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Protein

RNA binding motif protein, X-linked-like-1

Gene

RBMXL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

RNA-binding protein which may be involved in pre-mRNA splicing.By similarity

Miscellaneous

According to some authors, RBMXL1 is a RBMX retrogene on chromosome X which is likely to be functional.1 Publication

Caution

The first non-coding exon of RBMXL1 is in common with that of CCBL2.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
RNA binding motif protein, X-linked-like-1
Alternative name(s):
Heterogeneous nuclear ribonucleoprotein G-like 1
Gene namesi
Name:RBMXL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000213516.9
HGNCiHGNC:25073 RBMXL1
neXtProtiNX_Q96E39

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi494115
OpenTargetsiENSG00000213516
PharmGKBiPA165752300

Polymorphism and mutation databases

BioMutaiRBMXL1
DMDMi74760797

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004080051 – 390RNA binding motif protein, X-linked-like-1Add BLAST390

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki80Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei88PhosphoserineCombined sources1
Modified residuei161PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ96E39
MaxQBiQ96E39
PaxDbiQ96E39
PeptideAtlasiQ96E39
PRIDEiQ96E39
ProteomicsDBi76370

PTM databases

iPTMnetiQ96E39
PhosphoSitePlusiQ96E39
SwissPalmiQ96E39

Expressioni

Gene expression databases

BgeeiENSG00000213516 Expressed in 198 organ(s), highest expression level in cauda epididymis
ExpressionAtlasiQ96E39 baseline and differential
GenevisibleiQ96E39 HS

Organism-specific databases

HPAiHPA057707

Interactioni

Protein-protein interaction databases

BioGridi138936, 28 interactors
IntActiQ96E39, 10 interactors
MINTiQ96E39

Structurei

3D structure databases

ProteinModelPortaliQ96E39
SMRiQ96E39
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 86RRMPROSITE-ProRule annotationAdd BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi273 – 367Ser-richAdd BLAST95

Phylogenomic databases

eggNOGiENOG410IHG3 Eukaryota
ENOG4111GI6 LUCA
GeneTreeiENSGT00710000106295
HOGENOMiHOG000276235
HOVERGENiHBG063314
InParanoidiQ96E39
KOiK12885
OMAiYPDERDM
OrthoDBiEOG091G13K0
PhylomeDBiQ96E39
TreeFamiTF331833

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR012604 RBM1CTR
IPR000504 RRM_dom
IPR003954 RRM_dom_euk
PfamiView protein in Pfam
PF08081 RBM1CTR, 1 hit
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SM00361 RRM_1, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q96E39-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVEADRPGKL FIGGLNTETN EKALETVFGK YGRIVEVLLI KDRETNKSRG
60 70 80 90 100
FAFVTFESPA DAKDAARDMN GKSLDGKAIK VEQATKPSFE RGRHGPPPPP
110 120 130 140 150
RSRGPPRGFG AGRGGSGGTR GPPSRGGHMD DGGYSMNFNM SSSRGPLPVK
160 170 180 190 200
RGPPPRSGGP SPKRSAPSGL VRSSSGMGGR APLSRGRDSY GGPPRREPLP
210 220 230 240 250
SRRDVYLSPR DDGYSTKDSY SSRDYPSSRD TRDYAPPPRD YTYRDYGHSS
260 270 280 290 300
SRDDYPSRGY GDRDGYGRDR DYSDHPSGGS YRDSYESYGN SRSAPLTRGP
310 320 330 340 350
PPSYGGSSRY DDYSSSRDGY GGSRDSYSSS RSDLYSSCDR VGRQERGLPP
360 370 380 390
SVERGYPSSR DSYSSSSRGA PRGAGPGGSR SDRGGGRSRY
Length:390
Mass (Da):42,142
Last modified:December 1, 2001 - v1
Checksum:iE8D74676C3AE6420
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GUK8A0A1B0GUK8_HUMAN
RNA-binding motif protein, X-linked...
RBMXL1
158Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL832554 mRNA Translation: CAI46148.1
AL139416 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW73155.1
CH471097 Genomic DNA Translation: EAW73156.1
BC012942 mRNA Translation: AAH12942.1
CCDSiCCDS716.1
RefSeqiNP_001156008.1, NM_001162536.2
NP_062556.2, NM_019610.5
UniGeneiHs.481898

Genome annotation databases

EnsembliENST00000321792; ENSP00000318415; ENSG00000213516
ENST00000399794; ENSP00000446099; ENSG00000213516
GeneIDi494115
KEGGihsa:494115
UCSCiuc001dms.4 human

Similar proteinsi

Entry informationi

Entry nameiRMXL1_HUMAN
AccessioniPrimary (citable) accession number: Q96E39
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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