UniProtKB - Q96ED9 (HOOK2_HUMAN)

BLAST

>sp|Q96ED9|HOOK2_HUMAN Protein Hook homolog 2 OS=Homo sapiens OX=9606 GN=HOOK2 PE=1 SV=3
MSVDKAELCGSLLTWLQTFHVPSPCASPQDLSSGLAVAYVLNQIDPSWFNEAWLQGISED
PGPNWKLKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIGEFSDPAELGKLLQLVLG
CAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFL
SEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLL
LQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDEL
RQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRA
QLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEE
LRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRE
RQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAISILLK
RKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERY
RRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEE
KLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSRRGPLGRLASLNLRPTDKH

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History
Entry version 140 (07 Nov 2018)
Sequence version 3 (18 May 2010)
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Protein

Protein Hook homolog 2

Gene

HOOK2

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones.3 Publications

GO - Molecular functionⁱ

dynein light intermediate chain binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
identical protein binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 18799622
microtubule binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cytoplasmic microtubule organization
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cytoskeleton-dependent intracellular transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
early endosome to late endosome transport
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18799622
endocytosis
Source: ProtInc
Traceable author statementⁱ
- 9927460
endosome organization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18799622
endosome to lysosome transport
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18799622
lysosome organization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18799622
protein transport Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Protein transport, Transport

Biological process

Protein transport, Transport

Enzyme and pathway databases

SIGNORⁱ	Q96ED9

SIGNORⁱ

Q96ED9

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein Hook homolog 2 Short name: h-hook2 Short name: hHK2
Gene namesⁱ	Name:HOOK2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000095066.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:19885 HOOK2
MIMⁱ	607824 gene
neXtProtⁱ	NX_Q96ED9

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	29911
Open Targets More...OpenTargetsⁱ	ENSG00000095066
PharmGKBⁱ	PA134986864

Polymorphism and mutation databases

BioMutaⁱ	HOOK2
DMDMⁱ	296439323

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000219194	1 – 719	Protein Hook homolog 2Add BLAST		719

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	163	PhosphoserineCombined sources	1
Modified residueⁱ	230	PhosphothreonineCombined sources	1
Modified residueⁱ	710	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q96ED9
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96ED9
PaxDbⁱ	Q96ED9
PeptideAtlas More...PeptideAtlasⁱ	Q96ED9
PRIDEⁱ	Q96ED9
ProteomicsDBⁱ	76396 76397 [Q96ED9-2]

PTM databases

iPTMnetⁱ	Q96ED9
PhosphoSitePlusⁱ	Q96ED9

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000095066 Expressed in 179 organ(s), highest expression level in adenohypophysis
CleanExⁱ	HS_HOOK2
ExpressionAtlasⁱ	Q96ED9 baseline and differential
Genevisibleⁱ	Q96ED9 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA043519 HPA050351

HPAⁱ

HPA043519
HPA050351

Interactionⁱ

Subunit structureⁱ

Self-associates (PubMed:18799622). Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FAM160A2, and one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3 (PubMed:18799622). May interact directly with AKTIP/FTS, HOOK1 and HOOK3 (PubMed:18799622). Associates with several subunits of the homotypic vesicular sorting complex (the HOPS complex) including VPS16 and VPS41; these interactions may be indirect (PubMed:18799622). Interacts with CNTRL (PubMed:17140400). Interacts with microtubules (PubMed:11238449). Interacts with ZC3H14 (PubMed:19273536). Interacts with LRGUK (via guanylate kinase-like domain) (By similarity). Interacts with CCDC181 (By similarity).By similarity4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
ANKRD36BP1	Q96IX9	3	EBI-743290,EBI-744859
AP1M1	Q9BXS5	3	EBI-743290,EBI-541426
CCDC33	Q8N5R6	2	EBI-743290,EBI-740841
CWF19L2	Q2TBE0	3	EBI-743290,EBI-5453285
DUSP13	Q9UII6	3	EBI-743290,EBI-749800
KANSL1	Q7Z3B3	4	EBI-743290,EBI-740244
PIMREG	Q9BSJ6	3	EBI-10961706,EBI-2568609
RNF6	A0A0S2Z4G9	3	EBI-10961706,EBI-16428950
SUV39H1	O43463	4	EBI-743290,EBI-349968
UTP14C	Q08E77	3	EBI-743290,EBI-10225961
ZC2HC1C	Q53FD0	3	EBI-743290,EBI-740767

GO - Molecular functionⁱ

dynein light intermediate chain binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
identical protein binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 18799622
microtubule binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	118957, 67 interactors
CORUMⁱ	Q96ED9
IntActⁱ	Q96ED9, 124 interactors
Molecular INTeraction database More...MINTⁱ	Q96ED9
STRINGⁱ	9606.ENSP00000380785

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96ED9
SMRⁱ	Q96ED9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	6 – 122	Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST		117

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1 – 548	Sufficient for interaction with microtubulesAdd BLAST	548
Regionⁱ	1 – 161	Required for localization to the centrosome and induction of aggresome formationAdd BLAST	161
Regionⁱ	533 – 719	Required for localization to the centrosome and induction of aggresome formationAdd BLAST	187
Regionⁱ	584 – 719	Sufficient for interaction with CNTRL1 PublicationAdd BLAST	136

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	180 – 427	Sequence analysisAdd BLAST		248
Coiled coilⁱ	455 – 607	Sequence analysisAdd BLAST		153

Sequence similaritiesⁱ

Belongs to the hook family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	ENOG410IG1M Eukaryota ENOG410XQ3G LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00690000101702
HOGENOMⁱ	HOG000294112
HOVERGENⁱ	HBG051920
InParanoidⁱ	Q96ED9
KEGG Orthology (KO) More...KOⁱ	K16611
OMAⁱ	ERNTVYM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06O9
PhylomeDBⁱ	Q96ED9
TreeFamⁱ	TF320231

Family and domain databases

Gene3Dⁱ	1.10.418.10, 1 hit
InterProⁱ	View protein in InterPro IPR001715 CH-domain IPR036872 CH_dom_sf IPR008636 Hook-like_fam
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05622 HOOK, 1 hit
PROSITEⁱ	View protein in PROSITE PS50021 CH, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q96ED9-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVDKAELCG SLLTWLQTFH VPSPCASPQD LSSGLAVAYV LNQIDPSWFN 
        60         70         80         90        100
EAWLQGISED PGPNWKLKVS NLKMVLRSLV EYSQDVLAHP VSEEHLPDVS 
       110        120        130        140        150
LIGEFSDPAE LGKLLQLVLG CAISCEKKQD HIQRIMTLEE SVQHVVMEAI 
       160        170        180        190        200
QELMTKDTPD SLSPETYGNF DSQSRRYYFL SEEAEEGDEL QQRCLDLERQ 
       210        220        230        240        250
LMLLSEEKQS LAQENAGLRE RMGRPEGEGT PGLTAKKLLL LQSQLEQLQE 
       260        270        280        290        300
ENFRLESGRE DERLRCAELE REVAELQHRN QALTSLAQEA QALKDEMDEL 
       310        320        330        340        350
RQSSERAGQL EATLTSCRRR LGELRELRRQ VRQLEERNAG HAERTRQLED 
       360        370        380        390        400
ELRRAGSLRA QLEAQRRQVQ ELQGQRQEEA MKAEKWLFEC RNLEEKYESV 
       410        420        430        440        450
TKEKERLLAE RDSLREANEE LRCAQLQPRG LTQADPSLDP TSTPVDNLAA 
       460        470        480        490        500
EILPAELRET LLRLQLENKR LCRQEAADRE RQEELQRHLE DANRARHGLE 
       510        520        530        540        550
TQHRLNQQQL SELRAQVEDL QKALQEQGGK TEDAISILLK RKLEEHLQKL 
       560        570        580        590        600
HEADLELQRK REYIEELEPP TDSSTARRIE ELQHNLQKKD ADLRAMEERY 
       610        620        630        640        650
RRYVDKARMV MQTMEPKQRP AAGAPPELHS LRTQLRERDV RIRHLEMDFE 
       660        670        680        690        700
KSRSQREQEE KLLISAWYNM GMALQQRAGE ERAPAHAQSF LAQQRLATNS 
       710 
RRGPLGRLAS LNLRPTDKH

Length:719

Mass (Da):83,207

Last modified:May 18, 2010 - v3

Checksum:ⁱFDF5F8A53DEE9DB6

Isoform 2 (identifier: Q96ED9-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
534-535: Missing.

« Hide

        10         20         30         40         50
MSVDKAELCG SLLTWLQTFH VPSPCASPQD LSSGLAVAYV LNQIDPSWFN 
        60         70         80         90        100
EAWLQGISED PGPNWKLKVS NLKMVLRSLV EYSQDVLAHP VSEEHLPDVS 
       110        120        130        140        150
LIGEFSDPAE LGKLLQLVLG CAISCEKKQD HIQRIMTLEE SVQHVVMEAI 
       160        170        180        190        200
QELMTKDTPD SLSPETYGNF DSQSRRYYFL SEEAEEGDEL QQRCLDLERQ 
       210        220        230        240        250
LMLLSEEKQS LAQENAGLRE RMGRPEGEGT PGLTAKKLLL LQSQLEQLQE 
       260        270        280        290        300
ENFRLESGRE DERLRCAELE REVAELQHRN QALTSLAQEA QALKDEMDEL 
       310        320        330        340        350
RQSSERAGQL EATLTSCRRR LGELRELRRQ VRQLEERNAG HAERTRQLED 
       360        370        380        390        400
ELRRAGSLRA QLEAQRRQVQ ELQGQRQEEA MKAEKWLFEC RNLEEKYESV 
       410        420        430        440        450
TKEKERLLAE RDSLREANEE LRCAQLQPRG LTQADPSLDP TSTPVDNLAA 
       460        470        480        490        500
EILPAELRET LLRLQLENKR LCRQEAADRE RQEELQRHLE DANRARHGLE 
       510        520        530        540        550
TQHRLNQQQL SELRAQVEDL QKALQEQGGK TEDSILLKRK LEEHLQKLHE 
       560        570        580        590        600
ADLELQRKRE YIEELEPPTD SSTARRIEEL QHNLQKKDAD LRAMEERYRR 
       610        620        630        640        650
YVDKARMVMQ TMEPKQRPAA GAPPELHSLR TQLRERDVRI RHLEMDFEKS 
       660        670        680        690        700
RSQREQEEKL LISAWYNMGM ALQQRAGEER APAHAQSFLA QQRLATNSRR 
       710 
GPLGRLASLN LRPTDKH

Show »

Length:717

Mass (Da):83,022

Checksum:ⁱ980FCF8BA96E6E70

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

K7EJ48	K7EJ48_HUMAN	Protein Hook homolog 2 Protein Hook homolog 2	HOOK2	226	Annotation score:
K7EMR5	K7EMR5_HUMAN	Protein Hook homolog 2 Protein Hook homolog 2	HOOK2	157	Annotation score:
K7ENU5	K7ENU5_HUMAN	Protein Hook homolog 2 Protein Hook homolog 2	HOOK2	270	Annotation score:
K7EMG7	K7EMG7_HUMAN	Protein Hook homolog 2 Protein Hook homolog 2	HOOK2	127	Annotation score:
K7EJ65	K7EJ65_HUMAN	Protein Hook homolog 2 Protein Hook homolog 2	HOOK2	209	Annotation score:
K7EK29	K7EK29_HUMAN	Protein Hook homolog 2 Protein Hook homolog 2	HOOK2	93	Annotation score:
K7EJA7	K7EJA7_HUMAN	Protein Hook homolog 2 Protein Hook homolog 2	HOOK2	71	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	376	R → L in AAC09299 (PubMed:9927460).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_017575	10	G → R. Corresponds to variant dbSNP:rs2305376Ensembl.		1
Natural variantⁱVAR_017576	488	H → Q1 PublicationCorresponds to variant dbSNP:rs897804Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_009342	534 – 535	Missing in isoform 2. 1 Publication		2

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF044924 mRNA Translation: AAC09299.1 AC018761 Genomic DNA No translation available. BC012443 mRNA Translation: AAH12443.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS42507.1 [Q96ED9-2] CCDS42508.1 [Q96ED9-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001093646.1, NM_001100176.1 [Q96ED9-2] NP_037444.2, NM_013312.2 [Q96ED9-1]
UniGeneⁱ	Hs.30792

Genome annotation databases

Ensemblⁱ	ENST00000264827; ENSP00000264827; ENSG00000095066 [Q96ED9-2] ENST00000397668; ENSP00000380785; ENSG00000095066 [Q96ED9-1]
GeneIDⁱ	29911
KEGGⁱ	hsa:29911
UCSC genome browser More...UCSCⁱ	uc002muy.3 human [Q96ED9-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96ED9	Protein Hook homolog 2 (Fragment)		HUMAN		127	UniRef100_Q96ED9
Protein Hook homolog 2 (Fragment)		HUMAN		226
Protein Hook homolog 2 (Fragment)		HUMAN		270
Protein Hook homolog 2 (Fragment)		HUMAN		157
UPI000387C881		HUMAN		646
+1

Protein	Similar proteins		Species	Score	Length	Source
Q96ED9	Protein Hook homolog 2 (Fragment)		HUMAN		127	UniRef90_Q96ED9
protein Hook homolog 2 isoform X1		DELLE		720
Uncharacterized protein		MACMU		719
Uncharacterized protein		MACNE		719
Hook microtubule tethering protein 2		SAIBB		719
+181

Protein	Similar proteins		Species	Score	Length	Source
Q96ED9	Protein Hook homolog 2 (Fragment)		HUMAN		127	UniRef50_Q96ED9
protein Hook homolog 2 isoform X1		DELLE		720
Uncharacterized protein		Cebus capucinus imitator		719
Protein Hook homolog 2 isoform 1		CALJA		719
Protein Hook-like protein 2		MACMU		719
+246

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF044924 mRNA Translation: AAC09299.1 AC018761 Genomic DNA No translation available. BC012443 mRNA Translation: AAH12443.1
CCDSⁱ	CCDS42507.1 [Q96ED9-2] CCDS42508.1 [Q96ED9-1]
RefSeqⁱ	NP_001093646.1, NM_001100176.1 [Q96ED9-2] NP_037444.2, NM_013312.2 [Q96ED9-1]
UniGeneⁱ	Hs.30792

3D structure databases

ProteinModelPortalⁱ	Q96ED9
SMRⁱ	Q96ED9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	118957, 67 interactors
CORUMⁱ	Q96ED9
IntActⁱ	Q96ED9, 124 interactors
MINTⁱ	Q96ED9
STRINGⁱ	9606.ENSP00000380785

PTM databases

iPTMnetⁱ	Q96ED9
PhosphoSitePlusⁱ	Q96ED9

Polymorphism and mutation databases

BioMutaⁱ	HOOK2
DMDMⁱ	296439323

Proteomic databases

EPDⁱ	Q96ED9
MaxQBⁱ	Q96ED9
PaxDbⁱ	Q96ED9
PeptideAtlasⁱ	Q96ED9
PRIDEⁱ	Q96ED9
ProteomicsDBⁱ	76396 76397 [Q96ED9-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	29911
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000264827; ENSP00000264827; ENSG00000095066 [Q96ED9-2] ENST00000397668; ENSP00000380785; ENSG00000095066 [Q96ED9-1]
GeneIDⁱ	29911
KEGGⁱ	hsa:29911
UCSCⁱ	uc002muy.3 human [Q96ED9-1]

Organism-specific databases

CTDⁱ	29911
DisGeNETⁱ	29911
EuPathDBⁱ	HostDB:ENSG00000095066.11
GeneCardsⁱ	HOOK2
H-InvDBⁱ	HIX0014803
HGNCⁱ	HGNC:19885 HOOK2
HPAⁱ	HPA043519 HPA050351
MIMⁱ	607824 gene
neXtProtⁱ	NX_Q96ED9
OpenTargetsⁱ	ENSG00000095066
PharmGKBⁱ	PA134986864
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IG1M Eukaryota ENOG410XQ3G LUCA
GeneTreeⁱ	ENSGT00690000101702
HOGENOMⁱ	HOG000294112
HOVERGENⁱ	HBG051920
InParanoidⁱ	Q96ED9
KOⁱ	K16611
OMAⁱ	ERNTVYM
OrthoDBⁱ	EOG091G06O9
PhylomeDBⁱ	Q96ED9
TreeFamⁱ	TF320231

Enzyme and pathway databases

SIGNORⁱ	Q96ED9

SIGNORⁱ

Q96ED9

Miscellaneous databases

ChiTaRSⁱ	HOOK2 human
GeneWikiⁱ	HOOK2
GenomeRNAiⁱ	29911
Protein Ontology More...PROⁱ	PR:Q96ED9
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000095066 Expressed in 179 organ(s), highest expression level in adenohypophysis
CleanExⁱ	HS_HOOK2
ExpressionAtlasⁱ	Q96ED9 baseline and differential
Genevisibleⁱ	Q96ED9 HS

Family and domain databases

Gene3Dⁱ	1.10.418.10, 1 hit
InterProⁱ	View protein in InterPro IPR001715 CH-domain IPR036872 CH_dom_sf IPR008636 Hook-like_fam
Pfamⁱ	View protein in Pfam PF05622 HOOK, 1 hit
PROSITEⁱ	View protein in PROSITE PS50021 CH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HOOK2_HUMAN
Accessionⁱ	Q96ED9Primary (citable) accession number: Q96ED9 Secondary accession number(s): O60562
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 2, 2004
	Last sequence update:	May 18, 2010
	Last modified:	November 7, 2018
	This is version 140 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q96ED9 (HOOK2_HUMAN)

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Protein Hook homolog 2

HOOK2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Other locations

Cytoskeleton

Cytosol

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ