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UniProtKB - Q96DT5 (DYH11_HUMAN)

Entry version 175 (29 Sep 2021)
Sequence version 4 (04 Feb 2015)
Previous versions | rss
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Protein

Dynein axonemal heavy chain 11

Gene

DNAH11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1893 – 1900ATPSequence analysis8
Nucleotide bindingi2174 – 2181ATPSequence analysis8
Nucleotide bindingi2510 – 2517ATPSequence analysis8
Nucleotide bindingi2855 – 2862ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96DT5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dynein axonemal heavy chain 11Curated
Alternative name(s):
Axonemal beta dynein heavy chain 11
Ciliary dynein heavy chain 11
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DNAH11Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:2942, DNAH11

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603339, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96DT5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000105877

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Ciliary dyskinesia, primary, 7 (CILD7)3 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_072472117E → V in CILD7. 1 PublicationCorresponds to variant dbSNP:rs72655968Ensembl.1
Natural variantiVAR_0724732383L → P in CILD7. 1 PublicationCorresponds to variant dbSNP:rs72657353Ensembl.1
Natural variantiVAR_0138592997R → Q in CILD7; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs35865357EnsemblClinVar.1
Natural variantiVAR_0724744327L → S in CILD7. 1 PublicationCorresponds to variant dbSNP:rs72658826Ensembl.1

Keywords - Diseasei

Ciliopathy, Disease variant, Kartagener syndrome, Primary ciliary dyskinesia

Organism-specific databases

DisGeNET

More...DisGeNETi		8701

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		DNAH11

MalaCards human disease database

More...MalaCardsi		DNAH11
MIMi611884, phenotype

Open Targets

More...OpenTargetsi		ENSG00000105877

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		244, Primary ciliary dyskinesia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27396

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96DT5, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DNAH11

Domain mapping of disease mutations (DMDM)

More...DMDMi		311033455

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001146331 – 4516Dynein axonemal heavy chain 11Add BLAST4516

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96DT5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96DT5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96DT5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96DT5

PeptideAtlas

More...PeptideAtlasi		Q96DT5

PRoteomics IDEntifications database

More...PRIDEi		Q96DT5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		76319

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1190, 11 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q96DT5, 2 sites, 11 N-linked glycans (1 site), 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96DT5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96DT5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in airway epithelial cells (at protein level). Not detected in spermatozoa (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000105877, Expressed in right uterine tube and 123 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96DT5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96DT5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000105877, Tissue enhanced (epididymis, parathyroid gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Consists of at least two heavy chains and a number of intermediate and light chains.

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114244, 3 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000475939

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96DT5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96DT5

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 1854StemBy similarityAdd BLAST1854
Regioni1855 – 2076AAA 1By similarityAdd BLAST222
Regioni2136 – 2366AAA 2By similarityAdd BLAST231
Regioni2472 – 2719AAA 3By similarityAdd BLAST248
Regioni2817 – 3066AAA 4By similarityAdd BLAST250
Regioni3072 – 3403StalkBy similarityAdd BLAST332
Regioni3459 – 3686AAA 5By similarityAdd BLAST228
Regioni3896 – 4122AAA 6By similarityAdd BLAST227

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1274 – 1327Sequence analysisAdd BLAST54
Coiled coili3072 – 3136Sequence analysisAdd BLAST65
Coiled coili3312 – 3403Sequence analysisAdd BLAST92
Coiled coili3668 – 3703Sequence analysisAdd BLAST36

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the dynein heavy chain family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3595, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158880

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000038_4_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96DT5

Identification of Orthologs from Complete Genome Data

More...OMAi		ELDFWTM

Database of Orthologous Groups

More...OrthoDBi		1492at2759

TreeFam database of animal gene trees

More...TreeFami		TF316836

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.8.710, 1 hit
1.10.8.720, 1 hit
1.20.140.100, 1 hit
3.10.490.20, 1 hit
3.20.180.20, 1 hit
3.40.50.300, 5 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003593, AAA+_ATPase
IPR035699, AAA_6
IPR035706, AAA_9
IPR041658, AAA_lid_11
IPR042219, AAA_lid_11_sf
IPR041589, DNAH3_AAA_lid_1
IPR042222, Dynein_2_N
IPR043157, Dynein_AAA1S
IPR041466, Dynein_AAA5_ext
IPR041228, Dynein_C
IPR043160, Dynein_C_barrel
IPR024743, Dynein_HC_stalk
IPR024317, Dynein_heavy_chain_D4_dom
IPR004273, Dynein_heavy_D6_P-loop
IPR013602, Dynein_heavy_linker
IPR013594, Dynein_heavy_tail
IPR042228, Dynein_linker_3
IPR027417, P-loop_NTPase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12774, AAA_6, 1 hit
PF12780, AAA_8, 1 hit
PF12781, AAA_9, 1 hit
PF17857, AAA_lid_1, 1 hit
PF18198, AAA_lid_11, 1 hit
PF08385, DHC_N1, 1 hit
PF08393, DHC_N2, 1 hit
PF17852, Dynein_AAA_lid, 1 hit
PF18199, Dynein_C, 1 hit
PF03028, Dynein_heavy, 1 hit
PF12777, MT, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00382, AAA, 4 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q96DT5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAQVAAREA RDFREAPTLR LTSGAGLEAV GAVELEEEEE NEEEAAARRA 
        60         70         80         90        100
RSFAQDARVR FLGGRLAMML GFTEEKWSQY LESEDNRQVL GEFLESTSPA 
       110        120        130        140        150
CLVFSFAASG RLAASQEIPR DANHKLVFIS KKITESIGVN DFSQVVLFGE 
       160        170        180        190        200
LPALSLGHVS AFLDEILVPV LSNKNNHKSW SCFTSQDMEY HIEVMKKKMY 
       210        220        230        240        250
IFRGKMSRRT LLPIPTVAGK MDLDQNCSEN KPPSNERIIL HAIESVVIEW 
       260        270        280        290        300
SHQIQEIIER DSVQRLLNGL HLSPQAELDF WMMRRENLSC IYDQLQAPVV 
       310        320        330        340        350
LKMVKILTTK QSSYFPTLKD IFLAVENALL EAQDVELYLR PLRRHIQCLQ 
       360        370        380        390        400
ETEFPQTRIL IAPLFHTICL IWSHSKFYNT PARVIVLLQE FCNLFINQAT 
       410        420        430        440        450
AYLSPEDLLR GEIEESLEKV QVAVNILKTF KNSFFNYRKK LASYFMGRKL 
       460        470        480        490        500
RPWDFQSHLV FCRFDKFLDR LIKIEDIFAT TLEFEKLERL EFGGTKGAIL 
       510        520        530        540        550
NGQVHEMSEE LMELCKLFKQ STYDPSDCTN MEFESDYVAF KSKTLEFDRR 
       560        570        580        590        600
LGTIICEAFF NCNGLEAAFK LLTIFGNFLE KPVVMEIFSL HYSTLVHMFN 
       610        620        630        640        650
TELDVCKQLY NEHMKQIECG HVVLNKNMPF TSGNMKWAQQ VLQRLQMFWS 
       660        670        680        690        700
NFASLRYLFL GNPDHALVYQ KYVEMTTLLD QFESRIYNEW KSNVDEICEF 
       710        720        730        740        750
NLNQPLVKFS AINGLLCVNF DPKLVAVLRE VKYLLMLKKQ DIPDSALAIF 
       760        770        780        790        800
KKRNTILKYI GNLDLLVQGY NKLKQTLLEV EYPLIEDELR AIDEQLTAAT 
       810        820        830        840        850
TWLTWQDDCW GYIERVRAAT SELEHRVERT QKNVKVIQQT MRGWARCVLP 
       860        870        880        890        900
PRREHRREAA FTLEDKGDLF TKKYKLIQGD GCKIHNLVEE NRKLFKANPS 
       910        920        930        940        950
LDTWKIYVEF IDDIVVEGFF QAIMHDLDFF LKNTEKQLKP APFFQAQMIL 
       960        970        980        990       1000
LPPEIVFKPS LDREAGDGFY DLVEEMLCNS FRMSAQMNRI ATHLEIKNYQ 
      1010       1020       1030       1040       1050
NDMDNMLGLA EVRQEIMNRV VNVINKVLDF RNTLETHTYL WVDDRAEFMK 
      1060       1070       1080       1090       1100
HFLLYGHAVS SDEMDAHANE EIPEQPPTLE QFKEQIDIYE ALYVQMSKFE 
      1110       1120       1130       1140       1150
DFRVFDSWFK VDMKPFKVSL LTIIKKWSWM FQEHLLRFVI DSLNELQEFI 
      1160       1170       1180       1190       1200
KETDSGLQRE LNEGDHDGLV DIMVHLLAVR SRQRATDELF EPLKETITLL 
      1210       1220       1230       1240       1250
ESYGQKMPEQ VYIQLEELPE RWETTKKIAA TVRHEVSPLH NAEVTLIRKK 
      1260       1270       1280       1290       1300
CILFDAKQAE FRERFRHYAP LGFNAENPYT ALDKANEELE ALEEEMLQMQ 
      1310       1320       1330       1340       1350
ESTRLFEVAL PEYKQMKQCR KEIKLLKGLW DVIIYVRRSI DNWTKTQWRQ 
      1360       1370       1380       1390       1400
IHVEQMDVEL RRFAKEIWSL NKEVRVWDAY TGLEGTVKDM TASLRAITEL 
      1410       1420       1430       1440       1450
QSPALRDRHW HQLMKAIGVK FLINEATTLA DLLALRLHRV EDDVRRIVDK 
      1460       1470       1480       1490       1500
AVKELGTEKV ITEISQTWAT MKFSYEVHYR TGIPLLKSDE QLFETLEHNQ 
      1510       1520       1530       1540       1550
VQLQTLLQSK YVEYFIEQVL SWQNKLNIAD LVIFTWMEVQ RTWSHLESIF 
      1560       1570       1580       1590       1600
VCSEDIRIQL VKDARRFDGV DAEFKELMFK TAKVENVLEA TCRPNLYEKL 
      1610       1620       1630       1640       1650
KDLQSRLSLC EKALAEYLET KRIAFPRFYF VSSADLLDIL SKGAQPKQVT 
      1660       1670       1680       1690       1700
CHLAKLFDSI ADLQFEDNQD VSAHRAVGMY SKEKEYVPFQ AECECVGHVE 
      1710       1720       1730       1740       1750
TWLLQLEQTM QETVRHSITE AIVAYEEKPR ELWIFDFPAQ VALTSSQIWW 
      1760       1770       1780       1790       1800
TTDVGIAFSR LEEGYETALK DFHKKQISQL NTLITLLLGE LPPGDRQKIM 
      1810       1820       1830       1840       1850
TICTIDVHAR DVVAKLISQK VVSPQAFTWL SQLRHRWEDT QKHCFVNICD 
      1860       1870       1880       1890       1900
AQFQYFYEYL GNSPRLVITP LTDRCYITLT QSLHLTMSGA PAGPAGTGKT 
      1910       1920       1930       1940       1950
ETTKDLGRAL GMMVYVFNCS EQMDYKSIGN IYKGLVQTGA WGCFDEFNRI 
      1960       1970       1980       1990       2000
SVEVLSVVAV QVKMIHDAIR NRKKRFVFLG EAITLKPSVG IFITMNPGYA 
      2010       2020       2030       2040       2050
GRTELPENLK ALFRPCAMVA PDIELICEIL LVAEGFVDAR ALARKFITLY 
      2060       2070       2080       2090       2100
TLCKELLSKQ DHYDWGLRAI KSVLVVAGSL KRGDKNRPED QVLMRALRDF 
      2110       2120       2130       2140       2150
NMPKIVTDDI PVFLGLVGDL FPALDVPRRR KLHFEQMVRQ STLELRLQPE 
      2160       2170       2180       2190       2200
ESFILKVVQL EELLAVRHSV FVVGNAGTGK SKILRTLNRT YVNMKQKPVW 
      2210       2220       2230       2240       2250
NDLNPKAVTT DELFGFIHHA TREWKDGKIV YSYFIGLFSS ILREQANLKH 
      2260       2270       2280       2290       2300
DGPKWIVLDG DIDPMWIESL NTVMDDNKVL TLASNERIAL TPFMRLLFEI 
      2310       2320       2330       2340       2350
HHLRSATPAT VSRAGILYVN PQDLGWNPYV ASWIDRRRHQ SEKANLTILF 
      2360       2370       2380       2390       2400
DKYVPACLDK LRTSFKTITS IPESSLVQTL CVLLECLLTP ENVPSDSPKE 
      2410       2420       2430       2440       2450
VYEVYFVFAC IWAFGGTLLQ DQISDYQADF SRWWQKEMKA VKFPSQGTIF 
      2460       2470       2480       2490       2500
DYYVDHKTKK LLPWADKIAQ FTMDPDVPLQ TVLVHTTETA RLRYFMELLL 
      2510       2520       2530       2540       2550
EKGKPLMLVG NAGVGKTVFV GDTLASLSED YIVSRVPFNY YTTSTALQKI 
      2560       2570       2580       2590       2600
LEKPLEKKAG HNYGPGGNKK LIYFIDDMNM PEVDLYGTVQ PHTLIRQHID 
      2610       2620       2630       2640       2650
YGHWYDRQKV MLKEIHNCQY VACMNPMVGS FTINPRLQRH FTVFAFNFPS 
      2660       2670       2680       2690       2700
LDALNTIYGQ IFSFHFQQQA FAPSILRSGP TLIQATIAFH QTMMCNFLPT 
      2710       2720       2730       2740       2750
AIKFHYIFNL RDLSNVFQGI LFASPECLKG PLDLIHLWLH ESARVYGDKL 
      2760       2770       2780       2790       2800
IDKKDCDLFQ RRMLETAYKY FEGIDSHMLL QQPLIYCHFA DRGKDPHYMP 
      2810       2820       2830       2840       2850
VKDWEVLKTI LTETLDNYNE LNAAMHLVLF EDAMQHVCRI SRILRTPQGC 
      2860       2870       2880       2890       2900
ALLVGVGGSG KQSLSRLAAY LRGLEVFQIT LTEGYGIQEL RVDLANLYIR 
      2910       2920       2930       2940       2950
TGAKNMPTVF LLTDAQVLDE SFLVLINDLL ASGEIPDLFS DEDVDKIISG 
      2960       2970       2980       2990       3000
IHNEVHALGM VDSRENCWKF FMARVRLQLK IILCFSPVGR TLRVRARKFP 
      3010       3020       3030       3040       3050
AIVNCTAIDW FHAWPQEALV SVSRRFIEET KGIEPVHKDS ISLFMAHVHT 
      3060       3070       3080       3090       3100
TVNEMSTRYY QNERRHNYTT PKSFLEQISL FKNLLKKKQN EVSEKKERLV 
      3110       3120       3130       3140       3150
NGIQKLKTTA SQVGDLKARL ASQEAELQLR NHDAEALITK IGLQTEKVSR 
      3160       3170       3180       3190       3200
EKTIADAEER KVTAIQTEVF QKQRECEADL LKAEPALVAA TAALNTLNRV 
      3210       3220       3230       3240       3250
NLSELKAFPN PPIAVTNVTA AVMVLLAPRG RVPKDRSWKA AKVFMGKVDD 
      3260       3270       3280       3290       3300
FLQALINYDK EHIPENCLKV VNEHYLKDPE FNPNLIRTKS FAAAGLCAWV 
      3310       3320       3330       3340       3350
INIIKFYEVY CDVEPKRQAL AQANLELAAA TEKLEAIRKK LVDLDRNLSR 
      3360       3370       3380       3390       3400
LTASFEKATA EKVRCQEEVN QTNKTIKLAN RLVKELEAKK IRWGQSIKSF 
      3410       3420       3430       3440       3450
EAQEKTLCGD VLLTAAFVSY VGPFTRQYRQ ELVHCKWVPF LQQKVSIPLT 
      3460       3470       3480       3490       3500
EGLDLISMLT DDATIAAWNN EGLPSDRMST ENAAILTHCE RWPLVIDPQQ 
      3510       3520       3530       3540       3550
QGIKWIKNKY GMDLKVTHLG QKGFLNAIET ALAFGDVILI ENLEETIDPV 
      3560       3570       3580       3590       3600
LDPLLGRNTI KKGKYIRIGD KECEFNKNFR LILHTKLANP HYKPELQAQT 
      3610       3620       3630       3640       3650
TLLNFTVTED GLEAQLLAEV VSIERPDLEK LKLVLTKHQN DFKIELKYLE 
      3660       3670       3680       3690       3700
DDLLLRLSAA EGSFLDDTKL VERLEATKTT VAEIEHKVIE AKENERKINE 
      3710       3720       3730       3740       3750
ARECYRPVAA RASLLYFVIN DLQKINPLYQ FSLKAFNVLF HRAIEQADKV 
      3760       3770       3780       3790       3800
EDMQGRISIL MESITHAVFL YTSQALFEKD KLTFLSQMAF QILLRKKEID 
      3810       3820       3830       3840       3850
PLELDFLLRF TVEHTHLSPV DFLTSQSWSA IKAIAVMEEF RGIDRDVEGS 
      3860       3870       3880       3890       3900
AKQWRKWVES ECPEKEKLPQ EWKKKSLIQK LILLRAMRPD RMTYALRNFV 
      3910       3920       3930       3940       3950
EEKLGAKYVE RTRLDLVKAF EESSPATPIF FILSPGVDAL KDLEILGKRL 
      3960       3970       3980       3990       4000
GFTIDSGKFH NVSLGQGQET VAEVALEKAS KGGHWVILQN VHLVAKWLGT 
      4010       4020       4030       4040       4050
LEKLLERFSQ GSHRDYRVFM SAESAPTPDE HIIPQGLLEN SIKITNEPPT 
      4060       4070       4080       4090       4100
GMLANLHAAL YNFDQDTLEI CSKEQEFKSI LFSLCYFHAC VAGRLRFGPQ 
      4110       4120       4130       4140       4150
GWSRSYPFNP GDLTICASVL YNYLEANSKV PWEDLRYLFG EIMYGGHITD 
      4160       4170       4180       4190       4200
DWDRKLCRVY LEEFMNPSLT EDELMLAPGF AAPPYLDYAG YHQYIEEMLP 
      4210       4220       4230       4240       4250
PESPALYGLH PNAEIEFLTV TSNTLFRTLL EMQPRNALSG DELGQSTEEK 
      4260       4270       4280       4290       4300
VKNVLDDILE KLPEEFNMAE IMQKNSNRSP YVLVCFQECE RMNILIREIR 
      4310       4320       4330       4340       4350
ISLEQLDLSL KGELALSPAV EAQQFALSYD TVPDTWSKLA YPSTYGLAQW 
      4360       4370       4380       4390       4400
FNDLLLRCRE LDTWTQDLTL PAVVWLSGFF NPQSFLTAIM QTMARKNEWP 
      4410       4420       4430       4440       4450
LDKTRLTADV TKKTKEDYGH PPREGAYLHG LFMEGARWDT QAGTIVEARL 
      4460       4470       4480       4490       4500
KELACPMPVI FAKATPVDRQ ETKQTYECPV YRTKLRGPSY IWTFRLKSEE 
      4510 
KTAKWVLAGV ALLLEA
Length:4,516
Mass (Da):520,369
Last modified:February 4, 2015 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4F4F149CE7FF82D7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WYC6A0A087WYC6_HUMAN
Dynein axonemal heavy chain 11
DNAH11
4,523Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DFR0A0A0C4DFR0_HUMAN
Dynein axonemal heavy chain 11
DNAH11
4,523Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KQN2U3KQN2_HUMAN
Dynein axonemal heavy chain 11
DNAH11
174Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01385134E → L Requires 2 nucleotide substitutions. 1 PublicationCorresponds to variant dbSNP:rs398123604EnsemblClinVar.1
Natural variantiVAR_04294434E → V. Corresponds to variant dbSNP:rs2285944EnsemblClinVar.1
Natural variantiVAR_072472117E → V in CILD7. 1 PublicationCorresponds to variant dbSNP:rs72655968Ensembl.1
Natural variantiVAR_013852639Q → R1 PublicationCorresponds to variant dbSNP:rs12670130EnsemblClinVar.1
Natural variantiVAR_013853654S → C1 PublicationCorresponds to variant dbSNP:rs62441683EnsemblClinVar.1
Natural variantiVAR_0138541023V → A2 PublicationsCorresponds to variant dbSNP:rs10269582EnsemblClinVar.1
Natural variantiVAR_0138551038T → A2 PublicationsCorresponds to variant dbSNP:rs10224537EnsemblClinVar.1
Natural variantiVAR_0429451316M → V. Corresponds to variant dbSNP:rs17144788EnsemblClinVar.1
Natural variantiVAR_0138561635D → G1 PublicationCorresponds to variant dbSNP:rs17144835EnsemblClinVar.1
Natural variantiVAR_0724732383L → P in CILD7. 1 PublicationCorresponds to variant dbSNP:rs72657353Ensembl.1
Natural variantiVAR_0601412586Y → H. Corresponds to variant dbSNP:rs2003417EnsemblClinVar.1
Natural variantiVAR_0138572634N → S. Corresponds to variant dbSNP:rs9639393EnsemblClinVar.1
Natural variantiVAR_0138582675I → V. Corresponds to variant dbSNP:rs72657364EnsemblClinVar.1
Natural variantiVAR_0138592997R → Q in CILD7; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs35865357EnsemblClinVar.1
Natural variantiVAR_0138603467A → T1 PublicationCorresponds to variant dbSNP:rs2214326EnsemblClinVar.1
Natural variantiVAR_0138613708V → L. Corresponds to variant dbSNP:rs4722064EnsemblClinVar.1
Natural variantiVAR_0138623758S → P1 PublicationCorresponds to variant dbSNP:rs17145720EnsemblClinVar.1
Natural variantiVAR_0429464165M → V2 PublicationsCorresponds to variant dbSNP:rs6461613EnsemblClinVar.1
Natural variantiVAR_0138634170T → I2 PublicationsCorresponds to variant dbSNP:rs12537531EnsemblClinVar.1
Natural variantiVAR_0724744327L → S in CILD7. 1 PublicationCorresponds to variant dbSNP:rs72658826Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ320497 mRNA Translation: CAC60121.1
AC004595 Genomic DNA No translation available.
AC102952 Genomic DNA No translation available.
AC073102 Genomic DNA No translation available.
AC013481 Genomic DNA No translation available.
AC005078 Genomic DNA No translation available.
AC004002 Genomic DNA No translation available.
AC099653 Genomic DNA No translation available.
AJ132087 mRNA Translation: CAA10560.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS64602.1

NCBI Reference Sequences

More...RefSeqi		NP_001264044.1, NM_001277115.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000409508; ENSP00000475939; ENSG00000105877

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8701

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8701

UCSC genome browser

More...UCSCi		uc064bwj.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ320497 mRNA Translation: CAC60121.1
AC004595 Genomic DNA No translation available.
AC102952 Genomic DNA No translation available.
AC073102 Genomic DNA No translation available.
AC013481 Genomic DNA No translation available.
AC005078 Genomic DNA No translation available.
AC004002 Genomic DNA No translation available.
AC099653 Genomic DNA No translation available.
AJ132087 mRNA Translation: CAA10560.1
CCDSiCCDS64602.1
RefSeqiNP_001264044.1, NM_001277115.1

3D structure databases

SMRiQ96DT5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi114244, 3 interactors
STRINGi9606.ENSP00000475939

PTM databases

GlyConnecti1190, 11 N-Linked glycans (1 site)
GlyGeniQ96DT5, 2 sites, 11 N-linked glycans (1 site), 1 O-linked glycan (1 site)
iPTMnetiQ96DT5
PhosphoSitePlusiQ96DT5

Genetic variation databases

BioMutaiDNAH11
DMDMi311033455

Proteomic databases

EPDiQ96DT5
jPOSTiQ96DT5
MassIVEiQ96DT5
PaxDbiQ96DT5
PeptideAtlasiQ96DT5
PRIDEiQ96DT5
ProteomicsDBi76319

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		44039, 67 antibodies

The DNASU plasmid repository

More...DNASUi		8701

Genome annotation databases

EnsembliENST00000409508; ENSP00000475939; ENSG00000105877
GeneIDi8701
KEGGihsa:8701
UCSCiuc064bwj.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8701
DisGeNETi8701

GeneCards: human genes, protein and diseases

More...GeneCardsi		DNAH11
GeneReviewsiDNAH11
HGNCiHGNC:2942, DNAH11
HPAiENSG00000105877, Tissue enhanced (epididymis, parathyroid gland)
MalaCardsiDNAH11
MIMi603339, gene
611884, phenotype
neXtProtiNX_Q96DT5
OpenTargetsiENSG00000105877
Orphaneti244, Primary ciliary dyskinesia
PharmGKBiPA27396
VEuPathDBiHostDB:ENSG00000105877

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3595, Eukaryota
GeneTreeiENSGT00940000158880
HOGENOMiCLU_000038_4_0_1
InParanoidiQ96DT5
OMAiELDFWTM
OrthoDBi1492at2759
TreeFamiTF316836

Enzyme and pathway databases

PathwayCommonsiQ96DT5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8701, 4 hits in 988 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DNAH11, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		DNAH11

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8701
PharosiQ96DT5, Tbio

Protein Ontology

More...PROi		PR:Q96DT5
RNActiQ96DT5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000105877, Expressed in right uterine tube and 123 other tissues
ExpressionAtlasiQ96DT5, baseline and differential
GenevisibleiQ96DT5, HS

Family and domain databases

Gene3Di1.10.8.710, 1 hit
1.10.8.720, 1 hit
1.20.140.100, 1 hit
3.10.490.20, 1 hit
3.20.180.20, 1 hit
3.40.50.300, 5 hits
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR035699, AAA_6
IPR035706, AAA_9
IPR041658, AAA_lid_11
IPR042219, AAA_lid_11_sf
IPR041589, DNAH3_AAA_lid_1
IPR042222, Dynein_2_N
IPR043157, Dynein_AAA1S
IPR041466, Dynein_AAA5_ext
IPR041228, Dynein_C
IPR043160, Dynein_C_barrel
IPR024743, Dynein_HC_stalk
IPR024317, Dynein_heavy_chain_D4_dom
IPR004273, Dynein_heavy_D6_P-loop
IPR013602, Dynein_heavy_linker
IPR013594, Dynein_heavy_tail
IPR042228, Dynein_linker_3
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF12774, AAA_6, 1 hit
PF12780, AAA_8, 1 hit
PF12781, AAA_9, 1 hit
PF17857, AAA_lid_1, 1 hit
PF18198, AAA_lid_11, 1 hit
PF08385, DHC_N1, 1 hit
PF08393, DHC_N2, 1 hit
PF17852, Dynein_AAA_lid, 1 hit
PF18199, Dynein_C, 1 hit
PF03028, Dynein_heavy, 1 hit
PF12777, MT, 1 hit
SMARTiView protein in SMART
SM00382, AAA, 4 hits
SUPFAMiSSF52540, SSF52540, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDYH11_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96DT5
Secondary accession number(s): Q9UJ82
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: February 4, 2015
Last modified: September 29, 2021
This is version 175 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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