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Protein

F-box only protein 17

Gene

FBXO17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Also recognizes sulfated glycans. Does not bind high-mannose glycoproteins.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 17
Alternative name(s):
F-box only protein 26
Gene namesi
Name:FBXO17
Synonyms:FBG4, FBX17, FBX26, FBXO26
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000269190.5
HGNCiHGNC:18754 FBXO17
MIMi609094 gene
neXtProtiNX_Q96EF6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi257 – 258SW → AA: Reduces interaction with glycosylated concanavalin-A in vitro. 1 Publication2

Organism-specific databases

OpenTargetsiENSG00000269190
PharmGKBiPA38676

Polymorphism and mutation databases

BioMutaiFBXO17
DMDMi21263617

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001198981 – 278F-box only protein 17Add BLAST278

Proteomic databases

EPDiQ96EF6
MaxQBiQ96EF6
PaxDbiQ96EF6
PeptideAtlasiQ96EF6
PRIDEiQ96EF6
ProteomicsDBi76403

Expressioni

Tissue specificityi

Expressed in heart, skeletal muscle, liver and kidney. Expressed at lower levels in spleen and brain.1 Publication

Gene expression databases

BgeeiENSG00000269190
CleanExiHS_FBXO17
ExpressionAtlasiQ96EF6 baseline and differential
GenevisibleiQ96EF6 HS

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1 and CUL1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SKP1P6320814EBI-2510157,EBI-307486

Protein-protein interaction databases

BioGridi125424, 22 interactors
IntActiQ96EF6, 19 interactors
STRINGi9606.ENSP00000292852

Structurei

3D structure databases

ProteinModelPortaliQ96EF6
SMRiQ96EF6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 62F-boxPROSITE-ProRule annotationAdd BLAST48
Domaini99 – 275FBAPROSITE-ProRule annotationAdd BLAST177

Phylogenomic databases

eggNOGiENOG410J91C Eukaryota
ENOG4111NAA LUCA
GeneTreeiENSGT00390000003865
HOGENOMiHOG000231084
HOVERGENiHBG003593
InParanoidiQ96EF6
KOiK10101
OMAiNLIFNSC
OrthoDBiEOG091G0G3L

Family and domain databases

Gene3Di2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR007397 F-box-assoc_dom
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR008979 Galactose-bd-like_sf
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
PF04300 FBA, 1 hit
SMARTiView protein in SMART
SM01198 FBA, 1 hit
SM00256 FBOX, 1 hit
SUPFAMiSSF49785 SSF49785, 1 hit
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS51114 FBA, 1 hit
PS50181 FBOX, 1 hit

Sequencei

Sequence statusi: Complete.

Q96EF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGARLSRRRL PADPSLALDA LPPELLVQVL SHVPPRSLVT RCRPVCRAWR
60 70 80 90 100
DIVDGPTVWL LQLARDRSAE GRALYAVAQR CLPSNEDKEE FPLCALARYC
110 120 130 140 150
LRAPFGRNLI FNSCGEQGFR GWEVEHGGNG WAIEKNLTPV PGAPSQTCFV
160 170 180 190 200
TSFEWCSKRQ LVDLVMEGVW QELLDSAQIE ICVADWWGAR ENCGCVYQLR
210 220 230 240 250
VRLLDVYEKE VVKFSASPDP VLQWTERGCR QVSHVFTNFG KGIRYVSFEQ
260 270
YGRDVSSWVG HYGALVTHSS VRVRIRLS
Length:278
Mass (Da):31,479
Last modified:December 1, 2001 - v1
Checksum:iB44E577D6F3529D4
GO

Sequence cautioni

The sequence BAB71616 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF386743 mRNA Translation: AAL37625.1
AK057934 mRNA Translation: BAB71616.1 Different initiation.
BC012385 mRNA Translation: AAH12385.1
CCDSiCCDS12526.1
RefSeqiNP_079183.4, NM_024907.6
NP_680474.1, NM_148169.2
UniGeneiHs.531770

Genome annotation databases

EnsembliENST00000292852; ENSP00000292852; ENSG00000269190
ENST00000595329; ENSP00000470361; ENSG00000269190
ENST00000634982; ENSP00000488997; ENSG00000282954
ENST00000635115; ENSP00000489327; ENSG00000282954
GeneIDi115290
KEGGihsa:115290
UCSCiuc002okg.3 human

Similar proteinsi

Entry informationi

Entry nameiFBX17_HUMAN
AccessioniPrimary (citable) accession number: Q96EF6
Secondary accession number(s): Q96LQ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: December 1, 2001
Last modified: June 20, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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