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Protein

Protein CXorf40B

Gene

CXorf40B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein CXorf40B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000197021.8

Human Gene Nomenclature Database

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HGNCi
HGNC:17402 CXorf40B

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q96DE9

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000197021

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA142672057

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CXorf40B

Domain mapping of disease mutations (DMDM)

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DMDMi
68052373

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000797411 – 158Protein CXorf40BAdd BLAST158

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q96DE9

MaxQB - The MaxQuant DataBase

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MaxQBi
Q96DE9

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96DE9

PeptideAtlas

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PeptideAtlasi
Q96DE9

PRoteomics IDEntifications database

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PRIDEi
Q96DE9

ProteomicsDB human proteome resource

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ProteomicsDBi
76285

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000197021 Expressed in 89 organ(s), highest expression level in right adrenal gland

CleanEx database of gene expression profiles

More...
CleanExi
HS_CXorf40B

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96DE9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96DE9 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA060897

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000347339

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q96DE9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96DE9

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IVVW Eukaryota
ENOG4111IPV LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000012182

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG054454

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96DE9

Identification of Orthologs from Complete Genome Data

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OMAi
DHWHCTL

Database of Orthologous Groups

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OrthoDBi
EOG091G0NYV

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96DE9

TreeFam database of animal gene trees

More...
TreeFami
TF332845

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR007374 ASCH_domain
IPR033615 CXorf40
IPR015947 PUA-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR31666 PTHR31666, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01022 ASCH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF88697 SSF88697, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q96DE9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKFGCLSFRQ PYAGFVLNGI KTVETRWRPL LSSQRNCTIA VHIAHRDWEG
60 70 80 90 100
DACRELLVER LGMTPAQIQA LLRKGEKFGR GVIAGLVDIG ETLQCPEDLT
110 120 130 140 150
PDEVVELENQ AALTNLKQKY LTVISNPRWL LEPIPRKGGK DVFQVDIPEH

LIPLGHEV
Length:158
Mass (Da):17,780
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDC14535A4816F652
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5HY62Q5HY62_HUMAN
Protein CXorf40B
CXorf40B
146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3G8S4R3G8_HUMAN
Protein CXorf40B
CXorf40B
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3T8S4R3T8_HUMAN
Protein CXorf40B
CXorf40B
45Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
L43575 mRNA No translation available.
BX927209 Genomic DNA No translation available.
BC009523 mRNA Translation: AAH09523.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS35426.1

NCBI Reference Sequences

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RefSeqi
NP_001013867.1, NM_001013845.1
XP_005274755.1, XM_005274698.1
XP_005274756.1, XM_005274699.1
XP_005274757.1, XM_005274700.1
XP_005274758.1, XM_005274701.2
XP_005274759.1, XM_005274702.3
XP_006724889.1, XM_006724826.3
XP_011529482.1, XM_011531180.2
XP_016885074.1, XM_017029585.1
XP_016885075.1, XM_017029586.1
XP_016885076.1, XM_017029587.1
XP_016885077.1, XM_017029588.1
XP_016885078.1, XM_017029589.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.458216
Hs.545950

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000355203; ENSP00000347339; ENSG00000197021
ENST00000370404; ENSP00000359432; ENSG00000197021
ENST00000370406; ENSP00000359434; ENSG00000197021

Database of genes from NCBI RefSeq genomes

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GeneIDi
541578

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:541578

UCSC genome browser

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UCSCi
uc004fdy.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43575 mRNA No translation available.
BX927209 Genomic DNA No translation available.
BC009523 mRNA Translation: AAH09523.1
CCDSiCCDS35426.1
RefSeqiNP_001013867.1, NM_001013845.1
XP_005274755.1, XM_005274698.1
XP_005274756.1, XM_005274699.1
XP_005274757.1, XM_005274700.1
XP_005274758.1, XM_005274701.2
XP_005274759.1, XM_005274702.3
XP_006724889.1, XM_006724826.3
XP_011529482.1, XM_011531180.2
XP_016885074.1, XM_017029585.1
XP_016885075.1, XM_017029586.1
XP_016885076.1, XM_017029587.1
XP_016885077.1, XM_017029588.1
XP_016885078.1, XM_017029589.1
UniGeneiHs.458216
Hs.545950

3D structure databases

ProteinModelPortaliQ96DE9
SMRiQ96DE9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000347339

Polymorphism and mutation databases

BioMutaiCXorf40B
DMDMi68052373

Proteomic databases

EPDiQ96DE9
MaxQBiQ96DE9
PaxDbiQ96DE9
PeptideAtlasiQ96DE9
PRIDEiQ96DE9
ProteomicsDBi76285

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355203; ENSP00000347339; ENSG00000197021
ENST00000370404; ENSP00000359432; ENSG00000197021
ENST00000370406; ENSP00000359434; ENSG00000197021
GeneIDi541578
KEGGihsa:541578
UCSCiuc004fdy.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
541578
EuPathDBiHostDB:ENSG00000197021.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CXorf40B
HGNCiHGNC:17402 CXorf40B
HPAiHPA060897
neXtProtiNX_Q96DE9
OpenTargetsiENSG00000197021
PharmGKBiPA142672057

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IVVW Eukaryota
ENOG4111IPV LUCA
GeneTreeiENSGT00390000012182
HOVERGENiHBG054454
InParanoidiQ96DE9
OMAiDHWHCTL
OrthoDBiEOG091G0NYV
PhylomeDBiQ96DE9
TreeFamiTF332845

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
541578

Protein Ontology

More...
PROi
PR:Q96DE9

Gene expression databases

BgeeiENSG00000197021 Expressed in 89 organ(s), highest expression level in right adrenal gland
CleanExiHS_CXorf40B
ExpressionAtlasiQ96DE9 baseline and differential
GenevisibleiQ96DE9 HS

Family and domain databases

InterProiView protein in InterPro
IPR007374 ASCH_domain
IPR033615 CXorf40
IPR015947 PUA-like_sf
PANTHERiPTHR31666 PTHR31666, 1 hit
SMARTiView protein in SMART
SM01022 ASCH, 1 hit
SUPFAMiSSF88697 SSF88697, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCX04B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96DE9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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