UniProtKB - Q96DH6 (MSI2H_HUMAN)
Protein
RNA-binding protein Musashi homolog 2
Gene
MSI2
Organism
Homo sapiens (Human)
Status
Functioni
RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).By similarity
GO - Molecular functioni
- identical protein binding Source: IntAct
- RNA binding Source: UniProtKB
Keywordsi
Molecular function | RNA-binding |
Enzyme and pathway databases
PathwayCommonsi | Q96DH6 |
SIGNORi | Q96DH6 |
Names & Taxonomyi
Protein namesi | Recommended name: RNA-binding protein Musashi homolog 2Short name: Musashi-2 |
Gene namesi | Name:MSI2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18585, MSI2 |
MIMi | 607897, gene |
neXtProti | NX_Q96DH6 |
VEuPathDBi | HostDB:ENSG00000153944.10 |
Subcellular locationi
Other locations
Note: Associated with polysomes.By similarity
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Involvement in diseasei
Chromosomal aberrations involving MSI2 may contribute to disease progression in chronic myeloid leukemia. Translocation t(7;17)(p15;q23) with HOXA9; translocation t(7;17)(q32-34;q23).1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 217 – 218 | Breakpoint for translocation to form MSI2/HOXA9 fusion protein | 2 |
Organism-specific databases
DisGeNETi | 124540 |
OpenTargetsi | ENSG00000153944 |
PharmGKBi | PA38590 |
Miscellaneous databases
Pharosi | Q96DH6, Tbio |
Genetic variation databases
BioMutai | MSI2 |
DMDMi | 51316513 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
ChainiPRO_0000081652 | 1 – 328 | RNA-binding protein Musashi homolog 2Add BLAST | 328 | ||
Isoform 2 (identifier: Q96DH6-2) | |||||
Initiator methioninei | RemovedCombined sources |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | ||
Modified residuei | 6 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 228 | Omega-N-methylarginineCombined sources | 1 | ||
Modified residuei | 261 | Omega-N-methylarginineCombined sources | 1 | ||
Isoform 2 (identifier: Q96DH6-2) | |||||
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | ||
Modified residuei | 14 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Phosphorylated.By similarity
Keywords - PTMi
Acetylation, Methylation, PhosphoproteinProteomic databases
EPDi | Q96DH6 |
jPOSTi | Q96DH6 |
MassIVEi | Q96DH6 |
MaxQBi | Q96DH6 |
PaxDbi | Q96DH6 |
PeptideAtlasi | Q96DH6 |
PRIDEi | Q96DH6 |
ProteomicsDBi | 76288 [Q96DH6-1] 76289 [Q96DH6-2] 76290 [Q96DH6-3] |
PTM databases
iPTMneti | Q96DH6 |
PhosphoSitePlusi | Q96DH6 |
Expressioni
Tissue specificityi
Ubiquitous; detected at low levels.1 Publication
Inductioni
Up-regulated in astrocytes after brain injury.By similarity
Gene expression databases
Bgeei | ENSG00000153944, Expressed in quadriceps femoris and 219 other tissues |
ExpressionAtlasi | Q96DH6, baseline and differential |
Genevisiblei | Q96DH6, HS |
Organism-specific databases
HPAi | ENSG00000153944, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ96DH6
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 125873, 122 interactors |
IntActi | Q96DH6, 20 interactors |
STRINGi | 9606.ENSP00000284073 |
Miscellaneous databases
RNActi | Q96DH6, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q96DH6 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 21 – 111 | RRM 1PROSITE-ProRule annotationAdd BLAST | 91 | |
Domaini | 110 – 187 | RRM 2PROSITE-ProRule annotationAdd BLAST | 78 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 253 – 260 | Poly-Ala | 8 |
Sequence similaritiesi
Belongs to the Musashi family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG4205, Eukaryota |
GeneTreei | ENSGT00940000155420 |
HOGENOMi | CLU_012062_3_1_1 |
InParanoidi | Q96DH6 |
OMAi | VNECTIM |
OrthoDBi | 1565323at2759 |
PhylomeDBi | Q96DH6 |
TreeFami | TF325419 |
Family and domain databases
CDDi | cd12576, RRM1_MSI, 1 hit cd12323, RRM2_MSI, 1 hit |
Gene3Di | 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR034130, MSI_RRM1 IPR034126, MSI_RRM2 IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00076, RRM_1, 2 hits |
SMARTi | View protein in SMART SM00360, RRM, 2 hits |
SUPFAMi | SSF54928, SSF54928, 2 hits |
PROSITEi | View protein in PROSITE PS50102, RRM, 2 hits |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 14 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q96DH6-1) [UniParc]FASTAAdd to basket
Also known as: A
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEANGSQGTS GSANDSQHDP GKMFIGGLSW QTSPDSLRDY FSKFGEIREC
60 70 80 90 100
MVMRDPTTKR SRGFGFVTFA DPASVDKVLG QPHHELDSKT IDPKVAFPRR
110 120 130 140 150
AQPKMVTRTK KIFVGGLSAN TVVEDVKQYF EQFGKVEDAM LMFDKTTNRH
160 170 180 190 200
RGFGFVTFEN EDVVEKVCEI HFHEINNKMV ECKKAQPKEV MFPPGTRGRA
210 220 230 240 250
RGLPYTMDAF MLGMGMLGYP NFVATYGRGY PGFAPSYGYQ FPGFPAAAYG
260 270 280 290 300
PVAAAAVAAA RGSGSNPARP GGFPGANSPG PVADLYGPAS QDSGVGNYIS
310 320
AASPQPGSGF GHGIAGPLIA TAFTNGYH
Computationally mapped potential isoform sequencesi
There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB4DHE8 | B4DHE8_HUMAN | RNA-binding protein Musashi homolog... | MSI2 | 324 | Annotation score: | ||
B4DM51 | B4DM51_HUMAN | RNA-binding protein Musashi homolog... | MSI2 | 267 | Annotation score: | ||
J3QKT5 | J3QKT5_HUMAN | RNA-binding protein Musashi homolog... | MSI2 | 99 | Annotation score: | ||
A0A6Q8PF05 | A0A6Q8PF05_HUMAN | RNA-binding protein Musashi homolog... | MSI2 | 341 | Annotation score: | ||
A0A6Q8PFU8 | A0A6Q8PFU8_HUMAN | RNA-binding protein Musashi homolog... | MSI2 | 107 | Annotation score: | ||
A0A6Q8PHT3 | A0A6Q8PHT3_HUMAN | RNA-binding protein Musashi homolog... | MSI2 | 89 | Annotation score: | ||
J3KTC1 | J3KTC1_HUMAN | RNA-binding protein Musashi homolog... | MSI2 | 140 | Annotation score: | ||
A0A6Q8PFI2 | A0A6Q8PFI2_HUMAN | RNA-binding protein Musashi homolog... | MSI2 | 65 | Annotation score: | ||
A0A6Q8PH26 | A0A6Q8PH26_HUMAN | RNA-binding protein Musashi homolog... | MSI2 | 73 | Annotation score: | ||
A0A6Q8PHP1 | A0A6Q8PHP1_HUMAN | RNA-binding protein Musashi homolog... | MSI2 | 22 | Annotation score: | ||
There are more potential isoformsShow all |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_011169 | 1 – 104 | Missing in isoform 3. 1 PublicationAdd BLAST | 104 | |
Alternative sequenceiVSP_011168 | 1 – 21 | MEANG…QHDPG → MADLTSVLTSVMFSPSS in isoform 2. 1 PublicationAdd BLAST | 21 | |
Alternative sequenceiVSP_011170 | 243 – 255 | GFPAA…PVAAA → DYLPVSQDIIFIN in isoform 2 and isoform 3. 2 PublicationsAdd BLAST | 13 | |
Alternative sequenceiVSP_011171 | 256 – 328 | Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST | 73 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC001526 mRNA Translation: AAH01526.1 BC017560 mRNA Translation: AAH17560.1 AK093888 mRNA Translation: BAC04244.1 |
CCDSi | CCDS11596.1 [Q96DH6-1] CCDS11597.1 [Q96DH6-2] |
RefSeqi | NP_620412.1, NM_138962.3 [Q96DH6-1] NP_733839.1, NM_170721.1 [Q96DH6-2] |
Genome annotation databases
Ensembli | ENST00000284073; ENSP00000284073; ENSG00000153944 [Q96DH6-1] ENST00000322684; ENSP00000313616; ENSG00000153944 [Q96DH6-2] ENST00000579180; ENSP00000462264; ENSG00000153944 [Q96DH6-3] ENST00000674964; ENSP00000502137; ENSG00000153944 [Q96DH6-1] |
GeneIDi | 124540 |
KEGGi | hsa:124540 |
UCSCi | uc002iuz.2, human [Q96DH6-1] |
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC001526 mRNA Translation: AAH01526.1 BC017560 mRNA Translation: AAH17560.1 AK093888 mRNA Translation: BAC04244.1 |
CCDSi | CCDS11596.1 [Q96DH6-1] CCDS11597.1 [Q96DH6-2] |
RefSeqi | NP_620412.1, NM_138962.3 [Q96DH6-1] NP_733839.1, NM_170721.1 [Q96DH6-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6C8U | NMR | - | 1 | 21-111 | [»] | |
6DBP | X-ray | 1.60 | A/B | 22-104 | [»] | |
6NTY | X-ray | 2.10 | A/B | 21-111 | [»] | |
SMRi | Q96DH6 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 125873, 122 interactors |
IntActi | Q96DH6, 20 interactors |
STRINGi | 9606.ENSP00000284073 |
PTM databases
iPTMneti | Q96DH6 |
PhosphoSitePlusi | Q96DH6 |
Genetic variation databases
BioMutai | MSI2 |
DMDMi | 51316513 |
Proteomic databases
EPDi | Q96DH6 |
jPOSTi | Q96DH6 |
MassIVEi | Q96DH6 |
MaxQBi | Q96DH6 |
PaxDbi | Q96DH6 |
PeptideAtlasi | Q96DH6 |
PRIDEi | Q96DH6 |
ProteomicsDBi | 76288 [Q96DH6-1] 76289 [Q96DH6-2] 76290 [Q96DH6-3] |
Protocols and materials databases
Antibodypediai | 18327, 385 antibodies |
DNASUi | 124540 |
Genome annotation databases
Ensembli | ENST00000284073; ENSP00000284073; ENSG00000153944 [Q96DH6-1] ENST00000322684; ENSP00000313616; ENSG00000153944 [Q96DH6-2] ENST00000579180; ENSP00000462264; ENSG00000153944 [Q96DH6-3] ENST00000674964; ENSP00000502137; ENSG00000153944 [Q96DH6-1] |
GeneIDi | 124540 |
KEGGi | hsa:124540 |
UCSCi | uc002iuz.2, human [Q96DH6-1] |
Organism-specific databases
CTDi | 124540 |
DisGeNETi | 124540 |
GeneCardsi | MSI2 |
HGNCi | HGNC:18585, MSI2 |
HPAi | ENSG00000153944, Low tissue specificity |
MIMi | 607897, gene |
neXtProti | NX_Q96DH6 |
OpenTargetsi | ENSG00000153944 |
PharmGKBi | PA38590 |
VEuPathDBi | HostDB:ENSG00000153944.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4205, Eukaryota |
GeneTreei | ENSGT00940000155420 |
HOGENOMi | CLU_012062_3_1_1 |
InParanoidi | Q96DH6 |
OMAi | VNECTIM |
OrthoDBi | 1565323at2759 |
PhylomeDBi | Q96DH6 |
TreeFami | TF325419 |
Enzyme and pathway databases
PathwayCommonsi | Q96DH6 |
SIGNORi | Q96DH6 |
Miscellaneous databases
BioGRID-ORCSi | 124540, 27 hits in 873 CRISPR screens |
ChiTaRSi | MSI2, human |
GenomeRNAii | 124540 |
Pharosi | Q96DH6, Tbio |
PROi | PR:Q96DH6 |
RNActi | Q96DH6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000153944, Expressed in quadriceps femoris and 219 other tissues |
ExpressionAtlasi | Q96DH6, baseline and differential |
Genevisiblei | Q96DH6, HS |
Family and domain databases
CDDi | cd12576, RRM1_MSI, 1 hit cd12323, RRM2_MSI, 1 hit |
Gene3Di | 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR034130, MSI_RRM1 IPR034126, MSI_RRM2 IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00076, RRM_1, 2 hits |
SMARTi | View protein in SMART SM00360, RRM, 2 hits |
SUPFAMi | SSF54928, SSF54928, 2 hits |
PROSITEi | View protein in PROSITE PS50102, RRM, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MSI2H_HUMAN | |
Accessioni | Q96DH6Primary (citable) accession number: Q96DH6 Secondary accession number(s): Q7Z6M7, Q8N9T4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2004 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 158 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM