Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

CKLF-like MARVEL transmembrane domain-containing protein 5

Gene

CMTM5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
CKLF-like MARVEL transmembrane domain-containing protein 5
Alternative name(s):
Chemokine-like factor superfamily member 5
Gene namesi
Name:CMTM5
Synonyms:CKLFSF5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000166091.19
HGNCiHGNC:19176 CMTM5
MIMi607888 gene
neXtProtiNX_Q96DZ9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
Transmembranei186 – 206HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi116173
OpenTargetsiENSG00000166091
PharmGKBiPA38815

Polymorphism and mutation databases

BioMutaiCMTM5
DMDMi34922025

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001861051 – 223CKLF-like MARVEL transmembrane domain-containing protein 5Add BLAST223

Proteomic databases

PaxDbiQ96DZ9
PeptideAtlasiQ96DZ9
PRIDEiQ96DZ9
ProteomicsDBi76348
76349 [Q96DZ9-2]
76350 [Q96DZ9-3]
76351 [Q96DZ9-4]
76352 [Q96DZ9-5]

PTM databases

PhosphoSitePlusiQ96DZ9
SwissPalmiQ96DZ9

Expressioni

Tissue specificityi

Highly expressed in the brain.1 Publication

Gene expression databases

BgeeiENSG00000166091 Expressed in 122 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_CMTM5
ExpressionAtlasiQ96DZ9 baseline and differential
GenevisibleiQ96DZ9 HS

Organism-specific databases

HPAiHPA052338

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AACSQ86V213EBI-2548702,EBI-10259474
ACSF2Q96CM84EBI-2548702,EBI-2876502
ALDH18A1P548863EBI-2548702,EBI-1210304
APOA1P026475EBI-11522780,EBI-701692
ARMC9Q7Z3E5-23EBI-2548702,EBI-10256990
C12orf10Q86UA33EBI-2548702,EBI-10258793
COQ8AQ8NI605EBI-11522780,EBI-745535
CYP1A1P047983EBI-11522780,EBI-10194262
DDA1Q9BW613EBI-2548702,EBI-2510241
ECPASQ5VYK33EBI-2548702,EBI-521451
FAM114A1Q8IWE23EBI-2548702,EBI-2686288
FARS2O953633EBI-2548702,EBI-2513774
GAD1A0A0S2Z4D94EBI-11522780,EBI-16430771
GAD1Q8IVA83EBI-2548702,EBI-10209663
GAD1Q992595EBI-11522780,EBI-743184
GAD2Q053293EBI-2548702,EBI-9304251
GLTPQ9NZD23EBI-2548702,EBI-2859814
GTF3C1Q127893EBI-2548702,EBI-357956
LMO2P257913EBI-2548702,EBI-739696
MCEEQ96PE75EBI-11522780,EBI-10292326
MTERF3Q96E293EBI-2548702,EBI-7825321
NDRG4Q9ULP03EBI-2548702,EBI-10323810
NDRG4Q9ULP0-26EBI-11522780,EBI-11978907
PIMREGQ9BSJ63EBI-11522780,EBI-2568609
PITPNC1Q9UKF73EBI-2548702,EBI-749241
PLIN3O606643EBI-2548702,EBI-725795
PNPOQ9NVS93EBI-11522780,EBI-11030787
PPIFP304053EBI-2548702,EBI-5544229
PPP2R3CQ969Q63EBI-2548702,EBI-2561661
PTPN9P433784EBI-2548702,EBI-742898
PTPN9Q6IQ433EBI-2548702,EBI-10250413
RBFAQ8N0V33EBI-2548702,EBI-3232108
RMDN2Q96LZ73EBI-2548702,EBI-2806908
RNF185Q96GF13EBI-2548702,EBI-2340249
RSRC2Q7L4I2-23EBI-2548702,EBI-10256202
SDCBPO005603EBI-2548702,EBI-727004
SH3GLB1Q9Y3713EBI-2548702,EBI-2623095
SHMT2P348973EBI-11522780,EBI-352908
SNX1Q135963EBI-2548702,EBI-2822329
SPATA8Q6RVD63EBI-2548702,EBI-8635958
SPG21Q9NZD83EBI-2548702,EBI-742688
SSX3Q999093EBI-2548702,EBI-10295431
SUCLA2E5KS603EBI-2548702,EBI-10176959
SUCLA2Q9P2R75EBI-11522780,EBI-2269898
SYNE4Q8N2053EBI-2548702,EBI-7131783
TIMM44O436153EBI-2548702,EBI-861737
TPD52L3Q96J773EBI-2548702,EBI-932162
TTPAP496383EBI-2548702,EBI-10210710
TUBBQ5SU163EBI-2548702,EBI-10245038
TUBBQ6P6023EBI-2548702,EBI-10253109
TUFMP494113EBI-2548702,EBI-359097
VARS2Q5ST30-33EBI-2548702,EBI-10244969

GO - Molecular functioni

Protein-protein interaction databases

BioGridi125486, 59 interactors
IntActiQ96DZ9, 124 interactors
MINTiQ96DZ9
STRINGi9606.ENSP00000352270

Structurei

3D structure databases

ProteinModelPortaliQ96DZ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 213MARVELPROSITE-ProRule annotationAdd BLAST185

Sequence similaritiesi

Belongs to the chemokine-like factor family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4788 Eukaryota
ENOG4111IAF LUCA
GeneTreeiENSGT00530000063326
HOGENOMiHOG000290654
HOVERGENiHBG053619
InParanoidiQ96DZ9
OMAiYQTEMAP
OrthoDBiEOG091G0VCU
PhylomeDBiQ96DZ9
TreeFamiTF317387

Family and domain databases

InterProiView protein in InterPro
IPR008253 Marvel
PfamiView protein in Pfam
PF01284 MARVEL, 1 hit
PROSITEiView protein in PROSITE
PS51225 MARVEL, 1 hit

Sequences (6+)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96DZ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLSARDRRDR HPEEGVVAEL QGFAVDKAFL TSHKGILLET ELALTLIIFI
60 70 80 90 100
CFTASISAYM AAALLEFFIT LAFLFLYATQ YYQRFDRINW PCLLQGHGQS
110 120 130 140 150
GGPHPLDLLS HSAKVQPQPW PGLTPPGWHT PAAVPWVPAP APGFWSWLLW
160 170 180 190 200
FICFHSLGSS DFLRCVSAII IFLVVSFAAV TSRDGAAIAA FVFGIILVSI
210 220
FAYDAFKIYR TEMAPGASQG DQQ
Length:223
Mass (Da):24,653
Last modified:September 19, 2003 - v2
Checksum:i26AC880FFC8E1F50
GO
Isoform 2 (identifier: Q96DZ9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     94-160: Missing.

Show »
Length:156
Mass (Da):17,444
Checksum:iBF066295563A63F9
GO
Isoform 3 (identifier: Q96DZ9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-81: ALTLIIFICFTASISAYMAAALLEFFITLAFLFLYATQY → D
     94-160: Missing.

Show »
Length:118
Mass (Da):13,190
Checksum:iE96F4E1AC5898106
GO
Isoform 4 (identifier: Q96DZ9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-191: Missing.

Show »
Length:74
Mass (Da):8,255
Checksum:i0B09C89A6339756C
GO
Isoform 5 (identifier: Q96DZ9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-160: Missing.

Show »
Length:105
Mass (Da):11,482
Checksum:i0A61A85D1B903076
GO
Isoform 6 (identifier: Q96DZ9-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     94-191: Missing.

Show »
Length:125
Mass (Da):14,218
Checksum:i4AAF5DCA6BAD1838
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JAI6C9JAI6_HUMAN
CKLF-like MARVEL transmembrane doma...
CMTM5
118Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti192V → D in AAV69870 (PubMed:12782130).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00826443 – 191Missing in isoform 4. 1 PublicationAdd BLAST149
Alternative sequenceiVSP_00826343 – 160Missing in isoform 5. 1 PublicationAdd BLAST118
Alternative sequenceiVSP_00826243 – 81ALTLI…YATQY → D in isoform 3. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_04712094 – 191Missing in isoform 6. 1 PublicationAdd BLAST98
Alternative sequenceiVSP_00826594 – 160Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST67

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF479262 mRNA Translation: AAN73040.1
AY820135 mRNA Translation: AAV69870.1
AF527413 mRNA Translation: AAQ08985.1
AF527414 mRNA Translation: AAQ08986.1
AF527948 mRNA Translation: AAQ09008.2
AF527949 mRNA Translation: AAQ09009.1
AL049829 Genomic DNA No translation available.
BC013109 mRNA Translation: AAH13109.1
CCDSiCCDS32050.1 [Q96DZ9-6]
CCDS73617.1 [Q96DZ9-1]
CCDS73618.1 [Q96DZ9-5]
CCDS73619.1 [Q96DZ9-4]
CCDS9598.1 [Q96DZ9-2]
RefSeqiNP_001032365.1, NM_001037288.1 [Q96DZ9-6]
NP_001275673.1, NM_001288744.1 [Q96DZ9-5]
NP_001275674.1, NM_001288745.1 [Q96DZ9-4]
NP_001275675.1, NM_001288746.1 [Q96DZ9-1]
NP_612469.1, NM_138460.2 [Q96DZ9-2]
XP_016876442.1, XM_017020953.1
XP_016876443.1, XM_017020954.1
UniGeneiHs.99272

Genome annotation databases

EnsembliENST00000339180; ENSP00000344819; ENSG00000166091 [Q96DZ9-1]
ENST00000342473; ENSP00000344160; ENSG00000166091 [Q96DZ9-4]
ENST00000359320; ENSP00000352270; ENSG00000166091 [Q96DZ9-2]
ENST00000382809; ENSP00000372259; ENSG00000166091 [Q96DZ9-6]
ENST00000397227; ENSP00000380404; ENSG00000166091 [Q96DZ9-5]
GeneIDi116173
KEGGihsa:116173
UCSCiuc001wjs.3 human [Q96DZ9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF479262 mRNA Translation: AAN73040.1
AY820135 mRNA Translation: AAV69870.1
AF527413 mRNA Translation: AAQ08985.1
AF527414 mRNA Translation: AAQ08986.1
AF527948 mRNA Translation: AAQ09008.2
AF527949 mRNA Translation: AAQ09009.1
AL049829 Genomic DNA No translation available.
BC013109 mRNA Translation: AAH13109.1
CCDSiCCDS32050.1 [Q96DZ9-6]
CCDS73617.1 [Q96DZ9-1]
CCDS73618.1 [Q96DZ9-5]
CCDS73619.1 [Q96DZ9-4]
CCDS9598.1 [Q96DZ9-2]
RefSeqiNP_001032365.1, NM_001037288.1 [Q96DZ9-6]
NP_001275673.1, NM_001288744.1 [Q96DZ9-5]
NP_001275674.1, NM_001288745.1 [Q96DZ9-4]
NP_001275675.1, NM_001288746.1 [Q96DZ9-1]
NP_612469.1, NM_138460.2 [Q96DZ9-2]
XP_016876442.1, XM_017020953.1
XP_016876443.1, XM_017020954.1
UniGeneiHs.99272

3D structure databases

ProteinModelPortaliQ96DZ9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125486, 59 interactors
IntActiQ96DZ9, 124 interactors
MINTiQ96DZ9
STRINGi9606.ENSP00000352270

PTM databases

PhosphoSitePlusiQ96DZ9
SwissPalmiQ96DZ9

Polymorphism and mutation databases

BioMutaiCMTM5
DMDMi34922025

Proteomic databases

PaxDbiQ96DZ9
PeptideAtlasiQ96DZ9
PRIDEiQ96DZ9
ProteomicsDBi76348
76349 [Q96DZ9-2]
76350 [Q96DZ9-3]
76351 [Q96DZ9-4]
76352 [Q96DZ9-5]

Protocols and materials databases

DNASUi116173
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339180; ENSP00000344819; ENSG00000166091 [Q96DZ9-1]
ENST00000342473; ENSP00000344160; ENSG00000166091 [Q96DZ9-4]
ENST00000359320; ENSP00000352270; ENSG00000166091 [Q96DZ9-2]
ENST00000382809; ENSP00000372259; ENSG00000166091 [Q96DZ9-6]
ENST00000397227; ENSP00000380404; ENSG00000166091 [Q96DZ9-5]
GeneIDi116173
KEGGihsa:116173
UCSCiuc001wjs.3 human [Q96DZ9-1]

Organism-specific databases

CTDi116173
DisGeNETi116173
EuPathDBiHostDB:ENSG00000166091.19
GeneCardsiCMTM5
H-InvDBiHIX0011540
HGNCiHGNC:19176 CMTM5
HPAiHPA052338
MIMi607888 gene
neXtProtiNX_Q96DZ9
OpenTargetsiENSG00000166091
PharmGKBiPA38815
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4788 Eukaryota
ENOG4111IAF LUCA
GeneTreeiENSGT00530000063326
HOGENOMiHOG000290654
HOVERGENiHBG053619
InParanoidiQ96DZ9
OMAiYQTEMAP
OrthoDBiEOG091G0VCU
PhylomeDBiQ96DZ9
TreeFamiTF317387

Miscellaneous databases

GenomeRNAii116173
PROiPR:Q96DZ9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166091 Expressed in 122 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_CMTM5
ExpressionAtlasiQ96DZ9 baseline and differential
GenevisibleiQ96DZ9 HS

Family and domain databases

InterProiView protein in InterPro
IPR008253 Marvel
PfamiView protein in Pfam
PF01284 MARVEL, 1 hit
PROSITEiView protein in PROSITE
PS51225 MARVEL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCKLF5_HUMAN
AccessioniPrimary (citable) accession number: Q96DZ9
Secondary accession number(s): E9PH91, Q5PY48
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: September 19, 2003
Last modified: November 7, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again