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UniProtKB - Q96CQ1 (S2536_HUMAN)

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Protein

Solute carrier family 25 member 36

Gene

SLC25A36

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Transports preferentially cytosine and uracil (deoxy)nucleoside mono-, di-, and triphosphates by uniport and antiport mechanism. Also transports guanine but not adenine (deoxy)nucleotides. Is inhibited strongly by pyridoxal 5'-phosphate, 4,7-diphenyl-1,10-phenanthroline, tannic acid, and mercurials (mercury dichloride, Mersalyl acid, p-hydroxymercuribenzoate). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration.1 Publication

Kineticsi

The inhibitory constants (Ki) of these compounds are 1.3 um (UTP), 224 um (CTP), 276 um (GTP), and 181 um (ITP). CTP is the best substrate.1 Publication
  1. KM=1.19 mM for UTP (at 25 degrees Celsius)1 Publication
  2. KM=0.21 mM for CTP (at 25 degrees Celsius)1 Publication
  3. KM=2.5 mM for TTP (at 25 degrees Celsius)1 Publication
  4. KM=0.23 mM for GTP (at 25 degrees Celsius)1 Publication
  1. Vmax=30.7 µmol/min/g enzyme toward UTP (at 25 degrees Celsius)1 Publication
  2. Vmax=51.2 µmol/min/g enzyme toward CTP (at 25 degrees Celsius)1 Publication
  3. Vmax=8 µmol/min/g enzyme toward TTP (at 25 degrees Celsius)1 Publication
  4. Vmax=23.6 µmol/min/g enzyme toward GTP (at 25 degrees Celsius)1 Publication

GO - Molecular functioni

  • pyrimidine nucleotide transmembrane transporter activity Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

  • mitochondrial genome maintenance Source: UniProtKB
  • mitochondrial transport Source: GO_Central
  • mitochondrion organization Source: UniProtKB
  • pyrimidine nucleotide import into mitochondrion Source: GO_Central
  • pyrimidine nucleotide transport Source: UniProtKB
  • regulation of mitochondrial membrane potential Source: UniProtKB
View the complete GO annotation on QuickGO ...

Keywordsi

Biological processTransport

Protein family/group databases

TCDBi2.A.29.10.6 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 36
Gene namesi
Name:SLC25A36
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000114120.11
HGNCiHGNC:25554 SLC25A36
MIMi616149 gene
neXtProtiNX_Q96CQ1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 27Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei41 – 57Helical; Name=2Sequence analysisAdd BLAST17
Transmembranei111 – 131Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei180 – 200Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei226 – 246Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei291 – 311Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi55186
OpenTargetsiENSG00000114120
PharmGKBiPA142670908

Polymorphism and mutation databases

BioMutaiSLC25A36
DMDMi74760768

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002917971 – 311Solute carrier family 25 member 36Add BLAST311

Proteomic databases

EPDiQ96CQ1
MaxQBiQ96CQ1
PaxDbiQ96CQ1
PeptideAtlasiQ96CQ1
PRIDEiQ96CQ1
ProteomicsDBi76207
76208 [Q96CQ1-2]
76209 [Q96CQ1-3]
76210 [Q96CQ1-4]

PTM databases

iPTMnetiQ96CQ1
PhosphoSitePlusiQ96CQ1

Expressioni

Tissue specificityi

Expressed at moderate level.1 Publication

Gene expression databases

BgeeiENSG00000114120
CleanExiHS_SLC25A36
ExpressionAtlasiQ96CQ1 baseline and differential
GenevisibleiQ96CQ1 HS

Organism-specific databases

HPAiHPA027036

Interactioni

Protein-protein interaction databases

BioGridi120484, 4 interactors
IntActiQ96CQ1, 1 interactor
STRINGi9606.ENSP00000320688

Structurei

3D structure databases

ProteinModelPortaliQ96CQ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati4 – 108Solcar 1PROSITE-ProRule annotationAdd BLAST105
Repeati116 – 203Solcar 2PROSITE-ProRule annotationAdd BLAST88
Repeati224 – 308Solcar 3PROSITE-ProRule annotationAdd BLAST85

Sequence similaritiesi

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0757 Eukaryota
ENOG410XS20 LUCA
GeneTreeiENSGT00550000074670
HOGENOMiHOG000188210
HOVERGENiHBG059891
InParanoidiQ96CQ1
KOiK15116
OMAiESTLQWV
OrthoDBiEOG091G0BCW
PhylomeDBiQ96CQ1
TreeFamiTF314220

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96CQ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSQRDTLVHL FAGGCGGTVG AILTCPLEVV KTRLQSSSVT LYISEVQLNT 
        60         70         80         90        100
MAGASVNRVV SPGPLHCLKV ILEKEGPRSL FRGLGPNLVG VAPSRAIYFA 
       110        120        130        140        150
AYSNCKEKLN DVFDPDSTQV HMISAAMAGF TAITATNPIW LIKTRLQLDA 
       160        170        180        190        200
RNRGERRMGA FECVRKVYQT DGLKGFYRGM SASYAGISET VIHFVIYESI 
       210        220        230        240        250
KQKLLEYKTA STMENDEESV KEASDFVGMM LAAATSKTCA TTIAYPHEVV 
       260        270        280        290        300
RTRLREEGTK YRSFFQTLSL LVQEEGYGSL YRGLTTHLVR QIPNTAIMMA 
       310 
TYELVVYLLN G
Length:311
Mass (Da):34,283
Last modified:December 1, 2001 - v1
Checksum:iD87DFDF7BC992D83
GO
Isoform 2 (identifier: Q96CQ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     130-132: FTA → HFL
     133-311: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:132
Mass (Da):14,046
Checksum:i4763D55F1DE496D2
GO
Isoform 3 (identifier: Q96CQ1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     248-248: Missing.

Note: No experimental confirmation available.
Show »
Length:310
Mass (Da):34,153
Checksum:iF0D02800320CF2B9
GO
Isoform 4 (identifier: Q96CQ1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-157: Missing.

Note: Gene prediction based on EST data.
Show »
Length:154
Mass (Da):17,358
Checksum:iC4CE38F1CB1F9B69
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti216D → G in BAA91715 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0355171 – 157Missing in isoform 4. CuratedAdd BLAST157
Alternative sequenceiVSP_026240130 – 132FTA → HFL in isoform 2. 1 Publication3
Alternative sequenceiVSP_026241133 – 311Missing in isoform 2. 1 PublicationAdd BLAST179
Alternative sequenceiVSP_026242248Missing in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001480 mRNA Translation: BAA91715.1
AC108727 Genomic DNA No translation available.
AC132032 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79012.1
CH471052 Genomic DNA Translation: EAW79013.1
BC014064 mRNA Translation: AAH14064.1
BC019859 mRNA No translation available.
AL136803 mRNA Translation: CAB66737.2
CCDSiCCDS3114.1 [Q96CQ1-3]
CCDS46927.1 [Q96CQ1-1]
RefSeqiNP_001098117.1, NM_001104647.1 [Q96CQ1-1]
NP_060625.2, NM_018155.2 [Q96CQ1-3]
UniGeneiHs.144130

Genome annotation databases

EnsembliENST00000324194; ENSP00000320688; ENSG00000114120 [Q96CQ1-1]
ENST00000446041; ENSP00000401938; ENSG00000114120 [Q96CQ1-3]
ENST00000502594; ENSP00000423319; ENSG00000114120 [Q96CQ1-2]
ENST00000631654; ENSP00000487839; ENSG00000114120 [Q96CQ1-2]
GeneIDi55186
KEGGihsa:55186
UCSCiuc003etr.3 human [Q96CQ1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiS2536_HUMAN
AccessioniPrimary (citable) accession number: Q96CQ1
Secondary accession number(s): A8MYF7
, Q05CY1, Q9H0G8, Q9NVN5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: December 1, 2001
Last modified: July 18, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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