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Entry version 150 (12 Aug 2020)
Sequence version 2 (17 Oct 2006)
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Protein

TBC1 domain family member 31

Gene

TBC1D31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q96DN5

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q96DN5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TBC1 domain family member 31
Alternative name(s):
WD repeat-containing protein 67
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TBC1D31
Synonyms:WDR67
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000156787.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30888, TBC1D31

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96DN5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
93594

Open Targets

More...
OpenTargetsi
ENSG00000156787

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670600

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96DN5, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TBC1D31

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116242845

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000514201 – 1066TBC1 domain family member 31Add BLAST1066

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96DN5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96DN5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96DN5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96DN5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96DN5

PeptideAtlas

More...
PeptideAtlasi
Q96DN5

PRoteomics IDEntifications database

More...
PRIDEi
Q96DN5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
76299 [Q96DN5-1]
76300 [Q96DN5-2]
76301 [Q96DN5-3]

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q96DN5

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96DN5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96DN5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000156787, Expressed in secondary oocyte and 181 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96DN5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96DN5, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000156787, Tissue enhanced (lymphoid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
125037, 50 interactors

Protein interaction database and analysis system

More...
IntActi
Q96DN5, 22 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000287380

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96DN5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96DN5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati33 – 74WD 1Add BLAST42
Repeati75 – 116WD 2Add BLAST42
Repeati117 – 157WD 3Add BLAST41
Repeati158 – 200WD 4Add BLAST43
Repeati201 – 248WD 5Add BLAST48
Repeati249 – 296WD 6Add BLAST48
Repeati297 – 334WD 7Add BLAST38
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini424 – 599Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST176

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili728 – 861Sequence analysisAdd BLAST134
Coiled coili914 – 948Sequence analysisAdd BLAST35

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0295, Eukaryota
KOG1093, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000153859

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003330_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96DN5

Identification of Orthologs from Complete Genome Data

More...
OMAi
WFEYHPL

Database of Orthologous Groups

More...
OrthoDBi
858041at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96DN5

TreeFam database of animal gene trees

More...
TreeFami
TF324799

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000195, Rab-GTPase-TBC_dom
IPR035969, Rab-GTPase_TBC_sf
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00566, RabGAP-TBC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320, WD40, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47923, SSF47923, 1 hit
SSF50978, SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50086, TBC_RABGAP, 1 hit
PS00678, WD_REPEATS_1, 1 hit
PS50294, WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96DN5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQSTDLGNKE SGKIWHRKPS PATRDGIIVN IIHNTSDYHP KVLRFLNVAF
60 70 80 90 100
DGTGDCLIAG DHQGNIYVFD LHGNRFNLVQ RTAQACTALA FNLRRKSEFL
110 120 130 140 150
VALADYSIKC FDTVTKELVS WMRGHESSVF SISVHASGKY AITTSSDTAQ
160 170 180 190 200
LWDLDTFQRK RKLNIRQSVG IQKVFFLPLS NTILSCFKDN SIFAWECDTL
210 220 230 240 250
FCKYQLPAPP ESSSILYKVF AVTRDGRILA AGGKSNHLHL WCLEARQLFR
260 270 280 290 300
IIQMPTKVRA IRHLEFLPDS FDAGSNQVLG VLSQDGIMRF INMQTCKLLF
310 320 330 340 350
EIGSLDEGIS SSAISPHGRY IASIMENGSL NIYSVQALTQ EINKPPPPLV
360 370 380 390 400
KVIEDLPKNK LSSSDLKMKV TSGRVQQPAK SRESKMQTRI LKQDLTGDFE
410 420 430 440 450
SKKNELPDGL NKKRLQILLK GYGEYPTKYR MFIWRSLLQL PENHTAFSTL
460 470 480 490 500
IDKGTHVAFL NLQKKYPIKS RKLLRVLQRT LSALAHWSVI FSDTPYLPLL
510 520 530 540 550
AFPFVKLFQN NQLICFEVIA TLIINWCQHW FEYFPNPPIN ILSMIENVLA
560 570 580 590 600
FHDKELLQHF IDHDITSQLY AWPLLETVFS EVLTREEWLK LFDNIFSNHP
610 620 630 640 650
SFLLMTVVAY NICSRTPLLS CNLKDDFEFF FHHRNNLDIN VVIRQVYHLM
660 670 680 690 700
ETTPTDIHPD SMLNVFVALT KGQYPVFNQY PKFIVDYQTQ ERERIRNDEL
710 720 730 740 750
DYLRERQTVE DMQAKVDQQR VEDEAWYQKQ ELLRKAEETR REMLLQEEEK
760 770 780 790 800
MIQQRQRLAA VKRELKVKEM HLQDAARRRF LKLQQDQQEM ELRRLDDEIG
810 820 830 840 850
RKVYMRDREI AATARDLEMR QLELESQKRL YEKNLTENQE ALAKEMRADA
860 870 880 890 900
DAYRRKVDLE EHMFHKLIEA GETQSQKTQK VIKENLAKAE QACLNTDWQI
910 920 930 940 950
QSLHKQKCDD LQRNKCYQEV AKLLRENRRK EIEIINAMVE EEAKKWKEAE
960 970 980 990 1000
GKEFRLRSAK KASALSDASR KWFLKQEINA AVEHAENPCH KEEPRFQNEQ
1010 1020 1030 1040 1050
DSSCLPRTSQ LNDSSEMDPS TQISLNRRAV EWDTTGQNLI KKVRNLRQRL
1060
TARARHRCQT PHLLAA
Length:1,066
Mass (Da):124,189
Last modified:October 17, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE94983F65D9E5A38
GO
Isoform 2 (identifier: Q96DN5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     880-944: Missing.

Show »
Length:1,001
Mass (Da):116,481
Checksum:i511757E564C103AB
GO
Isoform 3 (identifier: Q96DN5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     802-832: Missing.
     880-944: Missing.

Show »
Length:970
Mass (Da):112,656
Checksum:i9323DDFBB78E1BEB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ERK7E7ERK7_HUMAN
TBC1 domain family member 31
TBC1D31
961Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EWW7E7EWW7_HUMAN
TBC1 domain family member 31
TBC1D31
943Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RI94E5RI94_HUMAN
TBC1 domain family member 31
TBC1D31
620Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RI27E5RI27_HUMAN
TBC1 domain family member 31
TBC1D31
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GYF1F5GYF1_HUMAN
TBC1 domain family member 31
TBC1D31
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RFG6E5RFG6_HUMAN
TBC1 domain family member 31
TBC1D31
247Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RG45E5RG45_HUMAN
TBC1 domain family member 31
TBC1D31
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YCY3H0YCY3_HUMAN
TBC1 domain family member 31
TBC1D31
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RHC6E5RHC6_HUMAN
TBC1 domain family member 31
TBC1D31
146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YCP2H0YCP2_HUMAN
TBC1 domain family member 31
TBC1D31
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH27237 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti358K → N in BAB71182 (PubMed:14702039).Curated1
Sequence conflicti718Q → S in AAH27237 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_027960414R → H. Corresponds to variant dbSNP:rs16897967Ensembl.1
Natural variantiVAR_027961709V → F. Corresponds to variant dbSNP:rs16898023Ensembl.1
Natural variantiVAR_0576321065A → T. Corresponds to variant dbSNP:rs34994118Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_043414802 – 832Missing in isoform 3. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_016184880 – 944Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST65

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK056434 mRNA Translation: BAB71182.1
AC100873 Genomic DNA No translation available.
AC104316 Genomic DNA No translation available.
BC027237 mRNA Translation: AAH27237.1 Different initiation.
BC101724 mRNA Translation: AAI01725.1
BC111954 mRNA Translation: AAI11955.1
BC143525 mRNA Translation: AAI43526.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47916.1 [Q96DN5-3]
CCDS6338.1 [Q96DN5-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001138560.1, NM_001145088.1 [Q96DN5-3]
NP_663622.2, NM_145647.3 [Q96DN5-1]
XP_005251160.1, XM_005251103.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000287380; ENSP00000287380; ENSG00000156787 [Q96DN5-1]
ENST00000327098; ENSP00000312701; ENSG00000156787 [Q96DN5-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
93594

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:93594

UCSC genome browser

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UCSCi
uc003ypp.3, human [Q96DN5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056434 mRNA Translation: BAB71182.1
AC100873 Genomic DNA No translation available.
AC104316 Genomic DNA No translation available.
BC027237 mRNA Translation: AAH27237.1 Different initiation.
BC101724 mRNA Translation: AAI01725.1
BC111954 mRNA Translation: AAI11955.1
BC143525 mRNA Translation: AAI43526.1
CCDSiCCDS47916.1 [Q96DN5-3]
CCDS6338.1 [Q96DN5-1]
RefSeqiNP_001138560.1, NM_001145088.1 [Q96DN5-3]
NP_663622.2, NM_145647.3 [Q96DN5-1]
XP_005251160.1, XM_005251103.1

3D structure databases

SMRiQ96DN5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi125037, 50 interactors
IntActiQ96DN5, 22 interactors
STRINGi9606.ENSP00000287380

PTM databases

CarbonylDBiQ96DN5
iPTMnetiQ96DN5
PhosphoSitePlusiQ96DN5

Polymorphism and mutation databases

BioMutaiTBC1D31
DMDMi116242845

Proteomic databases

EPDiQ96DN5
jPOSTiQ96DN5
MassIVEiQ96DN5
MaxQBiQ96DN5
PaxDbiQ96DN5
PeptideAtlasiQ96DN5
PRIDEiQ96DN5
ProteomicsDBi76299 [Q96DN5-1]
76300 [Q96DN5-2]
76301 [Q96DN5-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
13779, 35 antibodies

Genome annotation databases

EnsembliENST00000287380; ENSP00000287380; ENSG00000156787 [Q96DN5-1]
ENST00000327098; ENSP00000312701; ENSG00000156787 [Q96DN5-3]
GeneIDi93594
KEGGihsa:93594
UCSCiuc003ypp.3, human [Q96DN5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
93594
DisGeNETi93594
EuPathDBiHostDB:ENSG00000156787.16

GeneCards: human genes, protein and diseases

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GeneCardsi
TBC1D31
HGNCiHGNC:30888, TBC1D31
HPAiENSG00000156787, Tissue enhanced (lymphoid)
neXtProtiNX_Q96DN5
OpenTargetsiENSG00000156787
PharmGKBiPA142670600

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0295, Eukaryota
KOG1093, Eukaryota
GeneTreeiENSGT00940000153859
HOGENOMiCLU_003330_0_0_1
InParanoidiQ96DN5
OMAiWFEYHPL
OrthoDBi858041at2759
PhylomeDBiQ96DN5
TreeFamiTF324799

Enzyme and pathway databases

PathwayCommonsiQ96DN5
SignaLinkiQ96DN5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
93594, 24 hits in 862 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TBC1D31, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
93594
PharosiQ96DN5, Tdark

Protein Ontology

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PROi
PR:Q96DN5
RNActiQ96DN5, protein

Gene expression databases

BgeeiENSG00000156787, Expressed in secondary oocyte and 181 other tissues
ExpressionAtlasiQ96DN5, baseline and differential
GenevisibleiQ96DN5, HS

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR000195, Rab-GTPase-TBC_dom
IPR035969, Rab-GTPase_TBC_sf
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00566, RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00320, WD40, 7 hits
SUPFAMiSSF47923, SSF47923, 1 hit
SSF50978, SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50086, TBC_RABGAP, 1 hit
PS00678, WD_REPEATS_1, 1 hit
PS50294, WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTBC31_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96DN5
Secondary accession number(s): B7ZL19
, Q2M2J9, Q3MIR6, Q8TBP9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 17, 2006
Last modified: August 12, 2020
This is version 150 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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