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Protein

Receptor-transporting protein 4

Gene

RTP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable chaperone protein which facilitates trafficking and functional cell surface expression of some G-protein coupled receptors (GPCRs). Promotes functional expression of the bitter taste receptor TAS2R16 (PubMed:16720576). Also promotes functional expression of the opioid receptor heterodimer OPRD1-OPRM1 (By similarity).By similarity1 Publication

GO - Molecular functioni

  • olfactory receptor binding Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-transporting protein 4
Alternative name(s):
28 kDa interferon-responsive protein
3CxxC-type zinc finger protein 4
Gene namesi
Name:RTP4
Synonyms:IFRG28, Z3CXXC4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000136514.2
HGNCiHGNC:23992 RTP4
MIMi609350 gene
neXtProtiNX_Q96DX8

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 224CytoplasmicSequence analysisAdd BLAST224
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi64108
OpenTargetsiENSG00000136514
PharmGKBiPA143485606

Polymorphism and mutation databases

BioMutaiRTP4
DMDMi313104193

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001819951 – 246Receptor-transporting protein 4Add BLAST246

Proteomic databases

PaxDbiQ96DX8
PeptideAtlasiQ96DX8
PRIDEiQ96DX8
ProteomicsDBi76338

PTM databases

iPTMnetiQ96DX8
PhosphoSitePlusiQ96DX8

Expressioni

Tissue specificityi

Expressed in circumvallate papillae and testis.1 Publication

Inductioni

By interferons.

Gene expression databases

BgeeiENSG00000136514 Expressed in 140 organ(s), highest expression level in epithelium of bronchus
CleanExiHS_RTP4
GenevisibleiQ96DX8 HS

Organism-specific databases

HPAiHPA064887
HPA071189

Interactioni

Subunit structurei

Interacts with TASR16 (PubMed:16720576). Interacts with OPRD1 and OPRM1; the interaction promotes cell surface localization of the OPDR1-OPRM1 heterodimer (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ96DX8, 4 interactors
STRINGi9606.ENSP00000259030

Structurei

3D structure databases

ProteinModelPortaliQ96DX8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM7 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH22 Eukaryota
ENOG4111X4F LUCA
GeneTreeiENSGT00530000063222
HOGENOMiHOG000236274
InParanoidiQ96DX8
OMAiGNLQLDC
OrthoDBiEOG091G0DS4
PhylomeDBiQ96DX8
TreeFamiTF333246

Family and domain databases

InterProiView protein in InterPro
IPR026096 R-trans_p
IPR026690 RTP4
IPR027377 Znf-3CxxC
PANTHERiPTHR14402 PTHR14402, 1 hit
PTHR14402:SF8 PTHR14402:SF8, 1 hit
PfamiView protein in Pfam
PF13695 zf-3CxxC, 1 hit
SMARTiView protein in SMART
SM01328 zf-3CxxC, 1 hit

Sequencei

Sequence statusi: Complete.

Q96DX8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVVDFWTWEQ TFQELIQEAK PRATWTLKLD GNLQLDCLAQ GWKQYQQRAF
60 70 80 90 100
GWFRCSSCQR SWASAQVQIL CHTYWEHWTS QGQVRMRLFG QRCQKCSWSQ
110 120 130 140 150
YEMPEFSSDS TMRILSNLVQ HILKKYYGNG TRKSPEMPVI LEVSLEGSHD
160 170 180 190 200
TANCEACTLG ICGQGLKSCM TKPSKSLLPH LKTGNSSPGI GAVYLANQAK
210 220 230 240
NQSAEAKEAK GSGYEKLGPS RDPDPLNICV FILLLVFIVV KCFTSE
Length:246
Mass (Da):27,863
Last modified:November 30, 2010 - v3
Checksum:i74D61E554F1882CB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti66 – 67QV → KL in AAT70683 (PubMed:15550249).Curated2
Sequence conflicti66 – 67QV → KL in CAC14309 (Ref. 2) Curated2
Sequence conflicti131T → M in AAT70683 (PubMed:15550249).Curated1
Sequence conflicti131T → M in CAC14309 (Ref. 2) Curated1
Sequence conflicti131T → M in AAH13161 (PubMed:15489334).Curated1
Sequence conflicti169C → Y in AAT70683 (PubMed:15550249).Curated1
Sequence conflicti169C → Y in CAC14309 (Ref. 2) Curated1
Sequence conflicti169C → Y in AAH13161 (PubMed:15489334).Curated1
Sequence conflicti204A → D in AAT70683 (PubMed:15550249).Curated1
Sequence conflicti204A → D in CAC14309 (Ref. 2) Curated1
Sequence conflicti204A → D in AAH13161 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05773279T → I. Corresponds to variant dbSNP:rs1047584Ensembl.1
Natural variantiVAR_057733168S → N. Corresponds to variant dbSNP:rs35224605Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY562238 mRNA Translation: AAT70683.1
AJ251832 mRNA Translation: CAC14309.1
AC068299 Genomic DNA No translation available.
BC013161 mRNA Translation: AAH13161.1
CCDSiCCDS33910.1
RefSeqiNP_071430.2, NM_022147.2
UniGeneiHs.43388

Genome annotation databases

EnsembliENST00000259030; ENSP00000259030; ENSG00000136514
GeneIDi64108
KEGGihsa:64108
UCSCiuc003frm.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY562238 mRNA Translation: AAT70683.1
AJ251832 mRNA Translation: CAC14309.1
AC068299 Genomic DNA No translation available.
BC013161 mRNA Translation: AAH13161.1
CCDSiCCDS33910.1
RefSeqiNP_071430.2, NM_022147.2
UniGeneiHs.43388

3D structure databases

ProteinModelPortaliQ96DX8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ96DX8, 4 interactors
STRINGi9606.ENSP00000259030

PTM databases

iPTMnetiQ96DX8
PhosphoSitePlusiQ96DX8

Polymorphism and mutation databases

BioMutaiRTP4
DMDMi313104193

Proteomic databases

PaxDbiQ96DX8
PeptideAtlasiQ96DX8
PRIDEiQ96DX8
ProteomicsDBi76338

Protocols and materials databases

DNASUi64108
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259030; ENSP00000259030; ENSG00000136514
GeneIDi64108
KEGGihsa:64108
UCSCiuc003frm.4 human

Organism-specific databases

CTDi64108
DisGeNETi64108
EuPathDBiHostDB:ENSG00000136514.2
GeneCardsiRTP4
H-InvDBiHIX0003937
HGNCiHGNC:23992 RTP4
HPAiHPA064887
HPA071189
MIMi609350 gene
neXtProtiNX_Q96DX8
OpenTargetsiENSG00000136514
PharmGKBiPA143485606
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH22 Eukaryota
ENOG4111X4F LUCA
GeneTreeiENSGT00530000063222
HOGENOMiHOG000236274
InParanoidiQ96DX8
OMAiGNLQLDC
OrthoDBiEOG091G0DS4
PhylomeDBiQ96DX8
TreeFamiTF333246

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GenomeRNAii64108
PROiPR:Q96DX8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136514 Expressed in 140 organ(s), highest expression level in epithelium of bronchus
CleanExiHS_RTP4
GenevisibleiQ96DX8 HS

Family and domain databases

InterProiView protein in InterPro
IPR026096 R-trans_p
IPR026690 RTP4
IPR027377 Znf-3CxxC
PANTHERiPTHR14402 PTHR14402, 1 hit
PTHR14402:SF8 PTHR14402:SF8, 1 hit
PfamiView protein in Pfam
PF13695 zf-3CxxC, 1 hit
SMARTiView protein in SMART
SM01328 zf-3CxxC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRTP4_HUMAN
AccessioniPrimary (citable) accession number: Q96DX8
Secondary accession number(s): Q9H4F3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: November 30, 2010
Last modified: November 7, 2018
This is version 122 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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