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Entry version 163 (29 Sep 2021)
Sequence version 2 (16 May 2006)
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Protein

Calcium release-activated calcium channel protein 1

Gene

ORAI1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ca2+ release-activated Ca2+ (CRAC) channel subunit which mediates Ca2+ influx following depletion of intracellular Ca2+ stores and channel activation by the Ca2+ sensor, STIM1 (PubMed:16582901, PubMed:16645049, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:19249086, PubMed:23307288, PubMed:24351972, PubMed:24591628, PubMed:28219928, PubMed:20354224, PubMed:26956484).

CRAC channels are the main pathway for Ca2+ influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT (PubMed:16582901).

Plays a prominent role in Ca2+ influx at the basolateral membrane of mammary epithelial cells independently of the Ca2+ content of endoplasmic reticulum or Golgi stores. May mediate transepithelial transport of large quantities of Ca2+ for milk secretion.

By similarity13 Publications

Miscellaneous

In Greek mythology, the 'Orai' are the keepers of the gates of heaven: Eunomia (order or harmony), Dike (justice) and Eirene (peace).1 Publication

Caution

According to a report, ORAI1 has been shown to colocalize with UBQLN1 in the autophagosome as a target for autophagic degradation; ORAI1 is however not an autophagosomal protein.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Oxidation at Cys-195 leads to inactivation of channel activity.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channel, Calmodulin-binding, Ion channel
Biological processAdaptive immunity, Calcium transport, Immunity, Ion transport, Transport
LigandCalcium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q96D31

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-139853, Elevation of cytosolic Ca2+ levels
R-HSA-5578775, Ion homeostasis
R-HSA-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

SIGNOR Signaling Network Open Resource

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SIGNORi
Q96D31

Protein family/group databases

Transport Classification Database

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TCDBi
1.A.52.1.1, the ca(2+) release-activated ca(2+) (crac) channel (crac-c) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calcium release-activated calcium channel protein 1
Alternative name(s):
Protein orai-1
Transmembrane protein 142A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ORAI1
Synonyms:CRACM1, TMEM142A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:25896, ORAI1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
610277, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q96D31

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
HostDB:ENSG00000276045

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 87Cytoplasmic1 PublicationAdd BLAST87
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei88 – 105HelicalSequence analysisAdd BLAST18
Topological domaini106 – 119ExtracellularSequence analysisAdd BLAST14
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21
Topological domaini141 – 173CytoplasmicSequence analysisAdd BLAST33
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Topological domaini195 – 234ExtracellularSequence analysisAdd BLAST40
Transmembranei235 – 255HelicalSequence analysisAdd BLAST21
Topological domaini256 – 301Cytoplasmic1 PublicationAdd BLAST46

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Immunodeficiency 9 (IMD9)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn immune disorder characterized by recurrent infections, impaired activation and proliferative response of T-cells, decreased T-cell production of cytokines, and normal lymphocytes counts and serum immunoglobulin levels. In surviving patients ectodermal dysplasia with anhidrosis and non-progressive myopathy may be observed.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02622691R → W in IMD9. 1 PublicationCorresponds to variant dbSNP:rs118203993EnsemblClinVar.1
Myopathy, tubular aggregate, 2 (TAM2)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA rare congenital myopathy characterized by regular arrays of membrane tubules on muscle biopsies without additional histopathological hallmarks. Tubular aggregates in muscle are structures of variable appearance consisting of an outer tubule containing either one or more microtubule-like structures or amorphous material. TAM2 patients have myopathy and pupillary abnormalities.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07808398G → S in TAM2; constitutively active Ca(+2) channel, independently of STIM proteins; no effect on localization to the cell membrane. 1 PublicationCorresponds to variant dbSNP:rs786204796EnsemblClinVar.1
Natural variantiVAR_078084107V → M in TAM2; constitutively active Ca(+2) channel, independently of STIM proteins; no effect on localization to the cell membrane. 1 Publication1
Natural variantiVAR_078085184T → M in TAM2; mediates excessive Ca(2+) entry when gated by STIM1; no effect on localization to the cell membrane. 1 PublicationCorresponds to variant dbSNP:rs1555324111Ensembl.1
Natural variantiVAR_071473245P → L in TAM2; increases activation of the Ca2+ release-activated Ca2+ (CRAC) channel. 1 PublicationCorresponds to variant dbSNP:rs587777528EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi85 – 87KLK → ALA: Impairs interaction with CRACR2A/EFCAB4B. 1 Publication3
Mutagenesisi195C → S: Abolishes oxidation and channel inhibition. 2 Publications1
Mutagenesisi223N → A: Increases channel activity in T cells but does not affect cell surface location. 1 Publication1
Mutagenesisi273L → S: Strongly reduces the interaction with ATP2C1. 1 Publication1
Mutagenesisi281R → A: Strongly reduces calcium current. 1 Publication1
Mutagenesisi284D → A: Reduces the maximum current; when associated with A-287 and A-291. 1 Publication1
Mutagenesisi286L → S: Strongly reduces calcium current. 1 Publication1
Mutagenesisi287D → A: Reduces the maximum current; when associated with A-284 and A-291. 1 Publication1
Mutagenesisi289R → A: Strongly reduces calcium current. 1 Publication1
Mutagenesisi291D → A: Reduces the maximum current; when associated with A-284 and A-287. 1 Publication1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...
DisGeNETi
84876

MalaCards human disease database

More...
MalaCardsi
ORAI1
MIMi612782, phenotype
615883, phenotype

Open Targets

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OpenTargetsi
ENSG00000276045

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
317428, Combined immunodeficiency due to ORAI1 deficiency
3204, Stormorken-Sjaastad-Langslet syndrome
2593, Tubular aggregate myopathy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA162398445

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q96D31, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL2384891

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
2964

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
ORAI1

Domain mapping of disease mutations (DMDM)

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DMDMi
97180269

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002343811 – 301Calcium release-activated calcium channel protein 1Add BLAST301

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi223N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei295PhosphothreonineCombined sources1
Modified residuei298PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated (PubMed:19249086, PubMed:26956484). N-glycosylation inhibits channel activity in T cells (PubMed:26956484).2 Publications
Ubiquitinated.1 Publication
Cys-195 is oxidated, leading to inactivation of channel activity.2 Publications

Keywords - PTMi

Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96D31

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q96D31

MaxQB - The MaxQuant DataBase

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MaxQBi
Q96D31

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96D31

PeptideAtlas

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PeptideAtlasi
Q96D31

PRoteomics IDEntifications database

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PRIDEi
Q96D31

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
76249 [Q96D31-1]

Consortium for Top Down Proteomics

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TopDownProteomicsi
Q96D31-2 [Q96D31-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

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GlyGeni
Q96D31, 1 site

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q96D31

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q96D31

SwissPalm database of S-palmitoylation events

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SwissPalmi
Q96D31

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in naive CD4 and CD8 T cells (at protein level) (PubMed:26956484). Expressed at similar levels in naive and effector T helper cells (PubMed:20354224).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000276045, Expressed in muscle of leg and 144 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96D31, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96D31, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000276045, Tissue enhanced (skeletal)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with STIM1 and STIM2; this regulates channel activity (PubMed:17905723, PubMed:19249086, PubMed:24351972, PubMed:28219928, PubMed:27185316, PubMed:30481768).

Interacts with CALM; this may displace STIM1 and STIM2 and might thereby modulate channel activity (PubMed:23109337).

Interacts with CRACR2A/EFCAB4B; the interaction is direct and takes place in absence of Ca2+ (PubMed:20418871).

Forms a complex with CRACR2A/EFCAB4B and STIM1 at low concentration of Ca2+, the complex dissociates at elevated Ca2+ concentrations.

Interacts with ASPH (isoform 8) (PubMed:22586105).

Interacts with SLC35G1 (PubMed:22084111).

Interacts with UBQLN1 (PubMed:23307288).

Interacts with ADCY8; interaction is calcium store depletion independent; interaction occurs in membrane raft; interaction increases markedly after store depletion; positively regulates SOCE-induced adenylate cyclase activity; contributes to the targeting of ADCY8 to discrete regions of the plasma membrane that are shielded from other calcium events (PubMed:22494970).

Interacts with EFHB; the interaction takes place upon Ca2+-store depletion (PubMed:30481768).

Interacts (via N- and C-termini) with ATP2C2 (via N-terminus); this interaction regulates Ca2+ influx at the plasma membrane.

12 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

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GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
124321, 38 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q96D31

Database of interacting proteins

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DIPi
DIP-46289N

Protein interaction database and analysis system

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IntActi
Q96D31, 14 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000480616

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
Q96D31

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q96D31, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1301
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

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BMRBi
Q96D31

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96D31

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 51DisorderedSequence analysisAdd BLAST51
Regioni70 – 90Interaction with STIM1Add BLAST21
Regioni205 – 225DisorderedSequence analysisAdd BLAST21
Regioni272 – 292Interaction with STIM1Add BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 15Pro residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Orai family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4298, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00390000015354

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96D31

Identification of Orthologs from Complete Genome Data

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OMAi
ADHDYPR

Database for complete collections of gene phylogenies

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PhylomeDBi
Q96D31

TreeFam database of animal gene trees

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TreeFami
TF313576

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.140.140, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR012446, CRAC_channel
IPR038350, Orai_sf

The PANTHER Classification System

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PANTHERi
PTHR31501, PTHR31501, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF07856, Orai-1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative initiation. AlignAdd to basket
Isoform alpha (identifier: Q96D31-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHPEPAPPPS RSSPELPPSG GSTTSGSRRS RRRSGDGEPP GAPPPPPSAV
60 70 80 90 100
TYPDWIGQSY SEVMSLNEHS MQALSWRKLY LSRAKLKASS RTSALLSGFA
110 120 130 140 150
MVAMVEVQLD ADHDYPPGLL IAFSACTTVL VAVHLFALMI STCILPNIEA
160 170 180 190 200
VSNVHNLNSV KESPHERMHR HIELAWAFST VIGTLLFLAE VVLLCWVKFL
210 220 230 240 250
PLKKQPGQPR PTSKPPASGA AANVSTSGIT PGQAAAIAST TIMVPFGLIF
260 270 280 290 300
IVFAVHFYRS LVSHKTDRQF QELNELAEFA RLQDQLDHRG DHPLTPGSHY

A
Length:301
Mass (Da):32,668
Last modified:May 16, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF85F7C06F36628D4
GO
Isoform beta (identifier: Q96D31-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-70: Missing.

Show »
Length:231
Mass (Da):25,337
Checksum:i0F7EEBB6DADB9005
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH13386 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAI04634 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB55068 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti255V → F in BAB55068 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02622691R → W in IMD9. 1 PublicationCorresponds to variant dbSNP:rs118203993EnsemblClinVar.1
Natural variantiVAR_07808398G → S in TAM2; constitutively active Ca(+2) channel, independently of STIM proteins; no effect on localization to the cell membrane. 1 PublicationCorresponds to variant dbSNP:rs786204796EnsemblClinVar.1
Natural variantiVAR_078084107V → M in TAM2; constitutively active Ca(+2) channel, independently of STIM proteins; no effect on localization to the cell membrane. 1 Publication1
Natural variantiVAR_078085184T → M in TAM2; mediates excessive Ca(2+) entry when gated by STIM1; no effect on localization to the cell membrane. 1 PublicationCorresponds to variant dbSNP:rs1555324111Ensembl.1
Natural variantiVAR_038608218S → G2 PublicationsCorresponds to variant dbSNP:rs3741596EnsemblClinVar.1
Natural variantiVAR_071473245P → L in TAM2; increases activation of the Ca2+ release-activated Ca2+ (CRAC) channel. 1 PublicationCorresponds to variant dbSNP:rs587777528EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0444211 – 70Missing in isoform beta. CuratedAdd BLAST70

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
BC013386 mRNA Translation: AAH13386.1 Different initiation.
BC015369 mRNA Translation: AAH15369.2
BC075831 mRNA Translation: AAH75831.1
BC104633 mRNA Translation: AAI04634.1 Different initiation.
AK027372 mRNA Translation: BAB55068.1 Different initiation.

NCBI Reference Sequences

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RefSeqi
NP_116179.2, NM_032790.3 [Q96D31-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000617316; ENSP00000482568; ENSG00000276045 [Q96D31-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
84876

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:84876

UCSC genome browser

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UCSCi
uc031zps.1, human [Q96D31-1]

Keywords - Coding sequence diversityi

Alternative initiation

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

ORAI1base

ORAI1 mutation db

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC013386 mRNA Translation: AAH13386.1 Different initiation.
BC015369 mRNA Translation: AAH15369.2
BC075831 mRNA Translation: AAH75831.1
BC104633 mRNA Translation: AAI04634.1 Different initiation.
AK027372 mRNA Translation: BAB55068.1 Different initiation.
RefSeqiNP_116179.2, NM_032790.3 [Q96D31-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MAKNMR-B/D272-292[»]
4EHQX-ray1.90G69-88[»]
BMRBiQ96D31
SMRiQ96D31
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi124321, 38 interactors
CORUMiQ96D31
DIPiDIP-46289N
IntActiQ96D31, 14 interactors
STRINGi9606.ENSP00000480616

Chemistry databases

BindingDBiQ96D31
ChEMBLiCHEMBL2384891
GuidetoPHARMACOLOGYi2964

Protein family/group databases

TCDBi1.A.52.1.1, the ca(2+) release-activated ca(2+) (crac) channel (crac-c) family

PTM databases

GlyGeniQ96D31, 1 site
iPTMnetiQ96D31
PhosphoSitePlusiQ96D31
SwissPalmiQ96D31

Genetic variation databases

BioMutaiORAI1
DMDMi97180269

Proteomic databases

jPOSTiQ96D31
MassIVEiQ96D31
MaxQBiQ96D31
PaxDbiQ96D31
PeptideAtlasiQ96D31
PRIDEiQ96D31
ProteomicsDBi76249 [Q96D31-1]
TopDownProteomicsiQ96D31-2 [Q96D31-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
Q96D31, 12 sequenced antibodies

Antibodypedia a portal for validated antibodies

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Antibodypediai
73527, 510 antibodies

The DNASU plasmid repository

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DNASUi
84876

Genome annotation databases

EnsembliENST00000617316; ENSP00000482568; ENSG00000276045 [Q96D31-1]
GeneIDi84876
KEGGihsa:84876
UCSCiuc031zps.1, human [Q96D31-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
84876
DisGeNETi84876

GeneCards: human genes, protein and diseases

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GeneCardsi
ORAI1
HGNCiHGNC:25896, ORAI1
HPAiENSG00000276045, Tissue enhanced (skeletal)
MalaCardsiORAI1
MIMi610277, gene
612782, phenotype
615883, phenotype
neXtProtiNX_Q96D31
OpenTargetsiENSG00000276045
Orphaneti317428, Combined immunodeficiency due to ORAI1 deficiency
3204, Stormorken-Sjaastad-Langslet syndrome
2593, Tubular aggregate myopathy
PharmGKBiPA162398445
VEuPathDBiHostDB:ENSG00000276045

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4298, Eukaryota
GeneTreeiENSGT00390000015354
InParanoidiQ96D31
OMAiADHDYPR
PhylomeDBiQ96D31
TreeFamiTF313576

Enzyme and pathway databases

PathwayCommonsiQ96D31
ReactomeiR-HSA-139853, Elevation of cytosolic Ca2+ levels
R-HSA-5578775, Ion homeostasis
R-HSA-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
SIGNORiQ96D31

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
84876, 7 hits in 1012 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ORAI1, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ORAI1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84876
PharosiQ96D31, Tchem

Protein Ontology

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PROi
PR:Q96D31
RNActiQ96D31, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000276045, Expressed in muscle of leg and 144 other tissues
ExpressionAtlasiQ96D31, baseline and differential
GenevisibleiQ96D31, HS

Family and domain databases

Gene3Di1.20.140.140, 1 hit
InterProiView protein in InterPro
IPR012446, CRAC_channel
IPR038350, Orai_sf
PANTHERiPTHR31501, PTHR31501, 1 hit
PfamiView protein in Pfam
PF07856, Orai-1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCRCM1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96D31
Secondary accession number(s): Q3MHV3
, Q6DHX2, Q96BP7, Q96K71
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: September 29, 2021
This is version 163 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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