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Protein

Transcription termination factor 3, mitochondrial

Gene

MTERF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds promoter DNA and regulates initiation of transcription (PubMed:17662942). Required for normal mitochondrial transcription and translation, and for normal assembly of mitochondrial respiratory complexes. Required for normal mitochondrial function (By similarity). Maintains 16S rRNA levels and functions in mitochondrial ribosome assembly by regulating the biogenesis of the 39S ribosomal subunit (By similarity).By similarity1 Publication

GO - Molecular functioni

  • double-stranded DNA binding Source: InterPro
  • transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

  • macroautophagy Source: Reactome
  • mitochondrial ribosome assembly Source: GO_Central
  • mitochondrial transcription Source: GO_Central
  • mitochondrial translation Source: GO_Central
  • negative regulation of transcription, DNA-templated Source: UniProtKB

Keywordsi

Molecular functionDNA-binding
Biological processRibosome biogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-5205685 Pink/Parkin Mediated Mitophagy

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription termination factor 3, mitochondrial
Alternative name(s):
Mitochondrial transcription termination factor 3
Short name:
mTERF3
mTERF domain-containing protein 1, mitochondrial
Gene namesi
Name:MTERF3
Synonyms:MTERFD1
ORF Names:CGI-12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000156469.8
HGNCiHGNC:24258 MTERF3
MIMi616930 gene
neXtProtiNX_Q96E29

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000156469
PharmGKBiPA142671309

Polymorphism and mutation databases

BioMutaiMTERFD1
DMDMi74731522

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 68Mitochondrion1 PublicationAdd BLAST68
ChainiPRO_000025545769 – 417Transcription termination factor 3, mitochondrialAdd BLAST349

Proteomic databases

EPDiQ96E29
MaxQBiQ96E29
PaxDbiQ96E29
PeptideAtlasiQ96E29
PRIDEiQ96E29
ProteomicsDBi76367
76368 [Q96E29-2]

PTM databases

iPTMnetiQ96E29
PhosphoSitePlusiQ96E29

Expressioni

Tissue specificityi

Highly expressed in heart, liver, kidney and testis. Detected at lower levels in brain, spleen and lung.1 Publication

Gene expression databases

BgeeiENSG00000156469 Expressed in 224 organ(s), highest expression level in oocyte
CleanExiHS_MTERFD1
ExpressionAtlasiQ96E29 baseline and differential
GenevisibleiQ96E29 HS

Organism-specific databases

HPAiHPA002966

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi119209, 44 interactors
IntActiQ96E29, 31 interactors
MINTiQ96E29
STRINGi9606.ENSP00000287025

Structurei

Secondary structure

1417
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ96E29
SMRiQ96E29
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96E29

Family & Domainsi

Domaini

Contains seven structural repeats of about 35 residues, where each repeat contains three helices. The repeats form a superhelical structure with a solenoid shape.1 Publication

Sequence similaritiesi

Belongs to the mTERF family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1267 Eukaryota
ENOG410XT49 LUCA
GeneTreeiENSGT00390000005801
HOGENOMiHOG000044443
HOVERGENiHBG062577
InParanoidiQ96E29
KOiK15032
OMAiNNFYFVR
OrthoDBiEOG091G0AZ7
PhylomeDBiQ96E29
TreeFamiTF317943

Family and domain databases

Gene3Di1.25.70.10, 1 hit
InterProiView protein in InterPro
IPR003690 MTERF
IPR038538 MTERF_sf
PfamiView protein in Pfam
PF02536 mTERF, 1 hit
SMARTiView protein in SMART
SM00733 Mterf, 6 hits

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96E29-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALSAQQIPR WFNSVKLRSL INAAQLTKRF TRPARTLLHG FSAQPQISSD
60 70 80 90 100
NCFLQWGFKT YRTSSLWNSS QSTSSSSQEN NSAQSSLLPS MNEQSQKTQN
110 120 130 140 150
ISSFDSELFL EELDELPPLS PMQPISEEEA IQIIADPPLP PASFTLRDYV
160 170 180 190 200
DHSETLQKLV LLGVDLSKIE KHPEAANLLL RLDFEKDIKQ MLLFLKDVGI
210 220 230 240 250
EDNQLGAFLT KNHAIFSEDL ENLKTRVAYL HSKNFSKADV AQMVRKAPFL
260 270 280 290 300
LNFSVERLDN RLGFFQKELE LSVKKTRDLV VRLPRLLTGS LEPVKENMKV
310 320 330 340 350
YRLELGFKHN EIQHMITRIP KMLTANKMKL TETFDFVHNV MSIPHHIIVK
360 370 380 390 400
FPQVFNTRLF KVKERHLFLT YLGRAQYDPA KPNYISLDKL VSIPDEIFCE
410
EIAKASVQDF EKFLKTL
Length:417
Mass (Da):47,971
Last modified:March 1, 2004 - v2
Checksum:i2062EFE902584696
GO
Isoform 2 (identifier: Q96E29-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-90: Missing.

Show »
Length:327
Mass (Da):37,907
Checksum:i3C396BD9DC336AE6
GO
Isoform 3 (identifier: Q96E29-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-121: Missing.

Note: No experimental confirmation available.
Show »
Length:296
Mass (Da):34,358
Checksum:i539D802B0FB47ABE
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RIK9E5RIK9_HUMAN
Transcription termination factor 3,...
MTERF3
361Annotation score:
E5RIY4E5RIY4_HUMAN
Transcription termination factor 3,...
MTERF3
173Annotation score:
E5RI75E5RI75_HUMAN
Transcription termination factor 3,...
MTERF3
67Annotation score:

Sequence cautioni

The sequence AAD27721 differs from that shown. Reason: Frameshift at positions 261 and 262.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti153S → P in BAG50978 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053786396E → G. Corresponds to variant dbSNP:rs7461970Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0539851 – 121Missing in isoform 3. 1 PublicationAdd BLAST121
Alternative sequenceiVSP_0212921 – 90Missing in isoform 2. 1 PublicationAdd BLAST90

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132946 mRNA Translation: AAD27721.1 Frameshift.
AK001801 mRNA Translation: BAG50978.1
AP003465 Genomic DNA No translation available.
CH471060 Genomic DNA Translation: EAW91752.1
BC012995 mRNA Translation: AAH12995.2
CCDSiCCDS6270.1 [Q96E29-1]
RefSeqiNP_057026.3, NM_015942.4 [Q96E29-1]
UniGeneiHs.308613

Genome annotation databases

EnsembliENST00000287025; ENSP00000287025; ENSG00000156469 [Q96E29-1]
ENST00000522822; ENSP00000430138; ENSG00000156469 [Q96E29-3]
GeneIDi51001
KEGGihsa:51001
UCSCiuc003yhr.3 human [Q96E29-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132946 mRNA Translation: AAD27721.1 Frameshift.
AK001801 mRNA Translation: BAG50978.1
AP003465 Genomic DNA No translation available.
CH471060 Genomic DNA Translation: EAW91752.1
BC012995 mRNA Translation: AAH12995.2
CCDSiCCDS6270.1 [Q96E29-1]
RefSeqiNP_057026.3, NM_015942.4 [Q96E29-1]
UniGeneiHs.308613

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3M66X-ray1.60A148-417[»]
ProteinModelPortaliQ96E29
SMRiQ96E29
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119209, 44 interactors
IntActiQ96E29, 31 interactors
MINTiQ96E29
STRINGi9606.ENSP00000287025

PTM databases

iPTMnetiQ96E29
PhosphoSitePlusiQ96E29

Polymorphism and mutation databases

BioMutaiMTERFD1
DMDMi74731522

Proteomic databases

EPDiQ96E29
MaxQBiQ96E29
PaxDbiQ96E29
PeptideAtlasiQ96E29
PRIDEiQ96E29
ProteomicsDBi76367
76368 [Q96E29-2]

Protocols and materials databases

DNASUi51001
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000287025; ENSP00000287025; ENSG00000156469 [Q96E29-1]
ENST00000522822; ENSP00000430138; ENSG00000156469 [Q96E29-3]
GeneIDi51001
KEGGihsa:51001
UCSCiuc003yhr.3 human [Q96E29-1]

Organism-specific databases

CTDi51001
EuPathDBiHostDB:ENSG00000156469.8
GeneCardsiMTERF3
HGNCiHGNC:24258 MTERF3
HPAiHPA002966
MIMi616930 gene
neXtProtiNX_Q96E29
OpenTargetsiENSG00000156469
PharmGKBiPA142671309
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1267 Eukaryota
ENOG410XT49 LUCA
GeneTreeiENSGT00390000005801
HOGENOMiHOG000044443
HOVERGENiHBG062577
InParanoidiQ96E29
KOiK15032
OMAiNNFYFVR
OrthoDBiEOG091G0AZ7
PhylomeDBiQ96E29
TreeFamiTF317943

Enzyme and pathway databases

ReactomeiR-HSA-5205685 Pink/Parkin Mediated Mitophagy

Miscellaneous databases

EvolutionaryTraceiQ96E29
GenomeRNAii51001
PROiPR:Q96E29
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000156469 Expressed in 224 organ(s), highest expression level in oocyte
CleanExiHS_MTERFD1
ExpressionAtlasiQ96E29 baseline and differential
GenevisibleiQ96E29 HS

Family and domain databases

Gene3Di1.25.70.10, 1 hit
InterProiView protein in InterPro
IPR003690 MTERF
IPR038538 MTERF_sf
PfamiView protein in Pfam
PF02536 mTERF, 1 hit
SMARTiView protein in SMART
SM00733 Mterf, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMTEF3_HUMAN
AccessioniPrimary (citable) accession number: Q96E29
Secondary accession number(s): B3KMG6, G3V130, Q9Y301
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 1, 2004
Last modified: November 7, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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