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Entry version 155 (11 Dec 2019)
Sequence version 2 (11 Jan 2011)
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Protein

Zinc finger and BTB domain-containing protein 10

Gene

ZBTB10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri722 – 744C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri750 – 772C2H2-type 2PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 10
Alternative name(s):
Zinc finger protein RIN ZF
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZBTB10
Synonyms:RINZF, RINZFC
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000205189.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30953 ZBTB10

Online Mendelian Inheritance in Man (OMIM)

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MIMi
618576 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96DT7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
65986

Open Targets

More...
OpenTargetsi
ENSG00000205189

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134883318

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96DT7 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZBTB10

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373300

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000477251 – 871Zinc finger and BTB domain-containing protein 10Add BLAST871

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei126Omega-N-methylarginineCombined sources1
Modified residuei210PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki245Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki468Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki483Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki497Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei565PhosphoserineCombined sources1
Cross-linki573Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki672Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki684Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki696Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki706Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q96DT7

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96DT7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96DT7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96DT7

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96DT7

PeptideAtlas

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PeptideAtlasi
Q96DT7

PRoteomics IDEntifications database

More...
PRIDEi
Q96DT7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
76321 [Q96DT7-1]
76322 [Q96DT7-2]
76323 [Q96DT7-3]
76324 [Q96DT7-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q96DT7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96DT7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000205189 Expressed in 217 organ(s), highest expression level in placenta

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96DT7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA021554
HPA050569

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
122435, 48 interactors

Protein interaction database and analysis system

More...
IntActi
Q96DT7, 44 interactors

Molecular INTeraction database

More...
MINTi
Q96DT7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000387462

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96DT7 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96DT7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini364 – 433BTBPROSITE-ProRule annotationAdd BLAST70

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi39 – 58Pro-richAdd BLAST20
Compositional biasi101 – 228Gly-richAdd BLAST128

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri722 – 744C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri750 – 772C2H2-type 2PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157988

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231953

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96DT7

KEGG Orthology (KO)

More...
KOi
K10497

Identification of Orthologs from Complete Genome Data

More...
OMAi
CDRNVNT

Database of Orthologous Groups

More...
OrthoDBi
755439at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96DT7

TreeFam database of animal gene trees

More...
TreeFami
TF330979

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00651 BTB, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q96DT7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSFSEMNRRT LAFRGGGLVT ASGGGSTNNN AGGEASAWPP QPQPRQPPPP
60 70 80 90 100
APPALQPPNG RGADEEVELE GLEPQDLEAS AGPAAGAAEE AKELLLPQDA
110 120 130 140 150
GGPTSLGGGA GGPLLAERNR RTLAFRGGGG GGLGNNGSSR GRPETSVWPL
160 170 180 190 200
RHFNGRGPAT VDLELDALEG KELMQDGASL SDSTEDEEEG ASLGDGSGAE
210 220 230 240 250
GGSCSSSRRS GGDGGDEVEG SGVGAGEGET VQHFPLARPK SLMQKLQCSF
260 270 280 290 300
QTSWLKDFPW LRYSKDTGLM SCGWCQKTPA DGGSVDLPPV GHDELSRGTR
310 320 330 340 350
NYKKTLLLRH HVSTEHKLHE ANAQESEIPS EEGYCDFNSR PNENSYCYQL
360 370 380 390 400
LRQLNEQRKK GILCDVSIVV SGKIFKAHKN ILVAGSRFFK TLYCFSNKES
410 420 430 440 450
PNQNNTTHLD IAAVQGFSVI LDFLYSGNLV LTSQNAIEVM TVASYLQMSE
460 470 480 490 500
VVQTCRNFIK DALNISIKSE APESVVVDYN NRKPVNRDGL SSSRDQKIAS
510 520 530 540 550
FWATRNLTNL ASNVKIENDG CNVDEGQIEN YQMNDSSWVQ DGSPEMAENE
560 570 580 590 600
SEGQTKVFIW NNMGSQGIQE TGKTRRKNQT TKRFIYNIPP NNETNLEDCS
610 620 630 640 650
VMQPPVAYPE ENTLLIKEEP DLDGALLSGP DGDRNVNANL LAEAGTSQDG
660 670 680 690 700
GDAGTSHDFK YGLMPGPSND FKYGLIPGTS NDFKYGLIPG ASNDFKYGLL
710 720 730 740 750
PESWPKQETW ENGESSLIMN KLKCPHCSYV AKYRRTLKRH LLIHTGVRSF
760 770 780 790 800
SCDICGKLFT RREHVKRHSL VHKKDKKYKC MVCKKIFMLA ASVGIRHGSR
810 820 830 840 850
RYGVCVDCAD KSQPGGQEGV DQGQDTEFPR DEEYEENEVG EADEELVDDG
860 870
EDQNDPSRWD ESGEVCMSLD D
Length:871
Mass (Da):94,894
Last modified:January 11, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA823948FDC3D6AC1
GO
Isoform 2 (identifier: Q96DT7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     665-688: Missing.

Show »
Length:847
Mass (Da):92,311
Checksum:iCB68F78A442C1B61
GO
Isoform 3 (identifier: Q96DT7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-173: Missing.

Show »
Length:698
Mass (Da):77,424
Checksum:i1E67257D9A9BE0F0
GO
Isoform 4 (identifier: Q96DT7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-292: Missing.
     293-324: DELSRGTRNYKKTLLLRHHVSTEHKLHEANAQ → MTRLERSSHRTVICKVPGELVAREGKCASRAR

Show »
Length:579
Mass (Da):64,941
Checksum:iA1120EF9F0EC58AC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti324Q → P in CAC40989 (Ref. 1) Curated1
Sequence conflicti335C → W in CAC40989 (Ref. 1) Curated1
Sequence conflicti339S → R in CAC40989 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01838450P → T1 PublicationCorresponds to variant dbSNP:rs591989Ensembl.1
Natural variantiVAR_018385174M → I1 PublicationCorresponds to variant dbSNP:rs593747Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0403161 – 292Missing in isoform 4. 1 PublicationAdd BLAST292
Alternative sequenceiVSP_0403171 – 173Missing in isoform 3. 1 PublicationAdd BLAST173
Alternative sequenceiVSP_040318293 – 324DELSR…EANAQ → MTRLERSSHRTVICKVPGEL VAREGKCASRAR in isoform 4. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_040319665 – 688Missing in isoform 2. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ319673 mRNA Translation: CAC40989.1
AJ507398 Genomic DNA Translation: CAD45447.1
AK056913 mRNA Translation: BAB71309.1
AC009812 Genomic DNA No translation available.
BC050061 mRNA Translation: AAH50061.1
BC127098 mRNA Translation: AAI27099.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47880.1 [Q96DT7-1]
CCDS64920.1 [Q96DT7-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001099009.1, NM_001105539.2 [Q96DT7-1]
NP_001264074.1, NM_001277145.1 [Q96DT7-4]
NP_076418.3, NM_023929.4 [Q96DT7-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000379091; ENSP00000368384; ENSG00000205189 [Q96DT7-4]
ENST00000426744; ENSP00000416134; ENSG00000205189 [Q96DT7-2]
ENST00000430430; ENSP00000387462; ENSG00000205189 [Q96DT7-1]
ENST00000455036; ENSP00000412036; ENSG00000205189 [Q96DT7-1]
ENST00000610895; ENSP00000484716; ENSG00000205189 [Q96DT7-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
65986

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:65986

UCSC genome browser

More...
UCSCi
uc003ybv.6 human [Q96DT7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ319673 mRNA Translation: CAC40989.1
AJ507398 Genomic DNA Translation: CAD45447.1
AK056913 mRNA Translation: BAB71309.1
AC009812 Genomic DNA No translation available.
BC050061 mRNA Translation: AAH50061.1
BC127098 mRNA Translation: AAI27099.1
CCDSiCCDS47880.1 [Q96DT7-1]
CCDS64920.1 [Q96DT7-4]
RefSeqiNP_001099009.1, NM_001105539.2 [Q96DT7-1]
NP_001264074.1, NM_001277145.1 [Q96DT7-4]
NP_076418.3, NM_023929.4 [Q96DT7-2]

3D structure databases

SMRiQ96DT7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi122435, 48 interactors
IntActiQ96DT7, 44 interactors
MINTiQ96DT7
STRINGi9606.ENSP00000387462

PTM databases

iPTMnetiQ96DT7
PhosphoSitePlusiQ96DT7

Polymorphism and mutation databases

BioMutaiZBTB10
DMDMi317373300

Proteomic databases

EPDiQ96DT7
jPOSTiQ96DT7
MassIVEiQ96DT7
MaxQBiQ96DT7
PaxDbiQ96DT7
PeptideAtlasiQ96DT7
PRIDEiQ96DT7
ProteomicsDBi76321 [Q96DT7-1]
76322 [Q96DT7-2]
76323 [Q96DT7-3]
76324 [Q96DT7-4]

Genome annotation databases

EnsembliENST00000379091; ENSP00000368384; ENSG00000205189 [Q96DT7-4]
ENST00000426744; ENSP00000416134; ENSG00000205189 [Q96DT7-2]
ENST00000430430; ENSP00000387462; ENSG00000205189 [Q96DT7-1]
ENST00000455036; ENSP00000412036; ENSG00000205189 [Q96DT7-1]
ENST00000610895; ENSP00000484716; ENSG00000205189 [Q96DT7-3]
GeneIDi65986
KEGGihsa:65986
UCSCiuc003ybv.6 human [Q96DT7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
65986
DisGeNETi65986
EuPathDBiHostDB:ENSG00000205189.11

GeneCards: human genes, protein and diseases

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GeneCardsi
ZBTB10
HGNCiHGNC:30953 ZBTB10
HPAiHPA021554
HPA050569
MIMi618576 gene
neXtProtiNX_Q96DT7
OpenTargetsiENSG00000205189
PharmGKBiPA134883318

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000157988
HOGENOMiHOG000231953
InParanoidiQ96DT7
KOiK10497
OMAiCDRNVNT
OrthoDBi755439at2759
PhylomeDBiQ96DT7
TreeFamiTF330979

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZBTB10 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
65986
PharosiQ96DT7 Tbio

Protein Ontology

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PROi
PR:Q96DT7
RNActiQ96DT7 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000205189 Expressed in 217 organ(s), highest expression level in placenta
GenevisibleiQ96DT7 HS

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 2 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZBT10_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96DT7
Secondary accession number(s): A4FVD0
, Q86W96, Q8IXI9, Q96MH9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: January 11, 2011
Last modified: December 11, 2019
This is version 155 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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