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Protein

Sperm acrosome-associated protein 9

Gene

SPACA9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm acrosome-associated protein 9
Gene namesi
Name:SPACA9Imported
Synonyms:C9orf9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000165698.15
HGNCiHGNC:1367 SPACA9
neXtProtiNX_Q96E40

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle

Pathology & Biotechi

Organism-specific databases

DisGeNETi11092
OpenTargetsiENSG00000165698
PharmGKBiPA25983

Polymorphism and mutation databases

BioMutaiC9orf9
DMDMi68565255

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000896731 – 222Sperm acrosome-associated protein 9Add BLAST222

Proteomic databases

EPDiQ96E40
MaxQBiQ96E40
PaxDbiQ96E40
PeptideAtlasiQ96E40
PRIDEiQ96E40
ProteomicsDBi76371
76372 [Q96E40-2]

PTM databases

iPTMnetiQ96E40
PhosphoSitePlusiQ96E40

Expressioni

Gene expression databases

BgeeiENSG00000165698 Expressed in 194 organ(s), highest expression level in right testis
CleanExiHS_C9orf9
ExpressionAtlasiQ96E40 baseline and differential
GenevisibleiQ96E40 HS

Organism-specific databases

HPAiHPA022243
HPA051600

Interactioni

Subunit structurei

Interacts with CABP1 AND CALR.By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116273, 11 interactors
IntActiQ96E40, 11 interactors
MINTiQ96E40
STRINGi9606.ENSP00000298546

Structurei

3D structure databases

ProteinModelPortaliQ96E40
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi19 – 22Poly-Gln4

Phylogenomic databases

eggNOGiENOG410IGPD Eukaryota
ENOG4111PX9 LUCA
GeneTreeiENSGT00390000007746
HOGENOMiHOG000231485
HOVERGENiHBG061624
InParanoidiQ96E40
OMAiGCSKPPW
OrthoDBiEOG091G0MZL
PhylomeDBiQ96E40
TreeFamiTF328897

Family and domain databases

InterProiView protein in InterPro
IPR027818 SPACA9
PANTHERiPTHR32455 PTHR32455, 1 hit
PfamiView protein in Pfam
PF15120 SPACA9, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q96E40-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNEVKESLRS IEQKYKLFQQ QQLTFTAALE HCRENAHDKI RPISSIGQVQ
60 70 80 90 100
SYMEHYCNSS TDRRVLLMFL DICSELNKLC QHFEAVHSGT PVTNNLLEKC
110 120 130 140 150
KTLVSQSNDL SSLRAKYPHD VVNHLSCDEA RNHYGGVVSL IPLILDLMKE
160 170 180 190 200
WIAHSEKLPR KVLQHVSEPQ AHQESTRGAA RPAQAIGTQP RATKHKCRQL
210 220
TKASLKPRGC SKPPWRPPGG KL
Length:222
Mass (Da):25,166
Last modified:December 1, 2001 - v1
Checksum:iF052332EB5E6EC96
GO
Isoform 2 (identifier: Q96E40-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     166-168: VSE → GTT
     169-222: Missing.

Show »
Length:168
Mass (Da):19,289
Checksum:i3F2BEB99132B7631
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_056817104V → I. Corresponds to variant dbSNP:rs2231406Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014456166 – 168VSE → GTT in isoform 2. 2 Publications3
Alternative sequenceiVSP_014457169 – 222Missing in isoform 2. 2 PublicationsAdd BLAST54

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011375 mRNA Translation: CAB66158.1
AK075259 mRNA Translation: BAC11503.1
CR457210 mRNA Translation: CAG33491.1
AL445645 Genomic DNA No translation available.
BC012940 mRNA Translation: AAH12940.1
CCDSiCCDS6955.1 [Q96E40-2]
CCDS83434.1 [Q96E40-1]
RefSeqiNP_001303826.1, NM_001316897.1 [Q96E40-1]
NP_001303827.1, NM_001316898.1 [Q96E40-1]
NP_001303829.1, NM_001316900.1
NP_061829.3, NM_018956.4 [Q96E40-2]
UniGeneiHs.62595

Genome annotation databases

EnsembliENST00000350499; ENSP00000298546; ENSG00000165698 [Q96E40-2]
ENST00000356311; ENSP00000348659; ENSG00000165698 [Q96E40-1]
ENST00000372136; ENSP00000361209; ENSG00000165698 [Q96E40-1]
GeneIDi11092
KEGGihsa:11092
UCSCiuc004cbx.2 human [Q96E40-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011375 mRNA Translation: CAB66158.1
AK075259 mRNA Translation: BAC11503.1
CR457210 mRNA Translation: CAG33491.1
AL445645 Genomic DNA No translation available.
BC012940 mRNA Translation: AAH12940.1
CCDSiCCDS6955.1 [Q96E40-2]
CCDS83434.1 [Q96E40-1]
RefSeqiNP_001303826.1, NM_001316897.1 [Q96E40-1]
NP_001303827.1, NM_001316898.1 [Q96E40-1]
NP_001303829.1, NM_001316900.1
NP_061829.3, NM_018956.4 [Q96E40-2]
UniGeneiHs.62595

3D structure databases

ProteinModelPortaliQ96E40
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116273, 11 interactors
IntActiQ96E40, 11 interactors
MINTiQ96E40
STRINGi9606.ENSP00000298546

PTM databases

iPTMnetiQ96E40
PhosphoSitePlusiQ96E40

Polymorphism and mutation databases

BioMutaiC9orf9
DMDMi68565255

Proteomic databases

EPDiQ96E40
MaxQBiQ96E40
PaxDbiQ96E40
PeptideAtlasiQ96E40
PRIDEiQ96E40
ProteomicsDBi76371
76372 [Q96E40-2]

Protocols and materials databases

DNASUi11092
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000350499; ENSP00000298546; ENSG00000165698 [Q96E40-2]
ENST00000356311; ENSP00000348659; ENSG00000165698 [Q96E40-1]
ENST00000372136; ENSP00000361209; ENSG00000165698 [Q96E40-1]
GeneIDi11092
KEGGihsa:11092
UCSCiuc004cbx.2 human [Q96E40-1]

Organism-specific databases

CTDi11092
DisGeNETi11092
EuPathDBiHostDB:ENSG00000165698.15
GeneCardsiSPACA9
HGNCiHGNC:1367 SPACA9
HPAiHPA022243
HPA051600
neXtProtiNX_Q96E40
OpenTargetsiENSG00000165698
PharmGKBiPA25983
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGPD Eukaryota
ENOG4111PX9 LUCA
GeneTreeiENSGT00390000007746
HOGENOMiHOG000231485
HOVERGENiHBG061624
InParanoidiQ96E40
OMAiGCSKPPW
OrthoDBiEOG091G0MZL
PhylomeDBiQ96E40
TreeFamiTF328897

Miscellaneous databases

ChiTaRSiSPACA9 human
GenomeRNAii11092
PROiPR:Q96E40

Gene expression databases

BgeeiENSG00000165698 Expressed in 194 organ(s), highest expression level in right testis
CleanExiHS_C9orf9
ExpressionAtlasiQ96E40 baseline and differential
GenevisibleiQ96E40 HS

Family and domain databases

InterProiView protein in InterPro
IPR027818 SPACA9
PANTHERiPTHR32455 PTHR32455, 1 hit
PfamiView protein in Pfam
PF15120 SPACA9, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSACA9_HUMAN
AccessioniPrimary (citable) accession number: Q96E40
Secondary accession number(s): Q9UGQ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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