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Protein

Coiled-coil domain-containing protein 126

Gene

CCDC126

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 126
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCDC126
ORF Names:UNQ786/PRO1605
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000169193.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:22398 CCDC126

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96EE4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
90693

Open Targets

More...
OpenTargetsi
ENSG00000169193

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162381284

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CCDC126

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74731554

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000028881627 – 140Coiled-coil domain-containing protein 126Add BLAST114

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi110N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q96EE4

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96EE4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96EE4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96EE4

PeptideAtlas

More...
PeptideAtlasi
Q96EE4

PRoteomics IDEntifications database

More...
PRIDEi
Q96EE4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
76400

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96EE4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96EE4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000169193 Expressed in 180 organ(s), highest expression level in sperm

CleanEx database of gene expression profiles

More...
CleanExi
HS_CCDC126

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96EE4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96EE4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA026883

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
124755, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q96EE4, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000304355

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q96EE4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96EE4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IWQD Eukaryota
ENOG4111TJK LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153470

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000261681

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG095691

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96EE4

Identification of Orthologs from Complete Genome Data

More...
OMAi
RHQSSTE

Database of Orthologous Groups

More...
OrthoDBi
1333473at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96EE4

TreeFam database of animal gene trees

More...
TreeFami
TF332515

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027833 DUF4525

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15027 DUF4525, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q96EE4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFFTISRKNM SQKLSLLLLV FGLIWGLMLL HYTFQQPRHQ SSVKLREQIL
60 70 80 90 100
DLSKRYVKAL AEENKNTVDV ENGASMAGYA DLKRTIAVLL DDILQRLVKL
110 120 130 140
ENKVDYIVVN GSAANTTNGT SGNLVPVTTN KRTNVSGSIR
Length:140
Mass (Da):15,668
Last modified:November 23, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB020819761D784F1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J0J0C9J0J0_HUMAN
Coiled-coil domain-containing prote...
CCDC126
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAQ96871 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY358713 mRNA Translation: AAQ89075.1
AK289911 mRNA Translation: BAF82600.1
AC006026 Genomic DNA Translation: AAQ96871.1 Sequence problems.
CH236948 Genomic DNA Translation: EAL24252.1
CH471073 Genomic DNA Translation: EAW93792.1
BC012427 mRNA Translation: AAH12427.2
BC104638 mRNA Translation: AAI04639.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5384.1

NCBI Reference Sequences

More...
RefSeqi
NP_620126.2, NM_138771.3
XP_016868264.1, XM_017012775.1
XP_016868265.1, XM_017012776.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.232296

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000307471; ENSP00000304355; ENSG00000169193
ENST00000409765; ENSP00000386675; ENSG00000169193
ENST00000410069; ENSP00000386355; ENSG00000169193

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
90693

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:90693

UCSC genome browser

More...
UCSCi
uc003swl.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358713 mRNA Translation: AAQ89075.1
AK289911 mRNA Translation: BAF82600.1
AC006026 Genomic DNA Translation: AAQ96871.1 Sequence problems.
CH236948 Genomic DNA Translation: EAL24252.1
CH471073 Genomic DNA Translation: EAW93792.1
BC012427 mRNA Translation: AAH12427.2
BC104638 mRNA Translation: AAI04639.1
CCDSiCCDS5384.1
RefSeqiNP_620126.2, NM_138771.3
XP_016868264.1, XM_017012775.1
XP_016868265.1, XM_017012776.1
UniGeneiHs.232296

3D structure databases

ProteinModelPortaliQ96EE4
SMRiQ96EE4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124755, 4 interactors
IntActiQ96EE4, 2 interactors
STRINGi9606.ENSP00000304355

PTM databases

iPTMnetiQ96EE4
PhosphoSitePlusiQ96EE4

Polymorphism and mutation databases

BioMutaiCCDC126
DMDMi74731554

Proteomic databases

EPDiQ96EE4
jPOSTiQ96EE4
MaxQBiQ96EE4
PaxDbiQ96EE4
PeptideAtlasiQ96EE4
PRIDEiQ96EE4
ProteomicsDBi76400

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307471; ENSP00000304355; ENSG00000169193
ENST00000409765; ENSP00000386675; ENSG00000169193
ENST00000410069; ENSP00000386355; ENSG00000169193
GeneIDi90693
KEGGihsa:90693
UCSCiuc003swl.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
90693
DisGeNETi90693
EuPathDBiHostDB:ENSG00000169193.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CCDC126
HGNCiHGNC:22398 CCDC126
HPAiHPA026883
neXtProtiNX_Q96EE4
OpenTargetsiENSG00000169193
PharmGKBiPA162381284

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IWQD Eukaryota
ENOG4111TJK LUCA
GeneTreeiENSGT00940000153470
HOGENOMiHOG000261681
HOVERGENiHBG095691
InParanoidiQ96EE4
OMAiRHQSSTE
OrthoDBi1333473at2759
PhylomeDBiQ96EE4
TreeFamiTF332515

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CCDC126 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
90693

Protein Ontology

More...
PROi
PR:Q96EE4

Gene expression databases

BgeeiENSG00000169193 Expressed in 180 organ(s), highest expression level in sperm
CleanExiHS_CCDC126
ExpressionAtlasiQ96EE4 baseline and differential
GenevisibleiQ96EE4 HS

Family and domain databases

InterProiView protein in InterPro
IPR027833 DUF4525
PfamiView protein in Pfam
PF15027 DUF4525, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCC126_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96EE4
Secondary accession number(s): A8K1J6, Q6UWP1, Q75MQ6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: November 23, 2004
Last modified: January 16, 2019
This is version 117 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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