UniProtKB - Q96D42 (HAVR1_HUMAN)
Hepatitis A virus cellular receptor 1
HAVCR1
Functioni
Phosphatidylserine receptor that plays an important functional role in regulatory B-cells homeostasis including generation, expansion and suppressor functions (By similarity).
As P-selectin/SELPLG ligand, plays a specialized role in activated but not naive T-cell trafficking during inflammatory responses (PubMed:24703780).
Controls thereby T-cell accumulation in the inflamed central nervous system (CNS) and the induction of autoimmune disease (PubMed:24703780).
Regulates also expression of various anti-inflammatory cytokines and co-inhibitory ligands including IL10 (By similarity).
Acts as regulator of T-cell proliferation (By similarity).
May play a role in kidney injury and repair (PubMed:17471468).
By similarity2 Publications(Microbial infection) Acts as a receptor for Hepatitis A virus.
2 Publications(Microbial infection) Acts as a receptor for Ebolavirus and Marburg virus by binding exposed phosphatidyl-serine at the surface of virion membrane (PubMed:21536871).
Serves as a dual receptor for Ebolavirus by also interacting with envelope glycoprotein GP (PubMed:26487564).
2 Publications(Microbial infection) Acts as a receptor for Dengue virus by binding exposed phosphatidyl-serine at the surface of virion membrane (PubMed:23084921).
TIM1 and Dengue virus are co-internalized during virus entry (PubMed:29742433).
2 Publications(Microbial infection) Acts as a receptor for Zika virus by binding to envelope protein E.
1 Publication(Microbial infection) Plays a positive role in Chikungunya virus cell entry.
1 PublicationMiscellaneous
GO - Molecular functioni
- phosphatidylserine binding Source: GO_Central
- virus receptor activity Source: CACAO
GO - Biological processi
- phagocytosis, engulfment Source: GO_Central
- positive regulation of mast cell activation Source: GO_Central
Keywordsi
Molecular function | Host cell receptor for virus entry, Receptor |
Biological process | Host-virus interaction |
Enzyme and pathway databases
PathwayCommonsi | Q96D42 |
SignaLinki | Q96D42 |
Names & Taxonomyi
Protein namesi | Recommended name: Hepatitis A virus cellular receptor 1Short name: HAVcr-1 Alternative name(s): Kidney injury molecule 1 Short name: KIM-1 T-cell immunoglobulin and mucin domain-containing protein 1 Short name: TIMD-1 T-cell immunoglobulin mucin receptor 1 Short name: TIM Short name: TIM-1 T-cell membrane protein 1 CD_antigen: CD365 |
Gene namesi | Name:HAVCR1 Synonyms:KIM1, TIM1, TIMD1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17866, HAVCR1 |
MIMi | 606518, gene |
neXtProti | NX_Q96D42 |
VEuPathDBi | HostDB:ENSG00000113249 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein Curated
Other locations
- cell surface Source: GO_Central
- integral component of membrane Source: UniProtKB-KW
- motile cilium Source: CACAO
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 21 – 295 | ExtracellularSequence analysisAdd BLAST | 275 | |
Transmembranei | 296 – 316 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 317 – 364 | CytoplasmicSequence analysisAdd BLAST | 48 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 114 | N → A: About 60% loss of Chikungunya virus entry. 1 Publication | 1 | |
Mutagenesisi | 115 | D → A: About 25% loss of Chikungunya virus entry. 1 Publication | 1 | |
Mutagenesisi | 338 | K → R: About 50% loss of ubiquitination. 1 Publication | 1 | |
Mutagenesisi | 338 | K → R: Complete loss of ubiquitination; when associated with R-346. 1 Publication | 1 | |
Mutagenesisi | 346 | K → R: About 50% loss of ubiquitination. 1 Publication | 1 | |
Mutagenesisi | 346 | K → R: Complete loss of ubiquitination; when associated with R-338. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 26762 |
OpenTargetsi | ENSG00000113249 |
PharmGKBi | PA134924567 |
Miscellaneous databases
Pharosi | Q96D42, Tbio |
Genetic variation databases
BioMutai | HAVCR1 |
DMDMi | 73919877 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000014981 | 21 – 364 | Hepatitis A virus cellular receptor 1Add BLAST | 344 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 36 ↔ 105 | PROSITE-ProRule annotationCombined sources1 Publication | ||
Disulfide bondi | 46 ↔ 57 | PROSITE-ProRule annotationCombined sources1 Publication | ||
Disulfide bondi | 52 ↔ 104 | PROSITE-ProRule annotationCombined sources1 Publication | ||
Glycosylationi | 65 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 263 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 277 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 291 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Cross-linki | 338 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication | ||
Cross-linki | 346 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, Isopeptide bond, Ubl conjugationProteomic databases
jPOSTi | Q96D42 |
MassIVEi | Q96D42 |
MaxQBi | Q96D42 |
PaxDbi | Q96D42 |
PeptideAtlasi | Q96D42 |
PRIDEi | Q96D42 |
ProteomicsDBi | 76250 |
PTM databases
GlyGeni | Q96D42, 5 sites, 1 O-linked glycan (1 site) |
iPTMneti | Q96D42 |
PhosphoSitePlusi | Q96D42 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000113249, Expressed in colon and 98 other tissues |
ExpressionAtlasi | Q96D42, baseline and differential |
Genevisiblei | Q96D42, HS |
Organism-specific databases
HPAi | ENSG00000113249, Group enriched (intestine, kidney) |
Interactioni
Subunit structurei
(Microbial infection) Interacts with hepatitis A virus capsid proteins.
2 Publications(Microbial infection) Interacts with Ebolavirus envelope glycoprotein GP.
1 Publication(Microbial infection) Interacts with Zika virus envelope protein E.
1 PublicationBinary interactionsi
Q96D42
With | #Exp. | IntAct |
---|---|---|
S [P0DTC2] from Severe acute respiratory syndrome coronavirus 2. | 7 | EBI-953786,EBI-25474821 |
Protein-protein interaction databases
BioGRIDi | 117812, 28 interactors |
IntActi | Q96D42, 5 interactors |
STRINGi | 9606.ENSP00000344844 |
Miscellaneous databases
RNActi | Q96D42, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q96D42 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 21 – 121 | Ig-like V-typeAdd BLAST | 101 | |
Repeati | 138 – 143 | 1 | 6 | |
Repeati | 144 – 149 | 2 | 6 | |
Repeati | 150 – 155 | 3 | 6 | |
Repeati | 156 – 160 | 4 | 5 | |
Repeati | 161 – 165 | 5 | 5 | |
Repeati | 166 – 171 | 6 | 6 | |
Repeati | 172 – 177 | 7 | 6 | |
Repeati | 178 – 183 | 8 | 6 | |
Repeati | 184 – 189 | 9 | 6 | |
Repeati | 190 – 195 | 10 | 6 | |
Repeati | 196 – 201 | 11 | 6 | |
Repeati | 202 – 207 | 12 | 6 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 138 – 207 | 12 X 6 AA approximate tandem repeats of V-P-T-T-T-T]Add BLAST | 70 | |
Regioni | 216 – 257 | DisorderedSequence analysisAdd BLAST | 42 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 223 – 257 | Polar residuesSequence analysisAdd BLAST | 35 |
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S454, Eukaryota |
GeneTreei | ENSGT00940000159345 |
HOGENOMi | CLU_047504_2_1_1 |
InParanoidi | Q96D42 |
OMAi | CRYNGAI |
PhylomeDBi | Q96D42 |
TreeFami | TF336163 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003599, Ig_sub IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MHPQVVILSL ILHLADSVAG SVKVGGEAGP SVTLPCHYSG AVTSMCWNRG
60 70 80 90 100
SCSLFTCQNG IVWTNGTHVT YRKDTRYKLL GDLSRRDVSL TIENTAVSDS
110 120 130 140 150
GVYCCRVEHR GWFNDMKITV SLEIVPPKVT TTPIVTTVPT VTTVRTSTTV
160 170 180 190 200
PTTTTVPMTT VPTTTVPTTM SIPTTTTVLT TMTVSTTTSV PTTTSIPTTT
210 220 230 240 250
SVPVTTTVST FVPPMPLPRQ NHEPVATSPS SPQPAETHPT TLQGAIRREP
260 270 280 290 300
TSSPLYSYTT DGNDTVTESS DGLWNNNQTQ LFLEHSLLTA NTTKGIYAGV
310 320 330 340 350
CISVLVLLAL LGVIIAKKYF FKKEVQQLSV SFSSLQIKAL QNAVEKEVQA
360
EDNIYIENSL YATD
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PFX0 | E9PFX0_HUMAN | Hepatitis A virus cellular receptor... | HAVCR1 | 401 | Annotation score: | ||
E5RIF6 | E5RIF6_HUMAN | Hepatitis A virus cellular receptor... | HAVCR1 | 223 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 179 | L → P in AAC39862 (PubMed:9658108).Curated | 1 |
Polymorphismi
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_056080 | 51 | S → L. Corresponds to variant dbSNP:rs2270922Ensembl. | 1 | |
Natural variantiVAR_081334 | 157 – 161 | Missing 2 Publications | 5 | |
Natural variantiVAR_023323 | 200 | Missing 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF043724 mRNA Translation: AAC39862.1 CR457114 mRNA Translation: CAG33395.1 AC026777 Genomic DNA No translation available. BC013325 mRNA Translation: AAH13325.1 |
CCDSi | CCDS43392.1 |
RefSeqi | NP_001166864.1, NM_001173393.2 NP_001295085.1, NM_001308156.1 NP_036338.2, NM_012206.3 |
Genome annotation databases
Ensembli | ENST00000339252; ENSP00000344844; ENSG00000113249 ENST00000523175; ENSP00000427898; ENSG00000113249 |
GeneIDi | 26762 |
KEGGi | hsa:26762 |
MANE-Selecti | ENST00000523175.6; ENSP00000427898.1; NM_001173393.3; NP_001166864.1 |
UCSCi | uc003lwi.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF043724 mRNA Translation: AAC39862.1 CR457114 mRNA Translation: CAG33395.1 AC026777 Genomic DNA No translation available. BC013325 mRNA Translation: AAH13325.1 |
CCDSi | CCDS43392.1 |
RefSeqi | NP_001166864.1, NM_001173393.2 NP_001295085.1, NM_001308156.1 NP_036338.2, NM_012206.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5DZO | X-ray | 1.30 | A | 22-127 | [»] | |
5F70 | X-ray | 1.80 | A | 21-123 | [»] | |
SMRi | Q96D42 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 117812, 28 interactors |
IntActi | Q96D42, 5 interactors |
STRINGi | 9606.ENSP00000344844 |
PTM databases
GlyGeni | Q96D42, 5 sites, 1 O-linked glycan (1 site) |
iPTMneti | Q96D42 |
PhosphoSitePlusi | Q96D42 |
Genetic variation databases
BioMutai | HAVCR1 |
DMDMi | 73919877 |
Proteomic databases
jPOSTi | Q96D42 |
MassIVEi | Q96D42 |
MaxQBi | Q96D42 |
PaxDbi | Q96D42 |
PeptideAtlasi | Q96D42 |
PRIDEi | Q96D42 |
ProteomicsDBi | 76250 |
Protocols and materials databases
Antibodypediai | 2353, 1034 antibodies from 36 providers |
DNASUi | 26762 |
Genome annotation databases
Ensembli | ENST00000339252; ENSP00000344844; ENSG00000113249 ENST00000523175; ENSP00000427898; ENSG00000113249 |
GeneIDi | 26762 |
KEGGi | hsa:26762 |
MANE-Selecti | ENST00000523175.6; ENSP00000427898.1; NM_001173393.3; NP_001166864.1 |
UCSCi | uc003lwi.3, human |
Organism-specific databases
CTDi | 26762 |
DisGeNETi | 26762 |
GeneCardsi | HAVCR1 |
HGNCi | HGNC:17866, HAVCR1 |
HPAi | ENSG00000113249, Group enriched (intestine, kidney) |
MIMi | 606518, gene |
neXtProti | NX_Q96D42 |
OpenTargetsi | ENSG00000113249 |
PharmGKBi | PA134924567 |
VEuPathDBi | HostDB:ENSG00000113249 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S454, Eukaryota |
GeneTreei | ENSGT00940000159345 |
HOGENOMi | CLU_047504_2_1_1 |
InParanoidi | Q96D42 |
OMAi | CRYNGAI |
PhylomeDBi | Q96D42 |
TreeFami | TF336163 |
Enzyme and pathway databases
PathwayCommonsi | Q96D42 |
SignaLinki | Q96D42 |
Miscellaneous databases
BioGRID-ORCSi | 26762, 6 hits in 1031 CRISPR screens |
ChiTaRSi | HAVCR1, human |
GeneWikii | HAVCR1 |
GenomeRNAii | 26762 |
Pharosi | Q96D42, Tbio |
PROi | PR:Q96D42 |
RNActi | Q96D42, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000113249, Expressed in colon and 98 other tissues |
ExpressionAtlasi | Q96D42, baseline and differential |
Genevisiblei | Q96D42, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003599, Ig_sub IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HAVR1_HUMAN | |
Accessioni | Q96D42Primary (citable) accession number: Q96D42 Secondary accession number(s): O43656 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 30, 2005 |
Last sequence update: | April 10, 2019 | |
Last modified: | February 23, 2022 | |
This is version 157 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families