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Protein

Protein shisa-4

Gene

SHISA4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein shisa-4
Alternative name(s):
Transmembrane protein 58
Gene namesi
Name:SHISA4
Synonyms:C1orf40, TMEM58
ORF Names:UNQ583/PRO1153
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000198892.6
HGNCiHGNC:27139 SHISA4
MIMi617326 gene
neXtProtiNX_Q96DD7

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 87ExtracellularSequence analysisAdd BLAST60
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Topological domaini109 – 197CytoplasmicSequence analysisAdd BLAST89

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198892
PharmGKBiPA162403294

Polymorphism and mutation databases

BioMutaiSHISA4
DMDMi313104251

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000025409028 – 197Protein shisa-4Add BLAST170

Proteomic databases

MaxQBiQ96DD7
PaxDbiQ96DD7
PeptideAtlasiQ96DD7
PRIDEiQ96DD7
ProteomicsDBi76282

PTM databases

PhosphoSitePlusiQ96DD7

Expressioni

Gene expression databases

BgeeiENSG00000198892 Expressed in 91 organ(s), highest expression level in muscle of leg
CleanExiHS_SHISA4
GenevisibleiQ96DD7 HS

Organism-specific databases

HPAiHPA061273

Interactioni

Protein-protein interaction databases

IntActiQ96DD7, 3 interactors
STRINGi9606.ENSP00000355064

Structurei

3D structure databases

ProteinModelPortaliQ96DD7
SMRiQ96DD7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi131 – 195Pro-richAdd BLAST65

Sequence similaritiesi

Belongs to the shisa family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGGX Eukaryota
ENOG4111ZPQ LUCA
GeneTreeiENSGT00730000111186
HOGENOMiHOG000036834
HOVERGENiHBG054420
InParanoidiQ96DD7
OMAiCGTCYQR
OrthoDBiEOG091G0MPG
PhylomeDBiQ96DD7
TreeFamiTF332572

Family and domain databases

InterProiView protein in InterPro
IPR026910 Shisa
PANTHERiPTHR31395 PTHR31395, 1 hit
PfamiView protein in Pfam
PF13908 Shisa, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96DD7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPAGLRRAA PLTAIALLVL GAPLVLAGED CLWYLDRNGS WHPGFNCEFF
60 70 80 90 100
TFCCGTCYHR YCCRDLTLLI TERQQKHCLA FSPKTIAGIA SAVILFVAVV
110 120 130 140 150
ATTICCFLCS CCYLYRRRQQ LQSPFEGQEI PMTGIPVQPV YPYPQDPKAG
160 170 180 190
PAPPQPGFIY PPSGPAPQYP LYPAGPPVYN PAAPPPYMPP QPSYPGA
Length:197
Mass (Da):21,522
Last modified:November 30, 2010 - v3
Checksum:iD2D8DDB195D6AD8A
GO

Sequence cautioni

The sequence AAH09558 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028811159I → M3 PublicationsCorresponds to variant dbSNP:rs2250377Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358589 mRNA Translation: AAQ88952.1
AK294106 mRNA Translation: BAG57441.1
AK316312 mRNA Translation: BAH14683.1
AL513217 Genomic DNA No translation available.
BC009558 mRNA Translation: AAH09558.1 Different initiation.
BC061908 mRNA Translation: AAH61908.1
BC104444 mRNA Translation: AAI04445.1
BC104445 mRNA Translation: AAI04446.1
BC111855 mRNA Translation: AAI11856.1
CCDSiCCDS1416.1
RefSeqiNP_937792.2, NM_198149.2
XP_016855908.1, XM_017000419.1
UniGeneiHs.632471

Genome annotation databases

EnsembliENST00000362011; ENSP00000355064; ENSG00000198892
GeneIDi149345
KEGGihsa:149345
UCSCiuc001gxa.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358589 mRNA Translation: AAQ88952.1
AK294106 mRNA Translation: BAG57441.1
AK316312 mRNA Translation: BAH14683.1
AL513217 Genomic DNA No translation available.
BC009558 mRNA Translation: AAH09558.1 Different initiation.
BC061908 mRNA Translation: AAH61908.1
BC104444 mRNA Translation: AAI04445.1
BC104445 mRNA Translation: AAI04446.1
BC111855 mRNA Translation: AAI11856.1
CCDSiCCDS1416.1
RefSeqiNP_937792.2, NM_198149.2
XP_016855908.1, XM_017000419.1
UniGeneiHs.632471

3D structure databases

ProteinModelPortaliQ96DD7
SMRiQ96DD7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ96DD7, 3 interactors
STRINGi9606.ENSP00000355064

PTM databases

PhosphoSitePlusiQ96DD7

Polymorphism and mutation databases

BioMutaiSHISA4
DMDMi313104251

Proteomic databases

MaxQBiQ96DD7
PaxDbiQ96DD7
PeptideAtlasiQ96DD7
PRIDEiQ96DD7
ProteomicsDBi76282

Protocols and materials databases

DNASUi149345
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000362011; ENSP00000355064; ENSG00000198892
GeneIDi149345
KEGGihsa:149345
UCSCiuc001gxa.4 human

Organism-specific databases

CTDi149345
EuPathDBiHostDB:ENSG00000198892.6
GeneCardsiSHISA4
H-InvDBiHIX0200035
HGNCiHGNC:27139 SHISA4
HPAiHPA061273
MIMi617326 gene
neXtProtiNX_Q96DD7
OpenTargetsiENSG00000198892
PharmGKBiPA162403294
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGGX Eukaryota
ENOG4111ZPQ LUCA
GeneTreeiENSGT00730000111186
HOGENOMiHOG000036834
HOVERGENiHBG054420
InParanoidiQ96DD7
OMAiCGTCYQR
OrthoDBiEOG091G0MPG
PhylomeDBiQ96DD7
TreeFamiTF332572

Miscellaneous databases

ChiTaRSiSHISA4 human
GenomeRNAii149345
PROiPR:Q96DD7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198892 Expressed in 91 organ(s), highest expression level in muscle of leg
CleanExiHS_SHISA4
GenevisibleiQ96DD7 HS

Family and domain databases

InterProiView protein in InterPro
IPR026910 Shisa
PANTHERiPTHR31395 PTHR31395, 1 hit
PfamiView protein in Pfam
PF13908 Shisa, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSHSA4_HUMAN
AccessioniPrimary (citable) accession number: Q96DD7
Secondary accession number(s): B4DFI0
, B7ZAJ7, Q5VUU1, Q6P711, Q6UWY7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 30, 2010
Last modified: November 7, 2018
This is version 105 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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