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Protein

Pleckstrin homology domain-containing family B member 2

Gene

PLEKHB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in retrograde transport of recycling endosomes.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei20Phosphatidylserine1

GO - Molecular functioni

  • phosphatidylinositol-3,4,5-trisphosphate binding Source: GO_Central

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin homology domain-containing family B member 2
Short name:
PH domain-containing family B member 2
Alternative name(s):
Evectin-2
Gene namesi
Name:PLEKHB2
Synonyms:EVT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115762.16
HGNCiHGNC:19236 PLEKHB2
neXtProtiNX_Q96CS7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000115762
PharmGKBiPA134885873

Polymorphism and mutation databases

BioMutaiPLEKHB2
DMDMi48474928

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000538891 – 222Pleckstrin homology domain-containing family B member 2Add BLAST222

Proteomic databases

MaxQBiQ96CS7
PaxDbiQ96CS7
PeptideAtlasiQ96CS7
PRIDEiQ96CS7
ProteomicsDBi76216
76217 [Q96CS7-2]
76218 [Q96CS7-3]

PTM databases

iPTMnetiQ96CS7
PhosphoSitePlusiQ96CS7

Expressioni

Gene expression databases

BgeeiENSG00000115762 Expressed in 237 organ(s), highest expression level in pons
CleanExiHS_PLEKHB2
ExpressionAtlasiQ96CS7 baseline and differential
GenevisibleiQ96CS7 HS

Organism-specific databases

HPAiHPA075014

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi120370, 20 interactors
IntActiQ96CS7, 48 interactors
MINTiQ96CS7
STRINGi9606.ENSP00000385892

Structurei

Secondary structure

1222
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ96CS7
SMRiQ96CS7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 109PHPROSITE-ProRule annotationAdd BLAST108

Domaini

The PH domain specifically binds phosphatidylserine, which is enriched in recycling endosome membranes, it doesn't recognize PIPs.

Phylogenomic databases

eggNOGiENOG410IFNJ Eukaryota
ENOG4111G6I LUCA
GeneTreeiENSGT00390000013989
HOGENOMiHOG000253945
HOVERGENiHBG060487
InParanoidiQ96CS7
PhylomeDBiQ96CS7
TreeFamiTF331787

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit

Sequences (6+)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96CS7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAFVKSGWLL RQSTILKRWK KNWFDLWSDG HLIYYDDQTR QNIEDKVHMP
60 70 80 90 100
MDCINIRTGQ ECRDTQPPDG KSKDCMLQIV CRDGKTISLC AESTDDCLAW
110 120 130 140 150
KFTLQDSRTN TAYVGSAVMT DETSVVSSPP PYTAYAAPAP EQAYGYGPYG
160 170 180 190 200
GAYPPGTQVV YAANGQAYAV PYQYPYAGLY GQQPANQVII RERYRDNDSD
210 220
LALGMLAGAA TGMALGSLFW VF
Length:222
Mass (Da):24,736
Last modified:December 1, 2001 - v1
Checksum:i8924F61890D416A5
GO
Isoform 2 (identifier: Q96CS7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     142-222: QAYGYGPYGG...MALGSLFWVF → ELHSKGPKIH...PPPARPPALR

Note: No experimental confirmation available.
Show »
Length:309
Mass (Da):34,154
Checksum:iBB64D755DBDBD100
GO
Isoform 3 (identifier: Q96CS7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     142-142: Missing.

Note: No experimental confirmation available.
Show »
Length:221
Mass (Da):24,608
Checksum:i6740C7F3A491AB09
GO
Isoform 4 (identifier: Q96CS7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     99-222: AWKFTLQDSR...MALGSLFWVF → LMAMGHTVVR...CWQEQPRAWP

Show »
Length:170
Mass (Da):19,852
Checksum:i70B6C31C4BD6AA19
GO
Isoform 5 (identifier: Q96CS7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     142-222: QAYGYGPYGG...MALGSLFWVF → DFMDSSLLTK...CWQEQPRAWP

Show »
Length:178
Mass (Da):20,375
Checksum:i7903B0346AB5F5C0
GO
Isoform 6 (identifier: Q96CS7-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     141-141: E → EVGRTLSLQ

Note: Gene prediction based on EST data.
Show »
Length:230
Mass (Da):25,591
Checksum:i08562F08D30AEE66
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7WPA5B7WPA5_HUMAN
Pleckstrin homology domain-containi...
PLEKHB2
309Annotation score:
A0A0A0MSE9A0A0A0MSE9_HUMAN
Pleckstrin homology domain-containi...
PLEKHB2
236Annotation score:
A0A0A0MSI4A0A0A0MSI4_HUMAN
Pleckstrin homology domain-containi...
PLEKHB2
171Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti172Y → H in BAA91379 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04516399 – 222AWKFT…LFWVF → LMAMGHTVVRTRQELKLSTL RMGRRMPCPTSTHMQDFMDS SLLTKSSFESAIETTTATWH WACWQEQPRAWP in isoform 4. 1 PublicationAdd BLAST124
Alternative sequenceiVSP_047118141E → EVGRTLSLQ in isoform 6. Curated1
Alternative sequenceiVSP_009783142 – 222QAYGY…LFWVF → ELHSKGPKIHTTTSAKTQAV LPTRCFFPSESPIRRSVQIS VLLPAVNIRRRIKLTFPQPA RPRAPRSLCLWQTWFAGKRA PSLPTAATAPALPSCPSPPA PSKALPPSLAGWRSPSSAPL PPEQALAPRSFQLSKHQARP RPHRPGTPPVPAWPGVPPPP PARPPALR in isoform 2. 1 PublicationAdd BLAST81
Alternative sequenceiVSP_045164142 – 222QAYGY…LFWVF → DFMDSSLLTKSSFESAIETT TATWHWACWQEQPRAWP in isoform 5. 1 PublicationAdd BLAST81
Alternative sequenceiVSP_009784142Missing in isoform 3. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000790 mRNA Translation: BAA91379.1
AK123710 mRNA Translation: BAG53942.1
AK293880 mRNA Translation: BAG57269.1
AK302770 mRNA Translation: BAG63978.1
AK223338 mRNA Translation: BAD97058.1
AC073869 Genomic DNA No translation available.
AC131180 Genomic DNA No translation available.
AC009477 Genomic DNA Translation: AAX93135.1
CH471250 Genomic DNA Translation: EAW51261.1
CH471250 Genomic DNA Translation: EAW51263.1
CH471250 Genomic DNA Translation: EAW51266.1
BC001428 mRNA Translation: AAH01428.1
BC013991 mRNA Translation: AAH13991.1
BC050695 mRNA Translation: AAH50695.2
CCDSiCCDS2166.1 [Q96CS7-3]
CCDS46413.1 [Q96CS7-1]
CCDS58729.1 [Q96CS7-5]
CCDS58730.1 [Q96CS7-6]
CCDS58731.1 [Q96CS7-4]
RefSeqiNP_001094093.1, NM_001100623.1 [Q96CS7-1]
NP_001253991.1, NM_001267062.1
NP_001253992.1, NM_001267063.1
NP_001253993.1, NM_001267064.1
NP_001253994.1, NM_001267065.1 [Q96CS7-6]
NP_001253995.1, NM_001267066.1 [Q96CS7-5]
NP_001253996.1, NM_001267067.1
NP_001253997.1, NM_001267068.1 [Q96CS7-4]
NP_001296377.1, NM_001309448.1
NP_001296379.1, NM_001309450.1
NP_001296380.1, NM_001309451.1
NP_001296381.1, NM_001309452.1
NP_060428.2, NM_017958.2 [Q96CS7-3]
XP_016859900.1, XM_017004411.1 [Q96CS7-6]
XP_016859901.1, XM_017004412.1 [Q96CS7-1]
UniGeneiHs.469944
Hs.708368

Genome annotation databases

EnsembliENST00000234115; ENSP00000234115; ENSG00000115762 [Q96CS7-3]
ENST00000409158; ENSP00000386410; ENSG00000115762 [Q96CS7-6]
ENST00000409279; ENSP00000386666; ENSG00000115762 [Q96CS7-1]
ENST00000409612; ENSP00000386662; ENSG00000115762 [Q96CS7-1]
ENST00000438882; ENSP00000401193; ENSG00000115762 [Q96CS7-5]
ENST00000628582; ENSP00000487321; ENSG00000115762 [Q96CS7-4]
GeneIDi55041
KEGGihsa:55041
UCSCiuc002tsf.5 human [Q96CS7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000790 mRNA Translation: BAA91379.1
AK123710 mRNA Translation: BAG53942.1
AK293880 mRNA Translation: BAG57269.1
AK302770 mRNA Translation: BAG63978.1
AK223338 mRNA Translation: BAD97058.1
AC073869 Genomic DNA No translation available.
AC131180 Genomic DNA No translation available.
AC009477 Genomic DNA Translation: AAX93135.1
CH471250 Genomic DNA Translation: EAW51261.1
CH471250 Genomic DNA Translation: EAW51263.1
CH471250 Genomic DNA Translation: EAW51266.1
BC001428 mRNA Translation: AAH01428.1
BC013991 mRNA Translation: AAH13991.1
BC050695 mRNA Translation: AAH50695.2
CCDSiCCDS2166.1 [Q96CS7-3]
CCDS46413.1 [Q96CS7-1]
CCDS58729.1 [Q96CS7-5]
CCDS58730.1 [Q96CS7-6]
CCDS58731.1 [Q96CS7-4]
RefSeqiNP_001094093.1, NM_001100623.1 [Q96CS7-1]
NP_001253991.1, NM_001267062.1
NP_001253992.1, NM_001267063.1
NP_001253993.1, NM_001267064.1
NP_001253994.1, NM_001267065.1 [Q96CS7-6]
NP_001253995.1, NM_001267066.1 [Q96CS7-5]
NP_001253996.1, NM_001267067.1
NP_001253997.1, NM_001267068.1 [Q96CS7-4]
NP_001296377.1, NM_001309448.1
NP_001296379.1, NM_001309450.1
NP_001296380.1, NM_001309451.1
NP_001296381.1, NM_001309452.1
NP_060428.2, NM_017958.2 [Q96CS7-3]
XP_016859900.1, XM_017004411.1 [Q96CS7-6]
XP_016859901.1, XM_017004412.1 [Q96CS7-1]
UniGeneiHs.469944
Hs.708368

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3AJ4X-ray1.00A/B1-110[»]
3VIAX-ray1.75A/B1-110[»]
ProteinModelPortaliQ96CS7
SMRiQ96CS7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120370, 20 interactors
IntActiQ96CS7, 48 interactors
MINTiQ96CS7
STRINGi9606.ENSP00000385892

PTM databases

iPTMnetiQ96CS7
PhosphoSitePlusiQ96CS7

Polymorphism and mutation databases

BioMutaiPLEKHB2
DMDMi48474928

Proteomic databases

MaxQBiQ96CS7
PaxDbiQ96CS7
PeptideAtlasiQ96CS7
PRIDEiQ96CS7
ProteomicsDBi76216
76217 [Q96CS7-2]
76218 [Q96CS7-3]

Protocols and materials databases

DNASUi55041
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000234115; ENSP00000234115; ENSG00000115762 [Q96CS7-3]
ENST00000409158; ENSP00000386410; ENSG00000115762 [Q96CS7-6]
ENST00000409279; ENSP00000386666; ENSG00000115762 [Q96CS7-1]
ENST00000409612; ENSP00000386662; ENSG00000115762 [Q96CS7-1]
ENST00000438882; ENSP00000401193; ENSG00000115762 [Q96CS7-5]
ENST00000628582; ENSP00000487321; ENSG00000115762 [Q96CS7-4]
GeneIDi55041
KEGGihsa:55041
UCSCiuc002tsf.5 human [Q96CS7-1]

Organism-specific databases

CTDi55041
EuPathDBiHostDB:ENSG00000115762.16
GeneCardsiPLEKHB2
HGNCiHGNC:19236 PLEKHB2
HPAiHPA075014
neXtProtiNX_Q96CS7
OpenTargetsiENSG00000115762
PharmGKBiPA134885873
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFNJ Eukaryota
ENOG4111G6I LUCA
GeneTreeiENSGT00390000013989
HOGENOMiHOG000253945
HOVERGENiHBG060487
InParanoidiQ96CS7
PhylomeDBiQ96CS7
TreeFamiTF331787

Miscellaneous databases

ChiTaRSiPLEKHB2 human
GeneWikiiPLEKHB2
GenomeRNAii55041
PROiPR:Q96CS7

Gene expression databases

BgeeiENSG00000115762 Expressed in 237 organ(s), highest expression level in pons
CleanExiHS_PLEKHB2
ExpressionAtlasiQ96CS7 baseline and differential
GenevisibleiQ96CS7 HS

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPKHB2_HUMAN
AccessioniPrimary (citable) accession number: Q96CS7
Secondary accession number(s): B4DF08
, B4DZ66, B8ZZN1, Q53FF1, Q53TH7, Q86W37, Q9BV75, Q9NWK1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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