Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 143 (07 Apr 2021)
Sequence version 2 (25 Mar 2003)
Previous versions | rss
Add a publicationFeedback
Protein

Methyl-CpG-binding domain protein 6

Gene

MBD6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro).

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q96DN6

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5689603, UCH proteinases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Methyl-CpG-binding domain protein 6
Alternative name(s):
Methyl-CpG-binding protein MBD6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MBD6
Synonyms:KIAA1887
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20445, MBD6

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96DN6

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000166987.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
114785

Open Targets

More...
OpenTargetsi
ENSG00000166987

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134866196

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96DN6, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MBD6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
29336893

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000962671 – 1003Methyl-CpG-binding domain protein 6Add BLAST1003

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96DN6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96DN6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96DN6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96DN6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96DN6

PeptideAtlas

More...
PeptideAtlasi
Q96DN6

PRoteomics IDEntifications database

More...
PRIDEi
Q96DN6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
76302

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96DN6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96DN6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000166987, Expressed in thyroid gland and 214 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96DN6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96DN6, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000166987, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
125347, 10 interactors

Protein interaction database and analysis system

More...
IntActi
Q96DN6, 8 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000347896

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96DN6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96DN6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini11 – 81MBDPROSITE-ProRule annotationAdd BLAST71

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi140 – 846Pro-richAdd BLAST707

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The MBD domain is necessary for chromocentric localization.

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QR6I, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000064137

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96DN6

Identification of Orthologs from Complete Genome Data

More...
OMAi
SLFHCSD

Database of Orthologous Groups

More...
OrthoDBi
75997at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96DN6

TreeFam database of animal gene trees

More...
TreeFami
TF338183

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016177, DNA-bd_dom_sf
IPR037385, MBD5/MBD6
IPR001739, Methyl_CpG_DNA-bd

The PANTHER Classification System

More...
PANTHERi
PTHR16112, PTHR16112, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00391, MBD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54171, SSF54171, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50982, MBD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All

Q96DN6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNGGNESSGA DRAGGPVATS VPIGWQRCVR EGAVLYISPS GTELSSLEQT
60 70 80 90 100
RSYLLSDGTC KCGLECPLNV PKVFNFDPLA PVTPGGAGVG PASEEDMTKL
110 120 130 140 150
CNHRRKAVAM ATLYRSMETT CSHSSPGEGA SPQMFHTVSP GPPSARPPCR
160 170 180 190 200
VPPTTPLNGG PGSLPPEPPS VSQAFPTLAG PGGLFPPRLA DPVPSGGSSS
210 220 230 240 250
PRFLPRGNAP SPAPPPPPAI SLNAPSYNWG AALRSSLVPS DLGSPPAPHA
260 270 280 290 300
SSSPPSDPPL FHCSDALTPP PLPPSNNLPA HPGPASQPPV SSATMHLPLV
310 320 330 340 350
LGPLGGAPTV EGPGAPPFLA SSLLSAAAKA QHPPLPPPST LQGRRPRAQA
360 370 380 390 400
PSASHSSSLR PSQRRPRRPP TVFRLLEGRG PQTPRRSRPR APAPVPQPFS
410 420 430 440 450
LPEPSQPILP SVLSLLGLPT PGPSHSDGSF NLLGSDAHLP PPPTLSSGSP
460 470 480 490 500
PQPRHPIQPS LPGTTSGSLS SVPGAPAPPA ASKAPVVPSP VLQSPSEGLG
510 520 530 540 550
MGAGPACPLP PLAGGEAFPF PSPEQGLALS GAGFPGMLGA LPLPLSLGQP
560 570 580 590 600
PPSPLLNHSL FGVLTGGGGQ PPPEPLLPPP GGPGPPLAPG EPEGPSLLVA
610 620 630 640 650
SLLPPPPSDL LPPPSAPPSN LLASFLPLLA LGPTAGDGEG SAEGAGGPSG
660 670 680 690 700
EPFSGLGDLS PLLFPPLSAP PTLIALNSAL LAATLDPPSG TPPQPCVLSA
710 720 730 740 750
PQPGPPTSSV TTATTDPGAS SLGKAPSNSG RPPQLLSPLL GASLLGDLSS
760 770 780 790 800
LTSSPGALPS LLQPPGPLLS GQLGLQLLPG GGAPPPLSEA SSPLACLLQS
810 820 830 840 850
LQIPPEQPEA PCLPPESPAS ALEPEPARPP LSALAPPHGS PDPPVPELLT
860 870 880 890 900
GRGSGKRGRR GGGGLRGING EARPARGRKP GSRREPGRLA LKWGTRGGFN
910 920 930 940 950
GQMERSPRRT HHWQHNGELA EGGAEPKDPP PPGPHSEDLK VPPGVVRKSR
960 970 980 990 1000
RGRRRKYNPT RNSNSSRQDI TLEPSPTARA AVPLPPRARP GRPAKNKRRK

LAP
Length:1,003
Mass (Da):101,201
Last modified:March 25, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6C8E8693AA6A3BE6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VU14F8VU14_HUMAN
Methyl-CpG-binding domain protein 6
MBD6
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YHD1H0YHD1_HUMAN
Methyl-CpG-binding domain protein 6
MBD6
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VZD7F8VZD7_HUMAN
Methyl-CpG-binding domain protein 6
MBD6
45Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VPC4F8VPC4_HUMAN
Methyl-CpG-binding domain protein 6
MBD6
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YIU1H0YIU1_HUMAN
Methyl-CpG-binding domain protein 6
MBD6
190Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DGJ6A0A0C4DGJ6_HUMAN
Methyl-CpG-binding domain protein 6
MBD6
504Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VVK7F8VVK7_HUMAN
Methyl-CpG-binding domain protein 6
MBD6
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VNX1F8VNX1_HUMAN
Methyl-CpG-binding domain protein 6
MBD6
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YHN1H0YHN1_HUMAN
Methyl-CpG-binding domain protein 6
MBD6
27Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VW40F8VW40_HUMAN
Methyl-CpG-binding domain protein 6
MBD6
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti637D → G in BAB71176 (PubMed:14702039).Curated1
Sequence conflicti802Q → QQ in BAC04045 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK056399 mRNA Translation: BAB71176.1
AK093078 mRNA Translation: BAC04045.1
AB067474 mRNA Translation: BAB67780.1
AL834230 mRNA Translation: CAD38908.1
AC022506 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8944.1

NCBI Reference Sequences

More...
RefSeqi
NP_443129.3, NM_052897.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000355673; ENSP00000347896; ENSG00000166987

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
114785

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:114785

UCSC genome browser

More...
UCSCi
uc001soj.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056399 mRNA Translation: BAB71176.1
AK093078 mRNA Translation: BAC04045.1
AB067474 mRNA Translation: BAB67780.1
AL834230 mRNA Translation: CAD38908.1
AC022506 Genomic DNA No translation available.
CCDSiCCDS8944.1
RefSeqiNP_443129.3, NM_052897.3

3D structure databases

SMRiQ96DN6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi125347, 10 interactors
IntActiQ96DN6, 8 interactors
STRINGi9606.ENSP00000347896

PTM databases

iPTMnetiQ96DN6
PhosphoSitePlusiQ96DN6

Genetic variation databases

BioMutaiMBD6
DMDMi29336893

Proteomic databases

EPDiQ96DN6
jPOSTiQ96DN6
MassIVEiQ96DN6
MaxQBiQ96DN6
PaxDbiQ96DN6
PeptideAtlasiQ96DN6
PRIDEiQ96DN6
ProteomicsDBi76302

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
50110, 51 antibodies

Genome annotation databases

EnsembliENST00000355673; ENSP00000347896; ENSG00000166987
GeneIDi114785
KEGGihsa:114785
UCSCiuc001soj.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
114785
DisGeNETi114785

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MBD6
HGNCiHGNC:20445, MBD6
HPAiENSG00000166987, Low tissue specificity
neXtProtiNX_Q96DN6
OpenTargetsiENSG00000166987
PharmGKBiPA134866196
VEuPathDBiHostDB:ENSG00000166987.14

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QR6I, Eukaryota
GeneTreeiENSGT00530000064137
InParanoidiQ96DN6
OMAiSLFHCSD
OrthoDBi75997at2759
PhylomeDBiQ96DN6
TreeFamiTF338183

Enzyme and pathway databases

PathwayCommonsiQ96DN6
ReactomeiR-HSA-5689603, UCH proteinases

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
114785, 21 hits in 1003 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MBD6, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
114785
PharosiQ96DN6, Tdark

Protein Ontology

More...
PROi
PR:Q96DN6
RNActiQ96DN6, protein

Gene expression databases

BgeeiENSG00000166987, Expressed in thyroid gland and 214 other tissues
ExpressionAtlasiQ96DN6, baseline and differential
GenevisibleiQ96DN6, HS

Family and domain databases

InterProiView protein in InterPro
IPR016177, DNA-bd_dom_sf
IPR037385, MBD5/MBD6
IPR001739, Methyl_CpG_DNA-bd
PANTHERiPTHR16112, PTHR16112, 1 hit
SMARTiView protein in SMART
SM00391, MBD, 1 hit
SUPFAMiSSF54171, SSF54171, 1 hit
PROSITEiView protein in PROSITE
PS50982, MBD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMBD6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96DN6
Secondary accession number(s): Q8N3M0, Q8NA81, Q96Q00
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 25, 2003
Last modified: April 7, 2021
This is version 143 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again