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Protein

Gamma-tubulin complex component 3

Gene

TUBGCP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.

GO - Molecular functioni

  • gamma-tubulin binding Source: UniProtKB
  • structural constituent of cytoskeleton Source: GO_Central
  • structural molecule activity Source: ProtInc

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-tubulin complex component 3
Short name:
GCP-3
Short name:
hGCP3
Alternative name(s):
Gamma-ring complex protein 104 kDa
Short name:
h104p
Short name:
hGrip104
Spindle pole body protein Spc98 homolog
Short name:
hSpc98
Gene namesi
Name:TUBGCP3
Synonyms:GCP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000126216.12
HGNCiHGNC:18598 TUBGCP3
MIMi617818 gene
neXtProtiNX_Q96CW5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi10426
OpenTargetsiENSG00000126216
PharmGKBiPA38597

Polymorphism and mutation databases

DMDMi21362575

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000781182 – 907Gamma-tubulin complex component 3Add BLAST906

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei113PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ96CW5
MaxQBiQ96CW5
PaxDbiQ96CW5
PeptideAtlasiQ96CW5
PRIDEiQ96CW5
ProteomicsDBi76231
76232 [Q96CW5-2]
76233 [Q96CW5-3]

PTM databases

iPTMnetiQ96CW5
PhosphoSitePlusiQ96CW5

Expressioni

Tissue specificityi

Ubiquitously expressed.

Gene expression databases

BgeeiENSG00000126216 Expressed in 223 organ(s), highest expression level in female gonad
CleanExiHS_TUBGCP3
ExpressionAtlasiQ96CW5 baseline and differential
GenevisibleiQ96CW5 HS

Organism-specific databases

HPAiHPA043913

Interactioni

Subunit structurei

Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6. Interacts with CDK5RAP2; the interaction is leading to centrosomal localization of TUBGCP3 and CDK5RAP2. Interacts with NIN (via N-terminus); the interaction may promote recruitment of the gamma-tubulin ring complex to the centrosome (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115695, 167 interactors
CORUMiQ96CW5
IntActiQ96CW5, 39 interactors
MINTiQ96CW5
STRINGi9606.ENSP00000261965

Structurei

3D structure databases

ProteinModelPortaliQ96CW5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi825 – 829Poly-Glu5

Sequence similaritiesi

Belongs to the TUBGCP family.Curated

Phylogenomic databases

eggNOGiKOG2000 Eukaryota
ENOG410XQ5B LUCA
GeneTreeiENSGT00850000132278
HOGENOMiHOG000007959
HOVERGENiHBG031568
InParanoidiQ96CW5
KOiK16570
OMAiRYGCGDS
OrthoDBiEOG091G01V2
PhylomeDBiQ96CW5
TreeFamiTF300705

Family and domain databases

InterProiView protein in InterPro
IPR007259 GCP
PANTHERiPTHR19302 PTHR19302, 1 hit
PfamiView protein in Pfam
PF04130 Spc97_Spc98, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Experimental confirmation may be lacking for some isoforms.

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96CW5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATPDQKSPN VLLQNLCCRI LGRSEADVAQ QFQYAVRVIG SNFAPTVERD
60 70 80 90 100
EFLVAEKIKK ELIRQRREAD AALFSELHRK LHSQGVLKNK WSILYLLLSL
110 120 130 140 150
SEDPRRQPSK VSSYATLFAQ ALPRDAHSTP YYYARPQTLP LSYQDRSAQS
160 170 180 190 200
AQSSGSVGSS GISSIGLCAL SGPAPAPQSL LPGQSNQAPG VGDCLRQQLG
210 220 230 240 250
SRLAWTLTAN QPSSQATTSK GVPSAVSRNM TRSRREGDTG GTMEITEAAL
260 270 280 290 300
VRDILYVFQG IDGKNIKMNN TENCYKVEGK ANLSRSLRDT AVRLSELGWL
310 320 330 340 350
HNKIRRYTDQ RSLDRSFGLV GQSFCAALHQ ELREYYRLLS VLHSQLQLED
360 370 380 390 400
DQGVNLGLES SLTLRRLLVW TYDPKIRLKT LAALVDHCQG RKGGELASAV
410 420 430 440 450
HAYTKTGDPY MRSLVQHILS LVSHPVLSFL YRWIYDGELE DTYHEFFVAS
460 470 480 490 500
DPTVKTDRLW HDKYTLRKSM IPSFMTMDQS RKVLLIGKSI NFLHQVCHDQ
510 520 530 540 550
TPTTKMIAVT KSAESPQDAA DLFTDLENAF QGKIDAAYFE TSKYLLDVLN
560 570 580 590 600
KKYSLLDHMQ AMRRYLLLGQ GDFIRHLMDL LKPELVRPAT TLYQHNLTGI
610 620 630 640 650
LETAVRATNA QFDSPEILRR LDVRLLEVSP GDTGWDVFSL DYHVDGPIAT
660 670 680 690 700
VFTRECMSHY LRVFNFLWRA KRMEYILTDI RKGHMCNAKL LRNMPEFSGV
710 720 730 740 750
LHQCHILASE MVHFIHQMQY YITFEVLECS WDELWNKVQQ AQDLDHIIAA
760 770 780 790 800
HEVFLDTIIS RCLLDSDSRA LLNQLRAVFD QIIELQNAQD AIYRAALEEL
810 820 830 840 850
QRRLQFEEKK KQREIEGQWG VTAAEEEEEN KRIGEFKESI PKMCSQLRIL
860 870 880 890 900
THFYQGIVQQ FLVLLTTSSD ESLRFLSFRL DFNEHYKARE PRLRVSLGTR

GRRSSHT
Length:907
Mass (Da):103,571
Last modified:June 6, 2002 - v2
Checksum:i70FE2FDB7C80344D
GO
Isoform 2 (identifier: Q96CW5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     817-824: GQWGVTAA → VEMCLYCV
     825-907: Missing.

Show »
Length:824
Mass (Da):93,885
Checksum:iDF5AEDA7A34E531A
GO
Isoform 3 (identifier: Q96CW5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     391-434: RKGGELASAV...PVLSFLYRWI → PTRVFPTHVF...WHSLCFRTRL
     435-907: Missing.

Show »
Length:434
Mass (Da):48,647
Checksum:i9FB608525458BB54
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0J9YX56A0A0J9YX56_HUMAN
Gamma-tubulin complex component
TUBGCP3
129Annotation score:
A0A0J9YX63A0A0J9YX63_HUMAN
Gamma-tubulin complex component
TUBGCP3
212Annotation score:
A0A087WU06A0A087WU06_HUMAN
Gamma-tubulin complex component
TUBGCP3 hCG_27357
439Annotation score:
A0A087WZV5A0A087WZV5_HUMAN
Gamma-tubulin complex component
TUBGCP3
129Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti361S → I in CAA05832 (PubMed:9566969).Curated1
Sequence conflicti361S → I in CAA05833 (PubMed:9566969).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049251208T → S1 PublicationCorresponds to variant dbSNP:rs1044287Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001622391 – 434RKGGE…LYRWI → PTRVFPTHVFPTRDFPTRDF PMHVFPTRVFPTRVWHSLCF RTRL in isoform 3. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_001623435 – 907Missing in isoform 3. 1 PublicationAdd BLAST473
Alternative sequenceiVSP_001620817 – 824GQWGVTAA → VEMCLYCV in isoform 2. 3 Publications8
Alternative sequenceiVSP_001621825 – 907Missing in isoform 2. 3 PublicationsAdd BLAST83

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042378 mRNA Translation: AAC39727.1
AJ003061 mRNA Translation: CAA05832.1
AJ003062 mRNA Translation: CAA05833.1
BT009772 mRNA Translation: AAP88774.1
AK314785 mRNA Translation: BAG37319.1
AL139384 Genomic DNA No translation available.
AL160033 Genomic DNA No translation available.
CH471085 Genomic DNA Translation: EAX09164.1
BC007763 mRNA Translation: AAH07763.1
BC013781 mRNA Translation: AAH13781.1
BC046634 mRNA Translation: AAH46634.1
CCDSiCCDS66584.1 [Q96CW5-2]
CCDS9525.1 [Q96CW5-1]
RefSeqiNP_001273206.1, NM_001286277.1
NP_001273207.1, NM_001286278.1 [Q96CW5-2]
NP_001273208.1, NM_001286279.1
NP_006313.1, NM_006322.5 [Q96CW5-1]
UniGeneiHs.224152

Genome annotation databases

EnsembliENST00000261965; ENSP00000261965; ENSG00000126216 [Q96CW5-1]
ENST00000375669; ENSP00000364821; ENSG00000126216 [Q96CW5-2]
GeneIDi10426
KEGGihsa:10426
UCSCiuc001vse.3 human [Q96CW5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042378 mRNA Translation: AAC39727.1
AJ003061 mRNA Translation: CAA05832.1
AJ003062 mRNA Translation: CAA05833.1
BT009772 mRNA Translation: AAP88774.1
AK314785 mRNA Translation: BAG37319.1
AL139384 Genomic DNA No translation available.
AL160033 Genomic DNA No translation available.
CH471085 Genomic DNA Translation: EAX09164.1
BC007763 mRNA Translation: AAH07763.1
BC013781 mRNA Translation: AAH13781.1
BC046634 mRNA Translation: AAH46634.1
CCDSiCCDS66584.1 [Q96CW5-2]
CCDS9525.1 [Q96CW5-1]
RefSeqiNP_001273206.1, NM_001286277.1
NP_001273207.1, NM_001286278.1 [Q96CW5-2]
NP_001273208.1, NM_001286279.1
NP_006313.1, NM_006322.5 [Q96CW5-1]
UniGeneiHs.224152

3D structure databases

ProteinModelPortaliQ96CW5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115695, 167 interactors
CORUMiQ96CW5
IntActiQ96CW5, 39 interactors
MINTiQ96CW5
STRINGi9606.ENSP00000261965

PTM databases

iPTMnetiQ96CW5
PhosphoSitePlusiQ96CW5

Polymorphism and mutation databases

DMDMi21362575

Proteomic databases

EPDiQ96CW5
MaxQBiQ96CW5
PaxDbiQ96CW5
PeptideAtlasiQ96CW5
PRIDEiQ96CW5
ProteomicsDBi76231
76232 [Q96CW5-2]
76233 [Q96CW5-3]

Protocols and materials databases

DNASUi10426
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261965; ENSP00000261965; ENSG00000126216 [Q96CW5-1]
ENST00000375669; ENSP00000364821; ENSG00000126216 [Q96CW5-2]
GeneIDi10426
KEGGihsa:10426
UCSCiuc001vse.3 human [Q96CW5-1]

Organism-specific databases

CTDi10426
DisGeNETi10426
EuPathDBiHostDB:ENSG00000126216.12
GeneCardsiTUBGCP3
HGNCiHGNC:18598 TUBGCP3
HPAiHPA043913
MIMi617818 gene
neXtProtiNX_Q96CW5
OpenTargetsiENSG00000126216
PharmGKBiPA38597
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2000 Eukaryota
ENOG410XQ5B LUCA
GeneTreeiENSGT00850000132278
HOGENOMiHOG000007959
HOVERGENiHBG031568
InParanoidiQ96CW5
KOiK16570
OMAiRYGCGDS
OrthoDBiEOG091G01V2
PhylomeDBiQ96CW5
TreeFamiTF300705

Enzyme and pathway databases

ReactomeiR-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes

Miscellaneous databases

ChiTaRSiTUBGCP3 human
GeneWikiiTUBGCP3
GenomeRNAii10426
PROiPR:Q96CW5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000126216 Expressed in 223 organ(s), highest expression level in female gonad
CleanExiHS_TUBGCP3
ExpressionAtlasiQ96CW5 baseline and differential
GenevisibleiQ96CW5 HS

Family and domain databases

InterProiView protein in InterPro
IPR007259 GCP
PANTHERiPTHR19302 PTHR19302, 1 hit
PfamiView protein in Pfam
PF04130 Spc97_Spc98, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGCP3_HUMAN
AccessioniPrimary (citable) accession number: Q96CW5
Secondary accession number(s): O43631
, O60852, O60853, Q5T8L2, Q7Z4K1, Q96I79
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: June 6, 2002
Last modified: November 7, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
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