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Entry version 140 (18 Sep 2019)
Sequence version 2 (19 Sep 2003)
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Protein

CKLF-like MARVEL transmembrane domain-containing protein 5

Gene

CMTM5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine
Biological processChemotaxis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CKLF-like MARVEL transmembrane domain-containing protein 5
Alternative name(s):
Chemokine-like factor superfamily member 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CMTM5
Synonyms:CKLFSF5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19176 CMTM5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607888 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96DZ9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
Transmembranei186 – 206HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
116173

Open Targets

More...
OpenTargetsi
ENSG00000166091

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38815

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CMTM5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
34922025

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001861051 – 223CKLF-like MARVEL transmembrane domain-containing protein 5Add BLAST223

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96DZ9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96DZ9

PeptideAtlas

More...
PeptideAtlasi
Q96DZ9

PRoteomics IDEntifications database

More...
PRIDEi
Q96DZ9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
20482
76348 [Q96DZ9-1]
76349 [Q96DZ9-2]
76350 [Q96DZ9-3]
76351 [Q96DZ9-4]
76352 [Q96DZ9-5]

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96DZ9

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q96DZ9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in the brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000166091 Expressed in 122 organ(s), highest expression level in C1 segment of cervical spinal cord

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96DZ9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96DZ9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA052338

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
AACSQ86V213EBI-2548702,EBI-10259474
ACSF2Q96CM84EBI-2548702,EBI-2876502
ALDH18A1P548863EBI-2548702,EBI-1210304
APOA1P026475EBI-11522780,EBI-701692
ARMC9Q7Z3E5-23EBI-2548702,EBI-10256990
C12orf10Q86UA33EBI-2548702,EBI-10258793
COQ8AQ8NI605EBI-11522780,EBI-745535
CYP1A1P047983EBI-2548702,EBI-10194262
DDA1Q9BW613EBI-2548702,EBI-2510241
ECPASQ5VYK33EBI-2548702,EBI-521451
EMP3P548523EBI-2548702,EBI-3907816
FAM114A1Q8IWE23EBI-2548702,EBI-2686288
FARS2O953633EBI-2548702,EBI-2513774
GAD1A0A0S2Z4D94EBI-11522780,EBI-16430771
GAD1Q8IVA83EBI-2548702,EBI-10209663
GAD1Q992595EBI-11522780,EBI-743184
GAD2Q053293EBI-2548702,EBI-9304251
GLTPQ9NZD23EBI-2548702,EBI-2859814
GTF3C1Q127893EBI-2548702,EBI-357956
LMO2P257913EBI-2548702,EBI-739696
MCEEQ96PE75EBI-11522780,EBI-10292326
MTERF3Q96E293EBI-2548702,EBI-7825321
NDRG4Q9ULP03EBI-2548702,EBI-10323810
NDRG4Q9ULP0-26EBI-11522780,EBI-11978907
PIMREGQ9BSJ63EBI-11522780,EBI-2568609
PITPNC1Q9UKF73EBI-2548702,EBI-749241
PLIN3O606643EBI-2548702,EBI-725795
PNPOQ9NVS93EBI-11522780,EBI-11030787
PPIFP304053EBI-2548702,EBI-5544229
PPP2R3CQ969Q63EBI-2548702,EBI-2561661
PTPN9P433784EBI-2548702,EBI-742898
PTPN9Q6IQ433EBI-2548702,EBI-10250413
RBFAQ8N0V33EBI-2548702,EBI-3232108
RMDN2Q96LZ73EBI-2548702,EBI-2806908
RNF185Q96GF13EBI-2548702,EBI-2340249
RSRC2Q7L4I2-23EBI-2548702,EBI-10256202
SDCBPO005603EBI-2548702,EBI-727004
SH3GLB1Q9Y3713EBI-2548702,EBI-2623095
SHMT2P348973EBI-11522780,EBI-352908
SNX1Q135963EBI-2548702,EBI-2822329
SPATA8Q6RVD63EBI-2548702,EBI-8635958
SPG21Q9NZD83EBI-2548702,EBI-742688
SSX3Q999093EBI-2548702,EBI-10295431
SUCLA2E5KS603EBI-2548702,EBI-10176959
SUCLA2Q9P2R75EBI-11522780,EBI-2269898
SYNE4Q8N2053EBI-2548702,EBI-7131783
TIMM44O436153EBI-2548702,EBI-861737
TPD52L3Q96J773EBI-2548702,EBI-932162
TTPAP496383EBI-2548702,EBI-10210710
TUBBQ5SU163EBI-2548702,EBI-10245038
TUBBQ6P6023EBI-2548702,EBI-10253109
TUFMA0A384ME175EBI-11522780,EBI-12261790
TUFMP494113EBI-2548702,EBI-359097
VARS2Q5ST30-33EBI-2548702,EBI-10244969

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125486, 62 interactors

Protein interaction database and analysis system

More...
IntActi
Q96DZ9, 127 interactors

Molecular INTeraction database

More...
MINTi
Q96DZ9

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000344819

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 213MARVELPROSITE-ProRule annotationAdd BLAST185

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the chemokine-like factor family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4788 Eukaryota
ENOG4111IAF LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161867

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000290654

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96DZ9

Identification of Orthologs from Complete Genome Data

More...
OMAi
YQTEMAP

Database of Orthologous Groups

More...
OrthoDBi
1575715at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96DZ9

TreeFam database of animal gene trees

More...
TreeFami
TF317387

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008253 Marvel

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01284 MARVEL, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51225 MARVEL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96DZ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLSARDRRDR HPEEGVVAEL QGFAVDKAFL TSHKGILLET ELALTLIIFI
60 70 80 90 100
CFTASISAYM AAALLEFFIT LAFLFLYATQ YYQRFDRINW PCLLQGHGQS
110 120 130 140 150
GGPHPLDLLS HSAKVQPQPW PGLTPPGWHT PAAVPWVPAP APGFWSWLLW
160 170 180 190 200
FICFHSLGSS DFLRCVSAII IFLVVSFAAV TSRDGAAIAA FVFGIILVSI
210 220
FAYDAFKIYR TEMAPGASQG DQQ
Length:223
Mass (Da):24,653
Last modified:September 19, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i26AC880FFC8E1F50
GO
Isoform 2 (identifier: Q96DZ9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     94-160: Missing.

Show »
Length:156
Mass (Da):17,444
Checksum:iBF066295563A63F9
GO
Isoform 3 (identifier: Q96DZ9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-81: ALTLIIFICFTASISAYMAAALLEFFITLAFLFLYATQY → D
     94-160: Missing.

Show »
Length:118
Mass (Da):13,190
Checksum:iE96F4E1AC5898106
GO
Isoform 4 (identifier: Q96DZ9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-191: Missing.

Show »
Length:74
Mass (Da):8,255
Checksum:i0B09C89A6339756C
GO
Isoform 5 (identifier: Q96DZ9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-160: Missing.

Show »
Length:105
Mass (Da):11,482
Checksum:i0A61A85D1B903076
GO
Isoform 6 (identifier: Q96DZ9-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     94-191: Missing.

Show »
Length:125
Mass (Da):14,218
Checksum:i4AAF5DCA6BAD1838
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JAI6C9JAI6_HUMAN
CKLF-like MARVEL transmembrane doma...
CMTM5
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti192V → D in AAV69870 (PubMed:12782130).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00826443 – 191Missing in isoform 4. 1 PublicationAdd BLAST149
Alternative sequenceiVSP_00826343 – 160Missing in isoform 5. 1 PublicationAdd BLAST118
Alternative sequenceiVSP_00826243 – 81ALTLI…YATQY → D in isoform 3. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_04712094 – 191Missing in isoform 6. 1 PublicationAdd BLAST98
Alternative sequenceiVSP_00826594 – 160Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST67

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF479262 mRNA Translation: AAN73040.1
AY820135 mRNA Translation: AAV69870.1
AF527413 mRNA Translation: AAQ08985.1
AF527414 mRNA Translation: AAQ08986.1
AF527948 mRNA Translation: AAQ09008.2
AF527949 mRNA Translation: AAQ09009.1
AL049829 Genomic DNA No translation available.
BC013109 mRNA Translation: AAH13109.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32050.1 [Q96DZ9-6]
CCDS73617.1 [Q96DZ9-1]
CCDS73618.1 [Q96DZ9-5]
CCDS73619.1 [Q96DZ9-4]
CCDS9598.1 [Q96DZ9-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001032365.1, NM_001037288.1 [Q96DZ9-6]
NP_001275673.1, NM_001288744.1 [Q96DZ9-5]
NP_001275674.1, NM_001288745.1 [Q96DZ9-4]
NP_001275675.1, NM_001288746.1 [Q96DZ9-1]
NP_612469.1, NM_138460.2 [Q96DZ9-2]
XP_016876442.1, XM_017020953.1
XP_016876443.1, XM_017020954.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000339180; ENSP00000344819; ENSG00000166091 [Q96DZ9-1]
ENST00000342473; ENSP00000344160; ENSG00000166091 [Q96DZ9-4]
ENST00000359320; ENSP00000352270; ENSG00000166091 [Q96DZ9-2]
ENST00000382809; ENSP00000372259; ENSG00000166091 [Q96DZ9-6]
ENST00000397227; ENSP00000380404; ENSG00000166091 [Q96DZ9-5]
ENST00000649278; ENSP00000497215; ENSG00000166091 [Q96DZ9-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
116173

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:116173

UCSC genome browser

More...
UCSCi
uc001wjs.3 human [Q96DZ9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF479262 mRNA Translation: AAN73040.1
AY820135 mRNA Translation: AAV69870.1
AF527413 mRNA Translation: AAQ08985.1
AF527414 mRNA Translation: AAQ08986.1
AF527948 mRNA Translation: AAQ09008.2
AF527949 mRNA Translation: AAQ09009.1
AL049829 Genomic DNA No translation available.
BC013109 mRNA Translation: AAH13109.1
CCDSiCCDS32050.1 [Q96DZ9-6]
CCDS73617.1 [Q96DZ9-1]
CCDS73618.1 [Q96DZ9-5]
CCDS73619.1 [Q96DZ9-4]
CCDS9598.1 [Q96DZ9-2]
RefSeqiNP_001032365.1, NM_001037288.1 [Q96DZ9-6]
NP_001275673.1, NM_001288744.1 [Q96DZ9-5]
NP_001275674.1, NM_001288745.1 [Q96DZ9-4]
NP_001275675.1, NM_001288746.1 [Q96DZ9-1]
NP_612469.1, NM_138460.2 [Q96DZ9-2]
XP_016876442.1, XM_017020953.1
XP_016876443.1, XM_017020954.1

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi125486, 62 interactors
IntActiQ96DZ9, 127 interactors
MINTiQ96DZ9
STRINGi9606.ENSP00000344819

PTM databases

PhosphoSitePlusiQ96DZ9
SwissPalmiQ96DZ9

Polymorphism and mutation databases

BioMutaiCMTM5
DMDMi34922025

Proteomic databases

MassIVEiQ96DZ9
PaxDbiQ96DZ9
PeptideAtlasiQ96DZ9
PRIDEiQ96DZ9
ProteomicsDBi20482
76348 [Q96DZ9-1]
76349 [Q96DZ9-2]
76350 [Q96DZ9-3]
76351 [Q96DZ9-4]
76352 [Q96DZ9-5]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
116173
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339180; ENSP00000344819; ENSG00000166091 [Q96DZ9-1]
ENST00000342473; ENSP00000344160; ENSG00000166091 [Q96DZ9-4]
ENST00000359320; ENSP00000352270; ENSG00000166091 [Q96DZ9-2]
ENST00000382809; ENSP00000372259; ENSG00000166091 [Q96DZ9-6]
ENST00000397227; ENSP00000380404; ENSG00000166091 [Q96DZ9-5]
ENST00000649278; ENSP00000497215; ENSG00000166091 [Q96DZ9-2]
GeneIDi116173
KEGGihsa:116173
UCSCiuc001wjs.3 human [Q96DZ9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
116173
DisGeNETi116173

GeneCards: human genes, protein and diseases

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GeneCardsi
CMTM5
HGNCiHGNC:19176 CMTM5
HPAiHPA052338
MIMi607888 gene
neXtProtiNX_Q96DZ9
OpenTargetsiENSG00000166091
PharmGKBiPA38815

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4788 Eukaryota
ENOG4111IAF LUCA
GeneTreeiENSGT00940000161867
HOGENOMiHOG000290654
InParanoidiQ96DZ9
OMAiYQTEMAP
OrthoDBi1575715at2759
PhylomeDBiQ96DZ9
TreeFamiTF317387

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
116173

Pharos

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Pharosi
Q96DZ9

Protein Ontology

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PROi
PR:Q96DZ9

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000166091 Expressed in 122 organ(s), highest expression level in C1 segment of cervical spinal cord
ExpressionAtlasiQ96DZ9 baseline and differential
GenevisibleiQ96DZ9 HS

Family and domain databases

InterProiView protein in InterPro
IPR008253 Marvel
PfamiView protein in Pfam
PF01284 MARVEL, 1 hit
PROSITEiView protein in PROSITE
PS51225 MARVEL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCKLF5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96DZ9
Secondary accession number(s): E9PH91, Q5PY48
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: September 19, 2003
Last modified: September 18, 2019
This is version 140 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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