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Entry version 154 (13 Feb 2019)
Sequence version 1 (01 Dec 2001)
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Protein

Endoplasmic reticulum lectin 1

Gene

ERLEC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • unfolded protein binding Source: ParkinsonsUK-UCL

GO - Biological processi

  • ERAD pathway Source: ParkinsonsUK-UCL
  • negative regulation of retrograde protein transport, ER to cytosol Source: ParkinsonsUK-UCL
  • retrograde protein transport, ER to cytosol Source: GO_Central
  • transmembrane transport Source: Reactome
  • ubiquitin-dependent ERAD pathway Source: UniProtKB

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-382556 ABC-family proteins mediated transport
R-HSA-5358346 Hedgehog ligand biogenesis
R-HSA-5362768 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD
R-HSA-5678895 Defective CFTR causes cystic fibrosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Endoplasmic reticulum lectin 1
Alternative name(s):
ER lectin
Short name:
Erlectin
XTP3-transactivated gene B protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ERLEC1
Synonyms:C2orf30, XTP3TPB
ORF Names:UNQ1878/PRO4321
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000068912.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25222 ERLEC1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611229 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96DZ1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endoplasmic reticulum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi207R → A: Abolishes interaction with SEL1L. 1 Publication1
Mutagenesisi379G → S: Abolishes binding to KREMEN2. 1 Publication1
Mutagenesisi428R → A: Abolishes interaction with SEL1L. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
27248

Open Targets

More...
OpenTargetsi
ENSG00000068912

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165696636

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ERLEC1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74731510

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 33Sequence analysisAdd BLAST33
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000004218234 – 483Endoplasmic reticulum lectin 1Add BLAST450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi195N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Isoform 1 and isoform 2 are N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96DZ1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96DZ1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96DZ1

PeptideAtlas

More...
PeptideAtlasi
Q96DZ1

PRoteomics IDEntifications database

More...
PRIDEi
Q96DZ1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
76344
76345 [Q96DZ1-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96DZ1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96DZ1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000068912 Expressed in 204 organ(s), highest expression level in epithelial cell of pancreas

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96DZ1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96DZ1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA031501
HPA031502
HPA031503

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May form a complex with OS9, HSPA5, SYVN1, and SEL1L with which it interacts directly. Interacts (via PRKCSH 2 domain) with KREMEN2 (when glycosylated). Interacts with HSPA5.3 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
118096, 39 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q96DZ1

Protein interaction database and analysis system

More...
IntActi
Q96DZ1, 10 interactors

Molecular INTeraction database

More...
MINTi
Q96DZ1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000185150

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q96DZ1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96DZ1

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini111 – 180PRKCSH 1Add BLAST70
Domaini342 – 418PRKCSH 2Add BLAST77

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3394 Eukaryota
ENOG410XR8A LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063603

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000047563

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG057246

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96DZ1

KEGG Orthology (KO)

More...
KOi
K14008

Identification of Orthologs from Complete Genome Data

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OMAi
QYHEERE

Database of Orthologous Groups

More...
OrthoDBi
1475416at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96DZ1

TreeFam database of animal gene trees

More...
TreeFami
TF314309

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.70.130.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009011 Man6P_isomerase_rcpt-bd_dom_sf
IPR012913 OS9-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07915 PRKCSH, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q96DZ1-1) [UniParc]FASTAAdd to basket
Also known as: hXTP3B-long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEEGGGGVRS LVPGGPVLLV LCGLLEASGG GRALPQLSDD IPFRVNWPGT
60 70 80 90 100
EFSLPTTGVL YKEDNYVIMT TAHKEKYKCI LPLVTSGDEE EEKDYKGPNP
110 120 130 140 150
RELLEPLFKQ SSCSYRIESY WTYEVCHGKH IRQYHEEKET GQKINIHEYY
160 170 180 190 200
LGNMLAKNLL FEKEREAEEK EKSNEIPTKN IEGQMTPYYP VGMGNGTPCS
210 220 230 240 250
LKQNRPRSST VMYICHPESK HEILSVAEVT TCEYEVVILT PLLCSHPKYR
260 270 280 290 300
FRASPVNDIF CQSLPGSPFK PLTLRQLEQQ EEILRVPFRR NKEEDLQSTK
310 320 330 340 350
EERFPAIHKS IAIGSQPVLT VGTTHISKLT DDQLIKEFLS GSYCFRGGVG
360 370 380 390 400
WWKYEFCYGK HVHQYHEDKD SGKTSVVVGT WNQEEHIEWA KKNTARAYHL
410 420 430 440 450
QDDGTQTVRM VSHFYGNGDI CDITDKPRQV TVKLKCKESD SPHAVTVYML
460 470 480
EPHSCQYILG VESPVICKIL DTADENGLLS LPN
Length:483
Mass (Da):54,858
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i35F78A1468457468
GO
Isoform 2 (identifier: Q96DZ1-2) [UniParc]FASTAAdd to basket
Also known as: hXTP3B-short

The sequence of this isoform differs from the canonical sequence as follows:
     294-347: Missing.

Show »
Length:429
Mass (Da):48,882
Checksum:iCA13F3B6EC4BFC85
GO
Isoform 3 (identifier: Q96DZ1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     410-435: Missing.

Note: Gene prediction based on EST data.
Show »
Length:457
Mass (Da):51,911
Checksum:i0C66CC425B795C40
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti331D → G in BAA91974 (PubMed:14702039).Curated1
Sequence conflicti392K → E in BAA91974 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051493318V → L. Corresponds to variant dbSNP:rs2287345Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_015790294 – 347Missing in isoform 2. 2 PublicationsAdd BLAST54
Alternative sequenceiVSP_047155410 – 435Missing in isoform 3. CuratedAdd BLAST26

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY453410 mRNA Translation: AAR26725.1
AY358717 mRNA Translation: AAQ89079.1
AK001913 mRNA Translation: BAA91974.1
AK315477 mRNA Translation: BAG37861.1
AC007883 Genomic DNA Translation: AAY24352.1
CH471053 Genomic DNA Translation: EAX00164.1
BC013129 mRNA Translation: AAH13129.1
BC022228 mRNA Translation: AAH22228.1
AF131743 mRNA Translation: AAD20029.1
AF131849 mRNA Translation: AAD20060.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1848.1 [Q96DZ1-1]
CCDS46283.1 [Q96DZ1-3]
CCDS46284.1 [Q96DZ1-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001120869.1, NM_001127397.2 [Q96DZ1-3]
NP_001120870.1, NM_001127398.2 [Q96DZ1-2]
NP_056516.2, NM_015701.4 [Q96DZ1-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.438336
Hs.713845

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000185150; ENSP00000185150; ENSG00000068912 [Q96DZ1-1]
ENST00000378239; ENSP00000367485; ENSG00000068912 [Q96DZ1-2]
ENST00000405123; ENSP00000385629; ENSG00000068912 [Q96DZ1-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
27248

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:27248

UCSC genome browser

More...
UCSCi
uc002rxm.4 human [Q96DZ1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY453410 mRNA Translation: AAR26725.1
AY358717 mRNA Translation: AAQ89079.1
AK001913 mRNA Translation: BAA91974.1
AK315477 mRNA Translation: BAG37861.1
AC007883 Genomic DNA Translation: AAY24352.1
CH471053 Genomic DNA Translation: EAX00164.1
BC013129 mRNA Translation: AAH13129.1
BC022228 mRNA Translation: AAH22228.1
AF131743 mRNA Translation: AAD20029.1
AF131849 mRNA Translation: AAD20060.1
CCDSiCCDS1848.1 [Q96DZ1-1]
CCDS46283.1 [Q96DZ1-3]
CCDS46284.1 [Q96DZ1-2]
RefSeqiNP_001120869.1, NM_001127397.2 [Q96DZ1-3]
NP_001120870.1, NM_001127398.2 [Q96DZ1-2]
NP_056516.2, NM_015701.4 [Q96DZ1-1]
UniGeneiHs.438336
Hs.713845

3D structure databases

ProteinModelPortaliQ96DZ1
SMRiQ96DZ1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118096, 39 interactors
CORUMiQ96DZ1
IntActiQ96DZ1, 10 interactors
MINTiQ96DZ1
STRINGi9606.ENSP00000185150

PTM databases

iPTMnetiQ96DZ1
PhosphoSitePlusiQ96DZ1

Polymorphism and mutation databases

BioMutaiERLEC1
DMDMi74731510

Proteomic databases

EPDiQ96DZ1
jPOSTiQ96DZ1
PaxDbiQ96DZ1
PeptideAtlasiQ96DZ1
PRIDEiQ96DZ1
ProteomicsDBi76344
76345 [Q96DZ1-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
27248
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000185150; ENSP00000185150; ENSG00000068912 [Q96DZ1-1]
ENST00000378239; ENSP00000367485; ENSG00000068912 [Q96DZ1-2]
ENST00000405123; ENSP00000385629; ENSG00000068912 [Q96DZ1-3]
GeneIDi27248
KEGGihsa:27248
UCSCiuc002rxm.4 human [Q96DZ1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
27248
DisGeNETi27248
EuPathDBiHostDB:ENSG00000068912.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ERLEC1
HGNCiHGNC:25222 ERLEC1
HPAiHPA031501
HPA031502
HPA031503
MIMi611229 gene
neXtProtiNX_Q96DZ1
OpenTargetsiENSG00000068912
PharmGKBiPA165696636

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3394 Eukaryota
ENOG410XR8A LUCA
GeneTreeiENSGT00530000063603
HOGENOMiHOG000047563
HOVERGENiHBG057246
InParanoidiQ96DZ1
KOiK14008
OMAiQYHEERE
OrthoDBi1475416at2759
PhylomeDBiQ96DZ1
TreeFamiTF314309

Enzyme and pathway databases

ReactomeiR-HSA-382556 ABC-family proteins mediated transport
R-HSA-5358346 Hedgehog ligand biogenesis
R-HSA-5362768 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD
R-HSA-5678895 Defective CFTR causes cystic fibrosis

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
C2orf30

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
27248

Protein Ontology

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PROi
PR:Q96DZ1

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000068912 Expressed in 204 organ(s), highest expression level in epithelial cell of pancreas
ExpressionAtlasiQ96DZ1 baseline and differential
GenevisibleiQ96DZ1 HS

Family and domain databases

Gene3Di2.70.130.10, 2 hits
InterProiView protein in InterPro
IPR009011 Man6P_isomerase_rcpt-bd_dom_sf
IPR012913 OS9-like
PfamiView protein in Pfam
PF07915 PRKCSH, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiERLEC_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96DZ1
Secondary accession number(s): B2RDB4
, B5MC72, O95901, Q6UWN7, Q9NUY7, Q9UQL4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: December 1, 2001
Last modified: February 13, 2019
This is version 154 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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