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Entry version 156 (07 Oct 2020)
Sequence version 1 (01 Dec 2001)
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Protein

HAUS augmin-like complex subunit 1

Gene

HAUS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.3 Publications

Miscellaneous

HAUS1-depleted cells retain functional cell cycle checkpoints, but the depletion decreases the G2/M cell cycle compartment and induces apoptosis. The protein level remains constant through the cell cycle.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q96CS2

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259, Loss of Nlp from mitotic centrosomes
R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320, Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912, Anchoring of the basal body to the plasma membrane
R-HSA-8854518, AURKA Activation by TPX2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
HAUS augmin-like complex subunit 1
Alternative name(s):
Coiled-coil domain-containing protein 5
Enhancer of invasion-cluster
Short name:
HEI-C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HAUS1
Synonyms:CCDC5, HEIC
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000152240.12

Human Gene Nomenclature Database

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HGNCi
HGNC:25174, HAUS1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
608775, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96CS2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
115106

Open Targets

More...
OpenTargetsi
ENSG00000152240

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165429013

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96CS2, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HAUS1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
50400607

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000893951 – 278HAUS augmin-like complex subunit 1Add BLAST278

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96CS2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96CS2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96CS2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96CS2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96CS2

PeptideAtlas

More...
PeptideAtlasi
Q96CS2

PRoteomics IDEntifications database

More...
PRIDEi
Q96CS2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
76212 [Q96CS2-1]
76213 [Q96CS2-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96CS2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96CS2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Expressed in pancreas, kidney, skeletal muscle, liver and heart. Weakly expressed in lung, brain and placenta.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000152240, Expressed in subventricular zone (inner) (primate) and 203 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96CS2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96CS2, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000152240, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly. Associates with microtubules. The interaction with microtubules is strong during mitosis, while it is weak or absent during interphase. It is unclear whether this interaction is direct or indirect.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q96CS2
With#Exp.IntAct
AK8 [Q96MA6]3EBI-2514791,EBI-8466265
ARFIP2 [P53365]3EBI-2514791,EBI-638194
ATP6V1D [Q9Y5K8]3EBI-2514791,EBI-2684998
BFSP2 [Q13515]5EBI-2514791,EBI-10229433
BLOC1S6 [Q9UL45]3EBI-2514791,EBI-465781
BORCS6 [Q96GS4]3EBI-2514791,EBI-10193358
C3orf62 [Q6ZUJ4]4EBI-2514791,EBI-2837036
CAGE1 [Q8TC20]3EBI-2514791,EBI-10196469
CBY2 [Q8NA61]3EBI-2514791,EBI-741724
CCDC114 [Q96M63]3EBI-2514791,EBI-10173858
CCDC136 - isoform 2 [Q96JN2-2]3EBI-2514791,EBI-10171416
CCDC57 [Q2TAC2]3EBI-2514791,EBI-2808286
CCHCR1 - isoform 3 [Q8TD31-3]6EBI-2514791,EBI-10175300
CDR2 [Q01850]3EBI-2514791,EBI-1181367
CENPP [Q6IPU0]5EBI-2514791,EBI-10250303
CEP170P1 [Q96L14]3EBI-2514791,EBI-743488
CEP44 [Q9C0F1]4EBI-2514791,EBI-744115
CEP55 [Q53EZ4]3EBI-2514791,EBI-747776
CEP57L1 - isoform 2 [Q8IYX8-2]3EBI-2514791,EBI-10181988
CEP63 [Q96MT8]4EBI-2514791,EBI-741977
CEP70 [Q8NHQ1]3EBI-2514791,EBI-739624
CRSP9 [Q6IAZ5]3EBI-2514791,EBI-10283772
DCTN2 [Q13561]3EBI-2514791,EBI-715074
DMD [P11532]4EBI-2514791,EBI-295827
DTNBP1 [Q96EV8]3EBI-2514791,EBI-465804
FAM161B [Q96MY7]3EBI-2514791,EBI-7225287
FGFR1OP2 [Q9NVK5]3EBI-2514791,EBI-1104764
GOLGA2 [Q08379]3EBI-2514791,EBI-618309
HAUS4 [Q9H6D7]11EBI-2514791,EBI-2558168
HAUS6 [Q7Z4H7]11EBI-2514791,EBI-2558196
HGS [O14964]3EBI-2514791,EBI-740220
IFIT3 [O14879]3EBI-2514791,EBI-745127
IFT20 [Q8IY31]5EBI-2514791,EBI-744203
INCA1 [Q0VD86]3EBI-2514791,EBI-6509505
KDM1A [O60341]2EBI-2514791,EBI-710124
KIFC3 [Q9BVG8]3EBI-2514791,EBI-2125614
KRT1 [P04264]3EBI-2514791,EBI-298429
KRT15 [P19012]3EBI-2514791,EBI-739566
KRT18 [P05783]3EBI-2514791,EBI-297888
KRT19 [P08727]3EBI-2514791,EBI-742756
KRT3 [P12035]3EBI-2514791,EBI-2430095
KRT31 [Q15323]3EBI-2514791,EBI-948001
KRT38 [O76015]5EBI-2514791,EBI-1047263
KRT40 [Q6A162]3EBI-2514791,EBI-10171697
KXD1 [Q9BQD3]3EBI-2514791,EBI-739657
LDOC1 [O95751]3EBI-2514791,EBI-740738
LURAP1 [Q96LR2]4EBI-2514791,EBI-741355
MAD1L1 [Q9Y6D9]3EBI-2514791,EBI-742610
MAGEA6 [P43360]3EBI-2514791,EBI-1045155
MED4 [Q9NPJ6]3EBI-2514791,EBI-394607
MIPOL1 [Q8TD10]3EBI-2514791,EBI-2548751
MTUS2 [Q5JR59]3EBI-2514791,EBI-742948
NDC80 [O14777]3EBI-2514791,EBI-715849
NECAB2 - isoform 2 [Q7Z6G3-2]3EBI-2514791,EBI-10172876
NINL [Q9Y2I6]3EBI-2514791,EBI-719716
NUP54 [Q7Z3B4]3EBI-2514791,EBI-741048
NUP62 [P37198]3EBI-2514791,EBI-347978
PDE4DIP [Q5VU43]3EBI-2514791,EBI-1105124
PKN1 [Q16512]3EBI-2514791,EBI-602382
POLR3C [Q9BUI4]3EBI-2514791,EBI-5452779
SPAG5 [Q96R06]3EBI-2514791,EBI-413317
SSC5D [A1L4H1]3EBI-2514791,EBI-10172867
STX11 [O75558]3EBI-2514791,EBI-714135
SYCE1 [Q8N0S2]3EBI-2514791,EBI-6872807
SYCE3 [A1L190]4EBI-2514791,EBI-10283466
TEAD4 [Q15561]3EBI-2514791,EBI-747736
TFIP11 [Q9UBB9]3EBI-2514791,EBI-1105213
TFPT - isoform 2 [P0C1Z6-2]3EBI-2514791,EBI-10178002
TRAF1 [Q13077]3EBI-2514791,EBI-359224
TRIM23 [P36406]3EBI-2514791,EBI-740098
TRIM27 [P14373]3EBI-2514791,EBI-719493
TRIM54 [Q9BYV2]3EBI-2514791,EBI-2130429
TRIM69 [Q86WT6]3EBI-2514791,EBI-749955
TRIM69 - isoform 2 [Q86WT6-2]4EBI-2514791,EBI-11525489
TSG101 [Q99816]6EBI-2514791,EBI-346882
TXN2 [Q99757]3EBI-2514791,EBI-2932492
USHBP1 [Q8N6Y0]3EBI-2514791,EBI-739895
VPS37C [A5D8V6]3EBI-2514791,EBI-2559305
VPS52 [Q8N1B4]3EBI-2514791,EBI-2799833
WASHC3 [Q9Y3C0]10EBI-2514791,EBI-712969
Isoform 2 [Q96CS2-2]
With#Exp.IntAct
CEP70 [Q8NHQ1]3EBI-11742270,EBI-739624

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
125412, 160 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1847, HAUS complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q96CS2

Database of interacting proteins

More...
DIPi
DIP-48835N

Protein interaction database and analysis system

More...
IntActi
Q96CS2, 129 interactors

Molecular INTeraction database

More...
MINTi
Q96CS2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000282058

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96CS2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96CS2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili49 – 79Sequence analysisAdd BLAST31
Coiled coili124 – 177Sequence analysisAdd BLAST54
Coiled coili249 – 277Sequence analysisAdd BLAST29

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the HAUS1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QSQA, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006029

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_063322_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96CS2

KEGG Orthology (KO)

More...
KOi
K16584

Identification of Orthologs from Complete Genome Data

More...
OMAi
EEFRCGI

Database of Orthologous Groups

More...
OrthoDBi
1350537at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96CS2

TreeFam database of animal gene trees

More...
TreeFami
TF331717

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026243, HAUS1

The PANTHER Classification System

More...
PANTHERi
PTHR31570, PTHR31570, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR02087, HAUSAUGMINL1

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96CS2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPQEERETQ VAAWLKKIFG DHPIPQYEVN PRTTEILHHL SERNRVRDRD
60 70 80 90 100
VYLVIEDLKQ KASEYESEAK YLQDLLMESV NFSPANLSST GSRYLNALVD
110 120 130 140 150
SAVALETKDT SLASFIPAVN DLTSDLFRTK SKSEEIKIEL EKLEKNLTAT
160 170 180 190 200
LVLEKCLQED VKKAELHLST ERAKVDNRRQ NMDFLKAKSE EFRFGIKAAE
210 220 230 240 250
EQLSARGMDA SLSHQSLVAL SEKLARLKQQ TIPLKKKLES YLDLMPNPSL
260 270
AQVKIEEAKR ELDSIEAELT RRVDMMEL
Length:278
Mass (Da):31,863
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i06F6A1B9FCF0698A
GO
Isoform 2 (identifier: Q96CS2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: Missing.

Show »
Length:202
Mass (Da):22,744
Checksum:i9DD7AC01253BEFB7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ES67K7ES67_HUMAN
HAUS augmin-like complex subunit 1
HAUS1
107Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQT8K7EQT8_HUMAN
HAUS augmin-like complex subunit 1
HAUS1
123Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJA9K7EJA9_HUMAN
HAUS augmin-like complex subunit 1
HAUS1
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EK72K7EK72_HUMAN
HAUS augmin-like complex subunit 1
HAUS1
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EKH4K7EKH4_HUMAN
HAUS augmin-like complex subunit 1
HAUS1
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EM54K7EM54_HUMAN
HAUS augmin-like complex subunit 1
HAUS1
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC05036 differs from that shown. Reason: Frameshift.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0107811 – 76Missing in isoform 2. 1 PublicationAdd BLAST76

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY360137 mRNA Translation: AAQ63649.1
AK097403 mRNA Translation: BAC05036.1 Frameshift.
AK315605 mRNA Translation: BAG37974.1
BC005958 mRNA Translation: AAH05958.1
BC014003 mRNA Translation: AAH14003.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS11928.1 [Q96CS2-1]

NCBI Reference Sequences

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RefSeqi
NP_612452.1, NM_138443.3 [Q96CS2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000282058; ENSP00000282058; ENSG00000152240 [Q96CS2-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
115106

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:115106

UCSC genome browser

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UCSCi
uc002lbu.3, human [Q96CS2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY360137 mRNA Translation: AAQ63649.1
AK097403 mRNA Translation: BAC05036.1 Frameshift.
AK315605 mRNA Translation: BAG37974.1
BC005958 mRNA Translation: AAH05958.1
BC014003 mRNA Translation: AAH14003.1
CCDSiCCDS11928.1 [Q96CS2-1]
RefSeqiNP_612452.1, NM_138443.3 [Q96CS2-1]

3D structure databases

SMRiQ96CS2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi125412, 160 interactors
ComplexPortaliCPX-1847, HAUS complex
CORUMiQ96CS2
DIPiDIP-48835N
IntActiQ96CS2, 129 interactors
MINTiQ96CS2
STRINGi9606.ENSP00000282058

PTM databases

iPTMnetiQ96CS2
PhosphoSitePlusiQ96CS2

Polymorphism and mutation databases

BioMutaiHAUS1
DMDMi50400607

Proteomic databases

EPDiQ96CS2
jPOSTiQ96CS2
MassIVEiQ96CS2
MaxQBiQ96CS2
PaxDbiQ96CS2
PeptideAtlasiQ96CS2
PRIDEiQ96CS2
ProteomicsDBi76212 [Q96CS2-1]
76213 [Q96CS2-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
22454, 100 antibodies

Genome annotation databases

EnsembliENST00000282058; ENSP00000282058; ENSG00000152240 [Q96CS2-1]
GeneIDi115106
KEGGihsa:115106
UCSCiuc002lbu.3, human [Q96CS2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
115106
DisGeNETi115106
EuPathDBiHostDB:ENSG00000152240.12

GeneCards: human genes, protein and diseases

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GeneCardsi
HAUS1
HGNCiHGNC:25174, HAUS1
HPAiENSG00000152240, Low tissue specificity
MIMi608775, gene
neXtProtiNX_Q96CS2
OpenTargetsiENSG00000152240
PharmGKBiPA165429013

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QSQA, Eukaryota
GeneTreeiENSGT00390000006029
HOGENOMiCLU_063322_0_0_1
InParanoidiQ96CS2
KOiK16584
OMAiEEFRCGI
OrthoDBi1350537at2759
PhylomeDBiQ96CS2
TreeFamiTF331717

Enzyme and pathway databases

PathwayCommonsiQ96CS2
ReactomeiR-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259, Loss of Nlp from mitotic centrosomes
R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320, Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912, Anchoring of the basal body to the plasma membrane
R-HSA-8854518, AURKA Activation by TPX2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
115106, 726 hits in 881 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
HAUS1, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CCDC5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
115106
PharosiQ96CS2, Tbio

Protein Ontology

More...
PROi
PR:Q96CS2
RNActiQ96CS2, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000152240, Expressed in subventricular zone (inner) (primate) and 203 other tissues
ExpressionAtlasiQ96CS2, baseline and differential
GenevisibleiQ96CS2, HS

Family and domain databases

InterProiView protein in InterPro
IPR026243, HAUS1
PANTHERiPTHR31570, PTHR31570, 1 hit
PRINTSiPR02087, HAUSAUGMINL1

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHAUS1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96CS2
Secondary accession number(s): B2RDM7, Q8N837
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: December 1, 2001
Last modified: October 7, 2020
This is version 156 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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