UniProtKB - Q96DI7 (SNR40_HUMAN)

BLAST

>sp|Q96DI7|SNR40_HUMAN U5 small nuclear ribonucleoprotein 40 kDa protein OS=Homo sapiens OX=9606 GN=SNRNP40 PE=1 SV=1
MIEQQKRKGPELPLVPVKRQRHELLLGAGSGPGAGQQQATPGALLQAGPPRCSSLQAPIM
LLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTD
GSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD
IRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTG
LSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKI
AAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ

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History
Entry version 167 (12 Sep 2018)
Sequence version 1 (01 Dec 2001)
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Protein

U5 small nuclear ribonucleoprotein 40 kDa protein

Gene

SNRNP40

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Component of the U5 small nuclear ribonucleoprotein (snRNP) complex. The U5 snRNP is part of the spliceosome, a multiprotein complex that catalyzes the removal of introns from pre-messenger RNAs.1 Publication

GO - Molecular functionⁱ

RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mRNA splicing, via spliceosome Source: Reactome
RNA processing
Source: ProtInc
Traceable author statementⁱ
- 9774689
RNA splicing
Source: ProtInc
Traceable author statementⁱ
- 9774689
RNA splicing, via transesterification reactions
Source: UniProtKB
Traceable author statementⁱ
- 9774689

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	mRNA processing, mRNA splicing

Biological process

mRNA processing, mRNA splicing

Enzyme and pathway databases

Reactomeⁱ	R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72165 mRNA Splicing - Minor Pathway
SignaLinkⁱ	Q96DI7

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: U5 small nuclear ribonucleoprotein 40 kDa protein Short name: U5 snRNP 40 kDa protein Short name: U5-40K Alternative name(s): 38 kDa-splicing factor Prp8-binding protein Short name: hPRP8BP U5 snRNP-specific 40 kDa protein WD repeat-containing protein 57
Gene namesⁱ	Name:SNRNP40 Synonyms:PRP8BP, SFP38, WDR57
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000060688.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30857 SNRNP40
MIMⁱ	607797 gene
neXtProtⁱ	NX_Q96DI7

Keywords - Cellular componentⁱ

Nucleus, Spliceosome

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9410
Open Targets More...OpenTargetsⁱ	ENSG00000060688
PharmGKBⁱ	PA164726132

Polymorphism and mutation databases

BioMutaⁱ	SNRNP40
DMDMⁱ	67462075

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000051417	1 – 357	U5 small nuclear ribonucleoprotein 40 kDa proteinAdd BLAST		357

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	18	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	21	Asymmetric dimethylarginineBy similarity	1
Cross-linkⁱ	270	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMⁱ

Isopeptide bond, Methylation, Ubl conjugation

Proteomic databases

EPDⁱ	Q96DI7
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96DI7
PaxDbⁱ	Q96DI7
PeptideAtlas More...PeptideAtlasⁱ	Q96DI7
PRIDEⁱ	Q96DI7
ProteomicsDBⁱ	76291
TopDownProteomicsⁱ	Q96DI7-1 [Q96DI7-1]

PTM databases

iPTMnetⁱ	Q96DI7
PhosphoSitePlusⁱ	Q96DI7
SwissPalmⁱ	Q96DI7

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000060688 Expressed in 202 organ(s), highest expression level in lung
CleanExⁱ	HS_SNRNP40
ExpressionAtlasⁱ	Q96DI7 baseline and differential
Genevisibleⁱ	Q96DI7 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA026527 HPA027345

HPAⁱ

HPA026527
HPA027345

Interactionⁱ

Subunit structureⁱ

Identified in the spliceosome C complex. Part of the U5 snRNP complex. Interacts with PRPF8. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, WDR57, SNRNP40, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39.4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
PRPF8	Q6P2Q9	3	EBI-538492,EBI-538479

With

Entry

#Exp.

IntAct

Notes

PRPF8

Q6P2Q9

EBI-538492,EBI-538479

Protein-protein interaction databases

BioGridⁱ	114805, 80 interactors
CORUMⁱ	Q96DI7
IntActⁱ	Q96DI7, 30 interactors
Molecular INTeraction database More...MINTⁱ	Q96DI7
STRINGⁱ	9606.ENSP00000263694

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96DI7
SMRⁱ	Q96DI7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	64 – 103	WD 1Add BLAST	40
Repeatⁱ	107 – 146	WD 2Add BLAST	40
Repeatⁱ	149 – 189	WD 3Add BLAST	41
Repeatⁱ	191 – 230	WD 4Add BLAST	40
Repeatⁱ	233 – 272	WD 5Add BLAST	40
Repeatⁱ	283 – 322	WD 6Add BLAST	40
Repeatⁱ	325 – 357	WD 7Add BLAST	33

Keywords - Domainⁱ

Repeat, WD repeat

Phylogenomic databases

eggNOGⁱ	KOG0265 Eukaryota ENOG410XSEW LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00810000125363
HOGENOMⁱ	HOG000091644
HOVERGENⁱ	HBG105197
InParanoidⁱ	Q96DI7
KEGG Orthology (KO) More...KOⁱ	K12857
OMAⁱ	GDCENYG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DR4
PhylomeDBⁱ	Q96DI7
TreeFamⁱ	TF300039

Family and domain databases

Gene3Dⁱ	2.130.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR020472 G-protein_beta_WD-40_rep IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR019775 WD40_repeat_CS IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00400 WD40, 7 hits
PRINTSⁱ	PR00320 GPROTEINBRPT
SMARTⁱ	View protein in SMART SM00320 WD40, 7 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit
PROSITEⁱ	View protein in PROSITE PS00678 WD_REPEATS_1, 5 hits PS50082 WD_REPEATS_2, 7 hits PS50294 WD_REPEATS_REGION, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.ⁱShow all

Isoform 1 (identifier: Q96DI7-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIEQQKRKGP ELPLVPVKRQ RHELLLGAGS GPGAGQQQAT PGALLQAGPP 
        60         70         80         90        100
RCSSLQAPIM LLSGHEGEVY CCKFHPNGST LASAGFDRLI LLWNVYGDCD 
       110        120        130        140        150
NYATLKGHSG AVMELHYNTD GSMLFSASTD KTVAVWDSET GERVKRLKGH 
       160        170        180        190        200
TSFVNSCYPA RRGPQLVCTG SDDGTVKLWD IRKKAAIQTF QNTYQVLAVT 
       210        220        230        240        250
FNDTSDQIIS GGIDNDIKVW DLRQNKLTYT MRGHADSVTG LSLSSEGSYL 
       260        270        280        290        300
LSNAMDNTVR VWDVRPFAPK ERCVKIFQGN VHNFEKNLLR CSWSPDGSKI 
       310        320        330        340        350
AAGSADRFVY VWDTTSRRIL YKLPGHAGSI NEVAFHPDEP IIISASSDKR 

LYMGEIQ

Length:357

Mass (Da):39,311

Last modified:December 1, 2001 - v1

Checksum:ⁱDE8CADEB098E560C

Isoform 2 (identifier: Q96DI7-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
343-357: ISASSDKRLYMGEIQ → ETGFHRIGQG...ESKSNAPFSS

« Hide

        10         20         30         40         50
MIEQQKRKGP ELPLVPVKRQ RHELLLGAGS GPGAGQQQAT PGALLQAGPP 
        60         70         80         90        100
RCSSLQAPIM LLSGHEGEVY CCKFHPNGST LASAGFDRLI LLWNVYGDCD 
       110        120        130        140        150
NYATLKGHSG AVMELHYNTD GSMLFSASTD KTVAVWDSET GERVKRLKGH 
       160        170        180        190        200
TSFVNSCYPA RRGPQLVCTG SDDGTVKLWD IRKKAAIQTF QNTYQVLAVT 
       210        220        230        240        250
FNDTSDQIIS GGIDNDIKVW DLRQNKLTYT MRGHADSVTG LSLSSEGSYL 
       260        270        280        290        300
LSNAMDNTVR VWDVRPFAPK ERCVKIFQGN VHNFEKNLLR CSWSPDGSKI 
       310        320        330        340        350
AAGSADRFVY VWDTTSRRIL YKLPGHAGSI NEVAFHPDEP IIETGFHRIG 
       360        370        380        390        400
QGGHELLTSS NPPASASQSA GITGVSHCAQ LQTVFMWVSM SVSPLLISGE 

SKSNAPFSS

Note: No experimental confirmation available.

Show »

Length:409

Mass (Da):44,516

Checksum:ⁱ06BC77CD284995FF

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation
	Q9NSS8	Q9NSS8_HUMAN		U5 small nuclear ribonucleoprotein ... U5 small nuclear ribonucleoprotein 40 kDa protein (WD repeat domain 57 (U5 snRNP specific), isoform CRA_b)	SNRNP40 DKFZp434D199, WDR57, hCG_20041	127	Annotation score:

Sequence cautionⁱ

The sequence AAC64084 differs from that shown. Reason: Frameshift at position 319. An insertion/deletion of a short nucleotide stretch in its cDNA resulting in a frameshift.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	3	E → D in AAC69625 (PubMed:9774689).Curated	1
Sequence conflictⁱ	162 – 163	RG → KS in AAC69625 (PubMed:9774689).Curated	2
Sequence conflictⁱ	187	I → V in AAC64084 (PubMed:9731529).Curated	1
Sequence conflictⁱ	343	I → L (PubMed:9731529).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056395	343 – 357	ISASS…MGEIQ → ETGFHRIGQGGHELLTSSNP PASASQSAGITGVSHCAQLQ TVFMWVSMSVSPLLISGESK SNAPFSS in isoform 2. 1 PublicationAdd BLAST		15

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF090988 mRNA Translation: AAC69625.1 AK298823 mRNA Translation: BAG60953.1 AC114495 Genomic DNA No translation available. AL451070 Genomic DNA No translation available. BC001494 mRNA Translation: AAH01494.1 AF083383 mRNA Translation: AAC64084.1 Sequence problems.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS340.1 [Q96DI7-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_004805.2, NM_004814.2 [Q96DI7-1]
UniGeneⁱ	Hs.33962

Genome annotation databases

Ensemblⁱ	ENST00000263694; ENSP00000263694; ENSG00000060688 [Q96DI7-1]
GeneIDⁱ	9410
KEGGⁱ	hsa:9410
UCSC genome browser More...UCSCⁱ	uc001bso.4 human [Q96DI7-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96DI7	U5 small nuclear ribonucleoprotein 40 kDa protein		MACMU		401	UniRef100_Q96DI7
Small nuclear ribonucleoprotein U5 subunit 40		CERAT		401
U5 small nuclear ribonucleoprotein 40 kDa protein		MACFA		401
Small nuclear ribonucleoprotein U5 subunit 40		RHIBE		401
Small nuclear ribonucleoprotein U5 subunit 40		PAPAN		298
+12

Protein	Similar proteins		Species	Score	Length	Source
Q96DI7	U5 small nuclear ribonucleoprotein 40 kDa protein		MOUSE		358	UniRef90_Q96DI7
U5 small nuclear ribonucleoprotein 40 kDa protein		BOVIN		358
U5 small nuclear ribonucleoprotein 40 kDa protein		PONAB		357
U5 small nuclear ribonucleoprotein 40 kDa protein		MACMU		401
Small nuclear ribonucleoprotein U5 subunit 40		CERAT		401
+110
Q96DI7-2	U5 small nuclear ribonucleoprotein 40 kDa protein (Fragment)		HETGA		387	UniRef90_Q96DI7-2
SNRNP40 isoform 1		PONAB		330
Small nuclear ribonucleoprotein U5 subunit 40		PELSI		328
UPI00020ADF01		NOMLE		409
UPI000DC16D7C		THEGE		398
+2

Protein	Similar proteins		Species	Score	Length	Source
Q96DI7	U5 small nuclear ribonucleoprotein 40 kDa protein		BOVIN		358	UniRef50_Q96DI7
U5 small nuclear ribonucleoprotein 40 kDa protein		MOUSE		358
U5 small nuclear ribonucleoprotein 40 kDa protein		PONAB		357
U5 small nuclear ribonucleoprotein 40 kDa protein		MACMU		401
Small nuclear ribonucleoprotein U5 subunit 40		CERAT		401
+342

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF090988 mRNA Translation: AAC69625.1 AK298823 mRNA Translation: BAG60953.1 AC114495 Genomic DNA No translation available. AL451070 Genomic DNA No translation available. BC001494 mRNA Translation: AAH01494.1 AF083383 mRNA Translation: AAC64084.1 Sequence problems.
CCDSⁱ	CCDS340.1 [Q96DI7-1]
RefSeqⁱ	NP_004805.2, NM_004814.2 [Q96DI7-1]
UniGeneⁱ	Hs.33962

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3JCR	electron microscopy	7.00	D	1-357	[»]
	5MQF	electron microscopy	5.90	F	1-357	[»]
	5O9Z	electron microscopy	4.50	D	1-357	[»]
	5XJC	electron microscopy	3.60	E	1-357	[»]
ProteinModelPortalⁱ	Q96DI7
SMRⁱ	Q96DI7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114805, 80 interactors
CORUMⁱ	Q96DI7
IntActⁱ	Q96DI7, 30 interactors
MINTⁱ	Q96DI7
STRINGⁱ	9606.ENSP00000263694

PTM databases

iPTMnetⁱ	Q96DI7
PhosphoSitePlusⁱ	Q96DI7
SwissPalmⁱ	Q96DI7

Polymorphism and mutation databases

BioMutaⁱ	SNRNP40
DMDMⁱ	67462075

Proteomic databases

EPDⁱ	Q96DI7
MaxQBⁱ	Q96DI7
PaxDbⁱ	Q96DI7
PeptideAtlasⁱ	Q96DI7
PRIDEⁱ	Q96DI7
ProteomicsDBⁱ	76291
TopDownProteomicsⁱ	Q96DI7-1 [Q96DI7-1]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	9410
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000263694; ENSP00000263694; ENSG00000060688 [Q96DI7-1]
GeneIDⁱ	9410
KEGGⁱ	hsa:9410
UCSCⁱ	uc001bso.4 human [Q96DI7-1]

Organism-specific databases

CTDⁱ	9410
DisGeNETⁱ	9410
EuPathDBⁱ	HostDB:ENSG00000060688.12
GeneCardsⁱ	SNRNP40
HGNCⁱ	HGNC:30857 SNRNP40
HPAⁱ	HPA026527 HPA027345
MIMⁱ	607797 gene
neXtProtⁱ	NX_Q96DI7
OpenTargetsⁱ	ENSG00000060688
PharmGKBⁱ	PA164726132
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0265 Eukaryota ENOG410XSEW LUCA
GeneTreeⁱ	ENSGT00810000125363
HOGENOMⁱ	HOG000091644
HOVERGENⁱ	HBG105197
InParanoidⁱ	Q96DI7
KOⁱ	K12857
OMAⁱ	GDCENYG
OrthoDBⁱ	EOG091G0DR4
PhylomeDBⁱ	Q96DI7
TreeFamⁱ	TF300039

Enzyme and pathway databases

Reactomeⁱ	R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72165 mRNA Splicing - Minor Pathway
SignaLinkⁱ	Q96DI7

Miscellaneous databases

ChiTaRSⁱ	SNRNP40 human
GeneWikiⁱ	WDR57
GenomeRNAiⁱ	9410
Protein Ontology More...PROⁱ	PR:Q96DI7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000060688 Expressed in 202 organ(s), highest expression level in lung
CleanExⁱ	HS_SNRNP40
ExpressionAtlasⁱ	Q96DI7 baseline and differential
Genevisibleⁱ	Q96DI7 HS

Family and domain databases

Gene3Dⁱ	2.130.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR020472 G-protein_beta_WD-40_rep IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR019775 WD40_repeat_CS IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
Pfamⁱ	View protein in Pfam PF00400 WD40, 7 hits
PRINTSⁱ	PR00320 GPROTEINBRPT
SMARTⁱ	View protein in SMART SM00320 WD40, 7 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit
PROSITEⁱ	View protein in PROSITE PS00678 WD_REPEATS_1, 5 hits PS50082 WD_REPEATS_2, 7 hits PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SNR40_HUMAN
Accessionⁱ	Q96DI7Primary (citable) accession number: Q96DI7 Secondary accession number(s): B4DQJ1, O75938, O95320
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
	Last sequence update:	December 1, 2001
	Last modified:	September 12, 2018
	This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

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Supporting data

UniProtKB - Q96DI7 (SNR40_HUMAN)

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U5 small nuclear ribonucleoprotein 40 kDa protein

SNRNP40

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ