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UniProtKB - Q96D98 (EID2B_HUMAN)
Protein
EP300-interacting inhibitor of differentiation 2B
Gene
EID2B
Organism
Homo sapiens (Human)
Status
Functioni
Acts as a repressor of MYOD-dependent transcription, glucocorticoid receptor-dependent transcription, and muscle differentiation.
1 PublicationGO - Molecular functioni
- identical protein binding Source: IntAct
- transcription corepressor activity Source: GO_Central
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- muscle organ development Source: UniProtKB-KW
- negative regulation of myoblast differentiation Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: UniProtKB
Keywordsi
Molecular function | Developmental protein, Repressor |
Biological process | Differentiation, Myogenesis, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q96D98 |
SignaLinki | Q96D98 |
Names & Taxonomyi
Protein namesi | Recommended name: EP300-interacting inhibitor of differentiation 2BShort name: EID-2B Alternative name(s): EID-2-like inhibitor of differentiation 3 Short name: EID-3 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26796, EID2B |
MIMi | 617355, gene |
neXtProti | NX_Q96D98 |
VEuPathDBi | HostDB:ENSG00000176401 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nucleoplasm Source: GO_Central
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000176401 |
PharmGKBi | PA162384551 |
Miscellaneous databases
Pharosi | Q96D98, Tdark |
Genetic variation databases
BioMutai | EID2B |
DMDMi | 74731428 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000315903 | 1 – 161 | EP300-interacting inhibitor of differentiation 2BAdd BLAST | 161 |
Proteomic databases
MassIVEi | Q96D98 |
PaxDbi | Q96D98 |
PeptideAtlasi | Q96D98 |
PRIDEi | Q96D98 |
PTM databases
iPTMneti | Q96D98 |
PhosphoSitePlusi | Q96D98 |
Expressioni
Gene expression databases
Bgeei | ENSG00000176401, Expressed in cerebellar vermis and 176 other tissues |
Genevisiblei | Q96D98, HS |
Organism-specific databases
HPAi | ENSG00000176401, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer and heterodimer with EID2.
Interacts with HDAC1 and HDAC2.
1 PublicationBinary interactionsi
Q96D98
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 125972, 9 interactors |
IntActi | Q96D98, 11 interactors |
STRINGi | 9606.ENSP00000317564 |
Miscellaneous databases
RNActi | Q96D98, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 26 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 54 – 77 | DisorderedSequence analysisAdd BLAST | 24 |
Domaini
The C-terminal portion of EID2B is required for nuclear localization.1 Publication
Phylogenomic databases
eggNOGi | ENOG502TGX1, Eukaryota |
GeneTreei | ENSGT00940000154796 |
HOGENOMi | CLU_1721807_0_0_1 |
InParanoidi | Q96D98 |
OMAi | DANPPQM |
OrthoDBi | 1591360at2759 |
PhylomeDBi | Q96D98 |
TreeFami | TF337633 |
Family and domain databases
InterProi | View protein in InterPro IPR033258, EID IPR033259, EID-3 |
PANTHERi | PTHR15556, PTHR15556, 1 hit PTHR15556:SF4, PTHR15556:SF4, 1 hit |
i Sequence
Sequence statusi: Complete.
Q96D98-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAEPTGLLEM SELPGDSSVP QVGTASGVSD VLRGAVGGGV RVQEAREGPV
60 70 80 90 100
AEAARSMARM PGPVPGPIPS SVPGLASAPD PHQQLAFLEI NRQLLFREYL
110 120 130 140 150
DGSSMIPVRL LRDFEERRRL FVEGCKAREA AFDADPPQMD FAAVAFTVAL
160
TASEALSPLA D
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK096263 mRNA Translation: BAC04743.1 CH471126 Genomic DNA Translation: EAW56908.1 BC009725 mRNA Translation: AAH09725.2 |
CCDSi | CCDS12539.1 |
RefSeqi | NP_689574.1, NM_152361.2 |
Genome annotation databases
Ensembli | ENST00000326282; ENSP00000317564; ENSG00000176401 |
GeneIDi | 126272 |
KEGGi | hsa:126272 |
MANE-Selecti | ENST00000326282.5; ENSP00000317564.4; NM_152361.3; NP_689574.1 |
UCSCi | uc002olz.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK096263 mRNA Translation: BAC04743.1 CH471126 Genomic DNA Translation: EAW56908.1 BC009725 mRNA Translation: AAH09725.2 |
CCDSi | CCDS12539.1 |
RefSeqi | NP_689574.1, NM_152361.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 125972, 9 interactors |
IntActi | Q96D98, 11 interactors |
STRINGi | 9606.ENSP00000317564 |
PTM databases
iPTMneti | Q96D98 |
PhosphoSitePlusi | Q96D98 |
Genetic variation databases
BioMutai | EID2B |
DMDMi | 74731428 |
Proteomic databases
MassIVEi | Q96D98 |
PaxDbi | Q96D98 |
PeptideAtlasi | Q96D98 |
PRIDEi | Q96D98 |
Protocols and materials databases
Antibodypediai | 65436, 11 antibodies from 10 providers |
DNASUi | 126272 |
Genome annotation databases
Ensembli | ENST00000326282; ENSP00000317564; ENSG00000176401 |
GeneIDi | 126272 |
KEGGi | hsa:126272 |
MANE-Selecti | ENST00000326282.5; ENSP00000317564.4; NM_152361.3; NP_689574.1 |
UCSCi | uc002olz.1, human |
Organism-specific databases
CTDi | 126272 |
GeneCardsi | EID2B |
HGNCi | HGNC:26796, EID2B |
HPAi | ENSG00000176401, Low tissue specificity |
MIMi | 617355, gene |
neXtProti | NX_Q96D98 |
OpenTargetsi | ENSG00000176401 |
PharmGKBi | PA162384551 |
VEuPathDBi | HostDB:ENSG00000176401 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502TGX1, Eukaryota |
GeneTreei | ENSGT00940000154796 |
HOGENOMi | CLU_1721807_0_0_1 |
InParanoidi | Q96D98 |
OMAi | DANPPQM |
OrthoDBi | 1591360at2759 |
PhylomeDBi | Q96D98 |
TreeFami | TF337633 |
Enzyme and pathway databases
PathwayCommonsi | Q96D98 |
SignaLinki | Q96D98 |
Miscellaneous databases
BioGRID-ORCSi | 126272, 14 hits in 1050 CRISPR screens |
ChiTaRSi | EID2B, human |
GenomeRNAii | 126272 |
Pharosi | Q96D98, Tdark |
PROi | PR:Q96D98 |
RNActi | Q96D98, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000176401, Expressed in cerebellar vermis and 176 other tissues |
Genevisiblei | Q96D98, HS |
Family and domain databases
InterProi | View protein in InterPro IPR033258, EID IPR033259, EID-3 |
PANTHERi | PTHR15556, PTHR15556, 1 hit PTHR15556:SF4, PTHR15556:SF4, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | EID2B_HUMAN | |
Accessioni | Q96D98Primary (citable) accession number: Q96D98 Secondary accession number(s): Q8N8S0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | March 1, 2004 | |
Last modified: | February 23, 2022 | |
This is version 126 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot