Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zymogen granule protein 16 homolog B

Gene

ZG16B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

It is uncertain whether Met-1, Met-13 or Met-31 is the initiator.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
Zymogen granule protein 16 homolog B
Gene namesi
Name:ZG16B
ORF Names:UNQ773/PRO1567
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000162078.11
HGNCiHGNC:30456 ZG16B
neXtProtiNX_Q96DA0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi124220
OpenTargetsiENSG00000162078
PharmGKBiPA164727732

Polymorphism and mutation databases

BioMutaiZG16B
DMDMi152031723

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 52Sequence analysisAdd BLAST52
ChainiPRO_000024807353 – 208Zymogen granule protein 16 homolog BAdd BLAST156

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi197N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ96DA0
MaxQBiQ96DA0
PaxDbiQ96DA0
PeptideAtlasiQ96DA0
PRIDEiQ96DA0
ProteomicsDBi76263

PTM databases

GlyConnecti1909
iPTMnetiQ96DA0
PhosphoSitePlusiQ96DA0

Expressioni

Gene expression databases

BgeeiENSG00000162078 Expressed in 131 organ(s), highest expression level in minor salivary gland
ExpressionAtlasiQ96DA0 baseline and differential
GenevisibleiQ96DA0 HS

Organism-specific databases

HPAiHPA041125
HPA053549

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
UBQLN2Q9UHD94EBI-953824,EBI-947187

Protein-protein interaction databases

BioGridi125855, 70 interactors
IntActiQ96DA0, 7 interactors
STRINGi9606.ENSP00000371715

Structurei

Secondary structure

1208
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ96DA0
SMRiQ96DA0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 185Jacalin-type lectinPROSITE-ProRule annotationAdd BLAST133

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi38 – 46Poly-Leu9

Sequence similaritiesi

Belongs to the jacalin lectin family.PROSITE-ProRule annotationCurated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JCVC Eukaryota
ENOG41115HP LUCA
GeneTreeiENSGT00530000063886
HOGENOMiHOG000155786
InParanoidiQ96DA0
OMAiWNYPLEE
OrthoDBiEOG091G0Y3H
PhylomeDBiQ96DA0
TreeFamiTF333440

Family and domain databases

Gene3Di2.100.10.30, 1 hit
InterProiView protein in InterPro
IPR001229 Jacalin-like_lectin_dom
IPR036404 Jacalin-like_lectin_dom_sf
PfamiView protein in Pfam
PF01419 Jacalin, 1 hit
SMARTiView protein in SMART
SM00915 Jacalin, 1 hit
SUPFAMiSSF51101 SSF51101, 1 hit
PROSITEiView protein in PROSITE
PS51752 JACALIN_LECTIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q96DA0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGAQGAQESI KAMWRVPGTT RRPVTGESPG MHRPEAMLLL LTLALLGGPT
60 70 80 90 100
WAGKMYGPGG GKYFSTTEDY DHEITGLRVS VGLLLVKSVQ VKLGDSWDVK
110 120 130 140 150
LGALGGNTQE VTLQPGEYIT KVFVAFQAFL RGMVMYTSKD RYFYFGKLDG
160 170 180 190 200
QISSAYPSQE GQVLVGIYGQ YQLLGIKSIG FEWNYPLEEP TTEPPVNLTY

SANSPVGR
Length:208
Mass (Da):22,739
Last modified:July 10, 2007 - v3
Checksum:i313B0ED64B24CDB2
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DGN4A0A0C4DGN4_HUMAN
Zymogen granule protein 16 homolog ...
ZG16B
178Annotation score:
I3L1H9I3L1H9_HUMAN
Zymogen granule protein 16 homolog ...
ZG16B
69Annotation score:
I3L3X0I3L3X0_HUMAN
Zymogen granule protein 16 homolog ...
ZG16B
95Annotation score:

Sequence cautioni

The sequence AAQ89380 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAG34753 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060067133M → V. Corresponds to variant dbSNP:rs35533993Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY359021 mRNA Translation: AAQ89380.1 Different initiation.
AC005361 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85462.1
BC009722 mRNA Translation: AAH09722.2
AK311810 mRNA Translation: BAG34753.1 Different initiation.
CCDSiCCDS10479.2
RefSeqiNP_660295.2, NM_145252.2
UniGeneiHs.105887

Genome annotation databases

EnsembliENST00000382280; ENSP00000371715; ENSG00000162078
ENST00000634500; ENSP00000489035; ENSG00000283056
GeneIDi124220
KEGGihsa:124220
UCSCiuc002cru.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY359021 mRNA Translation: AAQ89380.1 Different initiation.
AC005361 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85462.1
BC009722 mRNA Translation: AAH09722.2
AK311810 mRNA Translation: BAG34753.1 Different initiation.
CCDSiCCDS10479.2
RefSeqiNP_660295.2, NM_145252.2
UniGeneiHs.105887

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3AQGX-ray2.75A/B53-208[»]
ProteinModelPortaliQ96DA0
SMRiQ96DA0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125855, 70 interactors
IntActiQ96DA0, 7 interactors
STRINGi9606.ENSP00000371715

PTM databases

GlyConnecti1909
iPTMnetiQ96DA0
PhosphoSitePlusiQ96DA0

Polymorphism and mutation databases

BioMutaiZG16B
DMDMi152031723

Proteomic databases

EPDiQ96DA0
MaxQBiQ96DA0
PaxDbiQ96DA0
PeptideAtlasiQ96DA0
PRIDEiQ96DA0
ProteomicsDBi76263

Protocols and materials databases

DNASUi124220
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382280; ENSP00000371715; ENSG00000162078
ENST00000634500; ENSP00000489035; ENSG00000283056
GeneIDi124220
KEGGihsa:124220
UCSCiuc002cru.4 human

Organism-specific databases

CTDi124220
DisGeNETi124220
EuPathDBiHostDB:ENSG00000162078.11
GeneCardsiZG16B
HGNCiHGNC:30456 ZG16B
HPAiHPA041125
HPA053549
neXtProtiNX_Q96DA0
OpenTargetsiENSG00000162078
PharmGKBiPA164727732
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JCVC Eukaryota
ENOG41115HP LUCA
GeneTreeiENSGT00530000063886
HOGENOMiHOG000155786
InParanoidiQ96DA0
OMAiWNYPLEE
OrthoDBiEOG091G0Y3H
PhylomeDBiQ96DA0
TreeFamiTF333440

Miscellaneous databases

GeneWikiiLOC124220
GenomeRNAii124220
PROiPR:Q96DA0

Gene expression databases

BgeeiENSG00000162078 Expressed in 131 organ(s), highest expression level in minor salivary gland
ExpressionAtlasiQ96DA0 baseline and differential
GenevisibleiQ96DA0 HS

Family and domain databases

Gene3Di2.100.10.30, 1 hit
InterProiView protein in InterPro
IPR001229 Jacalin-like_lectin_dom
IPR036404 Jacalin-like_lectin_dom_sf
PfamiView protein in Pfam
PF01419 Jacalin, 1 hit
SMARTiView protein in SMART
SM00915 Jacalin, 1 hit
SUPFAMiSSF51101 SSF51101, 1 hit
PROSITEiView protein in PROSITE
PS51752 JACALIN_LECTIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiZG16B_HUMAN
AccessioniPrimary (citable) accession number: Q96DA0
Secondary accession number(s): A6NIY1, B2R4F6, Q6UW28
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: July 10, 2007
Last modified: November 7, 2018
This is version 118 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again