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Protein

60S ribosomal export protein NMD3

Gene

NMD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.2 Publications

GO - Molecular functioni

  • protein binding, bridging Source: ParkinsonsUK-UCL
  • ribosomal large subunit binding Source: ParkinsonsUK-UCL
  • RNA binding Source: UniProtKB

GO - Biological processi

  • positive regulation of protein binding Source: ParkinsonsUK-UCL
  • positive regulation of protein localization to nucleolus Source: ParkinsonsUK-UCL
  • positive regulation of RNA biosynthetic process Source: ParkinsonsUK-UCL
  • ribosomal large subunit export from nucleus Source: ParkinsonsUK-UCL

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal export protein NMD3
Short name:
hNMD3
Gene namesi
Name:NMD3
ORF Names:CGI-07
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000169251.12
HGNCiHGNC:24250 NMD3
MIMi611021 gene
neXtProtiNX_Q96D46

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi405K → A: Reduces accumulation in the nucleus. Loss of nucleolar localization; when associated with A-406. 1 Publication1
Mutagenesisi406K → A: Reduces accumulation in the nucleus. Loss of nucleolar localization; when associated with A-405. 1 Publication1
Mutagenesisi480L → A: Reduces nuclear export. 1 Publication1
Mutagenesisi484L → A: Reduces nuclear export. 2 Publications1
Mutagenesisi487L → A: Reduces nuclear export. 2 Publications1

Organism-specific databases

OpenTargetsiENSG00000169251
PharmGKBiPA134884140

Polymorphism and mutation databases

BioMutaiNMD3
DMDMi74731412

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003235611 – 50360S ribosomal export protein NMD3Add BLAST503

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei258PhosphoserineCombined sources1
Modified residuei433PhosphothreonineCombined sources1
Modified residuei468PhosphoserineCombined sources1
Modified residuei470PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ96D46
MaxQBiQ96D46
PaxDbiQ96D46
PeptideAtlasiQ96D46
PRIDEiQ96D46
ProteomicsDBi76251

PTM databases

iPTMnetiQ96D46
PhosphoSitePlusiQ96D46

Expressioni

Gene expression databases

BgeeiENSG00000169251
CleanExiHS_NMD3
ExpressionAtlasiQ96D46 baseline and differential
GenevisibleiQ96D46 HS

Organism-specific databases

HPAiHPA035019

Interactioni

Subunit structurei

Found in a 60S ribosomal subunit export complex with RAN and XPO1. Interacts with XPO1. Associates with the 60S ribosomal subunit.1 Publication

GO - Molecular functioni

  • protein binding, bridging Source: ParkinsonsUK-UCL

Protein-protein interaction databases

BioGridi119259, 72 interactors
DIPiDIP-53427N
IntActiQ96D46, 7 interactors
MINTiQ96D46
STRINGi9606.ENSP00000307525

Structurei

3D structure databases

ProteinModelPortaliQ96D46
SMRiQ96D46
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni425 – 503Necessary for the nuclear export of the 60S ribosomal subunitAdd BLAST79

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi405 – 422Nuclear and nucleolar localization signalAdd BLAST18
Motifi480 – 489Nuclear export signal10

Sequence similaritiesi

Belongs to the NMD3 family.Curated

Phylogenomic databases

eggNOGiKOG2613 Eukaryota
COG1499 LUCA
GeneTreeiENSGT00390000005104
HOGENOMiHOG000168152
HOVERGENiHBG055100
InParanoidiQ96D46
KOiK07562
PhylomeDBiQ96D46
TreeFamiTF105744

Family and domain databases

InterProiView protein in InterPro
IPR007064 NMD3
PfamiView protein in Pfam
PF04981 NMD3, 1 hit

Sequencei

Sequence statusi: Complete.

Q96D46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYMAESTDR SPGHILCCEC GVPISPNPAN ICVACLRSKV DISQGIPKQV
60 70 80 90 100
SISFCKQCQR YFQPPGTWIQ CALESRELLA LCLKKIKAPL SKVRLVDAGF
110 120 130 140 150
VWTEPHSKRL KVKLTIQKEV MNGAILQQVF VVDYVVQSQM CGDCHRVEAK
160 170 180 190 200
DFWKAVIQVR QKTLHKKTFY YLEQLILKYG MHQNTLRIKE IHDGLDFYYS
210 220 230 240 250
SKQHAQKMVE FLQCTVPCRY KASQRLISQD IHSNTYNYKS TFSVEIVPIC
260 270 280 290 300
KDNVVCLSPK LAQSLGNMNQ ICVCIRVTSA IHLIDPNTLQ VADIDGSTFW
310 320 330 340 350
SHPFNSLCHP KQLEEFIVME CSIVQDIKRA AGAGMISKKH TLGEVWVQKT
360 370 380 390 400
SEMNTDKQYF CRTHLGHLLN PGDLVLGFDL ANCNLNDEHV NKMNSDRVPD
410 420 430 440 450
VVLIKKSYDR TKRQRRRNWK LKELAREREN MDTDDERQYQ DFLEDLEEDE
460 470 480 490 500
AIRKNVNIYR DSAIPVESDT DDEGAPRISL AEMLEDLHIS QDATGEEGAS

MLT
Length:503
Mass (Da):57,603
Last modified:December 1, 2001 - v1
Checksum:i5CEFD4E41FE2EBC1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti319M → I in AAD27716 (PubMed:10810093).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0395466E → K1 PublicationCorresponds to variant dbSNP:rs12490341Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132941 mRNA Translation: AAD27716.1
CH471052 Genomic DNA Translation: EAW78618.1
CH471052 Genomic DNA Translation: EAW78619.1
BC013317 mRNA Translation: AAH13317.1
CCDSiCCDS3194.1
RefSeqiNP_057022.2, NM_015938.4
XP_005247568.1, XM_005247511.1
XP_005247569.1, XM_005247512.1
UniGeneiHs.598836

Genome annotation databases

EnsembliENST00000351193; ENSP00000307525; ENSG00000169251
ENST00000460469; ENSP00000419004; ENSG00000169251
GeneIDi51068
KEGGihsa:51068
UCSCiuc003feb.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNMD3_HUMAN
AccessioniPrimary (citable) accession number: Q96D46
Secondary accession number(s): D3DNM7, Q9Y2Z6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: December 1, 2001
Last modified: June 20, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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