Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

EP300-interacting inhibitor of differentiation 2B

Gene

EID2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a repressor of MYOD-dependent transcription, glucocorticoid receptor-dependent transcription, and muscle differentiation.1 Publication

GO - Molecular functioni

  • identical protein binding Source: IntAct

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Repressor
Biological processDifferentiation, Myogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
EP300-interacting inhibitor of differentiation 2B
Short name:
EID-2B
Alternative name(s):
EID-2-like inhibitor of differentiation 3
Short name:
EID-3
Gene namesi
Name:EID2BImported
Synonyms:EID31 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000176401.5
HGNCiHGNC:26796 EID2B
MIMi617355 gene
neXtProtiNX_Q96D98

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000176401
PharmGKBiPA162384551

Polymorphism and mutation databases

BioMutaiEID2B
DMDMi74731428

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003159031 – 161EP300-interacting inhibitor of differentiation 2BAdd BLAST161

Proteomic databases

PaxDbiQ96D98
PRIDEiQ96D98
ProteomicsDBi76262

Expressioni

Gene expression databases

BgeeiENSG00000176401 Expressed in 160 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_EID2B
HS_EID3
GenevisibleiQ96D98 HS

Organism-specific databases

HPAiHPA064185

Interactioni

Subunit structurei

Homodimer and heterodimer with EID2. Interacts with HDAC1 and HDAC2.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi125972, 5 interactors
IntActiQ96D98, 12 interactors
STRINGi9606.ENSP00000317564

Structurei

3D structure databases

ProteinModelPortaliQ96D98
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The C-terminal portion of EID2B is required for nuclear localization.1 Publication

Phylogenomic databases

eggNOGiENOG410KEN2 Eukaryota
ENOG411199A LUCA
GeneTreeiENSGT00530000064390
HOGENOMiHOG000054219
InParanoidiQ96D98
OMAiLFVEGCR
OrthoDBiEOG091G0XPE
PhylomeDBiQ96D98
TreeFamiTF337633

Family and domain databases

InterProiView protein in InterPro
IPR033258 EID
IPR033259 EID-3
PANTHERiPTHR15556 PTHR15556, 1 hit
PTHR15556:SF4 PTHR15556:SF4, 1 hit

Sequencei

Sequence statusi: Complete.

Q96D98-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEPTGLLEM SELPGDSSVP QVGTASGVSD VLRGAVGGGV RVQEAREGPV
60 70 80 90 100
AEAARSMARM PGPVPGPIPS SVPGLASAPD PHQQLAFLEI NRQLLFREYL
110 120 130 140 150
DGSSMIPVRL LRDFEERRRL FVEGCKAREA AFDADPPQMD FAAVAFTVAL
160
TASEALSPLA D
Length:161
Mass (Da):16,985
Last modified:March 1, 2004 - v2
Checksum:iF378CD438AB12661
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096263 mRNA Translation: BAC04743.1
CH471126 Genomic DNA Translation: EAW56908.1
BC009725 mRNA Translation: AAH09725.2
CCDSiCCDS12539.1
RefSeqiNP_689574.1, NM_152361.2
UniGeneiHs.135181

Genome annotation databases

EnsembliENST00000326282; ENSP00000317564; ENSG00000176401
GeneIDi126272
KEGGihsa:126272
UCSCiuc002olz.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096263 mRNA Translation: BAC04743.1
CH471126 Genomic DNA Translation: EAW56908.1
BC009725 mRNA Translation: AAH09725.2
CCDSiCCDS12539.1
RefSeqiNP_689574.1, NM_152361.2
UniGeneiHs.135181

3D structure databases

ProteinModelPortaliQ96D98
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125972, 5 interactors
IntActiQ96D98, 12 interactors
STRINGi9606.ENSP00000317564

Polymorphism and mutation databases

BioMutaiEID2B
DMDMi74731428

Proteomic databases

PaxDbiQ96D98
PRIDEiQ96D98
ProteomicsDBi76262

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326282; ENSP00000317564; ENSG00000176401
GeneIDi126272
KEGGihsa:126272
UCSCiuc002olz.1 human

Organism-specific databases

CTDi126272
EuPathDBiHostDB:ENSG00000176401.5
GeneCardsiEID2B
HGNCiHGNC:26796 EID2B
HPAiHPA064185
MIMi617355 gene
neXtProtiNX_Q96D98
OpenTargetsiENSG00000176401
PharmGKBiPA162384551
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KEN2 Eukaryota
ENOG411199A LUCA
GeneTreeiENSGT00530000064390
HOGENOMiHOG000054219
InParanoidiQ96D98
OMAiLFVEGCR
OrthoDBiEOG091G0XPE
PhylomeDBiQ96D98
TreeFamiTF337633

Miscellaneous databases

GenomeRNAii126272
PROiPR:Q96D98
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000176401 Expressed in 160 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_EID2B
HS_EID3
GenevisibleiQ96D98 HS

Family and domain databases

InterProiView protein in InterPro
IPR033258 EID
IPR033259 EID-3
PANTHERiPTHR15556 PTHR15556, 1 hit
PTHR15556:SF4 PTHR15556:SF4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEID2B_HUMAN
AccessioniPrimary (citable) accession number: Q96D98
Secondary accession number(s): Q8N8S0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2004
Last modified: November 7, 2018
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again