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Protein

Ubiquitin thioesterase OTUB2

Gene

OTUB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of 'Lys-11'-,'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains.3 Publications

Miscellaneous

In the structure described by PubMed:15258613, the Asp-48 active site of the catalytic triad is located too far to interact directly with the active site His-224. A possible explanation is that OTUB2 is in inactive conformation in absence of ubiquitin and a conformation change may move Asp-48 in the proximity of His-224 in presence of ubiquitin substrate.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei481 Publication1
Active sitei51Nucleophile2 Publications1
Active sitei2241 Publication1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei226Required to orient and stabilize the active site H-2241 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • NEDD8-specific protease activity Source: GO_Central
  • thiol-dependent ubiquitin-specific protease activity Source: UniProtKB
  • ubiquitin binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5689896 Ovarian tumor domain proteases

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C65.002

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ubiquitin thioesterase OTUB2 (EC:3.4.19.121 Publication)
Alternative name(s):
Deubiquitinating enzyme OTUB2
OTU domain-containing ubiquitin aldehyde-binding protein 2
Otubain-2
Ubiquitin-specific-processing protease OTUB2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OTUB2
Synonyms:C14orf137, OTB2, OTU2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000089723.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20351 OTUB2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608338 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96DC9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi47G → P: Affects its ability to cleave 'K63'-linked ubiquitin. 1 Publication1
Mutagenesisi51C → S: Loss of function in vitro. 1 Publication1
Mutagenesisi226N → A: Abolishes deubiquitinase activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
78990

Open Targets

More...
OpenTargetsi
ENSG00000089723

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134861658

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
OTUB2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
44888285

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002210101 – 234Ubiquitin thioesterase OTUB2Add BLAST234

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96DC9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96DC9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96DC9

PeptideAtlas

More...
PeptideAtlasi
Q96DC9

PRoteomics IDEntifications database

More...
PRIDEi
Q96DC9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
76278
76279 [Q96DC9-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96DC9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96DC9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Expressed at higher level in brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000089723 Expressed in 150 organ(s), highest expression level in sperm

CleanEx database of gene expression profiles

More...
CleanExi
HS_OTUB2

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96DC9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA002329

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122461, 42 interactors

Protein interaction database and analysis system

More...
IntActi
Q96DC9, 24 interactors

Molecular INTeraction database

More...
MINTi
Q96DC9

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000203664

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1234
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q96DC9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96DC9

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q96DC9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini40 – 231OTUPROSITE-ProRule annotationAdd BLAST192

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C65 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3991 Eukaryota
ENOG410ZMN7 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006979

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000019496

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG053383

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96DC9

KEGG Orthology (KO)

More...
KOi
K09603

Identification of Orthologs from Complete Genome Data

More...
OMAi
ATECDHV

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0GDO

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96DC9

TreeFam database of animal gene trees

More...
TreeFami
TF314145

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003323 OTU_dom
IPR030299 OTUB2
IPR016615 Otubain
IPR038765 Papain_like_cys_pep_sf
IPR019400 Peptidase_C65_otubain

The PANTHER Classification System

More...
PANTHERi
PTHR12931 PTHR12931, 1 hit
PTHR12931:SF3 PTHR12931:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10275 Peptidase_C65, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF013503 Ubiquitin_thioesterase_Otubain, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001 SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50802 OTU, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q96DC9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSETSFNLIS EKCDILSILR DHPENRIYRR KIEELSKRFT AIRKTKGDGN
60 70 80 90 100
CFYRALGYSY LESLLGKSRE IFKFKERVLQ TPNDLLAAGF EEHKFRNFFN
110 120 130 140 150
AFYSVVELVE KDGSVSSLLK VFNDQSASDH IVQFLRLLTS AFIRNRADFF
160 170 180 190 200
RHFIDEEMDI KDFCTHEVEP MATECDHIQI TALSQALSIA LQVEYVDEMD
210 220 230
TALNHHVFPE AATPSVYLLY KTSHYNILYA ADKH
Length:234
Mass (Da):27,213
Last modified:March 1, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDF2DBD32A78F9929
GO
Isoform 2 (identifier: Q96DC9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-234: Missing.

Note: No experimental confirmation available.
Show »
Length:73
Mass (Da):8,637
Checksum:iD3382B36FCD3C74A
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00946574 – 234Missing in isoform 2. 1 PublicationAdd BLAST161

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY177201 mRNA Translation: AAO27703.1
AK025569 mRNA Translation: BAB15172.1
CR457345 mRNA Translation: CAG33626.1
AL079302 Genomic DNA No translation available.
BC009615 mRNA Translation: AAH09615.1
BC068058 mRNA Translation: AAH68058.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9917.1 [Q96DC9-1]

NCBI Reference Sequences

More...
RefSeqi
NP_075601.1, NM_023112.3 [Q96DC9-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.278815

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000203664; ENSP00000203664; ENSG00000089723 [Q96DC9-1]
ENST00000553723; ENSP00000451283; ENSG00000089723 [Q96DC9-2]
ENST00000617748; ENSP00000478628; ENSG00000277276 [Q96DC9-1]
ENST00000628711; ENSP00000487491; ENSG00000277276 [Q96DC9-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
78990

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:78990

UCSC genome browser

More...
UCSCi
uc001ych.5 human [Q96DC9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY177201 mRNA Translation: AAO27703.1
AK025569 mRNA Translation: BAB15172.1
CR457345 mRNA Translation: CAG33626.1
AL079302 Genomic DNA No translation available.
BC009615 mRNA Translation: AAH09615.1
BC068058 mRNA Translation: AAH68058.1
CCDSiCCDS9917.1 [Q96DC9-1]
RefSeqiNP_075601.1, NM_023112.3 [Q96DC9-1]
UniGeneiHs.278815

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TFFX-ray2.10A1-234[»]
4FJVX-ray2.05A/C1-234[»]
ProteinModelPortaliQ96DC9
SMRiQ96DC9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122461, 42 interactors
IntActiQ96DC9, 24 interactors
MINTiQ96DC9
STRINGi9606.ENSP00000203664

Protein family/group databases

MEROPSiC65.002

PTM databases

iPTMnetiQ96DC9
PhosphoSitePlusiQ96DC9

Polymorphism and mutation databases

BioMutaiOTUB2
DMDMi44888285

Proteomic databases

EPDiQ96DC9
MaxQBiQ96DC9
PaxDbiQ96DC9
PeptideAtlasiQ96DC9
PRIDEiQ96DC9
ProteomicsDBi76278
76279 [Q96DC9-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
78990
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000203664; ENSP00000203664; ENSG00000089723 [Q96DC9-1]
ENST00000553723; ENSP00000451283; ENSG00000089723 [Q96DC9-2]
ENST00000617748; ENSP00000478628; ENSG00000277276 [Q96DC9-1]
ENST00000628711; ENSP00000487491; ENSG00000277276 [Q96DC9-2]
GeneIDi78990
KEGGihsa:78990
UCSCiuc001ych.5 human [Q96DC9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
78990
DisGeNETi78990
EuPathDBiHostDB:ENSG00000089723.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
OTUB2
HGNCiHGNC:20351 OTUB2
HPAiHPA002329
MIMi608338 gene
neXtProtiNX_Q96DC9
OpenTargetsiENSG00000089723
PharmGKBiPA134861658

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3991 Eukaryota
ENOG410ZMN7 LUCA
GeneTreeiENSGT00390000006979
HOGENOMiHOG000019496
HOVERGENiHBG053383
InParanoidiQ96DC9
KOiK09603
OMAiATECDHV
OrthoDBiEOG091G0GDO
PhylomeDBiQ96DC9
TreeFamiTF314145

Enzyme and pathway databases

ReactomeiR-HSA-5689896 Ovarian tumor domain proteases

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
OTUB2 human
EvolutionaryTraceiQ96DC9

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
OTUB2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
78990

Protein Ontology

More...
PROi
PR:Q96DC9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000089723 Expressed in 150 organ(s), highest expression level in sperm
CleanExiHS_OTUB2
GenevisibleiQ96DC9 HS

Family and domain databases

InterProiView protein in InterPro
IPR003323 OTU_dom
IPR030299 OTUB2
IPR016615 Otubain
IPR038765 Papain_like_cys_pep_sf
IPR019400 Peptidase_C65_otubain
PANTHERiPTHR12931 PTHR12931, 1 hit
PTHR12931:SF3 PTHR12931:SF3, 1 hit
PfamiView protein in Pfam
PF10275 Peptidase_C65, 1 hit
PIRSFiPIRSF013503 Ubiquitin_thioesterase_Otubain, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50802 OTU, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOTUB2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96DC9
Secondary accession number(s): Q6IA10, Q9H6T1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2004
Last modified: December 5, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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