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Entry version 148 (07 Oct 2020)
Sequence version 2 (19 Sep 2003)
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Protein

CKLF-like MARVEL transmembrane domain-containing protein 5

Gene

CMTM5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine
Biological processChemotaxis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q96DZ9

Protein family/group databases

Transport Classification Database

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TCDBi
1.A.64.5.8, the plasmolipin (plasmolipin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CKLF-like MARVEL transmembrane domain-containing protein 5
Alternative name(s):
Chemokine-like factor superfamily member 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CMTM5
Synonyms:CKLFSF5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000166091.19

Human Gene Nomenclature Database

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HGNCi
HGNC:19176, CMTM5

Online Mendelian Inheritance in Man (OMIM)

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MIMi
607888, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q96DZ9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
Transmembranei186 – 206HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

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DisGeNETi
116173

Open Targets

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OpenTargetsi
ENSG00000166091

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA38815

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q96DZ9, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
CMTM5

Domain mapping of disease mutations (DMDM)

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DMDMi
34922025

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001861051 – 223CKLF-like MARVEL transmembrane domain-containing protein 5Add BLAST223

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96DZ9

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q96DZ9

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96DZ9

PeptideAtlas

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PeptideAtlasi
Q96DZ9

PRoteomics IDEntifications database

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PRIDEi
Q96DZ9

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
20482
76348 [Q96DZ9-1]
76349 [Q96DZ9-2]
76350 [Q96DZ9-3]
76351 [Q96DZ9-4]
76352 [Q96DZ9-5]

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q96DZ9

SwissPalm database of S-palmitoylation events

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SwissPalmi
Q96DZ9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in the brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000166091, Expressed in C1 segment of cervical spinal cord and 144 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96DZ9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96DZ9, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000166091, Group enriched (blood, brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q96DZ9
With#Exp.IntAct
AACS [Q86V21]3EBI-2548702,EBI-10259474
ACSF2 [Q96CM8]5EBI-2548702,EBI-2876502
ALDH18A1 [P54886]3EBI-2548702,EBI-1210304
APOA1 [P02647]3EBI-2548702,EBI-701692
ARMC9 - isoform 2 [Q7Z3E5-2]3EBI-2548702,EBI-10256990
CYP1A1 [P04798]3EBI-2548702,EBI-10194262
DDA1 [Q9BW61]3EBI-2548702,EBI-2510241
ECPAS [Q5VYK3]3EBI-2548702,EBI-521451
EMP3 [P54852]3EBI-2548702,EBI-3907816
FAM114A1 [Q8IWE2]3EBI-2548702,EBI-2686288
FARS2 [O95363]3EBI-2548702,EBI-2513774
GAD1 [Q8IVA8]3EBI-2548702,EBI-10209663
GAD1 [Q99259]4EBI-2548702,EBI-743184
GAD2 [Q05329]3EBI-2548702,EBI-9304251
GLTP [Q9NZD2]4EBI-2548702,EBI-2859814
GTF3C1 [Q12789]3EBI-2548702,EBI-357956
LMO2 [P25791]3EBI-2548702,EBI-739696
MCEE [Q96PE7]4EBI-2548702,EBI-10292326
MTERF3 [Q96E29]3EBI-2548702,EBI-7825321
MYG1 [Q9HB07]4EBI-2548702,EBI-709754
NDRG4 [Q9ULP0]3EBI-2548702,EBI-10323810
PITPNC1 [Q9UKF7]3EBI-2548702,EBI-749241
PLIN3 [O60664]3EBI-2548702,EBI-725795
PPIF [P30405]3EBI-2548702,EBI-5544229
PPP2R3C [Q969Q6]3EBI-2548702,EBI-2561661
PTPN9 [P43378]4EBI-2548702,EBI-742898
PTPN9 [Q6IQ43]3EBI-2548702,EBI-10250413
RBFA [Q8N0V3]3EBI-2548702,EBI-3232108
RMDN2 [Q96LZ7]3EBI-2548702,EBI-2806908
RNF185 [Q96GF1]3EBI-2548702,EBI-2340249
RSRC2 - isoform 2 [Q7L4I2-2]3EBI-2548702,EBI-10256202
SDCBP [O00560]3EBI-2548702,EBI-727004
SH3GLB1 [Q9Y371]3EBI-2548702,EBI-2623095
SHMT2 [P34897]4EBI-2548702,EBI-352908
SNX1 [Q13596]3EBI-2548702,EBI-2822329
SPATA8 [Q6RVD6]3EBI-2548702,EBI-8635958
SPG21 [Q9NZD8]3EBI-2548702,EBI-742688
SSX3 [Q99909]3EBI-2548702,EBI-10295431
SUCLA2 [E5KS60]3EBI-2548702,EBI-10176959
SYNE4 [Q8N205]3EBI-2548702,EBI-7131783
TIMM44 [O43615]3EBI-2548702,EBI-861737
TPD52L3 [Q96J77]3EBI-2548702,EBI-932162
TTPA [P49638]3EBI-2548702,EBI-10210710
TUBB [Q5SU16]3EBI-2548702,EBI-10245038
TUBB [Q6P602]3EBI-2548702,EBI-10253109
TUFM [P49411]3EBI-2548702,EBI-359097
VARS2 - isoform 3 [Q5ST30-3]3EBI-2548702,EBI-10244969
Isoform 2 [Q96DZ9-2]
With#Exp.IntAct
ABHD4 [Q8TB40]3EBI-11522780,EBI-7131019
ACSF2 [Q96CM8]3EBI-11522780,EBI-2876502
ACSM1 [Q08AH1]3EBI-11522780,EBI-2818055
APOA1 [P02647]6EBI-11522780,EBI-701692
APOA4 [P06727]3EBI-11522780,EBI-1222447
APOA5 [Q6Q788]3EBI-11522780,EBI-3936819
AQP6 [Q13520]3EBI-11522780,EBI-13059134
ARFIP1 [P53367]3EBI-11522780,EBI-2808808
ARFIP2 [P53365]3EBI-11522780,EBI-638194
BIK [Q13323]3EBI-11522780,EBI-700794
BNIP3 [Q12983]3EBI-11522780,EBI-749464
CAPNS2 [Q96L46]3EBI-11522780,EBI-12188723
CD160 [O95971]3EBI-11522780,EBI-4314390
CD40 [P25942]3EBI-11522780,EBI-525714
CD79A [P11912]3EBI-11522780,EBI-7797864
CLDN7 [O95471]3EBI-11522780,EBI-740744
COQ8A [Q8NI60]6EBI-11522780,EBI-745535
CPLX4 [Q7Z7G2]3EBI-11522780,EBI-18013275
CYP1A1 [P04798]3EBI-11522780,EBI-10194262
DDA1 [Q9BW61]3EBI-11522780,EBI-2510241
DHRSX [Q8N5I4]3EBI-11522780,EBI-3923585
ECPAS [Q5VYK3]3EBI-11522780,EBI-521451
ELOVL4 [Q9GZR5]3EBI-11522780,EBI-18535450
ERGIC3 [Q9Y282]3EBI-11522780,EBI-781551
FAM114A1 [Q8IWE2]3EBI-11522780,EBI-2686288
FARS2 [O95363]3EBI-11522780,EBI-2513774
FCGR2A - isoform 2 [P12318-2]3EBI-11522780,EBI-17187481
FCRL3 - isoform 6 [Q96P31-6]3EBI-11522780,EBI-17443171
FFAR2 [O15552]3EBI-11522780,EBI-2833872
FNDC9 [Q8TBE3]3EBI-11522780,EBI-12142257
GAD1 [A0A0S2Z4D9]4EBI-11522780,EBI-16430771
GAD1 [Q99259]6EBI-11522780,EBI-743184
GAD2 [Q05329]3EBI-11522780,EBI-9304251
GJB1 [P08034]3EBI-11522780,EBI-17565645
GPX8 [Q8TED1]3EBI-11522780,EBI-11721746
HSD17B13 [Q7Z5P4]3EBI-11522780,EBI-18053395
JAGN1 [Q8N5M9]3EBI-11522780,EBI-10266796
JOSD2 [Q8TAC2]3EBI-11522780,EBI-12205593
KASH5 [Q8N6L0]3EBI-11522780,EBI-749265
KCNJ6 [P48051]3EBI-11522780,EBI-12017638
KCNK5 [O95279]3EBI-11522780,EBI-3934936
KIR3DL3 [Q8N743]3EBI-11522780,EBI-17272405
LEUTX [A8MZ59]3EBI-11522780,EBI-17490413
LNX1 [Q8TBB1]3EBI-11522780,EBI-739832
LRRC4C [Q9HCJ2]3EBI-11522780,EBI-3925442
LRRC59 [Q96AG4]3EBI-11522780,EBI-358888
MCEE [Q96PE7]6EBI-11522780,EBI-10292326
MCEMP1 [Q8IX19]3EBI-11522780,EBI-2816356
MCFD2 [Q8NI22]3EBI-11522780,EBI-2689785
MEOX2 [Q6FHY5]3EBI-11522780,EBI-16439278
MFF - isoform 5 [Q9GZY8-5]3EBI-11522780,EBI-11956541
MGST3 [O14880]3EBI-11522780,EBI-724754
MIEF1 [Q9NQG6]3EBI-11522780,EBI-740987
MRM1 [Q6IN84]3EBI-11522780,EBI-5454865
MRRF [Q96E11]3EBI-11522780,EBI-2855755
MTERF3 [Q96E29]3EBI-11522780,EBI-7825321
MTIF3 [Q9H2K0]3EBI-11522780,EBI-3923617
MYG1 [Q9HB07]3EBI-11522780,EBI-709754
NDRG4 - isoform 2 [Q9ULP0-2]7EBI-11522780,EBI-11978907
NFU1 [Q9UMS0]3EBI-11522780,EBI-725252
NTAQ1 [Q96HA8]3EBI-11522780,EBI-741158
PBX3 [Q96AL5]3EBI-11522780,EBI-741171
PCNA [P12004]3EBI-11522780,EBI-358311
PIMREG [Q9BSJ6]3EBI-11522780,EBI-2568609
PITPNC1 - isoform 2 [Q9UKF7-2]3EBI-11522780,EBI-14223623
PLIN3 [O60664]3EBI-11522780,EBI-725795
PNPO [Q9NVS9]3EBI-11522780,EBI-11030787
POLL - isoform 2 [Q9UGP5-2]3EBI-11522780,EBI-10320765
PTPN9 [P43378]3EBI-11522780,EBI-742898
RBFA [Q8N0V3]3EBI-11522780,EBI-3232108
REEP2 [Q9BRK0]3EBI-11522780,EBI-11337973
RETREG3 [Q86VR2]3EBI-11522780,EBI-10192441
RHBDD1 [Q8TEB9]3EBI-11522780,EBI-9916444
RMDN2 [Q96LZ7]3EBI-11522780,EBI-2806908
RSRC2 [Q7L4I2]3EBI-11522780,EBI-953753
RUSF1 [Q96GQ5]3EBI-11522780,EBI-8636004
SAR1A [Q9NR31]3EBI-11522780,EBI-3920694
SCARA5 - isoform 2 [Q6ZMJ2-2]3EBI-11522780,EBI-12823227
SDCBP [O00560]3EBI-11522780,EBI-727004
SGCB [Q16585]3EBI-11522780,EBI-5663627
SH3GL1 [Q99961]3EBI-11522780,EBI-697911
SH3GLB1 [Q9Y371]3EBI-11522780,EBI-2623095
SHMT2 [P34897]3EBI-11522780,EBI-352908
SLC10A6 [Q3KNW5]3EBI-11522780,EBI-18159983
SLC18A2 [Q05940]3EBI-11522780,EBI-18036244
SLC30A4 [O14863]3EBI-11522780,EBI-13918058
SLC35C2 - isoform 3 [Q9NQQ7-3]3EBI-11522780,EBI-17295964
SLC7A14 [Q8TBB6]3EBI-11522780,EBI-5235586
SNX1 [Q13596]3EBI-11522780,EBI-2822329
SPG21 [Q9NZD8]3EBI-11522780,EBI-742688
SSX3 [Q99909]3EBI-11522780,EBI-10295431
SSX5 - isoform 2 [O60225-2]3EBI-11522780,EBI-12033476
STING1 [Q86WV6]3EBI-11522780,EBI-2800345
STOM [P27105]3EBI-11522780,EBI-1211440
SUCLA2 [Q9P2R7]6EBI-11522780,EBI-2269898
SYT16 [Q17RD7]3EBI-11522780,EBI-10238936
TBRG4 [Q969Z0]3EBI-11522780,EBI-702328
THAP4 [Q8WY91]3EBI-11522780,EBI-726691
TIMM44 [O43615]3EBI-11522780,EBI-861737
TLCD4 [Q96MV1]3EBI-11522780,EBI-12947623
TMED8 [Q6PL24]3EBI-11522780,EBI-11603430
TMEM139 [Q8IV31]3EBI-11522780,EBI-7238458
TMEM14B [Q9NUH8]3EBI-11522780,EBI-8638294
TMEM35A [Q53FP2]3EBI-11522780,EBI-11722971
TMEM80 [Q96HE8]3EBI-11522780,EBI-11742770
TMF1 [P82094]3EBI-11522780,EBI-949763
TSPAN31 [Q12999]3EBI-11522780,EBI-17678331
TTPA [P49638]3EBI-11522780,EBI-10210710
TUFM [A0A384ME17]6EBI-11522780,EBI-12261790

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
125486, 139 interactors

Protein interaction database and analysis system

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IntActi
Q96DZ9, 135 interactors

Molecular INTeraction database

More...
MINTi
Q96DZ9

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000344819

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96DZ9, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 213MARVELPROSITE-ProRule annotationAdd BLAST185

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the chemokine-like factor family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4788, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161867

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_108546_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96DZ9

Identification of Orthologs from Complete Genome Data

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OMAi
YQTEMAP

Database of Orthologous Groups

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OrthoDBi
1575715at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q96DZ9

TreeFam database of animal gene trees

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TreeFami
TF317387

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR008253, Marvel

Pfam protein domain database

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Pfami
View protein in Pfam
PF01284, MARVEL, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51225, MARVEL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96DZ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLSARDRRDR HPEEGVVAEL QGFAVDKAFL TSHKGILLET ELALTLIIFI
60 70 80 90 100
CFTASISAYM AAALLEFFIT LAFLFLYATQ YYQRFDRINW PCLLQGHGQS
110 120 130 140 150
GGPHPLDLLS HSAKVQPQPW PGLTPPGWHT PAAVPWVPAP APGFWSWLLW
160 170 180 190 200
FICFHSLGSS DFLRCVSAII IFLVVSFAAV TSRDGAAIAA FVFGIILVSI
210 220
FAYDAFKIYR TEMAPGASQG DQQ
Length:223
Mass (Da):24,653
Last modified:September 19, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i26AC880FFC8E1F50
GO
Isoform 2 (identifier: Q96DZ9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     94-160: Missing.

Show »
Length:156
Mass (Da):17,444
Checksum:iBF066295563A63F9
GO
Isoform 3 (identifier: Q96DZ9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-81: ALTLIIFICFTASISAYMAAALLEFFITLAFLFLYATQY → D
     94-160: Missing.

Show »
Length:118
Mass (Da):13,190
Checksum:iE96F4E1AC5898106
GO
Isoform 4 (identifier: Q96DZ9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-191: Missing.

Show »
Length:74
Mass (Da):8,255
Checksum:i0B09C89A6339756C
GO
Isoform 5 (identifier: Q96DZ9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-160: Missing.

Show »
Length:105
Mass (Da):11,482
Checksum:i0A61A85D1B903076
GO
Isoform 6 (identifier: Q96DZ9-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     94-191: Missing.

Show »
Length:125
Mass (Da):14,218
Checksum:i4AAF5DCA6BAD1838
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JAI6C9JAI6_HUMAN
CKLF-like MARVEL transmembrane doma...
CMTM5
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti192V → D in AAV69870 (PubMed:12782130).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00826443 – 191Missing in isoform 4. 1 PublicationAdd BLAST149
Alternative sequenceiVSP_00826343 – 160Missing in isoform 5. 1 PublicationAdd BLAST118
Alternative sequenceiVSP_00826243 – 81ALTLI…YATQY → D in isoform 3. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_04712094 – 191Missing in isoform 6. 1 PublicationAdd BLAST98
Alternative sequenceiVSP_00826594 – 160Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST67

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF479262 mRNA Translation: AAN73040.1
AY820135 mRNA Translation: AAV69870.1
AF527413 mRNA Translation: AAQ08985.1
AF527414 mRNA Translation: AAQ08986.1
AF527948 mRNA Translation: AAQ09008.2
AF527949 mRNA Translation: AAQ09009.1
AL049829 Genomic DNA No translation available.
BC013109 mRNA Translation: AAH13109.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32050.1 [Q96DZ9-6]
CCDS73617.1 [Q96DZ9-1]
CCDS73618.1 [Q96DZ9-5]
CCDS73619.1 [Q96DZ9-4]
CCDS9598.1 [Q96DZ9-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001032365.1, NM_001037288.1 [Q96DZ9-6]
NP_001275673.1, NM_001288744.1 [Q96DZ9-5]
NP_001275674.1, NM_001288745.1 [Q96DZ9-4]
NP_001275675.1, NM_001288746.1 [Q96DZ9-1]
NP_612469.1, NM_138460.2 [Q96DZ9-2]
XP_016876442.1, XM_017020953.1
XP_016876443.1, XM_017020954.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000339180; ENSP00000344819; ENSG00000166091 [Q96DZ9-1]
ENST00000342473; ENSP00000344160; ENSG00000166091 [Q96DZ9-4]
ENST00000359320; ENSP00000352270; ENSG00000166091 [Q96DZ9-2]
ENST00000382809; ENSP00000372259; ENSG00000166091 [Q96DZ9-6]
ENST00000397227; ENSP00000380404; ENSG00000166091 [Q96DZ9-5]
ENST00000649278; ENSP00000497215; ENSG00000166091 [Q96DZ9-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
116173

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:116173

UCSC genome browser

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UCSCi
uc001wjs.3, human [Q96DZ9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF479262 mRNA Translation: AAN73040.1
AY820135 mRNA Translation: AAV69870.1
AF527413 mRNA Translation: AAQ08985.1
AF527414 mRNA Translation: AAQ08986.1
AF527948 mRNA Translation: AAQ09008.2
AF527949 mRNA Translation: AAQ09009.1
AL049829 Genomic DNA No translation available.
BC013109 mRNA Translation: AAH13109.1
CCDSiCCDS32050.1 [Q96DZ9-6]
CCDS73617.1 [Q96DZ9-1]
CCDS73618.1 [Q96DZ9-5]
CCDS73619.1 [Q96DZ9-4]
CCDS9598.1 [Q96DZ9-2]
RefSeqiNP_001032365.1, NM_001037288.1 [Q96DZ9-6]
NP_001275673.1, NM_001288744.1 [Q96DZ9-5]
NP_001275674.1, NM_001288745.1 [Q96DZ9-4]
NP_001275675.1, NM_001288746.1 [Q96DZ9-1]
NP_612469.1, NM_138460.2 [Q96DZ9-2]
XP_016876442.1, XM_017020953.1
XP_016876443.1, XM_017020954.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi125486, 139 interactors
IntActiQ96DZ9, 135 interactors
MINTiQ96DZ9
STRINGi9606.ENSP00000344819

Protein family/group databases

TCDBi1.A.64.5.8, the plasmolipin (plasmolipin) family

PTM databases

PhosphoSitePlusiQ96DZ9
SwissPalmiQ96DZ9

Polymorphism and mutation databases

BioMutaiCMTM5
DMDMi34922025

Proteomic databases

jPOSTiQ96DZ9
MassIVEiQ96DZ9
PaxDbiQ96DZ9
PeptideAtlasiQ96DZ9
PRIDEiQ96DZ9
ProteomicsDBi20482
76348 [Q96DZ9-1]
76349 [Q96DZ9-2]
76350 [Q96DZ9-3]
76351 [Q96DZ9-4]
76352 [Q96DZ9-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
22460, 221 antibodies

The DNASU plasmid repository

More...
DNASUi
116173

Genome annotation databases

EnsembliENST00000339180; ENSP00000344819; ENSG00000166091 [Q96DZ9-1]
ENST00000342473; ENSP00000344160; ENSG00000166091 [Q96DZ9-4]
ENST00000359320; ENSP00000352270; ENSG00000166091 [Q96DZ9-2]
ENST00000382809; ENSP00000372259; ENSG00000166091 [Q96DZ9-6]
ENST00000397227; ENSP00000380404; ENSG00000166091 [Q96DZ9-5]
ENST00000649278; ENSP00000497215; ENSG00000166091 [Q96DZ9-2]
GeneIDi116173
KEGGihsa:116173
UCSCiuc001wjs.3, human [Q96DZ9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
116173
DisGeNETi116173
EuPathDBiHostDB:ENSG00000166091.19

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CMTM5
HGNCiHGNC:19176, CMTM5
HPAiENSG00000166091, Group enriched (blood, brain)
MIMi607888, gene
neXtProtiNX_Q96DZ9
OpenTargetsiENSG00000166091
PharmGKBiPA38815

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4788, Eukaryota
GeneTreeiENSGT00940000161867
HOGENOMiCLU_108546_0_0_1
InParanoidiQ96DZ9
OMAiYQTEMAP
OrthoDBi1575715at2759
PhylomeDBiQ96DZ9
TreeFamiTF317387

Enzyme and pathway databases

PathwayCommonsiQ96DZ9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
116173, 1 hit in 865 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
116173
PharosiQ96DZ9, Tbio

Protein Ontology

More...
PROi
PR:Q96DZ9
RNActiQ96DZ9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000166091, Expressed in C1 segment of cervical spinal cord and 144 other tissues
ExpressionAtlasiQ96DZ9, baseline and differential
GenevisibleiQ96DZ9, HS

Family and domain databases

InterProiView protein in InterPro
IPR008253, Marvel
PfamiView protein in Pfam
PF01284, MARVEL, 1 hit
PROSITEiView protein in PROSITE
PS51225, MARVEL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCKLF5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96DZ9
Secondary accession number(s): E9PH91, Q5PY48
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: September 19, 2003
Last modified: October 7, 2020
This is version 148 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. UniProtKB entry view manual
    User manual for the UniProtKB entry view
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