UniProtKB - Q96D37 (Q96D37_HUMAN)
Protein
Submitted name:
Proto-oncogene vav
Gene
VAV1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- guanyl-nucleotide exchange factor activity Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- small GTPase mediated signal transduction Source: InterPro
Keywordsi
Molecular function | Guanine-nucleotide releasing factorARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Proto-oncogene vavImportedSubmitted name: VAV1 proteinImported |
Gene namesi | Name:VAV1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12657, VAV1 |
VEuPathDBi | HostDB:ENSG00000141968.7 |
Expressioni
Gene expression databases
Bgeei | ENSG00000141968, Expressed in blood and 142 other tissues |
ExpressionAtlasi | Q96D37, baseline and differential |
Interactioni
Binary interactionsi
Q96D37
With | #Exp. | IntAct |
---|---|---|
ERBB2 [P04626] | 2 | EBI-7875353,EBI-641062 |
Protein-protein interaction databases
IntActi | Q96D37, 28 interactors |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 64 | Calponin-homology (CH)InterPro annotationAdd BLAST | 64 | |
Domaini | 139 – 318 | DHInterPro annotationAdd BLAST | 180 | |
Domaini | 347 – 449 | PHInterPro annotationAdd BLAST | 103 | |
Domaini | 460 – 509 | Phorbol-ester/DAG-typeInterPro annotationAdd BLAST | 50 | |
Domaini | 537 – 605 | SH3InterPro annotationAdd BLAST | 69 | |
Domaini | 616 – 710 | SH2InterPro annotationAdd BLAST | 95 | |
Domaini | 727 – 787 | SH3InterPro annotationAdd BLAST | 61 |
Keywords - Domaini
SH2 domainPROSITE-ProRule annotationARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotation, Zinc-fingerARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000159125 |
OMAi | QPYISRP |
OrthoDBi | 710582at2759 |
Family and domain databases
CDDi | cd00029, C1, 1 hit cd01223, PH_Vav, 1 hit cd00160, RhoGEF, 1 hit cd10405, SH2_Vav1, 1 hit cd11979, SH3_VAV1_1, 1 hit cd11976, SH3_VAV1_2, 1 hit |
Gene3Di | 1.10.418.10, 1 hit 1.20.900.10, 1 hit 2.30.29.30, 1 hit 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR001715, CH-domain IPR036872, CH_dom_sf IPR035899, DBL_dom_sf IPR000219, DH-domain IPR001331, GDS_CDC24_CS IPR002219, PE/DAG-bd IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR037832, PH_Vav IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR028530, Vav1 IPR035879, VAV1_SH2 IPR035730, VAV1_SH3_1 IPR035729, VAV1_SH3_2 |
PANTHERi | PTHR45818:SF2, PTHR45818:SF2, 1 hit |
Pfami | View protein in Pfam PF00130, C1_1, 1 hit PF00307, CH, 1 hit PF00169, PH, 1 hit PF00621, RhoGEF, 1 hit PF00017, SH2, 1 hit PF00018, SH3_1, 2 hits |
PRINTSi | PR00401, SH2DOMAIN PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00109, C1, 1 hit SM00233, PH, 1 hit SM00325, RhoGEF, 1 hit SM00252, SH2, 1 hit SM00326, SH3, 2 hits |
SUPFAMi | SSF47576, SSF47576, 1 hit SSF48065, SSF48065, 1 hit SSF50044, SSF50044, 1 hit SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50021, CH, 1 hit PS00741, DH_1, 1 hit PS50010, DH_2, 1 hit PS50003, PH_DOMAIN, 1 hit PS50001, SH2, 1 hit PS50002, SH3, 2 hits PS00479, ZF_DAG_PE_1, 1 hit PS50081, ZF_DAG_PE_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q96D37-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIVLPLYSRL DKRFLCLKNI RTFLSTCCEK FGLKRSELFE AFDLFDVQDF
60 70 80 90 100
GKVIYTLSAL SWTPIAQNRG IMPFPTEEES VGDEDIYSGL SDQIDDTVEE
110 120 130 140 150
DEDLYDCVEN EEAEGDEIYE DLMRSEPVSM PPKMTEYDKR CCCLREIQQT
160 170 180 190 200
EEKYTDTLGS IQQHFLKPLQ RFLKPQDIEI IFINIEDLLR VHTHFLKEMK
210 220 230 240 250
EALGTPGAAN LYQVFIKYKE RFLVYGRYCS QVESASKHLD RVAAAREDVQ
260 270 280 290 300
MKLEECSQRA NNGRFTLRDL LMVPMQRVLK YHLLLQELVK HTQEAMEKEN
310 320 330 340 350
LRLALDAMRD LAQCVNEVKR DNETLRQITN FQLSIENLDQ SLAHYGRPKI
360 370 380 390 400
DGELKITSVE RRSKMDRYAF LLDKALLICK RRGDSYDLKD FVNLHSFQVR
410 420 430 440 450
DDSSGDRDNK KWSHMFLLIE DQGAQGYELF FKTRELKKKW MEQFEMAISN
460 470 480 490 500
IYPENATANG HDFQMFSFEE TTSCKACQML LRGTFYQGYR CHRCRASAHK
510 520 530 540 550
ECLGRVPPCG RHGQDFPGTM KKDKLHRRAQ DKKRNELGLP KMEVFQEYYG
560 570 580 590 600
LPPPPGAIGP FLRLNPGDIV ELTKAEAEQN WWEGRNTSTN EIGWFPCNRV
610 620 630 640 650
KPYVHGPPQD LSVHLWYAGP MERAGAESIL ANRSDGTFLV RQRVKDAAEF
660 670 680 690 700
AISIKYNVEV KHIKIMTAEG LYRITEKKAF RGLTELVEFY QQNSLKDCFK
710 720 730 740 750
SLDTTLQFPF KEPEKRTISR PAVGSTKYFG TAKARYDFCA RDRSELSLKE
760 770 780 790
GDIIKILNKK GQQGWWRGEI YGRVGWFPAN YVEEDYSEYC
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP15498 | VAV_HUMAN | Proto-oncogene vav | VAV1 VAV | 845 | Annotation score: | ||
A0A0A0MR07 | A0A0A0MR07_HUMAN | Proto-oncogene vav | VAV1 | 823 | Annotation score: | ||
F5H5P4 | F5H5P4_HUMAN | Proto-oncogene vav | VAV1 | 789 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC010647 Genomic DNA No translation available. AC020895 Genomic DNA No translation available. AC020954 Genomic DNA No translation available. AC022156 Genomic DNA No translation available. BC013361 mRNA Translation: AAH13361.2 |
RefSeqi | NP_001245135.1, NM_001258206.1 NP_001245136.1, NM_001258207.1 NP_005419.2, NM_005428.3 |
Genome annotation databases
Ensembli | ENST00000599806; ENSP00000472803; ENSG00000141968 |
GeneIDi | 7409 |
KEGGi | hsa:7409 |
UCSCi | uc002mfv.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC010647 Genomic DNA No translation available. AC020895 Genomic DNA No translation available. AC020954 Genomic DNA No translation available. AC022156 Genomic DNA No translation available. BC013361 mRNA Translation: AAH13361.2 |
RefSeqi | NP_001245135.1, NM_001258206.1 NP_001245136.1, NM_001258207.1 NP_005419.2, NM_005428.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q96D37, 28 interactors |
Proteomic databases
PRIDEi | Q96D37 |
Protocols and materials databases
Antibodypediai | 665, 742 antibodies |
DNASUi | 7409 |
Genome annotation databases
Ensembli | ENST00000599806; ENSP00000472803; ENSG00000141968 |
GeneIDi | 7409 |
KEGGi | hsa:7409 |
UCSCi | uc002mfv.2, human |
Organism-specific databases
CTDi | 7409 |
HGNCi | HGNC:12657, VAV1 |
OpenTargetsi | ENSG00000141968 |
VEuPathDBi | HostDB:ENSG00000141968.7 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000159125 |
OMAi | QPYISRP |
OrthoDBi | 710582at2759 |
Miscellaneous databases
BioGRID-ORCSi | 7409, 7 hits in 990 CRISPR screens |
ChiTaRSi | VAV1, human |
GenomeRNAii | 7409 |
Gene expression databases
Bgeei | ENSG00000141968, Expressed in blood and 142 other tissues |
ExpressionAtlasi | Q96D37, baseline and differential |
Family and domain databases
CDDi | cd00029, C1, 1 hit cd01223, PH_Vav, 1 hit cd00160, RhoGEF, 1 hit cd10405, SH2_Vav1, 1 hit cd11979, SH3_VAV1_1, 1 hit cd11976, SH3_VAV1_2, 1 hit |
Gene3Di | 1.10.418.10, 1 hit 1.20.900.10, 1 hit 2.30.29.30, 1 hit 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR001715, CH-domain IPR036872, CH_dom_sf IPR035899, DBL_dom_sf IPR000219, DH-domain IPR001331, GDS_CDC24_CS IPR002219, PE/DAG-bd IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR037832, PH_Vav IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR028530, Vav1 IPR035879, VAV1_SH2 IPR035730, VAV1_SH3_1 IPR035729, VAV1_SH3_2 |
PANTHERi | PTHR45818:SF2, PTHR45818:SF2, 1 hit |
Pfami | View protein in Pfam PF00130, C1_1, 1 hit PF00307, CH, 1 hit PF00169, PH, 1 hit PF00621, RhoGEF, 1 hit PF00017, SH2, 1 hit PF00018, SH3_1, 2 hits |
PRINTSi | PR00401, SH2DOMAIN PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00109, C1, 1 hit SM00233, PH, 1 hit SM00325, RhoGEF, 1 hit SM00252, SH2, 1 hit SM00326, SH3, 2 hits |
SUPFAMi | SSF47576, SSF47576, 1 hit SSF48065, SSF48065, 1 hit SSF50044, SSF50044, 1 hit SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50021, CH, 1 hit PS00741, DH_1, 1 hit PS50010, DH_2, 1 hit PS50003, PH_DOMAIN, 1 hit PS50001, SH2, 1 hit PS50002, SH3, 2 hits PS00479, ZF_DAG_PE_1, 1 hit PS50081, ZF_DAG_PE_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q96D37_HUMAN | |
Accessioni | Q96D37Primary (citable) accession number: Q96D37 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 1, 2001 |
Last sequence update: | March 1, 2004 | |
Last modified: | April 7, 2021 | |
This is version 163 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |