Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

HAUS augmin-like complex subunit 1

Gene

HAUS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.3 Publications

Miscellaneous

HAUS1-depleted cells retain functional cell cycle checkpoints, but the depletion decreases the G2/M cell cycle compartment and induces apoptosis. The protein level remains constant through the cell cycle.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-8854518 AURKA Activation by TPX2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
HAUS augmin-like complex subunit 1
Alternative name(s):
Coiled-coil domain-containing protein 5
Enhancer of invasion-cluster
Short name:
HEI-C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HAUS1
Synonyms:CCDC5, HEIC
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000152240.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25174 HAUS1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608775 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96CS2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000152240

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165429013

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HAUS1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
50400607

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000893951 – 278HAUS augmin-like complex subunit 1Add BLAST278

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96CS2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96CS2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96CS2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96CS2

PeptideAtlas

More...
PeptideAtlasi
Q96CS2

PRoteomics IDEntifications database

More...
PRIDEi
Q96CS2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
76212
76213 [Q96CS2-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96CS2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96CS2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Expressed in pancreas, kidney, skeletal muscle, liver and heart. Weakly expressed in lung, brain and placenta.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000152240 Expressed in 189 organ(s), highest expression level in material anatomical entity

CleanEx database of gene expression profiles

More...
CleanExi
HS_CCDC5

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96CS2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96CS2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA040601
HPA040652

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly. Associates with microtubules. The interaction with microtubules is strong during mitosis, while it is weak or absent during interphase. It is unclear whether this interaction is direct or indirect.3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
AK8Q96MA63EBI-2514791,EBI-8466265
ARFIP2P533653EBI-2514791,EBI-638194
BLOC1S6Q9UL453EBI-2514791,EBI-465781
C3orf62Q6ZUJ43EBI-2514791,EBI-2837036
CAGE1Q8TC203EBI-2514791,EBI-10196469
CCDC114Q96M633EBI-2514791,EBI-10173858
CCDC136Q96JN2-23EBI-2514791,EBI-10171416
CCDC57Q2TAC23EBI-2514791,EBI-2808286
CCHCR1Q8TD31-35EBI-2514791,EBI-10175300
CDR2Q018503EBI-2514791,EBI-1181367
CEP170P1Q96L143EBI-2514791,EBI-743488
CEP44Q9C0F14EBI-2514791,EBI-744115
CEP55Q53EZ43EBI-2514791,EBI-747776
CEP57L1Q8IYX8-23EBI-2514791,EBI-10181988
CEP63Q96MT84EBI-2514791,EBI-741977
CEP70Q8NHQ13EBI-2514791,EBI-739624
CRSP9Q6IAZ53EBI-2514791,EBI-10283772
DCTN2Q135613EBI-2514791,EBI-715074
DMDP115323EBI-2514791,EBI-295827
DTNBP1Q96EV83EBI-2514791,EBI-465804
FGFR1OP2Q9NVK53EBI-2514791,EBI-1104764
GOLGA2Q083793EBI-2514791,EBI-618309
HAUS4Q9H6D711EBI-2514791,EBI-2558168
HAUS6Q7Z4H711EBI-2514791,EBI-2558196
IFIT3O148793EBI-2514791,EBI-745127
IFT20Q8IY315EBI-2514791,EBI-744203
INCA1Q0VD863EBI-2514791,EBI-6509505
KDM1AO603412EBI-2514791,EBI-710124
KIFC3Q9BVG83EBI-2514791,EBI-2125614
KRT15P190123EBI-2514791,EBI-739566
KRT18P057833EBI-2514791,EBI-297888
KRT19P087273EBI-2514791,EBI-742756
KRT31Q153233EBI-2514791,EBI-948001
KRT38O760153EBI-2514791,EBI-1047263
KRT40Q6A1623EBI-2514791,EBI-10171697
KXD1Q9BQD33EBI-2514791,EBI-739657
LDOC1O957513EBI-2514791,EBI-740738
LURAP1Q96LR23EBI-2514791,EBI-741355
MAD1L1Q9Y6D93EBI-2514791,EBI-742610
MAGEA6P433603EBI-2514791,EBI-1045155
MED4Q9NPJ63EBI-2514791,EBI-394607
MIPOL1Q8TD103EBI-2514791,EBI-2548751
MTUS2Q5JR593EBI-2514791,EBI-742948
NDC80O147773EBI-2514791,EBI-715849
NECAB2Q7Z6G3-23EBI-2514791,EBI-10172876
NINLQ9Y2I63EBI-2514791,EBI-719716
NUP54Q7Z3B43EBI-2514791,EBI-741048
NUP62P371983EBI-2514791,EBI-347978
PDE4DIPQ5VU433EBI-2514791,EBI-1105124
SPAG5Q96R063EBI-2514791,EBI-413317
SPERTQ8NA613EBI-2514791,EBI-741724
STX11O755583EBI-2514791,EBI-714135
SYCE1Q8N0S23EBI-2514791,EBI-6872807
SYCE3A1L1903EBI-2514791,EBI-10283466
TFIP11Q9UBB93EBI-2514791,EBI-1105213
TFPTP0C1Z6-23EBI-2514791,EBI-10178002
TRAF1Q130773EBI-2514791,EBI-359224
TRIM23P364063EBI-2514791,EBI-740098
TRIM27P143733EBI-2514791,EBI-719493
TRIM54Q9BYV23EBI-2514791,EBI-2130429
TRIM69Q86WT63EBI-2514791,EBI-749955
TSG101Q998165EBI-2514791,EBI-346882
USHBP1Q8N6Y03EBI-2514791,EBI-739895
VPS52Q8N1B43EBI-2514791,EBI-2799833
WASHC3Q9Y3C08EBI-2514791,EBI-712969

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125412, 141 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1847 HAUS complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q96CS2

Database of interacting proteins

More...
DIPi
DIP-48835N

Protein interaction database and analysis system

More...
IntActi
Q96CS2, 110 interactors

Molecular INTeraction database

More...
MINTi
Q96CS2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000282058

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q96CS2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96CS2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili49 – 79Sequence analysisAdd BLAST31
Coiled coili124 – 177Sequence analysisAdd BLAST54
Coiled coili249 – 277Sequence analysisAdd BLAST29

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the HAUS1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEUK Eukaryota
ENOG4111SPA LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006029

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000220811

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96CS2

KEGG Orthology (KO)

More...
KOi
K16584

Identification of Orthologs from Complete Genome Data

More...
OMAi
THQAIVQ

Database of Orthologous Groups

More...
OrthoDBi
1350537at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96CS2

TreeFam database of animal gene trees

More...
TreeFami
TF331717

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026243 HAUS1

The PANTHER Classification System

More...
PANTHERi
PTHR31570 PTHR31570, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR02087 HAUSAUGMINL1

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96CS2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPQEERETQ VAAWLKKIFG DHPIPQYEVN PRTTEILHHL SERNRVRDRD
60 70 80 90 100
VYLVIEDLKQ KASEYESEAK YLQDLLMESV NFSPANLSST GSRYLNALVD
110 120 130 140 150
SAVALETKDT SLASFIPAVN DLTSDLFRTK SKSEEIKIEL EKLEKNLTAT
160 170 180 190 200
LVLEKCLQED VKKAELHLST ERAKVDNRRQ NMDFLKAKSE EFRFGIKAAE
210 220 230 240 250
EQLSARGMDA SLSHQSLVAL SEKLARLKQQ TIPLKKKLES YLDLMPNPSL
260 270
AQVKIEEAKR ELDSIEAELT RRVDMMEL
Length:278
Mass (Da):31,863
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i06F6A1B9FCF0698A
GO
Isoform 2 (identifier: Q96CS2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: Missing.

Note: No experimental confirmation available.
Show »
Length:202
Mass (Da):22,744
Checksum:i9DD7AC01253BEFB7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ES67K7ES67_HUMAN
HAUS augmin-like complex subunit 1
HAUS1
107Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQT8K7EQT8_HUMAN
HAUS augmin-like complex subunit 1
HAUS1
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EM54K7EM54_HUMAN
HAUS augmin-like complex subunit 1
HAUS1
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EK72K7EK72_HUMAN
HAUS augmin-like complex subunit 1
HAUS1
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EKH4K7EKH4_HUMAN
HAUS augmin-like complex subunit 1
HAUS1
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJA9K7EJA9_HUMAN
HAUS augmin-like complex subunit 1
HAUS1
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC05036 differs from that shown. Reason: Frameshift at position 15.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0107811 – 76Missing in isoform 2. 1 PublicationAdd BLAST76

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY360137 mRNA Translation: AAQ63649.1
AK097403 mRNA Translation: BAC05036.1 Frameshift.
AK315605 mRNA Translation: BAG37974.1
BC005958 mRNA Translation: AAH05958.1
BC014003 mRNA Translation: AAH14003.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11928.1 [Q96CS2-1]

NCBI Reference Sequences

More...
RefSeqi
NP_612452.1, NM_138443.3 [Q96CS2-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.436617

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000282058; ENSP00000282058; ENSG00000152240 [Q96CS2-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
115106

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:115106

UCSC genome browser

More...
UCSCi
uc002lbu.3 human [Q96CS2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY360137 mRNA Translation: AAQ63649.1
AK097403 mRNA Translation: BAC05036.1 Frameshift.
AK315605 mRNA Translation: BAG37974.1
BC005958 mRNA Translation: AAH05958.1
BC014003 mRNA Translation: AAH14003.1
CCDSiCCDS11928.1 [Q96CS2-1]
RefSeqiNP_612452.1, NM_138443.3 [Q96CS2-1]
UniGeneiHs.436617

3D structure databases

ProteinModelPortaliQ96CS2
SMRiQ96CS2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125412, 141 interactors
ComplexPortaliCPX-1847 HAUS complex
CORUMiQ96CS2
DIPiDIP-48835N
IntActiQ96CS2, 110 interactors
MINTiQ96CS2
STRINGi9606.ENSP00000282058

PTM databases

iPTMnetiQ96CS2
PhosphoSitePlusiQ96CS2

Polymorphism and mutation databases

BioMutaiHAUS1
DMDMi50400607

Proteomic databases

EPDiQ96CS2
jPOSTiQ96CS2
MaxQBiQ96CS2
PaxDbiQ96CS2
PeptideAtlasiQ96CS2
PRIDEiQ96CS2
ProteomicsDBi76212
76213 [Q96CS2-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000282058; ENSP00000282058; ENSG00000152240 [Q96CS2-1]
GeneIDi115106
KEGGihsa:115106
UCSCiuc002lbu.3 human [Q96CS2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
115106
EuPathDBiHostDB:ENSG00000152240.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
HAUS1
HGNCiHGNC:25174 HAUS1
HPAiHPA040601
HPA040652
MIMi608775 gene
neXtProtiNX_Q96CS2
OpenTargetsiENSG00000152240
PharmGKBiPA165429013

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IEUK Eukaryota
ENOG4111SPA LUCA
GeneTreeiENSGT00390000006029
HOGENOMiHOG000220811
InParanoidiQ96CS2
KOiK16584
OMAiTHQAIVQ
OrthoDBi1350537at2759
PhylomeDBiQ96CS2
TreeFamiTF331717

Enzyme and pathway databases

ReactomeiR-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-8854518 AURKA Activation by TPX2

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
HAUS1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CCDC5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
115106

Protein Ontology

More...
PROi
PR:Q96CS2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000152240 Expressed in 189 organ(s), highest expression level in material anatomical entity
CleanExiHS_CCDC5
ExpressionAtlasiQ96CS2 baseline and differential
GenevisibleiQ96CS2 HS

Family and domain databases

InterProiView protein in InterPro
IPR026243 HAUS1
PANTHERiPTHR31570 PTHR31570, 1 hit
PRINTSiPR02087 HAUSAUGMINL1

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHAUS1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96CS2
Secondary accession number(s): B2RDM7, Q8N837
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: December 1, 2001
Last modified: January 16, 2019
This is version 144 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again