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Protein

Mdm2-binding protein

Gene

MTBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity). May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation.By similarity1 Publication

GO - Biological processi

Keywordsi

Biological processCell cycle, Growth arrest, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Mdm2-binding protein
Short name:
hMTBP
Gene namesi
Name:MTBP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000172167.7
HGNCiHGNC:7417 MTBP
MIMi605927 gene
neXtProtiNX_Q96DY7

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi27085
OpenTargetsiENSG00000172167
PharmGKBiPA31224

Polymorphism and mutation databases

DMDMi74731509

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003237451 – 904Mdm2-binding proteinAdd BLAST904

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei597PhosphoserineCombined sources1
Modified residuei639PhosphoserineCombined sources1
Modified residuei703PhosphoserineCombined sources1
Modified residuei707PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96DY7
MaxQBiQ96DY7
PaxDbiQ96DY7
PeptideAtlasiQ96DY7
PRIDEiQ96DY7
ProteomicsDBi76343

PTM databases

iPTMnetiQ96DY7
PhosphoSitePlusiQ96DY7

Expressioni

Gene expression databases

BgeeiENSG00000172167 Expressed in 109 organ(s), highest expression level in intestine
CleanExiHS_MTBP
ExpressionAtlasiQ96DY7 baseline and differential
GenevisibleiQ96DY7 HS

Organism-specific databases

HPAiHPA025694
HPA050594

Interactioni

Subunit structurei

Interacts with MDM2.1 Publication

Protein-protein interaction databases

BioGridi117988, 5 interactors
IntActiQ96DY7, 3 interactors
STRINGi9606.ENSP00000303398

Structurei

3D structure databases

ProteinModelPortaliQ96DY7
SMRiQ96DY7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni521 – 904Interaction with MDM2By similarityAdd BLAST384

Sequence similaritiesi

Belongs to the MTBP family.Curated

Phylogenomic databases

eggNOGiENOG410IIA4 Eukaryota
ENOG410YVAG LUCA
GeneTreeiENSGT00390000003305
HOGENOMiHOG000113675
HOVERGENiHBG108152
InParanoidiQ96DY7
OMAiFPEFCLK
OrthoDBiEOG091G01OL
PhylomeDBiQ96DY7
TreeFamiTF331503

Family and domain databases

InterProiView protein in InterPro
IPR039061 MTBP
IPR029418 MTBP_C
IPR029420 MTBP_central
IPR029421 MTBP_N
PANTHERiPTHR14382 PTHR14382, 1 hit
PfamiView protein in Pfam
PF14920 MTBP_C, 1 hit
PF14919 MTBP_mid, 1 hit
PF14918 MTBP_N, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.iShow all

Isoform 1 (identifier: Q96DY7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDRYLLLVIW GEGKFPSAAS REAEHGPEVS SGEGTENQPD FTAANVYHLL
60 70 80 90 100
KRSISASINP EDSTFPACSV GGIPGSKKWF FAVQAIYGFY QFCSSDWQEI
110 120 130 140 150
HFDTEKDKIE DVLQTNIEEC LGAVECFEEE DSNSRESLSL ADLYEEAAEN
160 170 180 190 200
LHQLSDKLPA PGRAMVDIIL LLSDKDPPKL KDYLPTVGAL KHLREWYSAK
210 220 230 240 250
ITIAGNHCEI NCQKIAEYLS ANVVSLEDLR NVIDSKELWR GKIQIWERKF
260 270 280 290 300
GFEISFPEFC LKGVTLKNFS TSNLNTDFLA KKIIPSKDKN ILPKVFHYYG
310 320 330 340 350
PALEFVQMIK LSDLPSCYMS DIEFELGLTN STKQNSVLLL EQISSLCSKV
360 370 380 390 400
GALFVLPCTI SNILIPPPNQ LSSRKWKEYI AKKPKTISVP DVEVKGECSS
410 420 430 440 450
YYLLLQGNGN RRCKATLIHS ANQINGSFAL NLIHGKMKTK TEEAKLSFPF
460 470 480 490 500
DLLSLPHFSG EQIVQREKQL ANVQVLALEE CLKRRKLAKQ PETVSVAELK
510 520 530 540 550
SLLVLTRKHF LDYFDAVIPK MILRKMDKIK TFNILNDFSP VEPNSSSLME
560 570 580 590 600
TNPLEWPERH VLQNLETFEK TKQKMRTGSL PHSSEQLLGH KEGPRDSITL
610 620 630 640 650
LDAKELLKYF TSDGLPIGDL QPLPIQKGEK TFVLTPELSP GKLQVLPFEK
660 670 680 690 700
ASVCHYHGIE YCLDDRKALE RDGGFSELQS RLIRYETQTT CTRESFPVPT
710 720 730 740 750
VLSPLPSPVV SSDPGSVPDG EVLQNELRTE VSRLKRRSKD LNCLYPRKRL
760 770 780 790 800
VKSESSESLL SQTTGNSNHY HHHVTSRKPQ TERSLPVTCP LVPIPSCETP
810 820 830 840 850
KLATKTSSGQ KSMHESKTSR QIKESRSQKH TRILKEVVTE TLKKHSITET
860 870 880 890 900
HECFTACSQR LFEISKFYLK DLKTSRGLFE EMKKTANNNA VQVIDWVLEK

TSKK
Length:904
Mass (Da):102,193
Last modified:December 1, 2001 - v1
Checksum:i753DF4A98AB62E4F
GO
Isoform 2 (identifier: Q96DY7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     326-329: LGLT → FTED
     330-904: Missing.

Note: No experimental confirmation available.
Show »
Length:329
Mass (Da):37,253
Checksum:iAB75C6597A082DAC
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YB28H0YB28_HUMAN
Mdm2-binding protein
MTBP
67Annotation score:

Sequence cautioni

The sequence BAB13965 differs from that shown. Probable cloning artifact. May result from internal priming due to genomic poly-A tracts.Curated
The sequence EAW92007 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056108326 – 329LGLT → FTED in isoform 2. 1 Publication4
Alternative sequenceiVSP_056109330 – 904Missing in isoform 2. 1 PublicationAdd BLAST575

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022122 mRNA Translation: BAB13965.1 Sequence problems.
AK300762 mRNA Translation: BAG62427.1
AC105142 Genomic DNA No translation available.
AC107877 Genomic DNA No translation available.
CH471060 Genomic DNA Translation: EAW92006.1
CH471060 Genomic DNA Translation: EAW92007.1 Sequence problems.
BC013136 mRNA Translation: AAH13136.1
CCDSiCCDS6333.1 [Q96DY7-1]
RefSeqiNP_071328.2, NM_022045.4 [Q96DY7-1]
UniGeneiHs.657656

Genome annotation databases

EnsembliENST00000305949; ENSP00000303398; ENSG00000172167 [Q96DY7-1]
ENST00000523373; ENSP00000430771; ENSG00000172167 [Q96DY7-3]
GeneIDi27085
KEGGihsa:27085
UCSCiuc003ypc.3 human [Q96DY7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMTBP_HUMAN
AccessioniPrimary (citable) accession number: Q96DY7
Secondary accession number(s): B4DUR5, Q9HA89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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