UniProtKB - Q96CT7 (CC124_HUMAN)
Protein
Coiled-coil domain-containing protein 124
Gene
CCDC124
Organism
Homo sapiens (Human)
Status
Functioni
Required for proper progression of late cytokinetic stages.1 Publication
GO - Molecular functioni
- RNA binding Source: UniProtKB
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- cell division Source: UniProtKB-KW
Keywordsi
Biological process | Cell cycle, Cell division |
Names & Taxonomyi
Protein namesi | Recommended name: Coiled-coil domain-containing protein 124 |
Gene namesi | Name:CCDC124 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25171 CCDC124 |
neXtProti | NX_Q96CT7 |
Subcellular locationi
Cytoskeleton
- centrosome 1 Publication
Other locations
- Midbody 1 Publication
Note: Colocalizes with gamma-tubulin at interphase, prophase, metaphase, and anaphase. Relocates from centrosome to midbody at telophase.
Cytoskeleton
- microtubule organizing center Source: UniProtKB-SubCell
Cytosol
- cytosol Source: HPA
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- midbody Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000007080 |
PharmGKBi | PA147358292 |
Miscellaneous databases
Pharosi | Q96CT7 |
Polymorphism and mutation databases
BioMutai | CCDC124 |
DMDMi | 74731379 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000263735 | 1 – 223 | Coiled-coil domain-containing protein 124Add BLAST | 223 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 141 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 194 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q96CT7 |
jPOSTi | Q96CT7 |
MassIVEi | Q96CT7 |
MaxQBi | Q96CT7 |
PaxDbi | Q96CT7 |
PeptideAtlasi | Q96CT7 |
PRIDEi | Q96CT7 |
ProteomicsDBi | 76221 |
PTM databases
iPTMneti | Q96CT7 |
PhosphoSitePlusi | Q96CT7 |
Expressioni
Tissue specificityi
Ubiquitously expressed.1 Publication
Gene expression databases
Bgeei | ENSG00000007080 Expressed in 170 organ(s), highest expression level in cerebellum |
ExpressionAtlasi | Q96CT7 baseline and differential |
Genevisiblei | Q96CT7 HS |
Organism-specific databases
HPAi | HPA041708 HPA046765 |
Interactioni
Subunit structurei
Interacts with RASGEF1B.
1 PublicationProtein-protein interaction databases
BioGridi | 125411, 34 interactors |
IntActi | Q96CT7, 32 interactors |
MINTi | Q96CT7 |
STRINGi | 9606.ENSP00000471455 |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 15 – 82 | Sequence analysisAdd BLAST | 68 |
Sequence similaritiesi
Belongs to the CCDC124 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG3223 Eukaryota ENOG410ZIM9 LUCA |
GeneTreei | ENSGT00390000012482 |
HOGENOMi | HOG000204343 |
InParanoidi | Q96CT7 |
OMAi | RHPEKRM |
OrthoDBi | 1585903at2759 |
PhylomeDBi | Q96CT7 |
TreeFami | TF105913 |
Family and domain databases
InterProi | View protein in InterPro IPR010422 Ccdc124/Oxs1 |
PANTHERi | PTHR21680 PTHR21680, 1 hit |
Pfami | View protein in Pfam PF06244 Ccdc124, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q96CT7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPKKFQGENT KSAAARARRA EAKAAADAKK QKELEDAYWK DDDKHVMRKE
60 70 80 90 100
QRKEEKEKRR LDQLERKKET QRLLEEEDSK LKGGKAPRVA TSSKVTRAQI
110 120 130 140 150
EDTLRRDHQL REAPDTAEKA KSHLEVPLEE NVNRRVLEEG SVEARTIEDA
160 170 180 190 200
IAVLSVAEEA ADRHPERRMR AAFTAFEEAQ LPRLKQENPN MRLSQLKQLL
210 220
KKEWLRSPDN PMNQRAVPFN APK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketM0R2F5 | M0R2F5_HUMAN | Coiled-coil domain-containing prote... | CCDC124 | 136 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_053809 | 138 | E → Q. Corresponds to variant dbSNP:rs8104153Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC013949 mRNA Translation: AAH13949.1 |
CCDSi | CCDS12369.1 |
RefSeqi | NP_001129675.1, NM_001136203.1 NP_612451.1, NM_138442.3 |
Genome annotation databases
Ensembli | ENST00000445755; ENSP00000408730; ENSG00000007080 ENST00000597436; ENSP00000471455; ENSG00000007080 |
GeneIDi | 115098 |
KEGGi | hsa:115098 |
UCSCi | uc002nhs.4 human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC013949 mRNA Translation: AAH13949.1 |
CCDSi | CCDS12369.1 |
RefSeqi | NP_001129675.1, NM_001136203.1 NP_612451.1, NM_138442.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGridi | 125411, 34 interactors |
IntActi | Q96CT7, 32 interactors |
MINTi | Q96CT7 |
STRINGi | 9606.ENSP00000471455 |
PTM databases
iPTMneti | Q96CT7 |
PhosphoSitePlusi | Q96CT7 |
Polymorphism and mutation databases
BioMutai | CCDC124 |
DMDMi | 74731379 |
Proteomic databases
EPDi | Q96CT7 |
jPOSTi | Q96CT7 |
MassIVEi | Q96CT7 |
MaxQBi | Q96CT7 |
PaxDbi | Q96CT7 |
PeptideAtlasi | Q96CT7 |
PRIDEi | Q96CT7 |
ProteomicsDBi | 76221 |
Protocols and materials databases
DNASUi | 115098 |
Genome annotation databases
Ensembli | ENST00000445755; ENSP00000408730; ENSG00000007080 ENST00000597436; ENSP00000471455; ENSG00000007080 |
GeneIDi | 115098 |
KEGGi | hsa:115098 |
UCSCi | uc002nhs.4 human |
Organism-specific databases
CTDi | 115098 |
GeneCardsi | CCDC124 |
HGNCi | HGNC:25171 CCDC124 |
HPAi | HPA041708 HPA046765 |
neXtProti | NX_Q96CT7 |
OpenTargetsi | ENSG00000007080 |
PharmGKBi | PA147358292 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3223 Eukaryota ENOG410ZIM9 LUCA |
GeneTreei | ENSGT00390000012482 |
HOGENOMi | HOG000204343 |
InParanoidi | Q96CT7 |
OMAi | RHPEKRM |
OrthoDBi | 1585903at2759 |
PhylomeDBi | Q96CT7 |
TreeFami | TF105913 |
Miscellaneous databases
ChiTaRSi | CCDC124 human |
GenomeRNAii | 115098 |
Pharosi | Q96CT7 |
PROi | PR:Q96CT7 |
Gene expression databases
Bgeei | ENSG00000007080 Expressed in 170 organ(s), highest expression level in cerebellum |
ExpressionAtlasi | Q96CT7 baseline and differential |
Genevisiblei | Q96CT7 HS |
Family and domain databases
InterProi | View protein in InterPro IPR010422 Ccdc124/Oxs1 |
PANTHERi | PTHR21680 PTHR21680, 1 hit |
Pfami | View protein in Pfam PF06244 Ccdc124, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CC124_HUMAN | |
Accessioni | Q96CT7Primary (citable) accession number: Q96CT7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 12, 2006 |
Last sequence update: | December 1, 2001 | |
Last modified: | October 16, 2019 | |
This is version 131 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - SIMILARITY comments
Index of protein domains and families - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations