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Entry version 139 (11 Dec 2019)
Sequence version 4 (11 Jan 2011)
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Protein

Rho guanine nucleotide exchange factor 26

Gene

ARHGEF26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-193648 NRAGE signals death through JNK
R-HSA-194840 Rho GTPase cycle
R-HSA-416482 G alpha (12/13) signalling events

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 26
Alternative name(s):
SH3 domain-containing guanine exchange factor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARHGEF26
Synonyms:SGEF
ORF Names:HMFN1864
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000114790.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24490 ARHGEF26

Online Mendelian Inheritance in Man (OMIM)

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MIMi
617552 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96DR7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi826W → R: Fails to localize at sites of membrane ruffling. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
26084

Open Targets

More...
OpenTargetsi
ENSG00000114790

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96DR7 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ARHGEF26

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373555

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003225681 – 871Rho guanine nucleotide exchange factor 26Add BLAST871

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei22PhosphoserineCombined sources1
Modified residuei392PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96DR7

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96DR7

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q96DR7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96DR7

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96DR7

PeptideAtlas

More...
PeptideAtlasi
Q96DR7

PRoteomics IDEntifications database

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PRIDEi
Q96DR7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
19196
76307 [Q96DR7-1]
76308 [Q96DR7-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96DR7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q96DR7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 is broadly expressed, with highest levels in liver (at protein level). Certain mRNA species appear to be specifically expressed in prostate and liver.2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Certain mRNA species appear to be up-regulated by androgens in prostate cancer cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000114790 Expressed in 198 organ(s), highest expression level in visceral pleura

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96DR7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96DR7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA017722
HPA049195

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ICAM1 and RHOG.

2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
117537, 18 interactors

Protein interaction database and analysis system

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IntActi
Q96DR7, 8 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000348828

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96DR7 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1871
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96DR7

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini439 – 623DHPROSITE-ProRule annotationAdd BLAST185
Domaini655 – 782PHPROSITE-ProRule annotationAdd BLAST128
Domaini789 – 850SH3PROSITE-ProRule annotationAdd BLAST62

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi106 – 173Pro-richAdd BLAST68

Keywords - Domaini

SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3523 Eukaryota
COG5422 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00950000182750

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000007536

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96DR7

KEGG Orthology (KO)

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KOi
K13744

Identification of Orthologs from Complete Genome Data

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OMAi
YTARQPD

Database of Orthologous Groups

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OrthoDBi
1176939at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96DR7

TreeFam database of animal gene trees

More...
TreeFami
TF316357

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00160 RhoGEF, 1 hit
cd11938 SH3_ARHGEF16_26, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.900.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035797 ARHGEF16/ARHGEF26_SH3
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00621 RhoGEF, 1 hit
PF14604 SH3_9, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SM00326 SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065 SSF48065, 1 hit
SSF50044 SSF50044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q96DR7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDGESEVDFS SNSITPLWRR RSIPQPHQVL GRSKPRPQSY QSPNGLLITD
60 70 80 90 100
FPVEDGGTLL AAQIPAQVPT ASDSRTVHRS PLLLGAQRRA VANGGTASPE
110 120 130 140 150
YRAASPRLRR PKSPKLPKAV PGGSPKSPAN GAVTLPAPPP PPVLRPPRTP
160 170 180 190 200
NAPAPCTPEE DLTGLTASPV PSPTANGLAA NNDSPGSGSQ SGRKAKDPER
210 220 230 240 250
GLFPGPQKSS SEQKLPLQRL PSQENELLEN PSVVLSTNSP AALKVGKQQI
260 270 280 290 300
IPKSLASEIK ISKSNNQNVE PHKRLLKVRS MVEGLGGPLG HAGEESEVDN
310 320 330 340 350
DVDSPGSLRR GLRSTSYRRA VVSGFDFDSP TSSKKKNRMS QPVLKVVMED
360 370 380 390 400
KEKFSSLGRI KKKMLKGQGT FDGEENAVLY QNYKEKALDI DSDEESEPKE
410 420 430 440 450
QKSDEKIVIH HKPLRSTWSQ LSAVKRKGLS QTVSQEERKR QEAIFEVISS
460 470 480 490 500
EHSYLLSLEI LIRMFKNSKE LSDTMTKTER HHLFSNITDV CEASKKFFIE
510 520 530 540 550
LEARHQNNIF IDDISDIVEK HTASTFDPYV KYCTNEVYQQ RTLQKLLATN
560 570 580 590 600
PSFKEVLSRI ESHEDCRNLP MISFLILPMQ RVTRLPLLMD TICQKTPKDS
610 620 630 640 650
PKYEVCKRAL KEVSKLVRLC NEGARKMERT EMMYTINSQL EFKIKPFPLV
660 670 680 690 700
SSSRWLVKRG ELTAYVEDTV LFSRRTSKQQ VYFFLFNDVL IITKKKSEES
710 720 730 740 750
YNVNDYSLRD QLLVESCDNE ELNSSPGKNS STMLYSRQSS ASHLFTLTVL
760 770 780 790 800
SNHANEKVEM LLGAETQSER ARWITALGHS SGKPPADRTS LTQVEIVRSF
810 820 830 840 850
TAKQPDELSL QVADVVLIYQ RVSDGWYEGE RLRDGERGWF PMECAKEITC
860 870
QATIDKNVER MGRLLGLETN V
Length:871
Mass (Da):97,346
Last modified:January 11, 2011 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE6EB57BAE7DD224B
GO
Isoform 2 (identifier: Q96DR7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     428-446: GLSQTVSQEERKRQEAIFE → VILIVGFMEMKDGRLRGGK
     447-871: Missing.

Show »
Length:446
Mass (Da):48,168
Checksum:i4D112FF2EDBD3C26
GO
Isoform 3 (identifier: Q96DR7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     790-871: SLTQVEIVRS...GRLLGLETNV → CG

Show »
Length:791
Mass (Da):88,134
Checksum:i3722051098F4B67B
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH16628 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAL27002 differs from that shown. Intron retention.Curated
The sequence BAB14159 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB14292 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti60L → S in AAL27001 (PubMed:12697679).Curated1
Sequence conflicti60L → S in AAS59842 (PubMed:15133129).Curated1
Sequence conflicti60L → S in BAG53860 (PubMed:14702039).Curated1
Sequence conflicti60L → S in AAH78655 (PubMed:15489334).Curated1
Sequence conflicti687N → K in AAH16628 (PubMed:15489334).Curated1
Sequence conflicti707S → T in AAH78655 (PubMed:15489334).Curated1
Sequence conflicti781S → R in AAL27001 (PubMed:12697679).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03942529V → LCombined sources5 PublicationsCorresponds to variant dbSNP:rs12493885Ensembl.1
Natural variantiVAR_05820560L → P1 PublicationCorresponds to variant dbSNP:rs12497267Ensembl.1
Natural variantiVAR_039426203F → S1 PublicationCorresponds to variant dbSNP:rs13096373Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_031934428 – 446GLSQT…EAIFE → VILIVGFMEMKDGRLRGGK in isoform 2. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_031935447 – 871Missing in isoform 2. 1 PublicationAdd BLAST425
Alternative sequenceiVSP_045570790 – 871SLTQV…LETNV → CG in isoform 3. 1 PublicationAdd BLAST82

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF415175 mRNA Translation: AAL27001.1
AF415176 mRNA Translation: AAL27002.1 Sequence problems.
AY552599 mRNA Translation: AAS59842.1
AK022655 mRNA Translation: BAB14159.1 Different initiation.
AK022884 mRNA Translation: BAB14292.1 Different initiation.
AK123040 mRNA Translation: BAG53860.1
AB073386 mRNA Translation: BAD38637.1
AC018452 Genomic DNA No translation available.
FJ695204 Genomic DNA No translation available.
BC016628 mRNA Translation: AAH16628.1 Different initiation.
BC078655 mRNA Translation: AAH78655.1
AL117429 mRNA Translation: CAB55918.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS46938.1 [Q96DR7-1]
CCDS58858.1 [Q96DR7-4]

Protein sequence database of the Protein Information Resource

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PIRi
T17228

NCBI Reference Sequences

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RefSeqi
NP_001238891.1, NM_001251962.1 [Q96DR7-1]
NP_001238892.1, NM_001251963.1 [Q96DR7-4]
NP_056410.3, NM_015595.3 [Q96DR7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000356448; ENSP00000348828; ENSG00000114790 [Q96DR7-1]
ENST00000465093; ENSP00000423418; ENSG00000114790 [Q96DR7-1]
ENST00000465817; ENSP00000423295; ENSG00000114790 [Q96DR7-3]
ENST00000496710; ENSP00000424446; ENSG00000114790 [Q96DR7-4]
ENST00000614308; ENSP00000481927; ENSG00000277101 [Q96DR7-1]
ENST00000618535; ENSP00000484367; ENSG00000277101 [Q96DR7-1]
ENST00000629129; ENSP00000486665; ENSG00000277101 [Q96DR7-3]
ENST00000630729; ENSP00000487265; ENSG00000277101 [Q96DR7-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
26084

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:26084

UCSC genome browser

More...
UCSCi
uc011bog.2 human [Q96DR7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF415175 mRNA Translation: AAL27001.1
AF415176 mRNA Translation: AAL27002.1 Sequence problems.
AY552599 mRNA Translation: AAS59842.1
AK022655 mRNA Translation: BAB14159.1 Different initiation.
AK022884 mRNA Translation: BAB14292.1 Different initiation.
AK123040 mRNA Translation: BAG53860.1
AB073386 mRNA Translation: BAD38637.1
AC018452 Genomic DNA No translation available.
FJ695204 Genomic DNA No translation available.
BC016628 mRNA Translation: AAH16628.1 Different initiation.
BC078655 mRNA Translation: AAH78655.1
AL117429 mRNA Translation: CAB55918.1
CCDSiCCDS46938.1 [Q96DR7-1]
CCDS58858.1 [Q96DR7-4]
PIRiT17228
RefSeqiNP_001238891.1, NM_001251962.1 [Q96DR7-1]
NP_001238892.1, NM_001251963.1 [Q96DR7-4]
NP_056410.3, NM_015595.3 [Q96DR7-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6MYEX-ray1.10B42-52[»]
SMRiQ96DR7
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi117537, 18 interactors
IntActiQ96DR7, 8 interactors
STRINGi9606.ENSP00000348828

PTM databases

iPTMnetiQ96DR7
PhosphoSitePlusiQ96DR7

Polymorphism and mutation databases

BioMutaiARHGEF26
DMDMi317373555

Proteomic databases

EPDiQ96DR7
jPOSTiQ96DR7
MassIVEiQ96DR7
MaxQBiQ96DR7
PaxDbiQ96DR7
PeptideAtlasiQ96DR7
PRIDEiQ96DR7
ProteomicsDBi19196
76307 [Q96DR7-1]
76308 [Q96DR7-3]

Genome annotation databases

EnsembliENST00000356448; ENSP00000348828; ENSG00000114790 [Q96DR7-1]
ENST00000465093; ENSP00000423418; ENSG00000114790 [Q96DR7-1]
ENST00000465817; ENSP00000423295; ENSG00000114790 [Q96DR7-3]
ENST00000496710; ENSP00000424446; ENSG00000114790 [Q96DR7-4]
ENST00000614308; ENSP00000481927; ENSG00000277101 [Q96DR7-1]
ENST00000618535; ENSP00000484367; ENSG00000277101 [Q96DR7-1]
ENST00000629129; ENSP00000486665; ENSG00000277101 [Q96DR7-3]
ENST00000630729; ENSP00000487265; ENSG00000277101 [Q96DR7-4]
GeneIDi26084
KEGGihsa:26084
UCSCiuc011bog.2 human [Q96DR7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
26084
DisGeNETi26084
EuPathDBiHostDB:ENSG00000114790.12

GeneCards: human genes, protein and diseases

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GeneCardsi
ARHGEF26
HGNCiHGNC:24490 ARHGEF26
HPAiHPA017722
HPA049195
MIMi617552 gene
neXtProtiNX_Q96DR7
OpenTargetsiENSG00000114790

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3523 Eukaryota
COG5422 LUCA
GeneTreeiENSGT00950000182750
HOGENOMiHOG000007536
InParanoidiQ96DR7
KOiK13744
OMAiYTARQPD
OrthoDBi1176939at2759
PhylomeDBiQ96DR7
TreeFamiTF316357

Enzyme and pathway databases

ReactomeiR-HSA-193648 NRAGE signals death through JNK
R-HSA-194840 Rho GTPase cycle
R-HSA-416482 G alpha (12/13) signalling events

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ARHGEF26 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
26084
PharosiQ96DR7 Tbio

Protein Ontology

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PROi
PR:Q96DR7
RNActiQ96DR7 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000114790 Expressed in 198 organ(s), highest expression level in visceral pleura
ExpressionAtlasiQ96DR7 baseline and differential
GenevisibleiQ96DR7 HS

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
cd11938 SH3_ARHGEF16_26, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035797 ARHGEF16/ARHGEF26_SH3
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00621 RhoGEF, 1 hit
PF14604 SH3_9, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARHGQ_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96DR7
Secondary accession number(s): B3KVP8
, E9PBD0, Q68CL1, Q6AZ96, Q6Q8Q8, Q96AW8, Q96DR6, Q9H9D7, Q9H9R2, Q9UFW5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: January 11, 2011
Last modified: December 11, 2019
This is version 139 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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