UniProtKB - Q96DH6 (MSI2H_HUMAN)
RNA-binding protein Musashi homolog 2
MSI2
Functioni
RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).
By similarityGO - Molecular functioni
- identical protein binding Source: IntAct
- poly(U) RNA binding Source: Ensembl
- RNA binding Source: UniProtKB
GO - Biological processi
- stem cell development Source: Ensembl
Keywordsi
Molecular function | RNA-binding |
Enzyme and pathway databases
PathwayCommonsi | Q96DH6 |
Reactomei | R-HSA-9013418, RHOBTB2 GTPase cycle |
SignaLinki | Q96DH6 |
SIGNORi | Q96DH6 |
Names & Taxonomyi
Protein namesi | Recommended name: RNA-binding protein Musashi homolog 2Short name: Musashi-2 |
Gene namesi | Name:MSI2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18585, MSI2 |
MIMi | 607897, gene |
neXtProti | NX_Q96DH6 |
VEuPathDBi | HostDB:ENSG00000153944 |
Subcellular locationi
Cytoplasm and Cytosol
Note: Associated with polysomes.By similarity
Cytosol
- cytosol Source: HPA
Other locations
- cytoplasm Source: GO_Central
- intracellular membrane-bounded organelle Source: HPA
- polysome Source: GO_Central
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Involvement in diseasei
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 217 – 218 | Breakpoint for translocation to form MSI2/HOXA9 fusion protein | 2 |
Organism-specific databases
DisGeNETi | 124540 |
OpenTargetsi | ENSG00000153944 |
PharmGKBi | PA38590 |
Miscellaneous databases
Pharosi | Q96DH6, Tbio |
Genetic variation databases
BioMutai | MSI2 |
DMDMi | 51316513 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
ChainiPRO_0000081652 | 1 – 328 | RNA-binding protein Musashi homolog 2Add BLAST | 328 | ||
Isoform 2 (identifier: Q96DH6-2) | |||||
Initiator methioninei | RemovedCombined sources |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | ||
Modified residuei | 6 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 228 | Omega-N-methylarginineCombined sources | 1 | ||
Modified residuei | 261 | Omega-N-methylarginineCombined sources | 1 | ||
Isoform 2 (identifier: Q96DH6-2) | |||||
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | ||
Modified residuei | 14 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Methylation, PhosphoproteinProteomic databases
EPDi | Q96DH6 |
jPOSTi | Q96DH6 |
MassIVEi | Q96DH6 |
MaxQBi | Q96DH6 |
PaxDbi | Q96DH6 |
PeptideAtlasi | Q96DH6 |
PRIDEi | Q96DH6 |
ProteomicsDBi | 76288 [Q96DH6-1] 76289 [Q96DH6-2] 76290 [Q96DH6-3] |
PTM databases
GlyGeni | Q96DH6, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q96DH6 |
PhosphoSitePlusi | Q96DH6 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000153944, Expressed in quadriceps femoris and 220 other tissues |
ExpressionAtlasi | Q96DH6, baseline and differential |
Genevisiblei | Q96DH6, HS |
Organism-specific databases
HPAi | ENSG00000153944, Low tissue specificity |
Interactioni
Binary interactionsi
Q96DH6
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 125873, 149 interactors |
IntActi | Q96DH6, 23 interactors |
MINTi | Q96DH6 |
STRINGi | 9606.ENSP00000284073 |
Miscellaneous databases
RNActi | Q96DH6, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q96DH6 |
SMRi | Q96DH6 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 21 – 111 | RRM 1PROSITE-ProRule annotationAdd BLAST | 91 | |
Domaini | 110 – 187 | RRM 2PROSITE-ProRule annotationAdd BLAST | 78 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 28 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 264 – 286 | DisorderedSequence analysisAdd BLAST | 23 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 17 | Polar residuesSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG4205, Eukaryota |
GeneTreei | ENSGT00940000155420 |
HOGENOMi | CLU_012062_3_1_1 |
InParanoidi | Q96DH6 |
OMAi | PLAREMW |
OrthoDBi | 1565323at2759 |
PhylomeDBi | Q96DH6 |
TreeFami | TF325419 |
Family and domain databases
CDDi | cd12576, RRM1_MSI, 1 hit cd12323, RRM2_MSI, 1 hit |
Gene3Di | 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR034130, MSI_RRM1 IPR034126, MSI_RRM2 IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00076, RRM_1, 2 hits |
SMARTi | View protein in SMART SM00360, RRM, 2 hits |
SUPFAMi | SSF54928, SSF54928, 2 hits |
PROSITEi | View protein in PROSITE PS50102, RRM, 2 hits |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 14 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEANGSQGTS GSANDSQHDP GKMFIGGLSW QTSPDSLRDY FSKFGEIREC
60 70 80 90 100
MVMRDPTTKR SRGFGFVTFA DPASVDKVLG QPHHELDSKT IDPKVAFPRR
110 120 130 140 150
AQPKMVTRTK KIFVGGLSAN TVVEDVKQYF EQFGKVEDAM LMFDKTTNRH
160 170 180 190 200
RGFGFVTFEN EDVVEKVCEI HFHEINNKMV ECKKAQPKEV MFPPGTRGRA
210 220 230 240 250
RGLPYTMDAF MLGMGMLGYP NFVATYGRGY PGFAPSYGYQ FPGFPAAAYG
260 270 280 290 300
PVAAAAVAAA RGSGSNPARP GGFPGANSPG PVADLYGPAS QDSGVGNYIS
310 320
AASPQPGSGF GHGIAGPLIA TAFTNGYH
Computationally mapped potential isoform sequencesi
There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB4DHE8 | B4DHE8_HUMAN | RNA-binding protein Musashi homolog... | MSI2 | 324 | Annotation score: | ||
B4DM51 | B4DM51_HUMAN | RNA-binding protein Musashi homolog... | MSI2 | 267 | Annotation score: | ||
A0A6Q8PF05 | A0A6Q8PF05_HUMAN | RNA-binding protein Musashi homolog... | MSI2 | 341 | Annotation score: | ||
J3QKT5 | J3QKT5_HUMAN | RNA-binding protein Musashi homolog... | MSI2 | 99 | Annotation score: | ||
A0A6Q8PFU8 | A0A6Q8PFU8_HUMAN | RNA-binding protein Musashi homolog... | MSI2 | 107 | Annotation score: | ||
A0A6Q8PHT3 | A0A6Q8PHT3_HUMAN | RNA-binding protein Musashi homolog... | MSI2 | 89 | Annotation score: | ||
J3KTC1 | J3KTC1_HUMAN | RNA-binding protein Musashi homolog... | MSI2 | 140 | Annotation score: | ||
A0A6Q8PGD8 | A0A6Q8PGD8_HUMAN | RNA-binding protein Musashi homolog... | MSI2 | 139 | Annotation score: | ||
A0A6Q8PFI2 | A0A6Q8PFI2_HUMAN | RNA-binding protein Musashi homolog... | MSI2 | 65 | Annotation score: | ||
A0A6Q8PH26 | A0A6Q8PH26_HUMAN | RNA-binding protein Musashi homolog... | MSI2 | 73 | Annotation score: | ||
There are more potential isoformsShow all |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_011169 | 1 – 104 | Missing in isoform 3. 1 PublicationAdd BLAST | 104 | |
Alternative sequenceiVSP_011168 | 1 – 21 | MEANG…QHDPG → MADLTSVLTSVMFSPSS in isoform 2. 1 PublicationAdd BLAST | 21 | |
Alternative sequenceiVSP_011170 | 243 – 255 | GFPAA…PVAAA → DYLPVSQDIIFIN in isoform 2 and isoform 3. 2 PublicationsAdd BLAST | 13 | |
Alternative sequenceiVSP_011171 | 256 – 328 | Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST | 73 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC001526 mRNA Translation: AAH01526.1 BC017560 mRNA Translation: AAH17560.1 AK093888 mRNA Translation: BAC04244.1 |
CCDSi | CCDS11596.1 [Q96DH6-1] CCDS11597.1 [Q96DH6-2] |
RefSeqi | NP_620412.1, NM_138962.3 [Q96DH6-1] NP_733839.1, NM_170721.1 [Q96DH6-2] |
Genome annotation databases
Ensembli | ENST00000284073.7; ENSP00000284073.2; ENSG00000153944.12 ENST00000322684.7; ENSP00000313616.3; ENSG00000153944.12 [Q96DH6-2] ENST00000579180.2; ENSP00000462264.1; ENSG00000153944.12 [Q96DH6-3] ENST00000674964.1; ENSP00000502137.1; ENSG00000153944.12 |
GeneIDi | 124540 |
KEGGi | hsa:124540 |
MANE-Selecti | ENST00000284073.7; ENSP00000284073.2; NM_138962.4; NP_620412.1 |
UCSCi | uc002iuz.2, human [Q96DH6-1] |
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC001526 mRNA Translation: AAH01526.1 BC017560 mRNA Translation: AAH17560.1 AK093888 mRNA Translation: BAC04244.1 |
CCDSi | CCDS11596.1 [Q96DH6-1] CCDS11597.1 [Q96DH6-2] |
RefSeqi | NP_620412.1, NM_138962.3 [Q96DH6-1] NP_733839.1, NM_170721.1 [Q96DH6-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6C8U | NMR | - | 1 | 21-111 | [»] | |
6DBP | X-ray | 1.60 | A/B | 22-104 | [»] | |
6NTY | X-ray | 2.10 | A/B | 21-111 | [»] | |
AlphaFoldDBi | Q96DH6 | |||||
SMRi | Q96DH6 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 125873, 149 interactors |
IntActi | Q96DH6, 23 interactors |
MINTi | Q96DH6 |
STRINGi | 9606.ENSP00000284073 |
PTM databases
GlyGeni | Q96DH6, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q96DH6 |
PhosphoSitePlusi | Q96DH6 |
Genetic variation databases
BioMutai | MSI2 |
DMDMi | 51316513 |
Proteomic databases
EPDi | Q96DH6 |
jPOSTi | Q96DH6 |
MassIVEi | Q96DH6 |
MaxQBi | Q96DH6 |
PaxDbi | Q96DH6 |
PeptideAtlasi | Q96DH6 |
PRIDEi | Q96DH6 |
ProteomicsDBi | 76288 [Q96DH6-1] 76289 [Q96DH6-2] 76290 [Q96DH6-3] |
Protocols and materials databases
Antibodypediai | 18327, 396 antibodies from 39 providers |
DNASUi | 124540 |
Genome annotation databases
Ensembli | ENST00000284073.7; ENSP00000284073.2; ENSG00000153944.12 ENST00000322684.7; ENSP00000313616.3; ENSG00000153944.12 [Q96DH6-2] ENST00000579180.2; ENSP00000462264.1; ENSG00000153944.12 [Q96DH6-3] ENST00000674964.1; ENSP00000502137.1; ENSG00000153944.12 |
GeneIDi | 124540 |
KEGGi | hsa:124540 |
MANE-Selecti | ENST00000284073.7; ENSP00000284073.2; NM_138962.4; NP_620412.1 |
UCSCi | uc002iuz.2, human [Q96DH6-1] |
Organism-specific databases
CTDi | 124540 |
DisGeNETi | 124540 |
GeneCardsi | MSI2 |
HGNCi | HGNC:18585, MSI2 |
HPAi | ENSG00000153944, Low tissue specificity |
MIMi | 607897, gene |
neXtProti | NX_Q96DH6 |
OpenTargetsi | ENSG00000153944 |
PharmGKBi | PA38590 |
VEuPathDBi | HostDB:ENSG00000153944 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4205, Eukaryota |
GeneTreei | ENSGT00940000155420 |
HOGENOMi | CLU_012062_3_1_1 |
InParanoidi | Q96DH6 |
OMAi | PLAREMW |
OrthoDBi | 1565323at2759 |
PhylomeDBi | Q96DH6 |
TreeFami | TF325419 |
Enzyme and pathway databases
PathwayCommonsi | Q96DH6 |
Reactomei | R-HSA-9013418, RHOBTB2 GTPase cycle |
SignaLinki | Q96DH6 |
SIGNORi | Q96DH6 |
Miscellaneous databases
BioGRID-ORCSi | 124540, 35 hits in 1075 CRISPR screens |
ChiTaRSi | MSI2, human |
GenomeRNAii | 124540 |
Pharosi | Q96DH6, Tbio |
PROi | PR:Q96DH6 |
RNActi | Q96DH6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000153944, Expressed in quadriceps femoris and 220 other tissues |
ExpressionAtlasi | Q96DH6, baseline and differential |
Genevisiblei | Q96DH6, HS |
Family and domain databases
CDDi | cd12576, RRM1_MSI, 1 hit cd12323, RRM2_MSI, 1 hit |
Gene3Di | 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR034130, MSI_RRM1 IPR034126, MSI_RRM2 IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00076, RRM_1, 2 hits |
SMARTi | View protein in SMART SM00360, RRM, 2 hits |
SUPFAMi | SSF54928, SSF54928, 2 hits |
PROSITEi | View protein in PROSITE PS50102, RRM, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | MSI2H_HUMAN | |
Accessioni | Q96DH6Primary (citable) accession number: Q96DH6 Secondary accession number(s): Q7Z6M7, Q8N9T4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2004 |
Last sequence update: | December 1, 2001 | |
Last modified: | May 25, 2022 | |
This is version 163 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families