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Protein

Protein Hook homolog 2

Gene

HOOK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones.3 Publications

GO - Molecular functioni

  • dynein light intermediate chain binding Source: GO_Central
  • identical protein binding Source: UniProtKB
  • microtubule binding Source: GO_Central

GO - Biological processi

  • cytoplasmic microtubule organization Source: GO_Central
  • cytoskeleton-dependent intracellular transport Source: GO_Central
  • early endosome to late endosome transport Source: UniProtKB
  • endocytosis Source: ProtInc
  • endosome organization Source: UniProtKB
  • endosome to lysosome transport Source: UniProtKB
  • lysosome organization Source: UniProtKB
  • protein transport Source: UniProtKB-KW

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

SIGNORiQ96ED9

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Hook homolog 2
Short name:
h-hook2
Short name:
hHK2
Gene namesi
Name:HOOK2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000095066.11
HGNCiHGNC:19885 HOOK2
MIMi607824 gene
neXtProtiNX_Q96ED9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi29911
OpenTargetsiENSG00000095066
PharmGKBiPA134986864

Polymorphism and mutation databases

BioMutaiHOOK2
DMDMi296439323

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002191941 – 719Protein Hook homolog 2Add BLAST719

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei163PhosphoserineCombined sources1
Modified residuei230PhosphothreonineCombined sources1
Modified residuei710PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96ED9
MaxQBiQ96ED9
PaxDbiQ96ED9
PeptideAtlasiQ96ED9
PRIDEiQ96ED9
ProteomicsDBi76396
76397 [Q96ED9-2]

PTM databases

iPTMnetiQ96ED9
PhosphoSitePlusiQ96ED9

Expressioni

Gene expression databases

BgeeiENSG00000095066 Expressed in 179 organ(s), highest expression level in adenohypophysis
CleanExiHS_HOOK2
ExpressionAtlasiQ96ED9 baseline and differential
GenevisibleiQ96ED9 HS

Organism-specific databases

HPAiHPA043519
HPA050351

Interactioni

Subunit structurei

Self-associates (PubMed:18799622). Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FAM160A2, and one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3 (PubMed:18799622). May interact directly with AKTIP/FTS, HOOK1 and HOOK3 (PubMed:18799622). Associates with several subunits of the homotypic vesicular sorting complex (the HOPS complex) including VPS16 and VPS41; these interactions may be indirect (PubMed:18799622). Interacts with CNTRL (PubMed:17140400). Interacts with microtubules (PubMed:11238449). Interacts with ZC3H14 (PubMed:19273536). Interacts with LRGUK (via guanylate kinase-like domain) (By similarity). Interacts with CCDC181 (By similarity).By similarity4 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi118957, 67 interactors
CORUMiQ96ED9
IntActiQ96ED9, 124 interactors
MINTiQ96ED9
STRINGi9606.ENSP00000380785

Structurei

3D structure databases

ProteinModelPortaliQ96ED9
SMRiQ96ED9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 122Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST117

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 548Sufficient for interaction with microtubulesAdd BLAST548
Regioni1 – 161Required for localization to the centrosome and induction of aggresome formationAdd BLAST161
Regioni533 – 719Required for localization to the centrosome and induction of aggresome formationAdd BLAST187
Regioni584 – 719Sufficient for interaction with CNTRL1 PublicationAdd BLAST136

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili180 – 427Sequence analysisAdd BLAST248
Coiled coili455 – 607Sequence analysisAdd BLAST153

Sequence similaritiesi

Belongs to the hook family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG1M Eukaryota
ENOG410XQ3G LUCA
GeneTreeiENSGT00690000101702
HOGENOMiHOG000294112
HOVERGENiHBG051920
InParanoidiQ96ED9
KOiK16611
OMAiERNTVYM
OrthoDBiEOG091G06O9
PhylomeDBiQ96ED9
TreeFamiTF320231

Family and domain databases

Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR008636 Hook-like_fam
PfamiView protein in Pfam
PF05622 HOOK, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96ED9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSVDKAELCG SLLTWLQTFH VPSPCASPQD LSSGLAVAYV LNQIDPSWFN
60 70 80 90 100
EAWLQGISED PGPNWKLKVS NLKMVLRSLV EYSQDVLAHP VSEEHLPDVS
110 120 130 140 150
LIGEFSDPAE LGKLLQLVLG CAISCEKKQD HIQRIMTLEE SVQHVVMEAI
160 170 180 190 200
QELMTKDTPD SLSPETYGNF DSQSRRYYFL SEEAEEGDEL QQRCLDLERQ
210 220 230 240 250
LMLLSEEKQS LAQENAGLRE RMGRPEGEGT PGLTAKKLLL LQSQLEQLQE
260 270 280 290 300
ENFRLESGRE DERLRCAELE REVAELQHRN QALTSLAQEA QALKDEMDEL
310 320 330 340 350
RQSSERAGQL EATLTSCRRR LGELRELRRQ VRQLEERNAG HAERTRQLED
360 370 380 390 400
ELRRAGSLRA QLEAQRRQVQ ELQGQRQEEA MKAEKWLFEC RNLEEKYESV
410 420 430 440 450
TKEKERLLAE RDSLREANEE LRCAQLQPRG LTQADPSLDP TSTPVDNLAA
460 470 480 490 500
EILPAELRET LLRLQLENKR LCRQEAADRE RQEELQRHLE DANRARHGLE
510 520 530 540 550
TQHRLNQQQL SELRAQVEDL QKALQEQGGK TEDAISILLK RKLEEHLQKL
560 570 580 590 600
HEADLELQRK REYIEELEPP TDSSTARRIE ELQHNLQKKD ADLRAMEERY
610 620 630 640 650
RRYVDKARMV MQTMEPKQRP AAGAPPELHS LRTQLRERDV RIRHLEMDFE
660 670 680 690 700
KSRSQREQEE KLLISAWYNM GMALQQRAGE ERAPAHAQSF LAQQRLATNS
710
RRGPLGRLAS LNLRPTDKH
Length:719
Mass (Da):83,207
Last modified:May 18, 2010 - v3
Checksum:iFDF5F8A53DEE9DB6
GO
Isoform 2 (identifier: Q96ED9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     534-535: Missing.

Show »
Length:717
Mass (Da):83,022
Checksum:i980FCF8BA96E6E70
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EJ48K7EJ48_HUMAN
Protein Hook homolog 2
HOOK2
226Annotation score:
K7EMR5K7EMR5_HUMAN
Protein Hook homolog 2
HOOK2
157Annotation score:
K7ENU5K7ENU5_HUMAN
Protein Hook homolog 2
HOOK2
270Annotation score:
K7EMG7K7EMG7_HUMAN
Protein Hook homolog 2
HOOK2
127Annotation score:
K7EJ65K7EJ65_HUMAN
Protein Hook homolog 2
HOOK2
209Annotation score:
K7EK29K7EK29_HUMAN
Protein Hook homolog 2
HOOK2
93Annotation score:
K7EJA7K7EJA7_HUMAN
Protein Hook homolog 2
HOOK2
71Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti376R → L in AAC09299 (PubMed:9927460).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01757510G → R. Corresponds to variant dbSNP:rs2305376Ensembl.1
Natural variantiVAR_017576488H → Q1 PublicationCorresponds to variant dbSNP:rs897804Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_009342534 – 535Missing in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044924 mRNA Translation: AAC09299.1
AC018761 Genomic DNA No translation available.
BC012443 mRNA Translation: AAH12443.1
CCDSiCCDS42507.1 [Q96ED9-2]
CCDS42508.1 [Q96ED9-1]
RefSeqiNP_001093646.1, NM_001100176.1 [Q96ED9-2]
NP_037444.2, NM_013312.2 [Q96ED9-1]
UniGeneiHs.30792

Genome annotation databases

EnsembliENST00000264827; ENSP00000264827; ENSG00000095066 [Q96ED9-2]
ENST00000397668; ENSP00000380785; ENSG00000095066 [Q96ED9-1]
GeneIDi29911
KEGGihsa:29911
UCSCiuc002muy.3 human [Q96ED9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044924 mRNA Translation: AAC09299.1
AC018761 Genomic DNA No translation available.
BC012443 mRNA Translation: AAH12443.1
CCDSiCCDS42507.1 [Q96ED9-2]
CCDS42508.1 [Q96ED9-1]
RefSeqiNP_001093646.1, NM_001100176.1 [Q96ED9-2]
NP_037444.2, NM_013312.2 [Q96ED9-1]
UniGeneiHs.30792

3D structure databases

ProteinModelPortaliQ96ED9
SMRiQ96ED9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118957, 67 interactors
CORUMiQ96ED9
IntActiQ96ED9, 124 interactors
MINTiQ96ED9
STRINGi9606.ENSP00000380785

PTM databases

iPTMnetiQ96ED9
PhosphoSitePlusiQ96ED9

Polymorphism and mutation databases

BioMutaiHOOK2
DMDMi296439323

Proteomic databases

EPDiQ96ED9
MaxQBiQ96ED9
PaxDbiQ96ED9
PeptideAtlasiQ96ED9
PRIDEiQ96ED9
ProteomicsDBi76396
76397 [Q96ED9-2]

Protocols and materials databases

DNASUi29911
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264827; ENSP00000264827; ENSG00000095066 [Q96ED9-2]
ENST00000397668; ENSP00000380785; ENSG00000095066 [Q96ED9-1]
GeneIDi29911
KEGGihsa:29911
UCSCiuc002muy.3 human [Q96ED9-1]

Organism-specific databases

CTDi29911
DisGeNETi29911
EuPathDBiHostDB:ENSG00000095066.11
GeneCardsiHOOK2
H-InvDBiHIX0014803
HGNCiHGNC:19885 HOOK2
HPAiHPA043519
HPA050351
MIMi607824 gene
neXtProtiNX_Q96ED9
OpenTargetsiENSG00000095066
PharmGKBiPA134986864
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG1M Eukaryota
ENOG410XQ3G LUCA
GeneTreeiENSGT00690000101702
HOGENOMiHOG000294112
HOVERGENiHBG051920
InParanoidiQ96ED9
KOiK16611
OMAiERNTVYM
OrthoDBiEOG091G06O9
PhylomeDBiQ96ED9
TreeFamiTF320231

Enzyme and pathway databases

SIGNORiQ96ED9

Miscellaneous databases

ChiTaRSiHOOK2 human
GeneWikiiHOOK2
GenomeRNAii29911
PROiPR:Q96ED9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000095066 Expressed in 179 organ(s), highest expression level in adenohypophysis
CleanExiHS_HOOK2
ExpressionAtlasiQ96ED9 baseline and differential
GenevisibleiQ96ED9 HS

Family and domain databases

Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR008636 Hook-like_fam
PfamiView protein in Pfam
PF05622 HOOK, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHOOK2_HUMAN
AccessioniPrimary (citable) accession number: Q96ED9
Secondary accession number(s): O60562
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 140 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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