UniProtKB - Q96CQ1 (S2536_HUMAN)
Solute carrier family 25 member 36
SLC25A36
Functioni
Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Transports preferentially cytosine and uracil (deoxy)nucleoside mono-, di-, and triphosphates by uniport and antiport mechanism. Also transports guanine but not adenine (deoxy)nucleotides. Is inhibited strongly by pyridoxal 5'-phosphate, 4,7-diphenyl-1,10-phenanthroline, tannic acid, and mercurials (mercury dichloride, Mersalyl acid, p-hydroxymercuribenzoate). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration.
1 PublicationKineticsi
- KM=1.19 mM for UTP (at 25 degrees Celsius)1 Publication
- KM=0.21 mM for CTP (at 25 degrees Celsius)1 Publication
- KM=2.5 mM for TTP (at 25 degrees Celsius)1 Publication
- KM=0.23 mM for GTP (at 25 degrees Celsius)1 Publication
- Vmax=30.7 µmol/min/g enzyme toward UTP (at 25 degrees Celsius)1 Publication
- Vmax=51.2 µmol/min/g enzyme toward CTP (at 25 degrees Celsius)1 Publication
- Vmax=8 µmol/min/g enzyme toward TTP (at 25 degrees Celsius)1 Publication
- Vmax=23.6 µmol/min/g enzyme toward GTP (at 25 degrees Celsius)1 Publication
GO - Molecular functioni
- pyrimidine nucleotide transmembrane transporter activity Source: UniProtKB
GO - Biological processi
- mitochondrial genome maintenance Source: UniProtKB
- mitochondrion organization Source: UniProtKB
- pyrimidine nucleotide import into mitochondrion Source: GO_Central
- pyrimidine nucleotide transport Source: UniProtKB
- regulation of mitochondrial membrane potential Source: UniProtKB
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
PathwayCommonsi | Q96CQ1 |
SignaLinki | Q96CQ1 |
Protein family/group databases
TCDBi | 2.A.29.10.6, the mitochondrial carrier (mc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Solute carrier family 25 member 36 |
Gene namesi | Name:SLC25A36 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25554, SLC25A36 |
MIMi | 616149, gene |
neXtProti | NX_Q96CQ1 |
VEuPathDBi | HostDB:ENSG00000114120 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB-SubCell
- mitochondrion Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 7 – 27 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Transmembranei | 41 – 57 | Helical; Name=2Sequence analysisAdd BLAST | 17 | |
Transmembranei | 111 – 131 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Transmembranei | 180 – 200 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Transmembranei | 226 – 246 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Transmembranei | 291 – 311 | Helical; Name=6Sequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePathology & Biotechi
Organism-specific databases
DisGeNETi | 55186 |
OpenTargetsi | ENSG00000114120 |
PharmGKBi | PA142670908 |
Miscellaneous databases
Pharosi | Q96CQ1, Tbio |
Genetic variation databases
BioMutai | SLC25A36 |
DMDMi | 74760768 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000291797 | 1 – 311 | Solute carrier family 25 member 36Add BLAST | 311 |
Proteomic databases
EPDi | Q96CQ1 |
jPOSTi | Q96CQ1 |
MassIVEi | Q96CQ1 |
MaxQBi | Q96CQ1 |
PaxDbi | Q96CQ1 |
PeptideAtlasi | Q96CQ1 |
PRIDEi | Q96CQ1 |
ProteomicsDBi | 76207 [Q96CQ1-1] 76208 [Q96CQ1-2] 76209 [Q96CQ1-3] 76210 [Q96CQ1-4] |
PTM databases
iPTMneti | Q96CQ1 |
PhosphoSitePlusi | Q96CQ1 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000114120, Expressed in caput epididymis and 251 other tissues |
ExpressionAtlasi | Q96CQ1, baseline and differential |
Genevisiblei | Q96CQ1, HS |
Organism-specific databases
HPAi | ENSG00000114120, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 120484, 7 interactors |
IntActi | Q96CQ1, 4 interactors |
STRINGi | 9606.ENSP00000320688 |
Miscellaneous databases
RNActi | Q96CQ1, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 4 – 108 | Solcar 1PROSITE-ProRule annotationAdd BLAST | 105 | |
Repeati | 116 – 203 | Solcar 2PROSITE-ProRule annotationAdd BLAST | 88 | |
Repeati | 224 – 308 | Solcar 3PROSITE-ProRule annotationAdd BLAST | 85 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0757, Eukaryota |
GeneTreei | ENSGT00940000154369 |
HOGENOMi | CLU_015166_6_0_1 |
InParanoidi | Q96CQ1 |
OMAi | HVHEGWR |
OrthoDBi | 1372287at2759 |
PhylomeDBi | Q96CQ1 |
TreeFami | TF314220 |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR002067, Mit_carrier IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
PRINTSi | PR00926, MITOCARRIER |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSQRDTLVHL FAGGCGGTVG AILTCPLEVV KTRLQSSSVT LYISEVQLNT
60 70 80 90 100
MAGASVNRVV SPGPLHCLKV ILEKEGPRSL FRGLGPNLVG VAPSRAIYFA
110 120 130 140 150
AYSNCKEKLN DVFDPDSTQV HMISAAMAGF TAITATNPIW LIKTRLQLDA
160 170 180 190 200
RNRGERRMGA FECVRKVYQT DGLKGFYRGM SASYAGISET VIHFVIYESI
210 220 230 240 250
KQKLLEYKTA STMENDEESV KEASDFVGMM LAAATSKTCA TTIAYPHEVV
260 270 280 290 300
RTRLREEGTK YRSFFQTLSL LVQEEGYGSL YRGLTTHLVR QIPNTAIMMA
310
TYELVVYLLN G
The sequence of this isoform differs from the canonical sequence as follows:
130-132: FTA → HFL
133-311: Missing.
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KQA4 | J3KQA4_HUMAN | Solute carrier family 25 member 36 | SLC25A36 | 285 | Annotation score: | ||
D6RCF5 | D6RCF5_HUMAN | Solute carrier family 25 member 36 | SLC25A36 | 89 | Annotation score: | ||
F6SDC8 | F6SDC8_HUMAN | Solute carrier family 25 member 36 | SLC25A36 | 132 | Annotation score: | ||
D6RB26 | D6RB26_HUMAN | Solute carrier family 25 member 36 | SLC25A36 | 86 | Annotation score: | ||
A0A3B3ISS3 | A0A3B3ISS3_HUMAN | Solute carrier family 25 member 36 | SLC25A36 | 139 | Annotation score: | ||
D6R8Y3 | D6R8Y3_HUMAN | Solute carrier family 25 member 36 | SLC25A36 | 67 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 216 | D → G in BAA91715 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_035517 | 1 – 157 | Missing in isoform 4. CuratedAdd BLAST | 157 | |
Alternative sequenceiVSP_026240 | 130 – 132 | FTA → HFL in isoform 2. 1 Publication | 3 | |
Alternative sequenceiVSP_026241 | 133 – 311 | Missing in isoform 2. 1 PublicationAdd BLAST | 179 | |
Alternative sequenceiVSP_026242 | 248 | Missing in isoform 3. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK001480 mRNA Translation: BAA91715.1 AC108727 Genomic DNA No translation available. AC132032 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW79012.1 CH471052 Genomic DNA Translation: EAW79013.1 BC014064 mRNA Translation: AAH14064.1 BC019859 mRNA No translation available. AL136803 mRNA Translation: CAB66737.2 |
CCDSi | CCDS3114.1 [Q96CQ1-3] CCDS46927.1 [Q96CQ1-1] |
RefSeqi | NP_001098117.1, NM_001104647.1 [Q96CQ1-1] NP_060625.2, NM_018155.2 [Q96CQ1-3] |
Genome annotation databases
Ensembli | ENST00000324194.12; ENSP00000320688.6; ENSG00000114120.14 ENST00000446041.6; ENSP00000401938.2; ENSG00000114120.14 [Q96CQ1-3] ENST00000502594.5; ENSP00000423319.1; ENSG00000114120.14 [Q96CQ1-2] ENST00000631654.1; ENSP00000487839.1; ENSG00000114120.14 [Q96CQ1-2] |
GeneIDi | 55186 |
KEGGi | hsa:55186 |
MANE-Selecti | ENST00000324194.12; ENSP00000320688.6; NM_001104647.3; NP_001098117.1 |
UCSCi | uc003etr.3, human [Q96CQ1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK001480 mRNA Translation: BAA91715.1 AC108727 Genomic DNA No translation available. AC132032 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW79012.1 CH471052 Genomic DNA Translation: EAW79013.1 BC014064 mRNA Translation: AAH14064.1 BC019859 mRNA No translation available. AL136803 mRNA Translation: CAB66737.2 |
CCDSi | CCDS3114.1 [Q96CQ1-3] CCDS46927.1 [Q96CQ1-1] |
RefSeqi | NP_001098117.1, NM_001104647.1 [Q96CQ1-1] NP_060625.2, NM_018155.2 [Q96CQ1-3] |
3D structure databases
AlphaFoldDBi | Q96CQ1 |
SMRi | Q96CQ1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 120484, 7 interactors |
IntActi | Q96CQ1, 4 interactors |
STRINGi | 9606.ENSP00000320688 |
Protein family/group databases
TCDBi | 2.A.29.10.6, the mitochondrial carrier (mc) family |
PTM databases
iPTMneti | Q96CQ1 |
PhosphoSitePlusi | Q96CQ1 |
Genetic variation databases
BioMutai | SLC25A36 |
DMDMi | 74760768 |
Proteomic databases
EPDi | Q96CQ1 |
jPOSTi | Q96CQ1 |
MassIVEi | Q96CQ1 |
MaxQBi | Q96CQ1 |
PaxDbi | Q96CQ1 |
PeptideAtlasi | Q96CQ1 |
PRIDEi | Q96CQ1 |
ProteomicsDBi | 76207 [Q96CQ1-1] 76208 [Q96CQ1-2] 76209 [Q96CQ1-3] 76210 [Q96CQ1-4] |
Protocols and materials databases
Antibodypediai | 18006, 73 antibodies from 15 providers |
DNASUi | 55186 |
Genome annotation databases
Ensembli | ENST00000324194.12; ENSP00000320688.6; ENSG00000114120.14 ENST00000446041.6; ENSP00000401938.2; ENSG00000114120.14 [Q96CQ1-3] ENST00000502594.5; ENSP00000423319.1; ENSG00000114120.14 [Q96CQ1-2] ENST00000631654.1; ENSP00000487839.1; ENSG00000114120.14 [Q96CQ1-2] |
GeneIDi | 55186 |
KEGGi | hsa:55186 |
MANE-Selecti | ENST00000324194.12; ENSP00000320688.6; NM_001104647.3; NP_001098117.1 |
UCSCi | uc003etr.3, human [Q96CQ1-1] |
Organism-specific databases
CTDi | 55186 |
DisGeNETi | 55186 |
GeneCardsi | SLC25A36 |
HGNCi | HGNC:25554, SLC25A36 |
HPAi | ENSG00000114120, Low tissue specificity |
MIMi | 616149, gene |
neXtProti | NX_Q96CQ1 |
OpenTargetsi | ENSG00000114120 |
PharmGKBi | PA142670908 |
VEuPathDBi | HostDB:ENSG00000114120 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0757, Eukaryota |
GeneTreei | ENSGT00940000154369 |
HOGENOMi | CLU_015166_6_0_1 |
InParanoidi | Q96CQ1 |
OMAi | HVHEGWR |
OrthoDBi | 1372287at2759 |
PhylomeDBi | Q96CQ1 |
TreeFami | TF314220 |
Enzyme and pathway databases
PathwayCommonsi | Q96CQ1 |
SignaLinki | Q96CQ1 |
Miscellaneous databases
BioGRID-ORCSi | 55186, 16 hits in 1077 CRISPR screens |
ChiTaRSi | SLC25A36, human |
GenomeRNAii | 55186 |
Pharosi | Q96CQ1, Tbio |
PROi | PR:Q96CQ1 |
RNActi | Q96CQ1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000114120, Expressed in caput epididymis and 251 other tissues |
ExpressionAtlasi | Q96CQ1, baseline and differential |
Genevisiblei | Q96CQ1, HS |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR002067, Mit_carrier IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
PRINTSi | PR00926, MITOCARRIER |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | S2536_HUMAN | |
Accessioni | Q96CQ1Primary (citable) accession number: Q96CQ1 Secondary accession number(s): A8MYF7 Q9NVN5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 26, 2007 |
Last sequence update: | December 1, 2001 | |
Last modified: | May 25, 2022 | |
This is version 156 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families