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UniProtKB - Q96ED9 (HOOK2_HUMAN)

Entry version 156 (10 Feb 2021)
Sequence version 3 (18 May 2010)
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Protein

Protein Hook homolog 2

Gene

HOOK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96ED9

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q96ED9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein Hook homolog 2
Short name:
h-hook2
Short name:
hHK2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HOOK2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:19885, HOOK2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607824, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96ED9

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000095066.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		29911

Open Targets

More...OpenTargetsi		ENSG00000095066

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134986864

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96ED9, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HOOK2

Domain mapping of disease mutations (DMDM)

More...DMDMi		296439323

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002191941 – 719Protein Hook homolog 2Add BLAST719

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei163PhosphoserineCombined sources1
Modified residuei230PhosphothreonineCombined sources1
Modified residuei710PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96ED9

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96ED9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96ED9

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96ED9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96ED9

PeptideAtlas

More...PeptideAtlasi		Q96ED9

PRoteomics IDEntifications database

More...PRIDEi		Q96ED9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		76396 [Q96ED9-1]
76397 [Q96ED9-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96ED9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96ED9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000095066, Expressed in adenohypophysis and 192 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96ED9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96ED9, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000095066, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Self-associates (PubMed:18799622).

Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FAM160A2, and one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3 (PubMed:18799622). May interact directly with AKTIP/FTS, HOOK1 and HOOK3 (PubMed:18799622). Associates with several subunits of the homotypic vesicular sorting complex (the HOPS complex) including VPS16 and VPS41; these interactions may be indirect (PubMed:18799622).

Interacts with CNTRL (PubMed:17140400).

Interacts with microtubules (PubMed:11238449).

Interacts with ZC3H14 (PubMed:19273536).

Interacts with LRGUK (via guanylate kinase-like domain) (By similarity).

Interacts with CCDC181 (By similarity).

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q96ED9
With#Exp.IntAct
AKTIP [Q9H8T0]3EBI-743290,EBI-711399
ANKRD36BP1 [Q96IX9]3EBI-743290,EBI-744859
AP1M1 [Q9BXS5]3EBI-743290,EBI-541426
CCDC33 [Q8N5R6]2EBI-743290,EBI-740841
CWF19L2 [Q2TBE0]3EBI-743290,EBI-5453285
DUSP13 [Q9UII6]3EBI-743290,EBI-749800
KANSL1 [Q7Z3B3]4EBI-743290,EBI-740244
RALBP1 [Q15311]3EBI-743290,EBI-749285
SUV39H1 [O43463]4EBI-743290,EBI-349968
UTP14C [Q08E77]3EBI-743290,EBI-10225961
ZC2HC1C [Q53FD0]3EBI-743290,EBI-740767
Isoform 2 [Q96ED9-2]
With#Exp.IntAct
AKTIP [Q9H8T0]3EBI-10961706,EBI-711399
ANKRD11 [X5D778]4EBI-10961706,EBI-17183751
AP1M1 [Q9BXS5]3EBI-10961706,EBI-541426
ATG5 [Q9H1Y0]3EBI-10961706,EBI-1047414
BYSL [Q13895]3EBI-10961706,EBI-358049
C1orf109 [Q9NX04]3EBI-10961706,EBI-8643161
CABP2 [Q9NPB3]3EBI-10961706,EBI-12011224
CBX8 [Q9HC52]3EBI-10961706,EBI-712912
CCDC198 [E9PSE9]3EBI-10961706,EBI-11748295
CDK18 [Q07002]3EBI-10961706,EBI-746238
CDKN1A [P38936]3EBI-10961706,EBI-375077
CEP95 [Q96GE4]3EBI-10961706,EBI-372775
CWF19L2 [Q2TBE0]3EBI-10961706,EBI-5453285
CYTH4 [Q9UIA0]3EBI-10961706,EBI-11521003
DCX - isoform 2 [O43602-2]3EBI-10961706,EBI-14148644
DDX6 [P26196]3EBI-10961706,EBI-351257
EIF3D [O15371]3EBI-10961706,EBI-353818
ENKD1 [Q9H0I2]3EBI-10961706,EBI-744099
FAM110A [Q9BQ89]3EBI-10961706,EBI-1752811
FAM161A [Q3B820]3EBI-10961706,EBI-719941
FAM161B [Q96MY7]3EBI-10961706,EBI-7225287
FAM50B [Q9Y247]3EBI-10961706,EBI-742802
FAM90A1 [Q86YD7]3EBI-10961706,EBI-6658203
FGF16 [O43320]3EBI-10961706,EBI-11479104
FLYWCH1 [Q4VC44]3EBI-10961706,EBI-719415
GAS2L2 [Q8NHY3]3EBI-10961706,EBI-7960826
GEM [P55040]3EBI-10961706,EBI-744104
GPKOW [Q92917]3EBI-10961706,EBI-746309
HDAC4 - isoform 2 [P56524-2]3EBI-10961706,EBI-11953488
HOXB5 [P09067]3EBI-10961706,EBI-3893317
IL16 - isoform 2 [Q14005-2]3EBI-10961706,EBI-17178971
IPP - isoform 2 [Q9Y573-2]3EBI-10961706,EBI-10976190
KIF9 [Q9HAQ2]3EBI-10961706,EBI-8472129
KRT1 [P04264]3EBI-10961706,EBI-298429
LENG1 [Q96BZ8]3EBI-10961706,EBI-726510
LNX1 [Q8TBB1]3EBI-10961706,EBI-739832
LRGUK [Q96M69]3EBI-10961706,EBI-9478535
MCRS1 [Q96EZ8]3EBI-10961706,EBI-348259
MFAP1 [P55081]3EBI-10961706,EBI-1048159
MGC50722 [Q8IVT4]3EBI-10961706,EBI-14086479
MORN3 [Q6PF18]3EBI-10961706,EBI-9675802
MPPED2 [Q15777]3EBI-10961706,EBI-2350461
MYLIP [Q8WY64]3EBI-10961706,EBI-6952711
NEK6 - isoform 4 [Q9HC98-4]3EBI-10961706,EBI-11750983
OAS1 - isoform p41 [P00973-2]3EBI-10961706,EBI-12081862
PARP11 - isoform 3 [Q9NR21-1]3EBI-10961706,EBI-17644640
PIMREG [Q9BSJ6]3EBI-10961706,EBI-2568609
PKP1 - isoform 1 [Q13835-2]3EBI-10961706,EBI-9087684
PKP2 - isoform 1 [Q99959-2]3EBI-10961706,EBI-10987518
PPP1R18 [Q6NYC8]3EBI-10961706,EBI-2557469
PPP1R26 [Q5T8A7]3EBI-10961706,EBI-308500
PRPF18 [Q99633]3EBI-10961706,EBI-2798416
PRPF31 [Q8WWY3]3EBI-10961706,EBI-1567797
PRR35 [P0CG20]3EBI-10961706,EBI-11986293
PSMA1 [P25786]3EBI-10961706,EBI-359352
RABGEF1 - isoform 3 [Q9UJ41-4]3EBI-10961706,EBI-14093916
RALBP1 [Q15311]3EBI-10961706,EBI-749285
RBM41 [Q96IZ5]3EBI-10961706,EBI-740773
RCOR3 - isoform 2 [Q9P2K3-2]3EBI-10961706,EBI-1504830
RGS8 - isoform 2 [P57771-2]3EBI-10961706,EBI-12058229
RNF169 [Q8NCN4]3EBI-10961706,EBI-6380946
RNF6 [A0A0S2Z4G9]3EBI-10961706,EBI-16428950
SCNM1 [Q9BWG6]3EBI-10961706,EBI-748391
SH2D4A [Q9H788]3EBI-10961706,EBI-747035
SNW1 [Q13573]3EBI-10961706,EBI-632715
SPATC1L - isoform 2 [Q9H0A9-2]3EBI-10961706,EBI-11995806
SUV39H1 [O43463]3EBI-10961706,EBI-349968
SYT17 [Q9BSW7]3EBI-10961706,EBI-745392
SYT6 - isoform 2 [Q5T7P8-2]3EBI-10961706,EBI-10246152
TBC1D22B [Q9NU19]3EBI-10961706,EBI-8787464
TBC1D30 - isoform 2 [Q9Y2I9-2]3EBI-10961706,EBI-17455779
TCEANC - isoform 2 [Q8N8B7-2]3EBI-10961706,EBI-11955057
TCHP [Q9BT92]3EBI-10961706,EBI-740781
TSGA10 [Q9BZW7]3EBI-10961706,EBI-744794
TSGA10IP [Q3SY00]3EBI-10961706,EBI-10241197
TTC23 - isoform 3 [Q5W5X9-3]3EBI-10961706,EBI-9090990
USP2 [O75604]3EBI-10961706,EBI-743272
UTP14C [Q5TAP6]3EBI-10961706,EBI-11737646
ZBTB47 [Q9UFB7]3EBI-10961706,EBI-7781767
ZC2HC1C - isoform 2 [Q53FD0-2]3EBI-10961706,EBI-14104088
ZFP1 [Q6P2D0]3EBI-10961706,EBI-2555749
ZFYVE26 - isoform 5 [Q68DK2-5]3EBI-10961706,EBI-8656416
ZGPAT - isoform 2 [Q8N5A5-2]3EBI-10961706,EBI-10183064
ZNF107 [Q9UII5]3EBI-10961706,EBI-7234993
ZNF250 - isoform 3 [P15622-3]3EBI-10961706,EBI-10177272
ZNF35 [P13682]3EBI-10961706,EBI-11041653
ZNF417 [Q8TAU3]3EBI-10961706,EBI-740727
ZNF48 [Q96MX3]3EBI-10961706,EBI-12006434
ZNF497 [Q6ZNH5]3EBI-10961706,EBI-10486136
ZNF572 [Q7Z3I7]3EBI-10961706,EBI-10172590
ZNF587 [Q96SQ5]3EBI-10961706,EBI-6427977
ZNF648 [Q5T619]3EBI-10961706,EBI-11985915
ZNF835 [Q9Y2P0]3EBI-10961706,EBI-5667516
ZNF844 [Q08AG5]3EBI-10961706,EBI-10225757

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		118957, 155 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q96ED9

Protein interaction database and analysis system

More...IntActi		Q96ED9, 138 interactors

Molecular INTeraction database

More...MINTi		Q96ED9

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000380785

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96ED9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96ED9

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 122Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST117

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 548Sufficient for interaction with microtubulesAdd BLAST548
Regioni1 – 161Required for localization to the centrosome and induction of aggresome formationAdd BLAST161
Regioni533 – 719Required for localization to the centrosome and induction of aggresome formationAdd BLAST187
Regioni584 – 719Sufficient for interaction with CNTRL1 PublicationAdd BLAST136

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili180 – 427Sequence analysisAdd BLAST248
Coiled coili455 – 607Sequence analysisAdd BLAST153

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the hook family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QTJ1, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160152

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_011214_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96ED9

Identification of Orthologs from Complete Genome Data

More...OMAi		MLCAQEE

Database of Orthologous Groups

More...OrthoDBi		398210at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96ED9

TreeFam database of animal gene trees

More...TreeFami		TF320231

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.418.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR008636, Hook_C
IPR043936, HOOK_N

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05622, HOOK, 1 hit
PF19047, HOOK_N, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50021, CH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96ED9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSVDKAELCG SLLTWLQTFH VPSPCASPQD LSSGLAVAYV LNQIDPSWFN 
        60         70         80         90        100
EAWLQGISED PGPNWKLKVS NLKMVLRSLV EYSQDVLAHP VSEEHLPDVS 
       110        120        130        140        150
LIGEFSDPAE LGKLLQLVLG CAISCEKKQD HIQRIMTLEE SVQHVVMEAI 
       160        170        180        190        200
QELMTKDTPD SLSPETYGNF DSQSRRYYFL SEEAEEGDEL QQRCLDLERQ 
       210        220        230        240        250
LMLLSEEKQS LAQENAGLRE RMGRPEGEGT PGLTAKKLLL LQSQLEQLQE 
       260        270        280        290        300
ENFRLESGRE DERLRCAELE REVAELQHRN QALTSLAQEA QALKDEMDEL 
       310        320        330        340        350
RQSSERAGQL EATLTSCRRR LGELRELRRQ VRQLEERNAG HAERTRQLED 
       360        370        380        390        400
ELRRAGSLRA QLEAQRRQVQ ELQGQRQEEA MKAEKWLFEC RNLEEKYESV 
       410        420        430        440        450
TKEKERLLAE RDSLREANEE LRCAQLQPRG LTQADPSLDP TSTPVDNLAA 
       460        470        480        490        500
EILPAELRET LLRLQLENKR LCRQEAADRE RQEELQRHLE DANRARHGLE 
       510        520        530        540        550
TQHRLNQQQL SELRAQVEDL QKALQEQGGK TEDAISILLK RKLEEHLQKL 
       560        570        580        590        600
HEADLELQRK REYIEELEPP TDSSTARRIE ELQHNLQKKD ADLRAMEERY 
       610        620        630        640        650
RRYVDKARMV MQTMEPKQRP AAGAPPELHS LRTQLRERDV RIRHLEMDFE 
       660        670        680        690        700
KSRSQREQEE KLLISAWYNM GMALQQRAGE ERAPAHAQSF LAQQRLATNS 
       710 
RRGPLGRLAS LNLRPTDKH
Length:719
Mass (Da):83,207
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFDF5F8A53DEE9DB6
GO
Isoform 2 (identifier: Q96ED9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     534-535: Missing.

Show »
Length:717
Mass (Da):83,022
Checksum:i980FCF8BA96E6E70
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EMR5K7EMR5_HUMAN
Protein Hook homolog 2
HOOK2
157Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJ48K7EJ48_HUMAN
Protein Hook homolog 2
HOOK2
226Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ENU5K7ENU5_HUMAN
Protein Hook homolog 2
HOOK2
270Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EMG7K7EMG7_HUMAN
Protein Hook homolog 2
HOOK2
127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EK29K7EK29_HUMAN
Protein Hook homolog 2
HOOK2
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJ65K7EJ65_HUMAN
Protein Hook homolog 2
HOOK2
209Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJA7K7EJA7_HUMAN
Protein Hook homolog 2
HOOK2
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti376R → L in AAC09299 (PubMed:9927460).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01757510G → R. Corresponds to variant dbSNP:rs2305376Ensembl.1
Natural variantiVAR_017576488H → Q1 PublicationCorresponds to variant dbSNP:rs897804Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_009342534 – 535Missing in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF044924 mRNA Translation: AAC09299.1
AC018761 Genomic DNA No translation available.
BC012443 mRNA Translation: AAH12443.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS42507.1 [Q96ED9-2]
CCDS42508.1 [Q96ED9-1]

NCBI Reference Sequences

More...RefSeqi		NP_001093646.1, NM_001100176.1 [Q96ED9-2]
NP_037444.2, NM_013312.2 [Q96ED9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000264827; ENSP00000264827; ENSG00000095066 [Q96ED9-2]
ENST00000397668; ENSP00000380785; ENSG00000095066 [Q96ED9-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		29911

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:29911

UCSC genome browser

More...UCSCi		uc002muy.3, human [Q96ED9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044924 mRNA Translation: AAC09299.1
AC018761 Genomic DNA No translation available.
BC012443 mRNA Translation: AAH12443.1
CCDSiCCDS42507.1 [Q96ED9-2]
CCDS42508.1 [Q96ED9-1]
RefSeqiNP_001093646.1, NM_001100176.1 [Q96ED9-2]
NP_037444.2, NM_013312.2 [Q96ED9-1]

3D structure databases

SMRiQ96ED9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi118957, 155 interactors
CORUMiQ96ED9
IntActiQ96ED9, 138 interactors
MINTiQ96ED9
STRINGi9606.ENSP00000380785

PTM databases

iPTMnetiQ96ED9
PhosphoSitePlusiQ96ED9

Genetic variation databases

BioMutaiHOOK2
DMDMi296439323

Proteomic databases

EPDiQ96ED9
jPOSTiQ96ED9
MassIVEiQ96ED9
MaxQBiQ96ED9
PaxDbiQ96ED9
PeptideAtlasiQ96ED9
PRIDEiQ96ED9
ProteomicsDBi76396 [Q96ED9-1]
76397 [Q96ED9-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		26165, 105 antibodies

The DNASU plasmid repository

More...DNASUi		29911

Genome annotation databases

EnsembliENST00000264827; ENSP00000264827; ENSG00000095066 [Q96ED9-2]
ENST00000397668; ENSP00000380785; ENSG00000095066 [Q96ED9-1]
GeneIDi29911
KEGGihsa:29911
UCSCiuc002muy.3, human [Q96ED9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		29911
DisGeNETi29911

GeneCards: human genes, protein and diseases

More...GeneCardsi		HOOK2
HGNCiHGNC:19885, HOOK2
HPAiENSG00000095066, Low tissue specificity
MIMi607824, gene
neXtProtiNX_Q96ED9
OpenTargetsiENSG00000095066
PharmGKBiPA134986864
VEuPathDBiHostDB:ENSG00000095066.11

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QTJ1, Eukaryota
GeneTreeiENSGT00940000160152
HOGENOMiCLU_011214_2_0_1
InParanoidiQ96ED9
OMAiMLCAQEE
OrthoDBi398210at2759
PhylomeDBiQ96ED9
TreeFamiTF320231

Enzyme and pathway databases

PathwayCommonsiQ96ED9
SIGNORiQ96ED9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		29911, 10 hits in 875 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		HOOK2, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		HOOK2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		29911
PharosiQ96ED9, Tbio

Protein Ontology

More...PROi		PR:Q96ED9
RNActiQ96ED9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000095066, Expressed in adenohypophysis and 192 other tissues
ExpressionAtlasiQ96ED9, baseline and differential
GenevisibleiQ96ED9, HS

Family and domain databases

Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR008636, Hook_C
IPR043936, HOOK_N
PfamiView protein in Pfam
PF05622, HOOK, 1 hit
PF19047, HOOK_N, 1 hit
PROSITEiView protein in PROSITE
PS50021, CH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHOOK2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96ED9
Secondary accession number(s): O60562
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: May 18, 2010
Last modified: February 10, 2021
This is version 156 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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