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Protein

GTP-binding protein Rhes

Gene

RASD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination.2 Publications

Miscellaneous

Reduces cell survival in striatal cells with Huntington disease by binding to mutant Huntington disease protein (mHTT; poly-Gln region with 82 repeats) and inducing sumoylation of mHTT.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi26 – 33GTPBy similarity8
Nucleotide bindingi73 – 77GTPBy similarity5
Nucleotide bindingi140 – 143GTPBy similarity4

GO - Molecular functioni

  • G-protein beta-subunit binding Source: UniProtKB
  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB-KW
  • phosphatidylinositol 3-kinase binding Source: Ensembl
  • ubiquitin conjugating enzyme binding Source: Ensembl

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein Rhes
Alternative name(s):
Ras homolog enriched in striatum
Tumor endothelial marker 2
Gene namesi
Name:RASD2
Synonyms:TEM2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100302.6
HGNCiHGNC:18229 RASD2
MIMi612842 gene
neXtProtiNX_Q96D21

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23551
OpenTargetsiENSG00000100302
PharmGKBiPA34237

Polymorphism and mutation databases

BioMutaiRASD2
DMDMi21362868

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000827201 – 263GTP-binding protein RhesAdd BLAST263
PropeptideiPRO_0000281375264 – 266Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei263Cysteine methyl esterBy similarity1
Lipidationi263S-farnesyl cysteineBy similarity1

Post-translational modificationi

Farnesylated. Farnesylation is required for membrane targeting (By similarity).By similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiQ96D21
PeptideAtlasiQ96D21
PRIDEiQ96D21
ProteomicsDBi76247

PTM databases

iPTMnetiQ96D21
PhosphoSitePlusiQ96D21

Expressioni

Tissue specificityi

Pancreatic endocrine cells (islets of Langerhans).1 Publication

Gene expression databases

BgeeiENSG00000100302 Expressed in 118 organ(s), highest expression level in caudate nucleus
CleanExiHS_RASD2
GenevisibleiQ96D21 HS

Organism-specific databases

HPAiHPA005839

Interactioni

Subunit structurei

Monomer (Potential). Interacts with PIK3CA and UBE2I (By similarity). Interacts with GNB1, GNB2 and GNB3. Interacts with HTT; interacts with mutant HTT (mHTT) with a much higher affinity than wild type HTT.By similarityCurated2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117095, 12 interactors
IntActiQ96D21, 2 interactors
MINTiQ96D21
STRINGi9606.ENSP00000216127

Structurei

3D structure databases

ProteinModelPortaliQ96D21
SMRiQ96D21
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni189 – 235Interaction with GNB1, GNB2 and GNB31 PublicationAdd BLAST47

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi48 – 56Effector region9

Sequence similaritiesi

Belongs to the small GTPase superfamily. RasD family.Curated

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00860000133678
HOGENOMiHOG000233973
HOVERGENiHBG009351
InParanoidiQ96D21
KOiK07844
OMAiDMDAYGM
OrthoDBiEOG091G0U2W
PhylomeDBiQ96D21
TreeFamiTF316238

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96D21-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMKTLSSGNC TLSVPAKNSY RMVVLGASRV GKSSIVSRFL NGRFEDQYTP
60 70 80 90 100
TIEDFHRKVY NIRGDMYQLD ILDTSGNHPF PAMRRLSILT GDVFILVFSL
110 120 130 140 150
DNRESFDEVK RLQKQILEVK SCLKNKTKEA AELPMVICGN KNDHGELCRQ
160 170 180 190 200
VPTTEAELLV SGDENCAYFE VSAKKNTNVD EMFYVLFSMA KLPHEMSPAL
210 220 230 240 250
HRKISVQYGD AFHPRPFCMR RVKEMDAYGM VSPFARRPSV NSDLKYIKAK
260
VLREGQARER DKCTIQ
Length:266
Mass (Da):30,366
Last modified:December 1, 2001 - v1
Checksum:i2E23A76F346F9EDD
GO

Sequence cautioni

The sequence AAG00868 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF279143 mRNA Translation: AAG00868.1 Different initiation.
CR456477 mRNA Translation: CAG30363.1
AL022334 Genomic DNA No translation available.
BC013419 mRNA Translation: AAH13419.1
CCDSiCCDS13916.1
RefSeqiNP_055125.2, NM_014310.3
XP_005261499.1, XM_005261442.4
XP_011528342.1, XM_011530040.2
XP_016884190.1, XM_017028701.1
XP_016884191.1, XM_017028702.1
UniGeneiHs.474711

Genome annotation databases

EnsembliENST00000216127; ENSP00000216127; ENSG00000100302
GeneIDi23551
KEGGihsa:23551
UCSCiuc003anx.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF279143 mRNA Translation: AAG00868.1 Different initiation.
CR456477 mRNA Translation: CAG30363.1
AL022334 Genomic DNA No translation available.
BC013419 mRNA Translation: AAH13419.1
CCDSiCCDS13916.1
RefSeqiNP_055125.2, NM_014310.3
XP_005261499.1, XM_005261442.4
XP_011528342.1, XM_011530040.2
XP_016884190.1, XM_017028701.1
XP_016884191.1, XM_017028702.1
UniGeneiHs.474711

3D structure databases

ProteinModelPortaliQ96D21
SMRiQ96D21
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117095, 12 interactors
IntActiQ96D21, 2 interactors
MINTiQ96D21
STRINGi9606.ENSP00000216127

PTM databases

iPTMnetiQ96D21
PhosphoSitePlusiQ96D21

Polymorphism and mutation databases

BioMutaiRASD2
DMDMi21362868

Proteomic databases

PaxDbiQ96D21
PeptideAtlasiQ96D21
PRIDEiQ96D21
ProteomicsDBi76247

Protocols and materials databases

DNASUi23551
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216127; ENSP00000216127; ENSG00000100302
GeneIDi23551
KEGGihsa:23551
UCSCiuc003anx.4 human

Organism-specific databases

CTDi23551
DisGeNETi23551
EuPathDBiHostDB:ENSG00000100302.6
GeneCardsiRASD2
HGNCiHGNC:18229 RASD2
HPAiHPA005839
MIMi612842 gene
neXtProtiNX_Q96D21
OpenTargetsiENSG00000100302
PharmGKBiPA34237
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00860000133678
HOGENOMiHOG000233973
HOVERGENiHBG009351
InParanoidiQ96D21
KOiK07844
OMAiDMDAYGM
OrthoDBiEOG091G0U2W
PhylomeDBiQ96D21
TreeFamiTF316238

Miscellaneous databases

ChiTaRSiRASD2 human
GeneWikiiRASD2
GenomeRNAii23551
PROiPR:Q96D21
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100302 Expressed in 118 organ(s), highest expression level in caudate nucleus
CleanExiHS_RASD2
GenevisibleiQ96D21 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRHES_HUMAN
AccessioniPrimary (citable) accession number: Q96D21
Secondary accession number(s): O95520, Q5THY8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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