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UniProtKB - Q96CQ1 (S2536_HUMAN)

Entry version 156 (25 May 2022)
Sequence version 1 (01 Dec 2001)
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Protein

Solute carrier family 25 member 36

Gene

SLC25A36

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Transports preferentially cytosine and uracil (deoxy)nucleoside mono-, di-, and triphosphates by uniport and antiport mechanism. Also transports guanine but not adenine (deoxy)nucleotides. Is inhibited strongly by pyridoxal 5'-phosphate, 4,7-diphenyl-1,10-phenanthroline, tannic acid, and mercurials (mercury dichloride, Mersalyl acid, p-hydroxymercuribenzoate). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration.

1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

The inhibitory constants (Ki) of these compounds are 1.3 um (UTP), 224 um (CTP), 276 um (GTP), and 181 um (ITP). CTP is the best substrate.1 Publication
  1. KM=1.19 mM for UTP (at 25 degrees Celsius)1 Publication
  2. KM=0.21 mM for CTP (at 25 degrees Celsius)1 Publication
  3. KM=2.5 mM for TTP (at 25 degrees Celsius)1 Publication
  4. KM=0.23 mM for GTP (at 25 degrees Celsius)1 Publication
  1. Vmax=30.7 µmol/min/g enzyme toward UTP (at 25 degrees Celsius)1 Publication
  2. Vmax=51.2 µmol/min/g enzyme toward CTP (at 25 degrees Celsius)1 Publication
  3. Vmax=8 µmol/min/g enzyme toward TTP (at 25 degrees Celsius)1 Publication
  4. Vmax=23.6 µmol/min/g enzyme toward GTP (at 25 degrees Celsius)1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96CQ1

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q96CQ1

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.29.10.6, the mitochondrial carrier (mc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier family 25 member 36
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC25A36
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:25554, SLC25A36

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		616149, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96CQ1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000114120

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei7 – 27Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei41 – 57Helical; Name=2Sequence analysisAdd BLAST17
Transmembranei111 – 131Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei180 – 200Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei226 – 246Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei291 – 311Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		55186

Open Targets

More...OpenTargetsi		ENSG00000114120

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142670908

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96CQ1, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SLC25A36

Domain mapping of disease mutations (DMDM)

More...DMDMi		74760768

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002917971 – 311Solute carrier family 25 member 36Add BLAST311

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96CQ1

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96CQ1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96CQ1

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96CQ1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96CQ1

PeptideAtlas

More...PeptideAtlasi		Q96CQ1

PRoteomics IDEntifications database

More...PRIDEi		Q96CQ1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		76207 [Q96CQ1-1]
76208 [Q96CQ1-2]
76209 [Q96CQ1-3]
76210 [Q96CQ1-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96CQ1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96CQ1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at moderate level.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000114120, Expressed in caput epididymis and 251 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96CQ1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96CQ1, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000114120, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120484, 7 interactors

Protein interaction database and analysis system

More...IntActi		Q96CQ1, 4 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000320688

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96CQ1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q96CQ1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96CQ1

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati4 – 108Solcar 1PROSITE-ProRule annotationAdd BLAST105
Repeati116 – 203Solcar 2PROSITE-ProRule annotationAdd BLAST88
Repeati224 – 308Solcar 3PROSITE-ProRule annotationAdd BLAST85

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0757, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154369

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_015166_6_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96CQ1

Identification of Orthologs from Complete Genome Data

More...OMAi		HVHEGWR

Database of Orthologous Groups

More...OrthoDBi		1372287at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96CQ1

TreeFam database of animal gene trees

More...TreeFami		TF314220

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.50.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002067, Mit_carrier
IPR018108, Mitochondrial_sb/sol_carrier
IPR023395, Mt_carrier_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00153, Mito_carr, 3 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00926, MITOCARRIER

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF103506, SSF103506, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50920, SOLCAR, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96CQ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSQRDTLVHL FAGGCGGTVG AILTCPLEVV KTRLQSSSVT LYISEVQLNT 
        60         70         80         90        100
MAGASVNRVV SPGPLHCLKV ILEKEGPRSL FRGLGPNLVG VAPSRAIYFA 
       110        120        130        140        150
AYSNCKEKLN DVFDPDSTQV HMISAAMAGF TAITATNPIW LIKTRLQLDA 
       160        170        180        190        200
RNRGERRMGA FECVRKVYQT DGLKGFYRGM SASYAGISET VIHFVIYESI 
       210        220        230        240        250
KQKLLEYKTA STMENDEESV KEASDFVGMM LAAATSKTCA TTIAYPHEVV 
       260        270        280        290        300
RTRLREEGTK YRSFFQTLSL LVQEEGYGSL YRGLTTHLVR QIPNTAIMMA 
       310 
TYELVVYLLN G
Length:311
Mass (Da):34,283
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD87DFDF7BC992D83
GO
Isoform 2 (identifier: Q96CQ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     130-132: FTA → HFL
     133-311: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:132
Mass (Da):14,046
Checksum:i4763D55F1DE496D2
GO
Isoform 3 (identifier: Q96CQ1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     248-248: Missing.

Show »
Length:310
Mass (Da):34,153
Checksum:iF0D02800320CF2B9
GO
Isoform 4 (identifier: Q96CQ1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-157: Missing.

Show »
Length:154
Mass (Da):17,358
Checksum:iC4CE38F1CB1F9B69
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KQA4J3KQA4_HUMAN
Solute carrier family 25 member 36
SLC25A36
285Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RCF5D6RCF5_HUMAN
Solute carrier family 25 member 36
SLC25A36
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6SDC8F6SDC8_HUMAN
Solute carrier family 25 member 36
SLC25A36
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RB26D6RB26_HUMAN
Solute carrier family 25 member 36
SLC25A36
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ISS3A0A3B3ISS3_HUMAN
Solute carrier family 25 member 36
SLC25A36
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R8Y3D6R8Y3_HUMAN
Solute carrier family 25 member 36
SLC25A36
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti216D → G in BAA91715 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0355171 – 157Missing in isoform 4. CuratedAdd BLAST157
Alternative sequenceiVSP_026240130 – 132FTA → HFL in isoform 2. 1 Publication3
Alternative sequenceiVSP_026241133 – 311Missing in isoform 2. 1 PublicationAdd BLAST179
Alternative sequenceiVSP_026242248Missing in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK001480 mRNA Translation: BAA91715.1
AC108727 Genomic DNA No translation available.
AC132032 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79012.1
CH471052 Genomic DNA Translation: EAW79013.1
BC014064 mRNA Translation: AAH14064.1
BC019859 mRNA No translation available.
AL136803 mRNA Translation: CAB66737.2

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3114.1 [Q96CQ1-3]
CCDS46927.1 [Q96CQ1-1]

NCBI Reference Sequences

More...RefSeqi		NP_001098117.1, NM_001104647.1 [Q96CQ1-1]
NP_060625.2, NM_018155.2 [Q96CQ1-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000324194.12; ENSP00000320688.6; ENSG00000114120.14
ENST00000446041.6; ENSP00000401938.2; ENSG00000114120.14 [Q96CQ1-3]
ENST00000502594.5; ENSP00000423319.1; ENSG00000114120.14 [Q96CQ1-2]
ENST00000631654.1; ENSP00000487839.1; ENSG00000114120.14 [Q96CQ1-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55186

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55186

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000324194.12; ENSP00000320688.6; NM_001104647.3; NP_001098117.1

UCSC genome browser

More...UCSCi		uc003etr.3, human [Q96CQ1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001480 mRNA Translation: BAA91715.1
AC108727 Genomic DNA No translation available.
AC132032 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79012.1
CH471052 Genomic DNA Translation: EAW79013.1
BC014064 mRNA Translation: AAH14064.1
BC019859 mRNA No translation available.
AL136803 mRNA Translation: CAB66737.2
CCDSiCCDS3114.1 [Q96CQ1-3]
CCDS46927.1 [Q96CQ1-1]
RefSeqiNP_001098117.1, NM_001104647.1 [Q96CQ1-1]
NP_060625.2, NM_018155.2 [Q96CQ1-3]

3D structure databases

AlphaFoldDBiQ96CQ1
SMRiQ96CQ1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120484, 7 interactors
IntActiQ96CQ1, 4 interactors
STRINGi9606.ENSP00000320688

Protein family/group databases

TCDBi2.A.29.10.6, the mitochondrial carrier (mc) family

PTM databases

iPTMnetiQ96CQ1
PhosphoSitePlusiQ96CQ1

Genetic variation databases

BioMutaiSLC25A36
DMDMi74760768

Proteomic databases

EPDiQ96CQ1
jPOSTiQ96CQ1
MassIVEiQ96CQ1
MaxQBiQ96CQ1
PaxDbiQ96CQ1
PeptideAtlasiQ96CQ1
PRIDEiQ96CQ1
ProteomicsDBi76207 [Q96CQ1-1]
76208 [Q96CQ1-2]
76209 [Q96CQ1-3]
76210 [Q96CQ1-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		18006, 73 antibodies from 15 providers

The DNASU plasmid repository

More...DNASUi		55186

Genome annotation databases

EnsembliENST00000324194.12; ENSP00000320688.6; ENSG00000114120.14
ENST00000446041.6; ENSP00000401938.2; ENSG00000114120.14 [Q96CQ1-3]
ENST00000502594.5; ENSP00000423319.1; ENSG00000114120.14 [Q96CQ1-2]
ENST00000631654.1; ENSP00000487839.1; ENSG00000114120.14 [Q96CQ1-2]
GeneIDi55186
KEGGihsa:55186
MANE-SelectiENST00000324194.12; ENSP00000320688.6; NM_001104647.3; NP_001098117.1
UCSCiuc003etr.3, human [Q96CQ1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55186
DisGeNETi55186

GeneCards: human genes, protein and diseases

More...GeneCardsi		SLC25A36
HGNCiHGNC:25554, SLC25A36
HPAiENSG00000114120, Low tissue specificity
MIMi616149, gene
neXtProtiNX_Q96CQ1
OpenTargetsiENSG00000114120
PharmGKBiPA142670908
VEuPathDBiHostDB:ENSG00000114120

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0757, Eukaryota
GeneTreeiENSGT00940000154369
HOGENOMiCLU_015166_6_0_1
InParanoidiQ96CQ1
OMAiHVHEGWR
OrthoDBi1372287at2759
PhylomeDBiQ96CQ1
TreeFamiTF314220

Enzyme and pathway databases

PathwayCommonsiQ96CQ1
SignaLinkiQ96CQ1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		55186, 16 hits in 1077 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SLC25A36, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55186
PharosiQ96CQ1, Tbio

Protein Ontology

More...PROi		PR:Q96CQ1
RNActiQ96CQ1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000114120, Expressed in caput epididymis and 251 other tissues
ExpressionAtlasiQ96CQ1, baseline and differential
GenevisibleiQ96CQ1, HS

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002067, Mit_carrier
IPR018108, Mitochondrial_sb/sol_carrier
IPR023395, Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153, Mito_carr, 3 hits
PRINTSiPR00926, MITOCARRIER
SUPFAMiSSF103506, SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920, SOLCAR, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS2536_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96CQ1
Secondary accession number(s): A8MYF7
, Q05CY1, Q9H0G8, Q9NVN5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: December 1, 2001
Last modified: May 25, 2022
This is version 156 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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