CCDC124

Functionⁱ

Required for proper progression of late cytokinetic stages.1 Publication

GO - Molecular functionⁱ

RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell cycle Source: UniProtKB-KW
cell division Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell cycle, Cell division

Biological process

Cell cycle, Cell division

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Coiled-coil domain-containing protein 124
Gene namesⁱ	Name:CCDC124
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000007080.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:25171 CCDC124
neXtProtⁱ	NX_Q96CT7

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000007080
PharmGKBⁱ	PA147358292

Polymorphism and mutation databases

BioMutaⁱ	CCDC124
DMDMⁱ	74731379

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000263735	1 – 223	Coiled-coil domain-containing protein 124Add BLAST		223

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	141	PhosphoserineCombined sources1 Publication		1
Modified residueⁱ	194	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q96CT7
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96CT7
PaxDbⁱ	Q96CT7
PeptideAtlas More...PeptideAtlasⁱ	Q96CT7
PRIDEⁱ	Q96CT7
ProteomicsDBⁱ	76221

PTM databases

iPTMnetⁱ	Q96CT7
PhosphoSitePlusⁱ	Q96CT7

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000007080 Expressed in 170 organ(s), highest expression level in cerebellum
CleanExⁱ	HS_CCDC124
ExpressionAtlasⁱ	Q96CT7 baseline and differential
Genevisibleⁱ	Q96CT7 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA041708 HPA046765

HPAⁱ

HPA041708
HPA046765

Interactionⁱ

Subunit structureⁱ

Interacts with RASGEF1B.1 Publication

Protein-protein interaction databases

BioGridⁱ	125411, 26 interactors
IntActⁱ	Q96CT7, 22 interactors

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96CT7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	15 – 82	Sequence analysisAdd BLAST		68

Sequence similaritiesⁱ

Belongs to the CCDC124 family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG3223 Eukaryota ENOG410ZIM9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000012482
HOGENOMⁱ	HOG000204343
HOVERGENⁱ	HBG080942
InParanoidⁱ	Q96CT7
OMAⁱ	RHPEKRM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0XXE
PhylomeDBⁱ	Q96CT7
TreeFamⁱ	TF105913

Family and domain databases

InterProⁱ	View protein in InterPro IPR010422 Ccdc124
PANTHERⁱ	PTHR21680 PTHR21680, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF06244 Ccdc124, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q96CT7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPKKFQGENT KSAAARARRA EAKAAADAKK QKELEDAYWK DDDKHVMRKE 
        60         70         80         90        100
QRKEEKEKRR LDQLERKKET QRLLEEEDSK LKGGKAPRVA TSSKVTRAQI 
       110        120        130        140        150
EDTLRRDHQL REAPDTAEKA KSHLEVPLEE NVNRRVLEEG SVEARTIEDA 
       160        170        180        190        200
IAVLSVAEEA ADRHPERRMR AAFTAFEEAQ LPRLKQENPN MRLSQLKQLL 
       210        220 
KKEWLRSPDN PMNQRAVPFN APK

Length:223

Mass (Da):25,835

Last modified:December 1, 2001 - v1

Checksum:ⁱDFC65D526057DE27

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	M0R2F5	M0R2F5_HUMAN		Coiled-coil domain-containing prote... Coiled-coil domain-containing protein 124	CCDC124	136	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_053809	138	E → Q. Corresponds to variant dbSNP:rs8104153Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC013949 mRNA Translation: AAH13949.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12369.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001129675.1, NM_001136203.1 NP_612451.1, NM_138442.3
UniGeneⁱ	Hs.100043

Genome annotation databases

Ensemblⁱ	ENST00000445755; ENSP00000408730; ENSG00000007080 ENST00000597436; ENSP00000471455; ENSG00000007080
GeneIDⁱ	115098
KEGGⁱ	hsa:115098
UCSC genome browser More...UCSCⁱ	uc002nhs.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96CT7	Uncharacterized protein		HUMAN		223	UniRef100_Q96CT7
CCDC124 isoform 1		PANTR		223
CCDC124 isoform 1		PONAB		223
Uncharacterized protein		PANPA		223
CCDC124 isoform 3 (Fragment)		PONAB		137
+2

Protein	Similar proteins		Species	Score	Length	Source
Q96CT7	Coiled-coil domain-containing protein 124		BOVIN		223	UniRef90_Q96CT7
Coiled-coil domain-containing protein 124		PONAB		223
Uncharacterized protein		HUMAN		223
CCDC124 isoform 1		PANTR		223
Uncharacterized protein		PANPA		223
+83

Protein	Similar proteins		Species	Score	Length	Source
Q96CT7	Coiled-coil domain-containing protein 124		BOVIN		223	UniRef50_Q96CT7
Coiled-coil domain-containing protein 124		PONAB		223
Uncharacterized protein		HUMAN		223
CCDC124 isoform 1		PANTR		223
Uncharacterized protein		PANPA		223
+85

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC013949 mRNA Translation: AAH13949.1
CCDSⁱ	CCDS12369.1
RefSeqⁱ	NP_001129675.1, NM_001136203.1 NP_612451.1, NM_138442.3
UniGeneⁱ	Hs.100043

3D structure databases

ProteinModelPortalⁱ	Q96CT7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	125411, 26 interactors
IntActⁱ	Q96CT7, 22 interactors

PTM databases

iPTMnetⁱ	Q96CT7
PhosphoSitePlusⁱ	Q96CT7

Polymorphism and mutation databases

BioMutaⁱ	CCDC124
DMDMⁱ	74731379

Proteomic databases

EPDⁱ	Q96CT7
MaxQBⁱ	Q96CT7
PaxDbⁱ	Q96CT7
PeptideAtlasⁱ	Q96CT7
PRIDEⁱ	Q96CT7
ProteomicsDBⁱ	76221

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	115098
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000445755; ENSP00000408730; ENSG00000007080 ENST00000597436; ENSP00000471455; ENSG00000007080
GeneIDⁱ	115098
KEGGⁱ	hsa:115098
UCSCⁱ	uc002nhs.4 human

Organism-specific databases

CTDⁱ	115098
EuPathDBⁱ	HostDB:ENSG00000007080.10
GeneCardsⁱ	CCDC124
HGNCⁱ	HGNC:25171 CCDC124
HPAⁱ	HPA041708 HPA046765
neXtProtⁱ	NX_Q96CT7
OpenTargetsⁱ	ENSG00000007080
PharmGKBⁱ	PA147358292
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3223 Eukaryota ENOG410ZIM9 LUCA
GeneTreeⁱ	ENSGT00390000012482
HOGENOMⁱ	HOG000204343
HOVERGENⁱ	HBG080942
InParanoidⁱ	Q96CT7
OMAⁱ	RHPEKRM
OrthoDBⁱ	EOG091G0XXE
PhylomeDBⁱ	Q96CT7
TreeFamⁱ	TF105913

Miscellaneous databases

ChiTaRSⁱ	CCDC124 human
GenomeRNAiⁱ	115098
Protein Ontology More...PROⁱ	PR:Q96CT7

Gene expression databases

Bgeeⁱ	ENSG00000007080 Expressed in 170 organ(s), highest expression level in cerebellum
CleanExⁱ	HS_CCDC124
ExpressionAtlasⁱ	Q96CT7 baseline and differential
Genevisibleⁱ	Q96CT7 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR010422 Ccdc124
PANTHERⁱ	PTHR21680 PTHR21680, 1 hit
Pfamⁱ	View protein in Pfam PF06244 Ccdc124, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CC124_HUMAN
Accessionⁱ	Q96CT7Primary (citable) accession number: Q96CT7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
	Last sequence update:	December 1, 2001
	Last modified:	November 7, 2018
	This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM

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UniProtKB - Q96CT7 (CC124_HUMAN)

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Coiled-coil domain-containing protein 124

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Other locations

Cytoskeleton

Cytosol

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ