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Entry version 160 (16 Oct 2019)
Sequence version 2 (06 Jun 2002)
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Protein

Gamma-tubulin complex component 3

Gene

TUBGCP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Gamma-tubulin complex component 3
Short name:
GCP-3
Short name:
hGCP3
Alternative name(s):
Gamma-ring complex protein 104 kDa
Short name:
h104p
Short name:
hGrip104
Spindle pole body protein Spc98 homolog
Short name:
hSpc98
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TUBGCP3
Synonyms:GCP3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18598 TUBGCP3

Online Mendelian Inheritance in Man (OMIM)

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MIMi
617818 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96CW5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10426

Open Targets

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OpenTargetsi
ENSG00000126216

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA38597

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96CW5

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TUBGCP3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
21362575

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000781182 – 907Gamma-tubulin complex component 3Add BLAST906

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei113PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96CW5

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96CW5

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q96CW5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96CW5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96CW5

PeptideAtlas

More...
PeptideAtlasi
Q96CW5

PRoteomics IDEntifications database

More...
PRIDEi
Q96CW5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
76231 [Q96CW5-1]
76232 [Q96CW5-2]
76233 [Q96CW5-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96CW5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96CW5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000126216 Expressed in 223 organ(s), highest expression level in female gonad

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96CW5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96CW5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043913

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6.

Interacts with CDK5RAP2; the interaction is leading to centrosomal localization of TUBGCP3 and CDK5RAP2.

Interacts with NIN (via N-terminus); the interaction may promote recruitment of the gamma-tubulin ring complex to the centrosome (By similarity).

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115695, 171 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q96CW5

Protein interaction database and analysis system

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IntActi
Q96CW5, 47 interactors

Molecular INTeraction database

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MINTi
Q96CW5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000261965

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi825 – 829Poly-Glu5

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TUBGCP family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2000 Eukaryota
ENOG410XQ5B LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157872

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000007959

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96CW5

KEGG Orthology (KO)

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KOi
K16570

Identification of Orthologs from Complete Genome Data

More...
OMAi
EYKVDAP

Database of Orthologous Groups

More...
OrthoDBi
480444at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96CW5

TreeFam database of animal gene trees

More...
TreeFami
TF300705

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR007259 GCP
IPR040457 GCP_C
IPR041470 GCP_N

The PANTHER Classification System

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PANTHERi
PTHR19302 PTHR19302, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF04130 GCP_C_terminal, 1 hit
PF17681 GCP_N_terminal, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Experimental confirmation may be lacking for some isoforms.

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96CW5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATPDQKSPN VLLQNLCCRI LGRSEADVAQ QFQYAVRVIG SNFAPTVERD
60 70 80 90 100
EFLVAEKIKK ELIRQRREAD AALFSELHRK LHSQGVLKNK WSILYLLLSL
110 120 130 140 150
SEDPRRQPSK VSSYATLFAQ ALPRDAHSTP YYYARPQTLP LSYQDRSAQS
160 170 180 190 200
AQSSGSVGSS GISSIGLCAL SGPAPAPQSL LPGQSNQAPG VGDCLRQQLG
210 220 230 240 250
SRLAWTLTAN QPSSQATTSK GVPSAVSRNM TRSRREGDTG GTMEITEAAL
260 270 280 290 300
VRDILYVFQG IDGKNIKMNN TENCYKVEGK ANLSRSLRDT AVRLSELGWL
310 320 330 340 350
HNKIRRYTDQ RSLDRSFGLV GQSFCAALHQ ELREYYRLLS VLHSQLQLED
360 370 380 390 400
DQGVNLGLES SLTLRRLLVW TYDPKIRLKT LAALVDHCQG RKGGELASAV
410 420 430 440 450
HAYTKTGDPY MRSLVQHILS LVSHPVLSFL YRWIYDGELE DTYHEFFVAS
460 470 480 490 500
DPTVKTDRLW HDKYTLRKSM IPSFMTMDQS RKVLLIGKSI NFLHQVCHDQ
510 520 530 540 550
TPTTKMIAVT KSAESPQDAA DLFTDLENAF QGKIDAAYFE TSKYLLDVLN
560 570 580 590 600
KKYSLLDHMQ AMRRYLLLGQ GDFIRHLMDL LKPELVRPAT TLYQHNLTGI
610 620 630 640 650
LETAVRATNA QFDSPEILRR LDVRLLEVSP GDTGWDVFSL DYHVDGPIAT
660 670 680 690 700
VFTRECMSHY LRVFNFLWRA KRMEYILTDI RKGHMCNAKL LRNMPEFSGV
710 720 730 740 750
LHQCHILASE MVHFIHQMQY YITFEVLECS WDELWNKVQQ AQDLDHIIAA
760 770 780 790 800
HEVFLDTIIS RCLLDSDSRA LLNQLRAVFD QIIELQNAQD AIYRAALEEL
810 820 830 840 850
QRRLQFEEKK KQREIEGQWG VTAAEEEEEN KRIGEFKESI PKMCSQLRIL
860 870 880 890 900
THFYQGIVQQ FLVLLTTSSD ESLRFLSFRL DFNEHYKARE PRLRVSLGTR

GRRSSHT
Length:907
Mass (Da):103,571
Last modified:June 6, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i70FE2FDB7C80344D
GO
Isoform 2 (identifier: Q96CW5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     817-824: GQWGVTAA → VEMCLYCV
     825-907: Missing.

Show »
Length:824
Mass (Da):93,885
Checksum:iDF5AEDA7A34E531A
GO
Isoform 3 (identifier: Q96CW5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     391-434: RKGGELASAV...PVLSFLYRWI → PTRVFPTHVF...WHSLCFRTRL
     435-907: Missing.

Show »
Length:434
Mass (Da):48,647
Checksum:i9FB608525458BB54
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WU06A0A087WU06_HUMAN
Gamma-tubulin complex component
TUBGCP3 hCG_27357
439Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ITE3A0A3B3ITE3_HUMAN
Gamma-tubulin complex component
TUBGCP3
612Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YX56A0A0J9YX56_HUMAN
Gamma-tubulin complex component
TUBGCP3
129Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YX63A0A0J9YX63_HUMAN
Gamma-tubulin complex component
TUBGCP3
212Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WZV5A0A087WZV5_HUMAN
Gamma-tubulin complex component
TUBGCP3
129Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti361S → I in CAA05832 (PubMed:9566969).Curated1
Sequence conflicti361S → I in CAA05833 (PubMed:9566969).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049251208T → S1 PublicationCorresponds to variant dbSNP:rs1044287Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_001622391 – 434RKGGE…LYRWI → PTRVFPTHVFPTRDFPTRDF PMHVFPTRVFPTRVWHSLCF RTRL in isoform 3. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_001623435 – 907Missing in isoform 3. 1 PublicationAdd BLAST473
Alternative sequenceiVSP_001620817 – 824GQWGVTAA → VEMCLYCV in isoform 2. 3 Publications8
Alternative sequenceiVSP_001621825 – 907Missing in isoform 2. 3 PublicationsAdd BLAST83

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF042378 mRNA Translation: AAC39727.1
AJ003061 mRNA Translation: CAA05832.1
AJ003062 mRNA Translation: CAA05833.1
BT009772 mRNA Translation: AAP88774.1
AK314785 mRNA Translation: BAG37319.1
AL139384 Genomic DNA No translation available.
AL160033 Genomic DNA No translation available.
CH471085 Genomic DNA Translation: EAX09164.1
BC007763 mRNA Translation: AAH07763.1
BC013781 mRNA Translation: AAH13781.1
BC046634 mRNA Translation: AAH46634.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS66584.1 [Q96CW5-2]
CCDS9525.1 [Q96CW5-1]

NCBI Reference Sequences

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RefSeqi
NP_001273206.1, NM_001286277.1
NP_001273207.1, NM_001286278.1 [Q96CW5-2]
NP_001273208.1, NM_001286279.1
NP_006313.1, NM_006322.5 [Q96CW5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000261965; ENSP00000261965; ENSG00000126216 [Q96CW5-1]
ENST00000375669; ENSP00000364821; ENSG00000126216 [Q96CW5-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10426

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10426

UCSC genome browser

More...
UCSCi
uc001vse.3 human [Q96CW5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042378 mRNA Translation: AAC39727.1
AJ003061 mRNA Translation: CAA05832.1
AJ003062 mRNA Translation: CAA05833.1
BT009772 mRNA Translation: AAP88774.1
AK314785 mRNA Translation: BAG37319.1
AL139384 Genomic DNA No translation available.
AL160033 Genomic DNA No translation available.
CH471085 Genomic DNA Translation: EAX09164.1
BC007763 mRNA Translation: AAH07763.1
BC013781 mRNA Translation: AAH13781.1
BC046634 mRNA Translation: AAH46634.1
CCDSiCCDS66584.1 [Q96CW5-2]
CCDS9525.1 [Q96CW5-1]
RefSeqiNP_001273206.1, NM_001286277.1
NP_001273207.1, NM_001286278.1 [Q96CW5-2]
NP_001273208.1, NM_001286279.1
NP_006313.1, NM_006322.5 [Q96CW5-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi115695, 171 interactors
CORUMiQ96CW5
IntActiQ96CW5, 47 interactors
MINTiQ96CW5
STRINGi9606.ENSP00000261965

PTM databases

iPTMnetiQ96CW5
PhosphoSitePlusiQ96CW5

Polymorphism and mutation databases

BioMutaiTUBGCP3
DMDMi21362575

Proteomic databases

EPDiQ96CW5
jPOSTiQ96CW5
MassIVEiQ96CW5
MaxQBiQ96CW5
PaxDbiQ96CW5
PeptideAtlasiQ96CW5
PRIDEiQ96CW5
ProteomicsDBi76231 [Q96CW5-1]
76232 [Q96CW5-2]
76233 [Q96CW5-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
10426

Genome annotation databases

EnsembliENST00000261965; ENSP00000261965; ENSG00000126216 [Q96CW5-1]
ENST00000375669; ENSP00000364821; ENSG00000126216 [Q96CW5-2]
GeneIDi10426
KEGGihsa:10426
UCSCiuc001vse.3 human [Q96CW5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10426
DisGeNETi10426

GeneCards: human genes, protein and diseases

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GeneCardsi
TUBGCP3
HGNCiHGNC:18598 TUBGCP3
HPAiHPA043913
MIMi617818 gene
neXtProtiNX_Q96CW5
OpenTargetsiENSG00000126216
PharmGKBiPA38597

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2000 Eukaryota
ENOG410XQ5B LUCA
GeneTreeiENSGT00940000157872
HOGENOMiHOG000007959
InParanoidiQ96CW5
KOiK16570
OMAiEYKVDAP
OrthoDBi480444at2759
PhylomeDBiQ96CW5
TreeFamiTF300705

Enzyme and pathway databases

ReactomeiR-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TUBGCP3 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TUBGCP3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10426
PharosiQ96CW5

Protein Ontology

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PROi
PR:Q96CW5

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000126216 Expressed in 223 organ(s), highest expression level in female gonad
ExpressionAtlasiQ96CW5 baseline and differential
GenevisibleiQ96CW5 HS

Family and domain databases

InterProiView protein in InterPro
IPR007259 GCP
IPR040457 GCP_C
IPR041470 GCP_N
PANTHERiPTHR19302 PTHR19302, 1 hit
PfamiView protein in Pfam
PF04130 GCP_C_terminal, 1 hit
PF17681 GCP_N_terminal, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGCP3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96CW5
Secondary accession number(s): O43631
, O60852, O60853, Q5T8L2, Q7Z4K1, Q96I79
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: June 6, 2002
Last modified: October 16, 2019
This is version 160 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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