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Protein

Polyadenylate-binding protein 5

Gene

PABPC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyadenylate-binding protein 5
Short name:
PABP-5
Short name:
Poly(A)-binding protein 5
Gene namesi
Name:PABPC5
Synonyms:PABP5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000174740.7
HGNCiHGNC:13629 PABPC5
MIMi300407 gene
neXtProtiNX_Q96DU9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000174740
PharmGKBiPA32884

Polymorphism and mutation databases

BioMutaiPABPC5
DMDMi28201851

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000817051 – 382Polyadenylate-binding protein 5Add BLAST382

Proteomic databases

EPDiQ96DU9
MaxQBiQ96DU9
PaxDbiQ96DU9
PeptideAtlasiQ96DU9
PRIDEiQ96DU9
ProteomicsDBi76329

PTM databases

iPTMnetiQ96DU9
PhosphoSitePlusiQ96DU9

Expressioni

Tissue specificityi

Expressed in fetal brain and in a range of adult tissues.

Gene expression databases

BgeeiENSG00000174740
CleanExiHS_PABPC5
ExpressionAtlasiQ96DU9 baseline and differential
GenevisibleiQ96DU9 HS

Organism-specific databases

HPAiHPA000164
HPA000165

Interactioni

Protein-protein interaction databases

BioGridi126753, 2 interactors
IntActiQ96DU9, 3 interactors
STRINGi9606.ENSP00000308012

Structurei

3D structure databases

ProteinModelPortaliQ96DU9
SMRiQ96DU9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 96RRM 1PROSITE-ProRule annotationAdd BLAST79
Domaini106 – 182RRM 2PROSITE-ProRule annotationAdd BLAST77
Domaini199 – 276RRM 3PROSITE-ProRule annotationAdd BLAST78
Domaini302 – 378RRM 4PROSITE-ProRule annotationAdd BLAST77

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0123 Eukaryota
ENOG410XR5X LUCA
GeneTreeiENSGT00760000118913
HOGENOMiHOG000217922
HOVERGENiHBG002295
InParanoidiQ96DU9
KOiK13126
OMAiFSEYGPT
OrthoDBiEOG091G03ZE
PhylomeDBiQ96DU9
TreeFamiTF300458

Family and domain databases

Gene3Di3.30.70.330, 4 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR006515 PABP_1234
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR003954 RRM_dom_euk
PfamiView protein in Pfam
PF00076 RRM_1, 4 hits
SMARTiView protein in SMART
SM00360 RRM, 4 hits
SM00361 RRM_1, 3 hits
SUPFAMiSSF54928 SSF54928, 2 hits
TIGRFAMsiTIGR01628 PABP-1234, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 4 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

Isoform 1 (identifier: Q96DU9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSGEPNPAG KKKKYLKAAL YVGDLDPDVT EDMLYKKFRP AGPLRFTRIC
60 70 80 90 100
RDPVTRSPLG YGYVNFRFPA DAEWALNTMN FDLINGKPFR LMWSQPDDRL
110 120 130 140 150
RKSGVGNIFI KNLDKSIDNR ALFYLFSAFG NILSCKVVCD DNGSKGYAYV
160 170 180 190 200
HFDSLAAANR AIWHMNGVRL NNRQVYVGRF KFPEERAAEV RTRDRATFTN
210 220 230 240 250
VFVKNIGDDI DDEKLKELFC EYGPTESVKV IRDASGKSKG FGFVRYETHE
260 270 280 290 300
AAQKAVLDLH GKSIDGKVLY VGRAQKKIER LAELRRRFER LRLKEKSRPP
310 320 330 340 350
GVPIYIKNLD ETINDEKLKE EFSSFGSISR AKVMMEVGQG KGFGVVCFSS
360 370 380
FEEATKAVDE MNGRIVGSKP LHVTLGQARR RC
Length:382
Mass (Da):43,331
Last modified:December 1, 2001 - v1
Checksum:i23B34751780C602B
GO
Isoform 2 (identifier: Q96DU9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.

Show »
Length:350
Mass (Da):39,941
Checksum:i18B7A6317A54FFCF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054049314N → S. Corresponds to variant dbSNP:rs7050077Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0474561 – 32Missing in isoform 2. CuratedAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278963 Genomic DNA Translation: CAC42826.1
AK290105 mRNA Translation: BAF82794.1
AL662874 Genomic DNA No translation available.
CH471115 Genomic DNA Translation: EAX02776.1
BC063113 mRNA Translation: AAH63113.1
AL122118 mRNA Translation: CAB59276.1
CCDSiCCDS14460.1 [Q96DU9-1]
PIRiT34543
RefSeqiNP_543022.1, NM_080832.2 [Q96DU9-1]
UniGeneiHs.246590

Genome annotation databases

EnsembliENST00000312600; ENSP00000308012; ENSG00000174740 [Q96DU9-1]
GeneIDi140886
KEGGihsa:140886
UCSCiuc004efg.4 human [Q96DU9-1]

Keywords - Coding sequence diversityi

Alternative initiation, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPABP5_HUMAN
AccessioniPrimary (citable) accession number: Q96DU9
Secondary accession number(s): A8K240
, Q5JQF4, Q6P529, Q9UFE5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: December 1, 2001
Last modified: June 20, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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