UniProtKB - Q96E40 (SACA9_HUMAN)
Protein
Sperm acrosome-associated protein 9
Gene
SPACA9
Organism
Homo sapiens (Human)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 117 | Essential for interaction with INCA1By similarity | 1 | |
Sitei | 119 | Essential for interaction with INCA1By similarity | 1 |
GO - Molecular functioni
- calcium-dependent protein binding Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | Q96E40 |
Names & Taxonomyi
Protein namesi | Recommended name: Sperm acrosome-associated protein 9 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000165698.15 |
HGNCi | HGNC:1367, SPACA9 |
MIMi | 618552, gene |
neXtProti | NX_Q96E40 |
Subcellular locationi
Cytoskeleton
- cilium basal body By similarity
Nucleus
- Nucleus By similarity
Other locations
Note: In caudal sperms localizes onto sperm head. Is also present on midpiece and principle piece of sperm tails. Acrosome and sperm tail localization is regulated by Y-chromosome.By similarity
Cytoskeleton
- ciliary basal body Source: UniProtKB
- cytoplasmic microtubule Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB
Other locations
- acrosomal vesicle Source: GO_Central
- ciliary base Source: GO_Central
- sperm flagellum Source: GO_Central
Keywords - Cellular componenti
Cell projection, Cilium, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Flagellum, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 11092 |
OpenTargetsi | ENSG00000165698 |
PharmGKBi | PA25983 |
Miscellaneous databases
Pharosi | Q96E40, Tdark |
Polymorphism and mutation databases
BioMutai | SPACA9 |
DMDMi | 68565255 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000089673 | 1 – 222 | Sperm acrosome-associated protein 9Add BLAST | 222 |
Proteomic databases
EPDi | Q96E40 |
jPOSTi | Q96E40 |
MassIVEi | Q96E40 |
MaxQBi | Q96E40 |
PaxDbi | Q96E40 |
PeptideAtlasi | Q96E40 |
PRIDEi | Q96E40 |
ProteomicsDBi | 76371 [Q96E40-1] 76372 [Q96E40-2] |
PTM databases
iPTMneti | Q96E40 |
PhosphoSitePlusi | Q96E40 |
Expressioni
Gene expression databases
Bgeei | ENSG00000165698, Expressed in right testis and 207 other tissues |
ExpressionAtlasi | Q96E40, baseline and differential |
Genevisiblei | Q96E40, HS |
Organism-specific databases
HPAi | ENSG00000165698, Group enriched (epididymis, fallopian tube, testis) |
Interactioni
Subunit structurei
Interacts with CABP1 AND CALR.
Interacts with INCA1.
By similarityBinary interactionsi
Hide detailsQ96E40
GO - Molecular functioni
- calcium-dependent protein binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 116273, 14 interactors |
IntActi | Q96E40, 15 interactors |
MINTi | Q96E40 |
STRINGi | 9606.ENSP00000298546 |
Miscellaneous databases
RNActi | Q96E40, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 19 – 22 | Poly-Gln | 4 |
Phylogenomic databases
eggNOGi | ENOG502QQV9, Eukaryota |
GeneTreei | ENSGT00390000007746 |
HOGENOMi | CLU_100443_0_0_1 |
InParanoidi | Q96E40 |
OMAi | MFLDICT |
OrthoDBi | 1252395at2759 |
PhylomeDBi | Q96E40 |
TreeFami | TF328897 |
Family and domain databases
InterProi | View protein in InterPro IPR027818, SPACA9 |
PANTHERi | PTHR32455, PTHR32455, 1 hit |
Pfami | View protein in Pfam PF15120, SPACA9, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q96E40-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNEVKESLRS IEQKYKLFQQ QQLTFTAALE HCRENAHDKI RPISSIGQVQ
60 70 80 90 100
SYMEHYCNSS TDRRVLLMFL DICSELNKLC QHFEAVHSGT PVTNNLLEKC
110 120 130 140 150
KTLVSQSNDL SSLRAKYPHD VVNHLSCDEA RNHYGGVVSL IPLILDLMKE
160 170 180 190 200
WIAHSEKLPR KVLQHVSEPQ AHQESTRGAA RPAQAIGTQP RATKHKCRQL
210 220
TKASLKPRGC SKPPWRPPGG KL
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_056817 | 104 | V → I. Corresponds to variant dbSNP:rs2231406Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_014456 | 166 – 168 | VSE → GTT in isoform 2. 2 Publications | 3 | |
Alternative sequenceiVSP_014457 | 169 – 222 | Missing in isoform 2. 2 PublicationsAdd BLAST | 54 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ011375 mRNA Translation: CAB66158.1 AK075259 mRNA Translation: BAC11503.1 CR457210 mRNA Translation: CAG33491.1 AL445645 Genomic DNA No translation available. BC012940 mRNA Translation: AAH12940.1 |
CCDSi | CCDS6955.1 [Q96E40-2] CCDS83434.1 [Q96E40-1] |
RefSeqi | NP_001303826.1, NM_001316897.1 [Q96E40-1] NP_001303827.1, NM_001316898.1 [Q96E40-1] NP_001303829.1, NM_001316900.1 NP_061829.3, NM_018956.4 [Q96E40-2] |
Genome annotation databases
Ensembli | ENST00000350499; ENSP00000298546; ENSG00000165698 [Q96E40-2] ENST00000356311; ENSP00000348659; ENSG00000165698 [Q96E40-1] ENST00000372136; ENSP00000361209; ENSG00000165698 [Q96E40-1] |
GeneIDi | 11092 |
KEGGi | hsa:11092 |
UCSCi | uc004cbx.2, human [Q96E40-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ011375 mRNA Translation: CAB66158.1 AK075259 mRNA Translation: BAC11503.1 CR457210 mRNA Translation: CAG33491.1 AL445645 Genomic DNA No translation available. BC012940 mRNA Translation: AAH12940.1 |
CCDSi | CCDS6955.1 [Q96E40-2] CCDS83434.1 [Q96E40-1] |
RefSeqi | NP_001303826.1, NM_001316897.1 [Q96E40-1] NP_001303827.1, NM_001316898.1 [Q96E40-1] NP_001303829.1, NM_001316900.1 NP_061829.3, NM_018956.4 [Q96E40-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 116273, 14 interactors |
IntActi | Q96E40, 15 interactors |
MINTi | Q96E40 |
STRINGi | 9606.ENSP00000298546 |
PTM databases
iPTMneti | Q96E40 |
PhosphoSitePlusi | Q96E40 |
Polymorphism and mutation databases
BioMutai | SPACA9 |
DMDMi | 68565255 |
Proteomic databases
EPDi | Q96E40 |
jPOSTi | Q96E40 |
MassIVEi | Q96E40 |
MaxQBi | Q96E40 |
PaxDbi | Q96E40 |
PeptideAtlasi | Q96E40 |
PRIDEi | Q96E40 |
ProteomicsDBi | 76371 [Q96E40-1] 76372 [Q96E40-2] |
Protocols and materials databases
Antibodypediai | 18219, 51 antibodies |
DNASUi | 11092 |
Genome annotation databases
Ensembli | ENST00000350499; ENSP00000298546; ENSG00000165698 [Q96E40-2] ENST00000356311; ENSP00000348659; ENSG00000165698 [Q96E40-1] ENST00000372136; ENSP00000361209; ENSG00000165698 [Q96E40-1] |
GeneIDi | 11092 |
KEGGi | hsa:11092 |
UCSCi | uc004cbx.2, human [Q96E40-1] |
Organism-specific databases
CTDi | 11092 |
DisGeNETi | 11092 |
EuPathDBi | HostDB:ENSG00000165698.15 |
GeneCardsi | SPACA9 |
HGNCi | HGNC:1367, SPACA9 |
HPAi | ENSG00000165698, Group enriched (epididymis, fallopian tube, testis) |
MIMi | 618552, gene |
neXtProti | NX_Q96E40 |
OpenTargetsi | ENSG00000165698 |
PharmGKBi | PA25983 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQV9, Eukaryota |
GeneTreei | ENSGT00390000007746 |
HOGENOMi | CLU_100443_0_0_1 |
InParanoidi | Q96E40 |
OMAi | MFLDICT |
OrthoDBi | 1252395at2759 |
PhylomeDBi | Q96E40 |
TreeFami | TF328897 |
Enzyme and pathway databases
PathwayCommonsi | Q96E40 |
Miscellaneous databases
BioGRID-ORCSi | 11092, 7 hits in 843 CRISPR screens |
ChiTaRSi | SPACA9, human |
GenomeRNAii | 11092 |
Pharosi | Q96E40, Tdark |
PROi | PR:Q96E40 |
RNActi | Q96E40, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000165698, Expressed in right testis and 207 other tissues |
ExpressionAtlasi | Q96E40, baseline and differential |
Genevisiblei | Q96E40, HS |
Family and domain databases
InterProi | View protein in InterPro IPR027818, SPACA9 |
PANTHERi | PTHR32455, PTHR32455, 1 hit |
Pfami | View protein in Pfam PF15120, SPACA9, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SACA9_HUMAN | |
Accessioni | Q96E40Primary (citable) accession number: Q96E40 Secondary accession number(s): Q9UGQ0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 5, 2005 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 136 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations