSDKTIK SFFPHSGKDC LLCFPETLPE SSLFSVEANS
210 220 230 240 250
SNSQKNEKAL TNIQNCMAEK RETVLIETQL KACASFIRTR LLLQFTQPQQ
260 270 280 290
TSFALERNLR TQQEIEDKMK GFSFKEDTLL LIAEVSVSLG FM
Note: Based on a readthrough transcript which may produce a ZHX1-C8orf76 fusion protein.
Length:292
Mass (Da):33,285
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3F5E55E9C6F23D93
GO
Isoform 1 (identifier: Q9UKY1-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q9UKY1.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:873
Mass (Da):98,098
GO
Isoform 3 (identifier: Q96K31-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q96K31.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:380
Mass (Da):43,273
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0X1KG80A0A0X1KG80_HUMAN
Zinc fingers and homeoboxes protein...
ZHX1-C8orf76
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC068228 Genomic DNA No translation available.
BC012379 mRNA Translation: AAH12379.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS56552.1 [Q96EF9-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001191109.1, NM_001204180.1 [Q96EF9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000357082; ENSP00000349593; ENSG00000259305 [Q96EF9-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100533106

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:100533106

UCSC genome browser

More...
UCSCi
uc003yqd.4, human [Q96EF9-1]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC068228 Genomic DNA No translation available.
BC012379 mRNA Translation: AAH12379.1
CCDSiCCDS56552.1 [Q96EF9-1]
RefSeqiNP_001191109.1, NM_001204180.1 [Q96EF9-1]

3D structure databases

SMRiQ96EF9
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000481928

PTM databases

iPTMnetiQ96EF9

Polymorphism and mutation databases

BioMutaiZHX1-C8orf76
DMDMi74731558

Proteomic databases

EPDiQ96EF9
jPOSTiQ96EF9
MassIVEiQ96EF9
PaxDbiQ96EF9
PeptideAtlasiQ96EF9
PRIDEiQ96EF9
ProteomicsDBi76404 [Q96EF9-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
77359, 19 antibodies

Genome annotation databases

EnsembliENST00000357082; ENSP00000349593; ENSG00000259305 [Q96EF9-1]
GeneIDi100533106
KEGGihsa:100533106
UCSCiuc003yqd.4, human [Q96EF9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
100533106
EuPathDBiHostDB:ENSG00000259305.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZHX1-C8orf76
HGNCiHGNC:42975, ZHX1-C8orf76
HPAiENSG00000259305, Low tissue specificity
neXtProtiNX_Q96EF9

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QW95, Eukaryota
GeneTreeiENSGT00390000011435
HOGENOMiCLU_044858_0_0_1
InParanoidiQ96EF9
OrthoDBi113584at2759
TreeFamiTF332319

Enzyme and pathway databases

PathwayCommonsiQ96EF9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
100533106, 2 hits in 437 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ZHX1-C8orf76, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
100533106
PharosiQ96EF9, Tdark

Protein Ontology

More...
PROi
PR:Q96EF9
RNActiQ96EF9, protein

Gene expression databases

BgeeiENSG00000259305, Expressed in liver and 111 other tissues
ExpressionAtlasiQ96EF9, baseline and differential
GenevisibleiQ96EF9, HS

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR041404, DUF5588
IPR011990, TPR-like_helical_dom_sf
PANTHERiPTHR31919, PTHR31919, 1 hit
PfamiView protein in Pfam
PF17826, DUF5588, 1 hit
SUPFAMiSSF48452, SSF48452, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZHX1R_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96EF9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: December 1, 2001
Last modified: December 2, 2020
This is version 112 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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