UniProtKB - Q96E93 (KLRG1_HUMAN)
Protein
Killer cell lectin-like receptor subfamily G member 1
Gene
KLRG1
Organism
Homo sapiens (Human)
Status
Functioni
Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells.1 Publication
GO - Molecular functioni
- carbohydrate binding Source: ProtInc
- signaling receptor activity Source: ProtInc
GO - Biological processi
- cell surface receptor signaling pathway Source: ProtInc
- cellular defense response Source: ProtInc
- inflammatory response Source: ProtInc
- innate immune response Source: UniProtKB-KW
Keywordsi
Molecular function | Receptor |
Biological process | Immunity, Innate immunity |
Ligand | Lectin |
Enzyme and pathway databases
PathwayCommonsi | Q96E93 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
Names & Taxonomyi
Protein namesi | Recommended name: Killer cell lectin-like receptor subfamily G member 1Alternative name(s): C-type lectin domain family 15 member A ITIM-containing receptor MAFA-L MAFA-like receptor Mast cell function-associated antigen |
Gene namesi | Name:KLRG1 Synonyms:CLEC15A, MAFA, MAFAL |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000139187.9 |
HGNCi | HGNC:6380, KLRG1 |
MIMi | 604874, gene |
neXtProti | NX_Q96E93 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type II membrane protein 1 Publication
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: ProtInc
- intracellular membrane-bounded organelle Source: HPA
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 38 | CytoplasmicSequence analysisAdd BLAST | 38 | |
Transmembranei | 39 – 59 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 60 – 195 | ExtracellularSequence analysisAdd BLAST | 136 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 10219 |
OpenTargetsi | ENSG00000139187 |
PharmGKBi | PA30170 |
Miscellaneous databases
Pharosi | Q96E93, Tbio |
Polymorphism and mutation databases
BioMutai | KLRG1 |
DMDMi | 74731536 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000331256 | 1 – 195 | Killer cell lectin-like receptor subfamily G member 1Add BLAST | 195 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 65 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 75 ↔ 86 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 97 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 103 ↔ 184 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 137 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 150 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 163 ↔ 176 | PROSITE-ProRule annotation1 Publication |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MassIVEi | Q96E93 |
MaxQBi | Q96E93 |
PaxDbi | Q96E93 |
PeptideAtlasi | Q96E93 |
PRIDEi | Q96E93 |
ProteomicsDBi | 76385 [Q96E93-1] 76386 [Q96E93-2] |
PTM databases
GlyGeni | Q96E93, 4 sites |
iPTMneti | Q96E93 |
PhosphoSitePlusi | Q96E93 |
Expressioni
Tissue specificityi
Expressed specifically on natural killer (NK) cells and T-cells, mainly CD8 T-cells.2 Publications
Inductioni
By pathogens and viruses infections.1 Publication
Gene expression databases
Bgeei | ENSG00000139187, Expressed in leukocyte and 128 other tissues |
ExpressionAtlasi | Q96E93, baseline and differential |
Genevisiblei | Q96E93, HS |
Organism-specific databases
HPAi | ENSG00000139187, Tissue enriched (blood) |
Interactioni
Subunit structurei
Forms a monomer and homodimer; disulfide-linked.
Interacts (via ITIM motif) with PTPN11 and INPP5D.
By similarityBinary interactionsi
Hide detailsQ96E93
Protein-protein interaction databases
BioGRIDi | 115514, 7 interactors |
IntActi | Q96E93, 7 interactors |
STRINGi | 9606.ENSP00000349477 |
Miscellaneous databases
RNActi | Q96E93, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q96E93 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q96E93 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 82 – 185 | C-type lectinPROSITE-ProRule annotationAdd BLAST | 104 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 5 – 10 | ITIM motif | 6 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 28 – 31 | Poly-Ser | 4 |
Domaini
Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. Upon phosphorylation of ITIM motif KLRG1 associates with the two phosphatases PTPN11 and INPP5D (By similarity).By similarity
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4297, Eukaryota |
GeneTreei | ENSGT00940000156296 |
HOGENOMi | CLU_049894_8_3_1 |
InParanoidi | Q96E93 |
OMAi | SCPDFWM |
OrthoDBi | 1299162at2759 |
PhylomeDBi | Q96E93 |
TreeFami | TF336674 |
Family and domain databases
CDDi | cd03593, CLECT_NK_receptors_like, 1 hit |
Gene3Di | 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR001304, C-type_lectin-like IPR016186, C-type_lectin-like/link_sf IPR016187, CTDL_fold IPR042190, KLRG1 IPR033992, NKR-like_CTLD |
PANTHERi | PTHR47648, PTHR47648, 1 hit |
Pfami | View protein in Pfam PF00059, Lectin_C, 1 hit |
SMARTi | View protein in SMART SM00034, CLECT, 1 hit |
SUPFAMi | SSF56436, SSF56436, 1 hit |
PROSITEi | View protein in PROSITE PS50041, C_TYPE_LECTIN_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q96E93-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTDSVIYSML ELPTATQAQN DYGPQQKSSS SRPSCSCLVA IALGLLTAVL
60 70 80 90 100
LSVLLYQWIL CQGSNYSTCA SCPSCPDRWM KYGNHCYYFS VEEKDWNSSL
110 120 130 140 150
EFCLARDSHL LVITDNQEMS LLQVFLSEAF CWIGLRNNSG WRWEDGSPLN
160 170 180 190
FSRISSNSFV QTCGAINKNG LQASSCEVPL HWVCKKCPFA DQALF
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5H8E3 | F5H8E3_HUMAN | Killer cell lectin-like receptor su... | KLRG1 | 80 | Annotation score: | ||
F5H207 | F5H207_HUMAN | Killer cell lectin-like receptor su... | KLRG1 | 81 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 32 | R → K in AAC34731 (PubMed:9765598).Curated | 1 | |
Sequence conflicti | 42 | A → T in AAC34731 (PubMed:9765598).Curated | 1 | |
Sequence conflicti | 182 | W → G in AAC34731 (PubMed:9765598).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_042750 | 58 | W → R. Corresponds to variant dbSNP:rs1805749Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_033151 | 187 – 195 | CPFADQALF → VRL in isoform 2. 3 Publications | 9 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF034952 mRNA Translation: AAC34731.1 AF081675 mRNA Translation: AAC32200.1 AF097358 mRNA Translation: AAD03719.1 AK316337 mRNA Translation: BAH14708.1 CH471116 Genomic DNA Translation: EAW88594.1 CH471116 Genomic DNA Translation: EAW88595.1 BC012621 mRNA Translation: AAH12621.1 |
CCDSi | CCDS8599.1 [Q96E93-2] CCDS86277.1 [Q96E93-1] |
RefSeqi | NP_001316028.1, NM_001329099.1 [Q96E93-1] NP_005801.3, NM_005810.3 [Q96E93-2] |
Genome annotation databases
Ensembli | ENST00000266551; ENSP00000266551; ENSG00000139187 [Q96E93-1] ENST00000356986; ENSP00000349477; ENSG00000139187 [Q96E93-2] |
GeneIDi | 10219 |
KEGGi | hsa:10219 |
UCSCi | uc001qvg.4, human [Q96E93-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF034952 mRNA Translation: AAC34731.1 AF081675 mRNA Translation: AAC32200.1 AF097358 mRNA Translation: AAD03719.1 AK316337 mRNA Translation: BAH14708.1 CH471116 Genomic DNA Translation: EAW88594.1 CH471116 Genomic DNA Translation: EAW88595.1 BC012621 mRNA Translation: AAH12621.1 |
CCDSi | CCDS8599.1 [Q96E93-2] CCDS86277.1 [Q96E93-1] |
RefSeqi | NP_001316028.1, NM_001329099.1 [Q96E93-1] NP_005801.3, NM_005810.3 [Q96E93-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3FF7 | X-ray | 1.80 | C/D | 75-186 | [»] | |
SMRi | Q96E93 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115514, 7 interactors |
IntActi | Q96E93, 7 interactors |
STRINGi | 9606.ENSP00000349477 |
PTM databases
GlyGeni | Q96E93, 4 sites |
iPTMneti | Q96E93 |
PhosphoSitePlusi | Q96E93 |
Polymorphism and mutation databases
BioMutai | KLRG1 |
DMDMi | 74731536 |
Proteomic databases
MassIVEi | Q96E93 |
MaxQBi | Q96E93 |
PaxDbi | Q96E93 |
PeptideAtlasi | Q96E93 |
PRIDEi | Q96E93 |
ProteomicsDBi | 76385 [Q96E93-1] 76386 [Q96E93-2] |
Protocols and materials databases
Antibodypediai | 23119, 424 antibodies |
DNASUi | 10219 |
Genome annotation databases
Ensembli | ENST00000266551; ENSP00000266551; ENSG00000139187 [Q96E93-1] ENST00000356986; ENSP00000349477; ENSG00000139187 [Q96E93-2] |
GeneIDi | 10219 |
KEGGi | hsa:10219 |
UCSCi | uc001qvg.4, human [Q96E93-1] |
Organism-specific databases
CTDi | 10219 |
DisGeNETi | 10219 |
EuPathDBi | HostDB:ENSG00000139187.9 |
GeneCardsi | KLRG1 |
HGNCi | HGNC:6380, KLRG1 |
HPAi | ENSG00000139187, Tissue enriched (blood) |
MIMi | 604874, gene |
neXtProti | NX_Q96E93 |
OpenTargetsi | ENSG00000139187 |
PharmGKBi | PA30170 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4297, Eukaryota |
GeneTreei | ENSGT00940000156296 |
HOGENOMi | CLU_049894_8_3_1 |
InParanoidi | Q96E93 |
OMAi | SCPDFWM |
OrthoDBi | 1299162at2759 |
PhylomeDBi | Q96E93 |
TreeFami | TF336674 |
Enzyme and pathway databases
PathwayCommonsi | Q96E93 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
Miscellaneous databases
BioGRID-ORCSi | 10219, 5 hits in 846 CRISPR screens |
ChiTaRSi | KLRG1, human |
EvolutionaryTracei | Q96E93 |
GeneWikii | KLRG1 |
GenomeRNAii | 10219 |
Pharosi | Q96E93, Tbio |
PROi | PR:Q96E93 |
RNActi | Q96E93, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000139187, Expressed in leukocyte and 128 other tissues |
ExpressionAtlasi | Q96E93, baseline and differential |
Genevisiblei | Q96E93, HS |
Family and domain databases
CDDi | cd03593, CLECT_NK_receptors_like, 1 hit |
Gene3Di | 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR001304, C-type_lectin-like IPR016186, C-type_lectin-like/link_sf IPR016187, CTDL_fold IPR042190, KLRG1 IPR033992, NKR-like_CTLD |
PANTHERi | PTHR47648, PTHR47648, 1 hit |
Pfami | View protein in Pfam PF00059, Lectin_C, 1 hit |
SMARTi | View protein in SMART SM00034, CLECT, 1 hit |
SUPFAMi | SSF56436, SSF56436, 1 hit |
PROSITEi | View protein in PROSITE PS50041, C_TYPE_LECTIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KLRG1_HUMAN | |
Accessioni | Q96E93Primary (citable) accession number: Q96E93 Secondary accession number(s): B7ZAM2, O43198, O75613 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 29, 2008 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 146 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations