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Protein

Dynein regulatory complex protein 10

Gene

IQCD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein regulatory complex protein 10By similarity
Alternative name(s):
IQ domain-containing protein D
Gene namesi
Name:IQCD
Synonyms:DRC10By similarity
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000166578.9
HGNCiHGNC:25168 IQCD
neXtProtiNX_Q96DY2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Flagellum

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000166578
PharmGKBiPA134901058

Polymorphism and mutation databases

BioMutaiIQCD
DMDMi143340095

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002825481 – 449Dynein regulatory complex protein 10Add BLAST449

Proteomic databases

EPDiQ96DY2
MaxQBiQ96DY2
PaxDbiQ96DY2
PeptideAtlasiQ96DY2
PRIDEiQ96DY2
ProteomicsDBi76339
76340 [Q96DY2-2]
76341 [Q96DY2-3]

PTM databases

iPTMnetiQ96DY2
PhosphoSitePlusiQ96DY2

Expressioni

Gene expression databases

BgeeiENSG00000166578 Expressed in 114 organ(s), highest expression level in testis
CleanExiHS_IQCD
ExpressionAtlasiQ96DY2 baseline and differential
GenevisibleiQ96DY2 HS

Organism-specific databases

HPAiHPA046810
HPA048782

Interactioni

Subunit structurei

Component of the nexin-dynein regulatory complex (N-DRC).By similarity

Protein-protein interaction databases

BioGridi125456, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ96DY2
SMRiQ96DY2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini400 – 429IQPROSITE-ProRule annotationAdd BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili90 – 125Sequence analysisAdd BLAST36

Sequence similaritiesi

Belongs to the DRC10 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IF8Y Eukaryota
ENOG410XT1P LUCA
GeneTreeiENSGT00730000111354
HOGENOMiHOG000060107
HOVERGENiHBG108008
InParanoidiQ96DY2
OMAiQKYDTEM
OrthoDBiEOG091G09F0
PhylomeDBiQ96DY2
TreeFamiTF326203

Family and domain databases

InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
PfamiView protein in Pfam
PF00612 IQ, 1 hit
SMARTiView protein in SMART
SM00015 IQ, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.iShow all

Isoform 1 (identifier: Q96DY2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALDILAMAP LYQAPAINRI GPKTDPSKRP ADPLKPLVLS RTKLTTIEAK
60 70 80 90 100
RIMSILDEAI YKVELVTLLS YVASNREDME GMLGEDVMRA VREHEDLCQV
110 120 130 140 150
LLENVRCLKE KERQLQEQKE AEEEGWLRDR LLSIELQKSS LSPLMQQIKD
160 170 180 190 200
STKNVLRLLL SNPQAARLLQ MQTQGRSAEA QNFIDSLIEL RGFLFEKLLT
210 220 230 240 250
SPMEARDKAQ FLQDISRQNS NNQQIIDTLE KELAERMKNR NAEVEKENFV
260 270 280 290 300
IQELKNHLHQ VLKFSENSLV RTKQEAEKQQ KADFRASQAR VAKIQQEILQ
310 320 330 340 350
LQSQFYNLVM ENREAEQALR KKKYKVETEI ENWIQKYDTE MGEKQEELED
360 370 380 390 400
LDAVHREEKI SLEELRRRHK VLVGEFAQIR EEREINSKKR MEAEQEMVRM
410 420 430 440
VRAATLIQAL WKGYLVRSLL RSKKKRGKGK AKDKEKGKQK GKEKGKGKK
Length:449
Mass (Da):52,359
Last modified:April 3, 2007 - v2
Checksum:i559F1BD39CB8CB11
GO
Isoform 2 (identifier: Q96DY2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     244-345: Missing.

Note: No experimental confirmation available.
Show »
Length:347
Mass (Da):40,094
Checksum:i597F86E32161856F
GO
Isoform 3 (identifier: Q96DY2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     244-327: VEKENFVIQE...ALRKKKYKVE → VLFHSIAEIT...PPRPANFLYF
     328-449: Missing.

Note: No experimental confirmation available.
Show »
Length:327
Mass (Da):37,958
Checksum:iC71356DAB061A1F8
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VZV9F8VZV9_HUMAN
Dynein regulatory complex protein 1...
IQCD
412Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_056921136L → V. Corresponds to variant dbSNP:rs7966313Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_024178244 – 345Missing in isoform 2. 1 PublicationAdd BLAST102
Alternative sequenceiVSP_024179244 – 327VEKEN…KYKVE → VLFHSIAEITEEATQIFCWL GFSSMIDFFFKMESRSVVQT RVQWCNLDSLQPLPPRFKRF SHHSLPSSWDYRRMPPRPAN FLYF in isoform 3. 1 PublicationAdd BLAST84
Alternative sequenceiVSP_024180328 – 449Missing in isoform 3. 1 PublicationAdd BLAST122

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127152 mRNA Translation: BAC86856.1
AC089999 Genomic DNA No translation available.
BC013151 mRNA Translation: AAH13151.1
CCDSiCCDS81743.1 [Q96DY2-1]
CCDS9167.1 [Q96DY2-2]
RefSeqiNP_001317381.1, NM_001330452.1 [Q96DY2-1]
NP_612460.1, NM_138451.2 [Q96DY2-2]
XP_005253890.1, XM_005253833.4 [Q96DY2-1]
XP_011536164.1, XM_011537862.2 [Q96DY2-1]
XP_011536165.1, XM_011537863.2 [Q96DY2-1]
UniGeneiHs.568276

Genome annotation databases

EnsembliENST00000299732; ENSP00000299732; ENSG00000166578 [Q96DY2-2]
ENST00000416617; ENSP00000400669; ENSG00000166578 [Q96DY2-1]
GeneIDi115811
KEGGihsa:115811
UCSCiuc001tuu.4 human [Q96DY2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127152 mRNA Translation: BAC86856.1
AC089999 Genomic DNA No translation available.
BC013151 mRNA Translation: AAH13151.1
CCDSiCCDS81743.1 [Q96DY2-1]
CCDS9167.1 [Q96DY2-2]
RefSeqiNP_001317381.1, NM_001330452.1 [Q96DY2-1]
NP_612460.1, NM_138451.2 [Q96DY2-2]
XP_005253890.1, XM_005253833.4 [Q96DY2-1]
XP_011536164.1, XM_011537862.2 [Q96DY2-1]
XP_011536165.1, XM_011537863.2 [Q96DY2-1]
UniGeneiHs.568276

3D structure databases

ProteinModelPortaliQ96DY2
SMRiQ96DY2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125456, 1 interactor

PTM databases

iPTMnetiQ96DY2
PhosphoSitePlusiQ96DY2

Polymorphism and mutation databases

BioMutaiIQCD
DMDMi143340095

Proteomic databases

EPDiQ96DY2
MaxQBiQ96DY2
PaxDbiQ96DY2
PeptideAtlasiQ96DY2
PRIDEiQ96DY2
ProteomicsDBi76339
76340 [Q96DY2-2]
76341 [Q96DY2-3]

Protocols and materials databases

DNASUi115811
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299732; ENSP00000299732; ENSG00000166578 [Q96DY2-2]
ENST00000416617; ENSP00000400669; ENSG00000166578 [Q96DY2-1]
GeneIDi115811
KEGGihsa:115811
UCSCiuc001tuu.4 human [Q96DY2-1]

Organism-specific databases

CTDi115811
EuPathDBiHostDB:ENSG00000166578.9
GeneCardsiIQCD
HGNCiHGNC:25168 IQCD
HPAiHPA046810
HPA048782
neXtProtiNX_Q96DY2
OpenTargetsiENSG00000166578
PharmGKBiPA134901058
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF8Y Eukaryota
ENOG410XT1P LUCA
GeneTreeiENSGT00730000111354
HOGENOMiHOG000060107
HOVERGENiHBG108008
InParanoidiQ96DY2
OMAiQKYDTEM
OrthoDBiEOG091G09F0
PhylomeDBiQ96DY2
TreeFamiTF326203

Miscellaneous databases

ChiTaRSiIQCD human
GenomeRNAii115811
PROiPR:Q96DY2

Gene expression databases

BgeeiENSG00000166578 Expressed in 114 organ(s), highest expression level in testis
CleanExiHS_IQCD
ExpressionAtlasiQ96DY2 baseline and differential
GenevisibleiQ96DY2 HS

Family and domain databases

InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
PfamiView protein in Pfam
PF00612 IQ, 1 hit
SMARTiView protein in SMART
SM00015 IQ, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDRC10_HUMAN
AccessioniPrimary (citable) accession number: Q96DY2
Secondary accession number(s): Q6ZSU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: September 12, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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