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Protein

Hepatitis A virus cellular receptor 1

Gene

HAVCR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4 (By similarity). May play a role in kidney injury and repair.By similarity1 Publication
(Microbial infection) Acts as a receptor for Hepatitis A virus.2 Publications
(Microbial infection) Acts as a receptor for Ebolavirus and Marburg virus by binding exposed phosphatidyl-serine at the surface of virion membrane.1 Publication
(Microbial infection) Acts as a receptor for Dengue virus by binding exposed phosphatidyl-serine at the surface of virion membrane.1 Publication

Miscellaneous

The extracellular part of the protein can be cleaved and detected in urine and is in correlation with the expression in the kidney.

GO - Molecular functioni

  • virus receptor activity Source: CACAO

Keywordsi

Molecular functionHost cell receptor for virus entry, Receptor
Biological processHost-virus interaction

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatitis A virus cellular receptor 1
Short name:
HAVcr-1
Alternative name(s):
Kidney injury molecule 1
Short name:
KIM-1
T-cell immunoglobulin and mucin domain-containing protein 1
Short name:
TIMD-1
T-cell immunoglobulin mucin receptor 1
Short name:
TIM
Short name:
TIM-1
T-cell membrane protein 1
CD_antigen: CD365
Gene namesi
Name:HAVCR1
Synonyms:KIM1, TIM1, TIMD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000113249.12
HGNCiHGNC:17866 HAVCR1
MIMi606518 gene
neXtProtiNX_Q96D42

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 290ExtracellularSequence analysisAdd BLAST270
Transmembranei291 – 311HelicalSequence analysisAdd BLAST21
Topological domaini312 – 359CytoplasmicSequence analysisAdd BLAST48

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi26762
MalaCardsiHAVCR1
PharmGKBiPA134924567

Polymorphism and mutation databases

BioMutaiHAVCR1
DMDMi73919877

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001498121 – 359Hepatitis A virus cellular receptor 1Add BLAST339

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 105PROSITE-ProRule annotation
Disulfide bondi46 ↔ 57PROSITE-ProRule annotation
Disulfide bondi52 ↔ 104PROSITE-ProRule annotation
Glycosylationi65N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi258N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi272N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi286N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ96D42
PaxDbiQ96D42
PeptideAtlasiQ96D42
PRIDEiQ96D42
ProteomicsDBi76250

PTM databases

iPTMnetiQ96D42
PhosphoSitePlusiQ96D42

Expressioni

Tissue specificityi

Widely expressed, with highest levels in kidney and testis. Expressed by activated CD4+ T-cells during the development of helper T-cells responses.1 Publication

Inductioni

Up-regulated in the kidney in renal diseases (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000113249 Expressed in 77 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_HAVCR1
ExpressionAtlasiQ96D42 baseline and differential
GenevisibleiQ96D42 HS

Organism-specific databases

HPAiCAB075697
HPA007173

Interactioni

Subunit structurei

(Microbial infection) Interacts with hepatitis A virus capsid proteins.2 Publications

Protein-protein interaction databases

BioGridi117812, 1 interactor
IntActiQ96D42, 3 interactors
STRINGi9606.ENSP00000344844

Structurei

Secondary structure

1359
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ96D42
SMRiQ96D42
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 121Ig-like V-typeAdd BLAST101
Repeati138 – 14316
Repeati144 – 14926
Repeati150 – 15536
Repeati156 – 16045
Repeati161 – 16656
Repeati167 – 17266
Repeati173 – 17876
Repeati179 – 18486
Repeati185 – 19096
Repeati191 – 196106
Repeati197 – 202116

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni138 – 20211 X 6 AA approximate tandem repeats of V-P-T-T-T-T]Add BLAST65

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi130 – 205Thr-richAdd BLAST76

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. TIM family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZDR Eukaryota
ENOG410YSF7 LUCA
InParanoidiQ96D42
KOiK20413
PhylomeDBiQ96D42
TreeFamiTF336163

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q96D42-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHPQVVILSL ILHLADSVAG SVKVGGEAGP SVTLPCHYSG AVTSMCWNRG
60 70 80 90 100
SCSLFTCQNG IVWTNGTHVT YRKDTRYKLL GDLSRRDVSL TIENTAVSDS
110 120 130 140 150
GVYCCRVEHR GWFNDMKITV SLEIVPPKVT TTPIVTTVPT VTTVRTSTTV
160 170 180 190 200
PTTTTVPTTT VPTTMSIPTT TTVLTTMTVS TTTSVPTTTS IPTTTSVPVT
210 220 230 240 250
TTVSTFVPPM PLPRQNHEPV ATSPSSPQPA ETHPTTLQGA IRREPTSSPL
260 270 280 290 300
YSYTTDGNDT VTESSDGLWN NNQTQLFLEH SLLTANTTKG IYAGVCISVL
310 320 330 340 350
VLLALLGVII AKKYFFKKEV QQLSVSFSSL QIKALQNAVE KEVQAEDNIY

IENSLYATD
Length:359
Mass (Da):38,720
Last modified:August 30, 2005 - v2
Checksum:iD24BA2C932903ECA
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PFX0E9PFX0_HUMAN
Hepatitis A virus cellular receptor...
HAVCR1
401Annotation score:
E5RIF6E5RIF6_HUMAN
Hepatitis A virus cellular receptor...
HAVCR1
223Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti174L → P in AAC39862 (PubMed:9658108).Curated1

Polymorphismi

Infection by hepatitis A virus (HAV) protects individuals from atopy if they carry insertion of the variants Met-Thr-Thr-Val-Pro-157 and Met-Thr-Thr-Thr-Val-Pro-157. Modernisation has led to a reduction in HAV seroprevalence and thus, may be, to an increase of expression of atopy, such as asthma, allergic rhinitis and atopic dermatitis. Allelic variation does not affect HAV-infection rates in Caucasians, Asians and African Americans.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05608051S → L. Corresponds to variant dbSNP:rs2270922Ensembl.1
Natural variantiVAR_023321157P → PMTTTVP. 1
Natural variantiVAR_023322157P → PMTTVP3 Publications1
Natural variantiVAR_023323195Missing 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043724 mRNA Translation: AAC39862.1
CR457114 mRNA Translation: CAG33395.1
AC026777 Genomic DNA No translation available.
BC013325 mRNA Translation: AAH13325.1
RefSeqiNP_001166864.1, NM_001173393.2
NP_001295085.1, NM_001308156.1
NP_036338.2, NM_012206.3
UniGeneiHs.129711

Genome annotation databases

EnsembliENST00000339252; ENSP00000344844; ENSG00000113249
ENST00000523175; ENSP00000427898; ENSG00000113249
GeneIDi26762
KEGGihsa:26762
UCSCiuc003lwi.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043724 mRNA Translation: AAC39862.1
CR457114 mRNA Translation: CAG33395.1
AC026777 Genomic DNA No translation available.
BC013325 mRNA Translation: AAH13325.1
RefSeqiNP_001166864.1, NM_001173393.2
NP_001295085.1, NM_001308156.1
NP_036338.2, NM_012206.3
UniGeneiHs.129711

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5DZOX-ray1.30A22-127[»]
5F70X-ray1.80A21-123[»]
ProteinModelPortaliQ96D42
SMRiQ96D42
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117812, 1 interactor
IntActiQ96D42, 3 interactors
STRINGi9606.ENSP00000344844

PTM databases

iPTMnetiQ96D42
PhosphoSitePlusiQ96D42

Polymorphism and mutation databases

BioMutaiHAVCR1
DMDMi73919877

Proteomic databases

MaxQBiQ96D42
PaxDbiQ96D42
PeptideAtlasiQ96D42
PRIDEiQ96D42
ProteomicsDBi76250

Protocols and materials databases

DNASUi26762
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339252; ENSP00000344844; ENSG00000113249
ENST00000523175; ENSP00000427898; ENSG00000113249
GeneIDi26762
KEGGihsa:26762
UCSCiuc003lwi.3 human

Organism-specific databases

CTDi26762
DisGeNETi26762
EuPathDBiHostDB:ENSG00000113249.12
GeneCardsiHAVCR1
HGNCiHGNC:17866 HAVCR1
HPAiCAB075697
HPA007173
MalaCardsiHAVCR1
MIMi606518 gene
neXtProtiNX_Q96D42
PharmGKBiPA134924567
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZDR Eukaryota
ENOG410YSF7 LUCA
InParanoidiQ96D42
KOiK20413
PhylomeDBiQ96D42
TreeFamiTF336163

Miscellaneous databases

ChiTaRSiHAVCR1 human
GeneWikiiHAVCR1
GenomeRNAii26762
PROiPR:Q96D42
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000113249 Expressed in 77 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_HAVCR1
ExpressionAtlasiQ96D42 baseline and differential
GenevisibleiQ96D42 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHAVR1_HUMAN
AccessioniPrimary (citable) accession number: Q96D42
Secondary accession number(s): O43656
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: August 30, 2005
Last modified: October 10, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  4. SIMILARITY comments
    Index of protein domains and families
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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