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Protein

Netrin-G2

Gene

NTNG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.1 Publication

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Netrin-G2
Alternative name(s):
Laminet-2
Gene namesi
Name:NTNG2
Synonyms:KIAA1857, LMNT2
ORF Names:UNQ9381/PRO34206
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000196358.10
HGNCiHGNC:14288 NTNG2
neXtProtiNX_Q96CW9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi84628
OpenTargetsiENSG00000196358
PharmGKBiPA134962540

Polymorphism and mutation databases

BioMutaiNTNG2
DMDMi317373402

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000001709518 – 507Netrin-G2Add BLAST490
PropeptideiPRO_0000017096508 – 530Removed in mature formSequence analysisAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi22 ↔ 391 Publication
Disulfide bondi61 ↔ 811 Publication
Disulfide bondi69 ↔ 771 Publication
Glycosylationi122N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi128N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi171 ↔ 1951 Publication
Disulfide bondi287 ↔ 2961 Publication
Disulfide bondi289 ↔ 3051 Publication
Disulfide bondi307 ↔ 3161 Publication
Glycosylationi310N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi319 ↔ 3441 Publication
Disulfide bondi353 ↔ 362Sequence analysis
Disulfide bondi355 ↔ 373Sequence analysis
Disulfide bondi376 ↔ 385Sequence analysis
Disulfide bondi388 ↔ 406Sequence analysis
Glycosylationi395N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi409 ↔ 421Sequence analysis
Disulfide bondi411 ↔ 427Sequence analysis
Glycosylationi422N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi429 ↔ 438Sequence analysis
Disulfide bondi441 ↔ 451Sequence analysis
Disulfide bondi456 ↔ 469By similarity
Disulfide bondi463 ↔ 475By similarity
Disulfide bondi477 ↔ 486By similarity
Lipidationi507GPI-anchor amidated glycineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ96CW9
PeptideAtlasiQ96CW9
PRIDEiQ96CW9
ProteomicsDBi76235
76236 [Q96CW9-2]

PTM databases

iPTMnetiQ96CW9
PhosphoSitePlusiQ96CW9

Expressioni

Gene expression databases

BgeeiENSG00000196358
CleanExiHS_NTNG2
GenevisibleiQ96CW9 HS

Organism-specific databases

HPAiHPA061242
HPA065089
HPA071290

Interactioni

Subunit structurei

Interacts with LRRC4.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi124157, 1 interactor
IntActiQ96CW9, 4 interactors
MINTiQ96CW9
STRINGi9606.ENSP00000376921

Structurei

Secondary structure

1530
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi22 – 28Combined sources7
Beta strandi31 – 36Combined sources6
Helixi46 – 49Combined sources4
Beta strandi51 – 56Combined sources6
Beta strandi66 – 68Combined sources3
Beta strandi71 – 73Combined sources3
Turni74 – 76Combined sources3
Beta strandi79 – 81Combined sources3
Beta strandi83 – 85Combined sources3
Turni86 – 88Combined sources3
Helixi92 – 95Combined sources4
Beta strandi107 – 109Combined sources3
Turni113 – 116Combined sources4
Beta strandi121 – 133Combined sources13
Beta strandi137 – 143Combined sources7
Beta strandi147 – 156Combined sources10
Beta strandi162 – 170Combined sources9
Helixi171 – 175Combined sources5
Helixi182 – 184Combined sources3
Helixi187 – 189Combined sources3
Turni198 – 204Combined sources7
Beta strandi205 – 207Combined sources3
Beta strandi210 – 213Combined sources4
Helixi216 – 223Combined sources8
Turni224 – 227Combined sources4
Helixi230 – 239Combined sources10
Helixi243 – 246Combined sources4
Beta strandi248 – 258Combined sources11
Helixi271 – 273Combined sources3
Beta strandi277 – 282Combined sources6
Beta strandi284 – 287Combined sources4
Beta strandi296 – 299Combined sources4
Beta strandi302 – 305Combined sources4
Beta strandi311 – 313Combined sources3
Beta strandi324 – 326Combined sources3
Turni336 – 338Combined sources3

3D structure databases

ProteinModelPortaliQ96CW9
SMRiQ96CW9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 286Laminin N-terminalPROSITE-ProRule annotationAdd BLAST252
Domaini287 – 346Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST60
Domaini353 – 408Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST56
Domaini409 – 453Laminin EGF-like 3PROSITE-ProRule annotationAdd BLAST45

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni69 – 88NGL discriminant loop IAdd BLAST20
Regioni201 – 203NGL discriminant loop II3
Regioni264 – 267NGL discriminant loop III4

Domaini

The laminin N-terminal domain mediates 1:1 binding to NGL ligand with sub-micromolar affinity. Three NGL-binding loops mediate discrimination for LRRC4C/NGL1 among other NGLs by binding specifically to its LRR repeats. This specificity drives the sorting of a mixed population of molecules into discrete cell surface subdomains.

Keywords - Domaini

Laminin EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3512 Eukaryota
ENOG410XS7U LUCA
GeneTreeiENSGT00890000139348
HOGENOMiHOG000231614
HOVERGENiHBG052676
InParanoidiQ96CW9
KOiK16359
OMAiQHCQHCR
OrthoDBiEOG091G05AV
PhylomeDBiQ96CW9
TreeFamiTF333945

Family and domain databases

Gene3Di2.60.120.1490, 1 hit
InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR002049 Laminin_EGF
IPR008211 Laminin_N
IPR038684 Laminin_N_sf
PfamiView protein in Pfam
PF00053 Laminin_EGF, 3 hits
PF00055 Laminin_N, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 1 hit
SM00180 EGF_Lam, 3 hits
SM00136 LamNT, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 3 hits
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS01248 EGF_LAM_1, 2 hits
PS50027 EGF_LAM_2, 3 hits
PS51117 LAMININ_NTER, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96CW9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLHLLALFLH CLPLASGDYD ICKSWVTTDE GPTWEFYACQ PKVMRLKDYV
60 70 80 90 100
KVKVEPSGIT CGDPPERFCS HENPYLCSNE CDASNPDLAH PPRLMFDKEE
110 120 130 140 150
EGLATYWQSI TWSRYPSPLE ANITLSWNKT VELTDDVVMT FEYGRPTVMV
160 170 180 190 200
LEKSLDNGRT WQPYQFYAED CMEAFGMSAR RARDMSSSSA HRVLCTEEYS
210 220 230 240 250
RWAGSKKEKH VRFEVRDRFA IFAGPDLRNM DNLYTRLESA KGLKEFFTLT
260 270 280 290 300
DLRMRLLRPA LGGTYVQREN LYKYFYAISN IEVIGRCKCN LHANLCSMRE
310 320 330 340 350
GSLQCECEHN TTGPDCGKCK KNFRTRSWRA GSYLPLPHGS PNACATAGSF
360 370 380 390 400
GNCECYGHSN RCSYIDFLNV VTCVSCKHNT RGQHCQHCRL GYYRNGSAEL
410 420 430 440 450
DDENVCIECN CNQIGSVHDR CNETGFCECR EGAAGPKCDD CLPTHYWRQG
460 470 480 490 500
CYPNVCDDDQ LLCQNGGTCL QNQRCACPRG YTGVRCEQPR CDPADDDGGL
510 520 530
DCDRAPGAAP RPATLLGCLL LLGLAARLGR
Length:530
Mass (Da):59,799
Last modified:January 11, 2011 - v2
Checksum:iB93A8A7E0E5A8CA3
GO
Isoform 2 (identifier: Q96CW9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     352-422: NCECYGHSNR...QIGSVHDRCN → TLQTPPPGRS...DPGGPWLGSQ
     423-530: Missing.

Note: No experimental confirmation available.
Show »
Length:422
Mass (Da):47,491
Checksum:i9A4B38913B097AF9
GO

Sequence cautioni

The sequence BAB47486 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047847346T → A3 PublicationsCorresponds to variant dbSNP:rs4962173Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013147352 – 422NCECY…HDRCN → TLQTPPPGRSPSALRGSRRG LANVKEPAGSRPQISEMLLG CTVTLHQGSVGPHIPPKLSL PDPGGPWLGSQ in isoform 2. 1 PublicationAdd BLAST71
Alternative sequenceiVSP_013148423 – 530Missing in isoform 2. 1 PublicationAdd BLAST108

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058760 mRNA Translation: BAB47486.2 Different initiation.
AY358165 mRNA Translation: AAQ88532.1
AL353631 Genomic DNA No translation available.
AL159997 Genomic DNA No translation available.
BC013770 mRNA Translation: AAH13770.1
CCDSiCCDS6946.1 [Q96CW9-1]
RefSeqiNP_115925.2, NM_032536.2 [Q96CW9-1]
XP_011517409.1, XM_011519107.2 [Q96CW9-1]
UniGeneiHs.163642
Hs.387968

Genome annotation databases

EnsembliENST00000372179; ENSP00000361252; ENSG00000196358 [Q96CW9-2]
ENST00000393229; ENSP00000376921; ENSG00000196358 [Q96CW9-1]
GeneIDi84628
KEGGihsa:84628
UCSCiuc004cbh.3 human [Q96CW9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNTNG2_HUMAN
AccessioniPrimary (citable) accession number: Q96CW9
Secondary accession number(s): Q5JUJ2, Q6UXY0, Q96JH0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: January 11, 2011
Last modified: June 20, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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