HOOK2

Functionⁱ

Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones.3 Publications

GO - Molecular functionⁱ

dynein light intermediate chain binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
identical protein binding
Source: UniProtKB
Inferred from physical interactionⁱ
- Ref.7
  "An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex."
  Xu L., Sowa M.E., Chen J., Li X., Gygi S.P., Harper J.W.
  Mol. Biol. Cell 19:5059-5071(2008) [PubMed] [Europe PMC] [Abstract]
  Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE FHF COMPLEX, FUNCTION, SELF-ASSOCIATION, INTERACTION WITH AKTIP; HOOK1; HOOK3; VPS16 AND VPS41.
microtubule binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Protein transport, Transport

Biological process

Protein transport, Transport

Enzyme and pathway databases

PathwayCommonsⁱ	Q96ED9
SIGNORⁱ	Q96ED9

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein Hook homolog 2 Short name: h-hook2 Short name: hHK2
Gene namesⁱ	Name:HOOK2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000095066.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:19885, HOOK2
MIMⁱ	607824, gene
neXtProtⁱ	NX_Q96ED9

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	29911
Open Targets More...OpenTargetsⁱ	ENSG00000095066
PharmGKBⁱ	PA134986864

Miscellaneous databases

Pharosⁱ	Q96ED9, Tbio

Pharosⁱ

Q96ED9, Tbio

Polymorphism and mutation databases

BioMutaⁱ	HOOK2
DMDMⁱ	296439323

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000219194	1 – 719	Protein Hook homolog 2Add BLAST		719

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	163	PhosphoserineCombined sources	1
Modified residueⁱ	230	PhosphothreonineCombined sources	1
Modified residueⁱ	710	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q96ED9
jPOSTⁱ	Q96ED9
MassIVEⁱ	Q96ED9
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96ED9
PaxDbⁱ	Q96ED9
PeptideAtlas More...PeptideAtlasⁱ	Q96ED9
PRIDEⁱ	Q96ED9
ProteomicsDBⁱ	76396 [Q96ED9-1] 76397 [Q96ED9-2]

PTM databases

iPTMnetⁱ	Q96ED9
PhosphoSitePlusⁱ	Q96ED9

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000095066, Expressed in adenohypophysis and 192 other tissues
ExpressionAtlasⁱ	Q96ED9, baseline and differential
Genevisibleⁱ	Q96ED9, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000095066, Low tissue specificity

HPAⁱ

ENSG00000095066, Low tissue specificity

Interactionⁱ

Subunit structureⁱ

Self-associates (PubMed:18799622).

Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FAM160A2, and one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3 (PubMed:18799622). May interact directly with AKTIP/FTS, HOOK1 and HOOK3 (PubMed:18799622). Associates with several subunits of the homotypic vesicular sorting complex (the HOPS complex) including VPS16 and VPS41; these interactions may be indirect (PubMed:18799622).

Interacts with CNTRL (PubMed:17140400).

Interacts with microtubules (PubMed:11238449).

Interacts with ZC3H14 (PubMed:19273536).

Interacts with LRGUK (via guanylate kinase-like domain) (By similarity).

Interacts with CCDC181 (By similarity).

By similarity4 Publications

Binary interactionsⁱ

Q96ED9

With	#Exp.	IntAct
AKTIP [Q9H8T0]	3	EBI-743290,EBI-711399
ANKRD36BP1 [Q96IX9]	3	EBI-743290,EBI-744859
AP1M1 [Q9BXS5]	3	EBI-743290,EBI-541426
CCDC33 [Q8N5R6]	2	EBI-743290,EBI-740841
CWF19L2 [Q2TBE0]	3	EBI-743290,EBI-5453285
DUSP13 [Q9UII6]	3	EBI-743290,EBI-749800
KANSL1 [Q7Z3B3]	4	EBI-743290,EBI-740244
RALBP1 [Q15311]	3	EBI-743290,EBI-749285
SUV39H1 [O43463]	4	EBI-743290,EBI-349968
UTP14C [Q08E77]	3	EBI-743290,EBI-10225961
ZC2HC1C [Q53FD0]	3	EBI-743290,EBI-740767

Isoform 2 [Q96ED9-2]

With	#Exp.	IntAct
AKTIP [Q9H8T0]	3	EBI-10961706,EBI-711399
ANKRD11 [X5D778]	4	EBI-10961706,EBI-17183751
AP1M1 [Q9BXS5]	3	EBI-10961706,EBI-541426
ATG5 [Q9H1Y0]	3	EBI-10961706,EBI-1047414
BYSL [Q13895]	3	EBI-10961706,EBI-358049
C1orf109 [Q9NX04]	3	EBI-10961706,EBI-8643161
CABP2 [Q9NPB3]	3	EBI-10961706,EBI-12011224
CBX8 [Q9HC52]	3	EBI-10961706,EBI-712912
CCDC198 [E9PSE9]	3	EBI-10961706,EBI-11748295
CDK18 [Q07002]	3	EBI-10961706,EBI-746238
CDKN1A [P38936]	3	EBI-10961706,EBI-375077
CEP95 [Q96GE4]	3	EBI-10961706,EBI-372775
CWF19L2 [Q2TBE0]	3	EBI-10961706,EBI-5453285
CYTH4 [Q9UIA0]	3	EBI-10961706,EBI-11521003
DCX - isoform 2 [O43602-2]	3	EBI-10961706,EBI-14148644
DDX6 [P26196]	3	EBI-10961706,EBI-351257
EIF3D [O15371]	3	EBI-10961706,EBI-353818
ENKD1 [Q9H0I2]	3	EBI-10961706,EBI-744099
FAM110A [Q9BQ89]	3	EBI-10961706,EBI-1752811
FAM161A [Q3B820]	3	EBI-10961706,EBI-719941
FAM161B [Q96MY7]	3	EBI-10961706,EBI-7225287
FAM50B [Q9Y247]	3	EBI-10961706,EBI-742802
FAM90A1 [Q86YD7]	3	EBI-10961706,EBI-6658203
FGF16 [O43320]	3	EBI-10961706,EBI-11479104
FLYWCH1 [Q4VC44]	3	EBI-10961706,EBI-719415
GAS2L2 [Q8NHY3]	3	EBI-10961706,EBI-7960826
GEM [P55040]	3	EBI-10961706,EBI-744104
GPKOW [Q92917]	3	EBI-10961706,EBI-746309
HDAC4 - isoform 2 [P56524-2]	3	EBI-10961706,EBI-11953488
HOXB5 [P09067]	3	EBI-10961706,EBI-3893317
IL16 - isoform 2 [Q14005-2]	3	EBI-10961706,EBI-17178971
IPP - isoform 2 [Q9Y573-2]	3	EBI-10961706,EBI-10976190
KIF9 [Q9HAQ2]	3	EBI-10961706,EBI-8472129
KRT1 [P04264]	3	EBI-10961706,EBI-298429
LENG1 [Q96BZ8]	3	EBI-10961706,EBI-726510
LNX1 [Q8TBB1]	3	EBI-10961706,EBI-739832
LRGUK [Q96M69]	3	EBI-10961706,EBI-9478535
MCRS1 [Q96EZ8]	3	EBI-10961706,EBI-348259
MFAP1 [P55081]	3	EBI-10961706,EBI-1048159
MGC50722 [Q8IVT4]	3	EBI-10961706,EBI-14086479
MORN3 [Q6PF18]	3	EBI-10961706,EBI-9675802
MPPED2 [Q15777]	3	EBI-10961706,EBI-2350461
MYLIP [Q8WY64]	3	EBI-10961706,EBI-6952711
NEK6 - isoform 4 [Q9HC98-4]	3	EBI-10961706,EBI-11750983
OAS1 - isoform p41 [P00973-2]	3	EBI-10961706,EBI-12081862
PARP11 - isoform 3 [Q9NR21-1]	3	EBI-10961706,EBI-17644640
PIMREG [Q9BSJ6]	3	EBI-10961706,EBI-2568609
PKP1 - isoform 1 [Q13835-2]	3	EBI-10961706,EBI-9087684
PKP2 - isoform 1 [Q99959-2]	3	EBI-10961706,EBI-10987518
PPP1R18 [Q6NYC8]	3	EBI-10961706,EBI-2557469
PPP1R26 [Q5T8A7]	3	EBI-10961706,EBI-308500
PRPF18 [Q99633]	3	EBI-10961706,EBI-2798416
PRPF31 [Q8WWY3]	3	EBI-10961706,EBI-1567797
PRR35 [P0CG20]	3	EBI-10961706,EBI-11986293
PSMA1 [P25786]	3	EBI-10961706,EBI-359352
RABGEF1 - isoform 3 [Q9UJ41-4]	3	EBI-10961706,EBI-14093916
RALBP1 [Q15311]	3	EBI-10961706,EBI-749285
RBM41 [Q96IZ5]	3	EBI-10961706,EBI-740773
RCOR3 - isoform 2 [Q9P2K3-2]	3	EBI-10961706,EBI-1504830
RGS8 - isoform 2 [P57771-2]	3	EBI-10961706,EBI-12058229
RNF169 [Q8NCN4]	3	EBI-10961706,EBI-6380946
RNF6 [A0A0S2Z4G9]	3	EBI-10961706,EBI-16428950
SCNM1 [Q9BWG6]	3	EBI-10961706,EBI-748391
SH2D4A [Q9H788]	3	EBI-10961706,EBI-747035
SNW1 [Q13573]	3	EBI-10961706,EBI-632715
SPATC1L - isoform 2 [Q9H0A9-2]	3	EBI-10961706,EBI-11995806
SUV39H1 [O43463]	3	EBI-10961706,EBI-349968
SYT17 [Q9BSW7]	3	EBI-10961706,EBI-745392
SYT6 - isoform 2 [Q5T7P8-2]	3	EBI-10961706,EBI-10246152
TBC1D22B [Q9NU19]	3	EBI-10961706,EBI-8787464
TBC1D30 - isoform 2 [Q9Y2I9-2]	3	EBI-10961706,EBI-17455779
TCEANC - isoform 2 [Q8N8B7-2]	3	EBI-10961706,EBI-11955057
TCHP [Q9BT92]	3	EBI-10961706,EBI-740781
TSGA10 [Q9BZW7]	3	EBI-10961706,EBI-744794
TSGA10IP [Q3SY00]	3	EBI-10961706,EBI-10241197
TTC23 - isoform 3 [Q5W5X9-3]	3	EBI-10961706,EBI-9090990
USP2 [O75604]	3	EBI-10961706,EBI-743272
UTP14C [Q5TAP6]	3	EBI-10961706,EBI-11737646
ZBTB47 [Q9UFB7]	3	EBI-10961706,EBI-7781767
ZC2HC1C - isoform 2 [Q53FD0-2]	3	EBI-10961706,EBI-14104088
ZFP1 [Q6P2D0]	3	EBI-10961706,EBI-2555749
ZFYVE26 - isoform 5 [Q68DK2-5]	3	EBI-10961706,EBI-8656416
ZGPAT - isoform 2 [Q8N5A5-2]	3	EBI-10961706,EBI-10183064
ZNF107 [Q9UII5]	3	EBI-10961706,EBI-7234993
ZNF250 - isoform 3 [P15622-3]	3	EBI-10961706,EBI-10177272
ZNF35 [P13682]	3	EBI-10961706,EBI-11041653
ZNF417 [Q8TAU3]	3	EBI-10961706,EBI-740727
ZNF48 [Q96MX3]	3	EBI-10961706,EBI-12006434
ZNF497 [Q6ZNH5]	3	EBI-10961706,EBI-10486136
ZNF572 [Q7Z3I7]	3	EBI-10961706,EBI-10172590
ZNF587 [Q96SQ5]	3	EBI-10961706,EBI-6427977
ZNF648 [Q5T619]	3	EBI-10961706,EBI-11985915
ZNF835 [Q9Y2P0]	3	EBI-10961706,EBI-5667516
ZNF844 [Q08AG5]	3	EBI-10961706,EBI-10225757

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	118957, 72 interactors
CORUMⁱ	Q96ED9
IntActⁱ	Q96ED9, 137 interactors
Molecular INTeraction database More...MINTⁱ	Q96ED9
STRINGⁱ	9606.ENSP00000380785

Miscellaneous databases

RNActⁱ	Q96ED9, protein

RNActⁱ

Q96ED9, protein

Structureⁱ

3D structure databases

SMRⁱ	Q96ED9
ModBaseⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	6 – 122	Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST		117

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1 – 548	Sufficient for interaction with microtubulesAdd BLAST	548
Regionⁱ	1 – 161	Required for localization to the centrosome and induction of aggresome formationAdd BLAST	161
Regionⁱ	533 – 719	Required for localization to the centrosome and induction of aggresome formationAdd BLAST	187
Regionⁱ	584 – 719	Sufficient for interaction with CNTRL1 PublicationAdd BLAST	136

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	180 – 427	Sequence analysisAdd BLAST		248
Coiled coilⁱ	455 – 607	Sequence analysisAdd BLAST		153

Sequence similaritiesⁱ

Belongs to the hook family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	ENOG502QTJ1, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000160152
HOGENOMⁱ	CLU_011214_2_0_1
InParanoidⁱ	Q96ED9
KEGG Orthology (KO) More...KOⁱ	K16611
OMAⁱ	MLCAQEE
Database of Orthologous Groups More...OrthoDBⁱ	398210at2759
PhylomeDBⁱ	Q96ED9
TreeFamⁱ	TF320231

Family and domain databases

Gene3Dⁱ	1.10.418.10, 1 hit
InterProⁱ	View protein in InterPro IPR001715, CH-domain IPR036872, CH_dom_sf IPR008636, Hook-like_fam
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05622, HOOK, 1 hit
PROSITEⁱ	View protein in PROSITE PS50021, CH, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q96ED9-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVDKAELCG SLLTWLQTFH VPSPCASPQD LSSGLAVAYV LNQIDPSWFN 
        60         70         80         90        100
EAWLQGISED PGPNWKLKVS NLKMVLRSLV EYSQDVLAHP VSEEHLPDVS 
       110        120        130        140        150
LIGEFSDPAE LGKLLQLVLG CAISCEKKQD HIQRIMTLEE SVQHVVMEAI 
       160        170        180        190        200
QELMTKDTPD SLSPETYGNF DSQSRRYYFL SEEAEEGDEL QQRCLDLERQ 
       210        220        230        240        250
LMLLSEEKQS LAQENAGLRE RMGRPEGEGT PGLTAKKLLL LQSQLEQLQE 
       260        270        280        290        300
ENFRLESGRE DERLRCAELE REVAELQHRN QALTSLAQEA QALKDEMDEL 
       310        320        330        340        350
RQSSERAGQL EATLTSCRRR LGELRELRRQ VRQLEERNAG HAERTRQLED 
       360        370        380        390        400
ELRRAGSLRA QLEAQRRQVQ ELQGQRQEEA MKAEKWLFEC RNLEEKYESV 
       410        420        430        440        450
TKEKERLLAE RDSLREANEE LRCAQLQPRG LTQADPSLDP TSTPVDNLAA 
       460        470        480        490        500
EILPAELRET LLRLQLENKR LCRQEAADRE RQEELQRHLE DANRARHGLE 
       510        520        530        540        550
TQHRLNQQQL SELRAQVEDL QKALQEQGGK TEDAISILLK RKLEEHLQKL 
       560        570        580        590        600
HEADLELQRK REYIEELEPP TDSSTARRIE ELQHNLQKKD ADLRAMEERY 
       610        620        630        640        650
RRYVDKARMV MQTMEPKQRP AAGAPPELHS LRTQLRERDV RIRHLEMDFE 
       660        670        680        690        700
KSRSQREQEE KLLISAWYNM GMALQQRAGE ERAPAHAQSF LAQQRLATNS 
       710 
RRGPLGRLAS LNLRPTDKH

Length:719

Mass (Da):83,207

Last modified:May 18, 2010 - v3

Checksum:ⁱFDF5F8A53DEE9DB6

GO

Isoform 2 (identifier: Q96ED9-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
534-535: Missing.

« Hide

        10         20         30         40         50
MSVDKAELCG SLLTWLQTFH VPSPCASPQD LSSGLAVAYV LNQIDPSWFN 
        60         70         80         90        100
EAWLQGISED PGPNWKLKVS NLKMVLRSLV EYSQDVLAHP VSEEHLPDVS 
       110        120        130        140        150
LIGEFSDPAE LGKLLQLVLG CAISCEKKQD HIQRIMTLEE SVQHVVMEAI 
       160        170        180        190        200
QELMTKDTPD SLSPETYGNF DSQSRRYYFL SEEAEEGDEL QQRCLDLERQ 
       210        220        230        240        250
LMLLSEEKQS LAQENAGLRE RMGRPEGEGT PGLTAKKLLL LQSQLEQLQE 
       260        270        280        290        300
ENFRLESGRE DERLRCAELE REVAELQHRN QALTSLAQEA QALKDEMDEL 
       310        320        330        340        350
RQSSERAGQL EATLTSCRRR LGELRELRRQ VRQLEERNAG HAERTRQLED 
       360        370        380        390        400
ELRRAGSLRA QLEAQRRQVQ ELQGQRQEEA MKAEKWLFEC RNLEEKYESV 
       410        420        430        440        450
TKEKERLLAE RDSLREANEE LRCAQLQPRG LTQADPSLDP TSTPVDNLAA 
       460        470        480        490        500
EILPAELRET LLRLQLENKR LCRQEAADRE RQEELQRHLE DANRARHGLE 
       510        520        530        540        550
TQHRLNQQQL SELRAQVEDL QKALQEQGGK TEDSILLKRK LEEHLQKLHE 
       560        570        580        590        600
ADLELQRKRE YIEELEPPTD SSTARRIEEL QHNLQKKDAD LRAMEERYRR 
       610        620        630        640        650
YVDKARMVMQ TMEPKQRPAA GAPPELHSLR TQLRERDVRI RHLEMDFEKS 
       660        670        680        690        700
RSQREQEEKL LISAWYNMGM ALQQRAGEER APAHAQSFLA QQRLATNSRR 
       710 
GPLGRLASLN LRPTDKH

Show »

Length:717

Mass (Da):83,022

Checksum:ⁱ980FCF8BA96E6E70

GO

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

K7EJ48	K7EJ48_HUMAN	Protein Hook homolog 2 Protein Hook homolog 2	HOOK2	226	Annotation score:
K7EMR5	K7EMR5_HUMAN	Protein Hook homolog 2 Protein Hook homolog 2	HOOK2	157	Annotation score:
K7ENU5	K7ENU5_HUMAN	Protein Hook homolog 2 Protein Hook homolog 2	HOOK2	270	Annotation score:
K7EMG7	K7EMG7_HUMAN	Protein Hook homolog 2 Protein Hook homolog 2	HOOK2	127	Annotation score:
K7EK29	K7EK29_HUMAN	Protein Hook homolog 2 Protein Hook homolog 2	HOOK2	93	Annotation score:
K7EJ65	K7EJ65_HUMAN	Protein Hook homolog 2 Protein Hook homolog 2	HOOK2	209	Annotation score:
K7EJA7	K7EJA7_HUMAN	Protein Hook homolog 2 Protein Hook homolog 2	HOOK2	71	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	376	R → L in AAC09299 (PubMed:9927460).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_017575	10	G → R. Corresponds to variant dbSNP:rs2305376Ensembl.		1
Natural variantⁱVAR_017576	488	H → Q1 PublicationCorresponds to variant dbSNP:rs897804Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_009342	534 – 535	Missing in isoform 2. 1 Publication		2

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF044924 mRNA Translation: AAC09299.1 AC018761 Genomic DNA No translation available. BC012443 mRNA Translation: AAH12443.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS42507.1 [Q96ED9-2] CCDS42508.1 [Q96ED9-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001093646.1, NM_001100176.1 [Q96ED9-2] NP_037444.2, NM_013312.2 [Q96ED9-1]

Genome annotation databases

Ensemblⁱ	ENST00000264827; ENSP00000264827; ENSG00000095066 [Q96ED9-2] ENST00000397668; ENSP00000380785; ENSG00000095066 [Q96ED9-1]
GeneIDⁱ	29911
KEGGⁱ	hsa:29911
UCSC genome browser More...UCSCⁱ	uc002muy.3, human [Q96ED9-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96ED9	Protein Hook homolog 2 (Fragment)		HUMAN		226	UniRef100_Q96ED9
Protein Hook homolog 2 (Fragment)		HUMAN		270
Protein Hook homolog 2 (Fragment)		HUMAN		127
Protein Hook homolog 2 (Fragment)		HUMAN		157
+2

Protein	Similar proteins		Species	Score	Length	Source
Q96ED9	Protein Hook homolog 2 (Fragment)		HUMAN		226	UniRef90_Q96ED9
protein Hook homolog 2 isoform X1		DELLE		720
Protein Hook homolog 2 isoform 1		CALJA		719
protein Hook homolog 2 isoform X1		ODORO		719
Calponin-homology (CH) domain-containing protein		LYNCA		719
+205

Protein	Similar proteins		Species	Score	Length	Source
Q96ED9	Protein Hook homolog 2 (Fragment)		HUMAN		226	UniRef50_Q96ED9
protein Hook homolog 2 isoform X1		DELLE		720
Protein Hook homolog 2 isoform 1		CALJA		719
Hook microtubule tethering protein 2		FELCA		719
Hook microtubule tethering protein 2		AILME		719
+387

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF044924 mRNA Translation: AAC09299.1 AC018761 Genomic DNA No translation available. BC012443 mRNA Translation: AAH12443.1
CCDSⁱ	CCDS42507.1 [Q96ED9-2] CCDS42508.1 [Q96ED9-1]
RefSeqⁱ	NP_001093646.1, NM_001100176.1 [Q96ED9-2] NP_037444.2, NM_013312.2 [Q96ED9-1]

3D structure databases

SMRⁱ	Q96ED9
ModBaseⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	118957, 72 interactors
CORUMⁱ	Q96ED9
IntActⁱ	Q96ED9, 137 interactors
MINTⁱ	Q96ED9
STRINGⁱ	9606.ENSP00000380785

PTM databases

iPTMnetⁱ	Q96ED9
PhosphoSitePlusⁱ	Q96ED9

Polymorphism and mutation databases

BioMutaⁱ	HOOK2
DMDMⁱ	296439323

Proteomic databases

EPDⁱ	Q96ED9
jPOSTⁱ	Q96ED9
MassIVEⁱ	Q96ED9
MaxQBⁱ	Q96ED9
PaxDbⁱ	Q96ED9
PeptideAtlasⁱ	Q96ED9
PRIDEⁱ	Q96ED9
ProteomicsDBⁱ	76396 [Q96ED9-1] 76397 [Q96ED9-2]

Protocols and materials databases

Antibodypediaⁱ	26165, 105 antibodies
The DNASU plasmid repository More...DNASUⁱ	29911

Genome annotation databases

Ensemblⁱ	ENST00000264827; ENSP00000264827; ENSG00000095066 [Q96ED9-2] ENST00000397668; ENSP00000380785; ENSG00000095066 [Q96ED9-1]
GeneIDⁱ	29911
KEGGⁱ	hsa:29911
UCSCⁱ	uc002muy.3, human [Q96ED9-1]

Organism-specific databases

CTDⁱ	29911
DisGeNETⁱ	29911
EuPathDBⁱ	HostDB:ENSG00000095066.11
GeneCardsⁱ	HOOK2
HGNCⁱ	HGNC:19885, HOOK2
HPAⁱ	ENSG00000095066, Low tissue specificity
MIMⁱ	607824, gene
neXtProtⁱ	NX_Q96ED9
OpenTargetsⁱ	ENSG00000095066
PharmGKBⁱ	PA134986864
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG502QTJ1, Eukaryota
GeneTreeⁱ	ENSGT00940000160152
HOGENOMⁱ	CLU_011214_2_0_1
InParanoidⁱ	Q96ED9
KOⁱ	K16611
OMAⁱ	MLCAQEE
OrthoDBⁱ	398210at2759
PhylomeDBⁱ	Q96ED9
TreeFamⁱ	TF320231

Enzyme and pathway databases

PathwayCommonsⁱ	Q96ED9
SIGNORⁱ	Q96ED9

Miscellaneous databases

BioGRID-ORCSⁱ	29911, 10 hits in 872 CRISPR screens
ChiTaRSⁱ	HOOK2, human
GeneWikiⁱ	HOOK2
GenomeRNAiⁱ	29911
Pharosⁱ	Q96ED9, Tbio
Protein Ontology More...PROⁱ	PR:Q96ED9
RNActⁱ	Q96ED9, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000095066, Expressed in adenohypophysis and 192 other tissues
ExpressionAtlasⁱ	Q96ED9, baseline and differential
Genevisibleⁱ	Q96ED9, HS

Family and domain databases

Gene3Dⁱ	1.10.418.10, 1 hit
InterProⁱ	View protein in InterPro IPR001715, CH-domain IPR036872, CH_dom_sf IPR008636, Hook-like_fam
Pfamⁱ	View protein in Pfam PF05622, HOOK, 1 hit
PROSITEⁱ	View protein in PROSITE PS50021, CH, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HOOK2_HUMAN
Accessionⁱ	Q96ED9Primary (citable) accession number: Q96ED9 Secondary accession number(s): O60562
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 2, 2004
	Last sequence update:	May 18, 2010
	Last modified:	August 12, 2020
	This is version 153 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteome

Documents

Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

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UniProtKB - Q96ED9 (HOOK2_HUMAN)

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Protein Hook homolog 2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

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<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Keywords - PTMi

Proteomic databases

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Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Q96ED9

Isoform 2 [Q96ED9-2]

GO - Molecular functioni

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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Coiled coil

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

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Keywords - Coding sequence diversityi

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Sequence databases

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PTM databases

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Proteomic databases

Protocols and materials databases

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Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ