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Protein

Ras-related protein Rab-3C

Gene

RAB3C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Protein transport. Probably involved in vesicular traffic (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi37 – 45GTPBy similarity9
Nucleotide bindingi56 – 62GTPBy similarity7
Nucleotide bindingi85 – 89GTPBy similarity5
Nucleotide bindingi143 – 146GTPBy similarity4
Nucleotide bindingi173 – 175GTPBy similarity3

GO - Molecular functioni

  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB-KW
  • GTP-dependent protein binding Source: Ensembl
  • myosin V binding Source: UniProtKB

GO - Biological processi

  • antigen processing and presentation Source: UniProtKB
  • protein transport Source: UniProtKB-KW
  • regulation of exocytosis Source: Ensembl

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-8873719 RAB geranylgeranylation

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-3C
Gene namesi
Name:RAB3C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000152932.7
HGNCiHGNC:30269 RAB3C
MIMi612829 gene
neXtProtiNX_Q96E17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi115827
OpenTargetsiENSG00000152932
PharmGKBiPA134874100

Polymorphism and mutation databases

BioMutaiRAB3C
DMDMi23396832

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001210851 – 227Ras-related protein Rab-3CAdd BLAST227

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei196PhosphoserineBy similarity1
Modified residuei198PhosphoserineBy similarity1
Modified residuei206PhosphothreonineBy similarity1
Lipidationi225S-geranylgeranyl cysteineBy similarity1
Modified residuei227Cysteine methyl esterBy similarity1
Lipidationi227S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

EPDiQ96E17
MaxQBiQ96E17
PaxDbiQ96E17
PeptideAtlasiQ96E17
PRIDEiQ96E17
ProteomicsDBi76365

PTM databases

iPTMnetiQ96E17
PhosphoSitePlusiQ96E17
SwissPalmiQ96E17

Expressioni

Tissue specificityi

Expressed in brain, placenta and lung.1 Publication

Gene expression databases

BgeeiENSG00000152932
CleanExiHS_RAB3C
GenevisibleiQ96E17 HS

Organism-specific databases

HPAiHPA003160
HPA048156

Interactioni

Subunit structurei

Interacts with RIMS1, RIMS2, RPH3A and RPH3AL.By similarity

GO - Molecular functioni

  • GTP-dependent protein binding Source: Ensembl
  • myosin V binding Source: UniProtKB

Protein-protein interaction databases

BioGridi125459, 2 interactors
IntActiQ96E17, 3 interactors
STRINGi9606.ENSP00000282878

Structurei

3D structure databases

ProteinModelPortaliQ96E17
SMRiQ96E17
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi59 – 67Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0093 Eukaryota
ENOG410ZZXQ LUCA
GeneTreeiENSGT00890000139330
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ96E17
KOiK07883
OMAiQQPGCNC
OrthoDBiEOG091G0J64
PhylomeDBiQ96E17
TreeFamiTF313199

Family and domain databases

CDDicd01865 Rab3, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR037872 Rab3
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequencei

Sequence statusi: Complete.

Q96E17-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRHEAPMQMA SAQDARYGQK DSSDQNFDYM FKLLIIGNSS VGKTSFLFRY
60 70 80 90 100
ADDSFTSAFV STVGIDFKVK TVFKNEKRIK LQIWDTAGQE RYRTITTAYY
110 120 130 140 150
RGAMGFILMY DITNEESFNA VQDWSTQIKT YSWDNAQVIL VGNKCDMEDE
160 170 180 190 200
RVISTERGQH LGEQLGFEFF ETSAKDNINV KQTFERLVDI ICDKMSESLE
210 220
TDPAITAAKQ NTRLKETPPP PQPNCAC
Length:227
Mass (Da):25,952
Last modified:December 1, 2001 - v1
Checksum:i7352E205DEFAC72D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY026936 mRNA Translation: AAK08968.1
BC013033 mRNA Translation: AAH13033.1
CCDSiCCDS3976.1
RefSeqiNP_001304844.1, NM_001317915.1
NP_612462.1, NM_138453.3
UniGeneiHs.4290
Hs.482173

Genome annotation databases

EnsembliENST00000282878; ENSP00000282878; ENSG00000152932
GeneIDi115827
KEGGihsa:115827
UCSCiuc003jrp.4 human

Similar proteinsi

Entry informationi

Entry nameiRAB3C_HUMAN
AccessioniPrimary (citable) accession number: Q96E17
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: December 1, 2001
Last modified: June 20, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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